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GaInX_3(X=S,se,Te):Ultra-low thermal conductivity and excellent thermoelectric performance

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Chinese Physics B 2024年第8期33卷 460-465页

作者：段志福丁长浩丁中科肖威华谢芳罗南南曾犟唐黎明陈克求 Department of Physics School of Physics and ElectronicsHunan UniversityChangsha 410082China College of Physical Science and Engineering Technology Yichun UniversityYichun 336000China

seeking intrinsically low thermal conductivity materials is a viable strategy in the pursuit of high-performance thermoelectric ***,by using first-principles calculations and semiclassical Boltzmann transport theory,we systemically investigate the carrier transport and thermoelectric properties of monolayer Janus GaInX_(3)(X=S,se,Te).It is found that the lattice thermal conductivities can reach values as low as 3.07 W·m^(-1)·K^(-1),1.16 W·m^(-1)·K^(-1)and 0.57 W·m^(-1)·K^(-1)for GaInS_(3),GaInse_(3),and GaInTe_(3),respectively,at room *** notably low thermal conductivity is attributed to strong acoustic-optical phonon coupling caused by the presence of low-frequency optical phonons in GaInX_(3) ***,by integrating the charac teristics of electronic and thermal transport,the dimensionless figure of merit ZT can reach maximum values of 0.95,2.37,and 3.00 for GaInS_(3),GaInse_(3),and GaInTe_(3),*** results suggest that monolayer Janus GaInX_(3)(X=S,se,Te)is a promising candidate for thermoelectric and heat management applications.

关键词： thermoelectric performance thermal conductivity Boltzmann transport two-dimensional materials

GC-MS analysis of volatile compounds of Perilla frutescens Britton var. Japonica accessions: morphological and seasonal variability

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Asian Pacific Journal of Tropical Medicine 2017年第7期10卷 705-714页

作者： Bimal Kumar Ghimire Ji Hye Yoo chang yeon Yu Ill-Min Chung Department of Applied Life Science Konkuk University Bioherb Research Institute Kangwon National University

Objective: To investigate the composition of volatile compounds in the different accessions of Perilla frutescens(P. frutescens) collected from various habitats of China and Japan. Methods: In the present study, the essential oil from the leaves of P. frutescens cultivars from China and Japan was extracted by hydro-distillation and the chemical composition and concentration of the volatile components present in the oils were determined by gas chromatography–mass spectrometry(GC–MS) analysis. Results: Among the volatile components, the major proportion was of perilla ketone, which was followed by elemicin and beta-caryophyllene in the Chinese Perilla cultivars. The main component in the oil extracted from the Japanese accessions was myristicin, which was followed by perilla ketone and beta-caryophyllene. We could distinguish seven chemotypes, namely the perilla ketone(PK) type, perilla ketone, myristicin(PM) type, perilla ketone, unknown(PU) type, perilla ketone, beta-caryophyllene, myristicine(PB) type, perilla ketone, myristicin, unknown(PMU) type, perilla ketone, elemicine, myristicin, beta-caryophyllene(PEMB) type, and the perilla ketone, limonene, betacryophyllene, myristicin(L) type. Most of the accessions possessed higher essential oil content before the flowering time than at the flowering stage. The average plant height, leaf length, leaf width of the Chinese accessions was higher than those of the Japanese accessions. Conclusion:The results revealed that the harvest time and geographical origin caused polymorphisms in the essential oil composition and morphological traits in the Perilla accessions originating from China and Japan. Therefore, these chemotypes with desirable characters might be useful for industrial exploitation and for determining the harvest time.

关键词： Perilla frutescens Essential oil GC–MS analysis Morphological character Harvesting time

Dielectrophoretic assembly of semiconducting single-walled carbon nanotube transistor

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 126-129页

作者： se-Hun KWON Young-Keun JEONG Soongeun KWON Myung-chang KANG Hyung-Woo LEE National Core Research Center for Hybrid Materials Solution Pusan National University Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 305-701 Korea

A novel burning technique for making a semiconducting single-walled carbon nanotubes (SWNTs) transistor assembled by the dielectrophoretic force was suggested. The fabrication process consisted of two steps. First, to align and attach a bundle of SWNTs between the source and drain, the alternating (AC) voltage was applied to the electrodes. When a bundle of SWNTs was connected between two electrodes, some of metallic nanotubes and semi-conducing nanotubes existed together. The second step is to burn the metallic SWNTS by applying the voltage between two electrodes. With increasing the voltage, more current flowed through the metallic SWNTs, thus, the metallic SWNTs burnt earlier than the semiconducting one. This technique enables to obtain only semi-conducting SWNTs connection in the transistor. Through the I—V characteristic graph, the moment of metallic SWNTs burning and the characteristic of semi-conducing nanotubes were verified.

关键词：碳纳米管晶体管单壁碳纳米管束半导体燃烧技术制造过程 SWNTs 管连接特性图

Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

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Bone Research 2015年第1期3卷 40-45页

作者： Douglas J DiGirolamo Vandana Singhal Xiaoli chang se-Jin Lee Emily L Germain-Lee Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Bone & Osteogenesis Imperfecta Department Kennedy Krieger Institute Department of Molecular Biology and Genetics Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University School of Medicine

Osteogenesis imperfecta（OI） comprises a group of heritable connective tissue disorders generally defined by recurrent fractures, low bone mass, short stature and skeletal fragility. Beyond the skeletal complications of OI,many patients also report intolerance to physical activity, fatigue and muscle weakness. Indeed, recent studies have demonstrated that skeletal muscle is also negatively affected by OI, both directly and indirectly. Given the well-established interdependence of bone and skeletal muscle in both physiology and pathophysiology and the observations of skeletal muscle pathology in patients with OI, we investigated the therapeutic potential of simultaneous anabolic targeting of both bone and skeletal muscle using a soluble activin receptor 2B（ACVR2B） in a mouse model of type Ⅲ OI（oim）. Treatment of 12-week-old oim mice with ACVR2 B for 4 weeks resulted in significant increases in both bone and muscle that were similar to those observed in healthy,wild-type littermates. This proof of concept study provides encouraging evidence for a holistic approach to treating the deleterious consequences of OI in the musculoskeletal system.

关键词： bone Administration of soluble activin receptor 2B increases bone and muscle mass in a mouse model of osteogenesis imperfecta

Crystal structure of Arabidopsis thaliana RabA1a

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Journal of Integrative Plant Biology 2019年第2期61卷 93-109页

作者： Ji-Sook Yun Sung Chul Ha Shinae Kim yeon-Gil Kim Hyeran Kim Jeong Ho chang Department of Biology Education Kyungpook National University Beamline Science Division Pohang Accelerator Laboratory 3. Department of Biological Sciences Kangwon National University

RabGTPase is a member of the Ras superfamily of small GTPases, which share a GTP-binding pocket containing highly conserved motifs that promote GTP hydrolysis. In Arabidopsis, the RabA group, which corresponds to the Rabgroup in animals, functions in the recycling of endosomes that control docking and fusion during vesicle transport. However, their molecular mechanisms remain unknown. In this study, we determined the crystal structures of the GDP-bound inactive form and both GppNHp-and GTP-bound active forms of RabA1a, at resolutions of 2.8, 2.6, and 2.6 A?,respectively. A bound sulfate ion in the active site of the GDP-bound structure stabilized Switch Ⅱ by bridging the interaction between a magnesium ion and *** of the two states of RabA1a with Rabproteins revealed clear differences in the Switch Ⅰ and Ⅱ loops. These results suggested that conformational change of the Switch regions of RabA1a, derived by GTP or GDP binding, could maintain subcellular membrane traffic through the specific interaction of effector molecules.

关键词： GDP Crystal structure of Arabidopsis thaliana RabA Figure

伴肠母细胞分化的结直肠腺癌8例临床病理学分析

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中华病理学杂志 2024年第4期53卷 370-376页

作者：汪琪张岩谭聪倪淑娟黄丹常彬盛伟琪王磊复旦大学附属肿瘤医院病理科复旦大学上海医学院肿瘤学系上海200032 上海中医药大学附属曙光医院病理科上海201203

目的探讨伴肠母细胞分化的结直肠腺癌(colorectal adenocarcinoma with enteroblastic differentiation,CAED)临床病理学特征。方法收集复旦大学附属肿瘤医院2017年1月至2023年8月8例CAED,对其组织病理学、免疫组织化学及分子特征和预... 详细信息

目的探讨伴肠母细胞分化的结直肠腺癌(colorectal adenocarcinoma with enteroblastic differentiation,CAED)临床病理学特征。方法收集复旦大学附属肿瘤医院2017年1月至2023年8月8例CAED,对其组织病理学、免疫组织化学及分子特征和预后进行分析,并进行文献复习。结果8例CAED中,男性6例,女性2例,平均年龄为58岁(29~77岁,中位年龄61.5岁),其中5例术前血清甲胎蛋白升高(14.0~286.6μg/L)。4例发生于结肠,4例发生于直肠。2例临床分期为Ⅳ期,初诊时已发生远处转移(1例初诊时发现肝脏转移,1例初诊时发现肺、骨和全身多发淋巴结转移),其余6例为局部进展期(Ⅱ~Ⅲ期),3例术后发生远处转移(肝脏1例、肺1例、腹膜1例),2例患者分别于术后9、24个月死亡。肿瘤由不同比例的肠母细胞分化的腺癌成分(30%~100%)和经典管状腺癌成分构成,前者形态类似胚胎发育时期肠黏膜上皮:立方状或柱状肿瘤细胞排列成管状、乳头状、筛状或实性巢状,胞质透亮。免疫组织化学染色结果显示,肿瘤细胞至少表达一种癌胚蛋白(SALL4、Glypican-3、甲胎蛋白)。3例肿瘤细胞伴鳞状分化。与原发灶相比,转移灶中CAED成分及鳞状分化成分所占比例均增高。原发灶和/或转移灶行KRAS、NRAS、BRAF基因突变检测示:5例为野生型,2例显示KRAS基因第2号外显子(G13D)突变。结论CAED是一种罕见的结直肠恶性肿瘤,恶性程度较高,准确的病理诊断具有预后预测价值。肠母细胞分化的组织学特征,血清甲胎蛋白的增高及癌胚蛋白的表达对于该肿瘤的诊断具有重要的价值。

关键词：结直肠肿瘤腺癌甲胎蛋白肠母细胞分化

Impact of old age on clinical and angiographic characteristics of coronary artery spasm as assessed by acetylcholine provocation test

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Journal of Geriatric Cardiology 2016年第10期13卷 824-829页

作者： Woong Gil Choi Soo Hyun Kim seung-Woon Rha Kang-Yin CHEN Yong-Jian LI Byoung Geol Choi se yeon Choi Jin Won Kim Eung Ju Kim chang Gyu Park Hong seog seo Dong Joo Oh Department of Internal Medicine School of Medicine Kunkuk University Chungbuk South Korea Cardiovascular Center Korea University Guro Hospital Seoul South Korea Department of Cardiology the Second Hospital of Tianjin Medical University Tianjin China Department of Cardiology Nankai Hospital Tianjin Medical University Tianjin China

吸烟并且另外的风险因素作为变体咽峡炎或冠的动脉痉挛(CAS ) 的重要因素众所周知。然而，与冠的动脉痉挛上的年龄有关的临床的特征是 *** 很少与不足道的冠的动脉损害评估了 3155 个连续病人。病人们经历了醋胆素(Ach ) 为 CAS 的正式... 详细信息

吸烟并且另外的风险因素作为变体咽峡炎或冠的动脉痉挛(CAS ) 的重要因素众所周知。然而，与冠的动脉痉挛上的年龄有关的临床的特征是 *** 很少与不足道的冠的动脉损害评估了 3155 个连续病人。病人们经历了醋胆素(Ach ) 为 CAS 的正式就职的挑衅测试。CAS 是被定义 >70% 钠在 Ach 期间变窄冠的动脉挑衅测试。Ach 挑衅测试的结果在年龄组之中被比较；< 45 年(组 1 ) ， 45-54 年(组 2 ) ， 55-64 年(组 3 ) ，和 .ResultsOlder 病人有高血压，糖尿病，而是更低的发生的更高的发生的 65 年(组 4 ) 与更年轻的病人相比当前的吸烟、男性别评价。积极 Ach 挑衅测试发现经常与老化被显示出(47.36% 对 58.3% 对 62.6% 对 61.5% ；P < 0.001 ) 。Multivariate 逻辑分析证明年龄，男性，和心肌的桥牌是学习显示出的在场的 Ach 挑衅 *** 导致的 CAS 的独立预言者老年是为导致 Ach 的重要冠的动脉痉挛的独立预言者。

关键词：试验评估冠状动脉临床特征碱激发老年人乙酰痉挛血管造影

Exosome-guided direct reprogramming of tumor-associated macrophages from protumorigenic to antitumorigenic to fight cancer

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Bioactive Materials 2023年第7期25卷 527-540页

作者： Hyosuk Kim Hyun-Ju Park Hyo Won chang Ji Hyun Back Su Jin Lee Yae Eun Park Eun Hye Kim yeonsun Hong Gijung Kwak Ick Chan Kwon Ji Eun Lee Yoon se Lee Sang Yoon Kim Yoosoo Yang Sun Hwa Kim Medicinal Materials Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Functional Genomics KRIBB School of BioscienceKorea University of Science and Technology(UST)Daejeon34141Republic of Korea Department of Otolaryngology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul05505Republic of Korea Chemical&Biological Integrative Research Center Biomedical Research InstituteKorea Institute of Science and TechnologySeoul02792Republic of Korea Department of Biotechnology College of Life Sciences and BiotechnologyKorea UniversitySeoul02841Republic of Korea Department of Life Sciences Korea UniversitySeoul02841Republic of Korea

Highly immunosuppressive tumor microenvironment containing various protumoral immune cells accelerates malignant transformation and treatment *** particular,tumor-associated macrophages(TAMs),as the predominant infiltrated immune cells in a tumor,play a pivotal role in regulating the immunosuppressive tumor *** a potential therapeutic strategy to counteract TAMs,here we explore an exosome-guided in situ direct reprogramming of tumor-supportive M2-polarized TAMs into tumor-attacking M1-type *** derived from M1-type macrophages(M1-Exo)promote a phenotypic switch from anti-inflammatory M2-like TAMs toward pro-inflammatory M1-type macrophages with high conversion *** M1 macrophages possessing protein-expression profiles similar to those of classically activated M1 macrophages display significantly increased phagocytic function and robust cross-presentation ability,potentiating antitumor immunity surrounding the ***,these M1-Exo also lead to the conversion of human patient-derived TAMs into M1-like macrophages that highly express MHC class II,offering the clinical potential of autologous and allogeneic exosome-guided direct TAM reprogramming for arming macrophages to join the fight against cancer.

关键词： Exosome Cancer therapy Tumor microenvironment Tumor-associated macrophage Direct conversion

Mitochondria-targeting drug conjugates for cytotoxic, anti-oxidizing and sensing purposes:current strategies and future perspectives

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Acta Pharmaceutica Sinica B 2018年第6期8卷 862-880页

作者： Gantumur Battogtokh yeon Su Choi Dong seop Kang Sang Jun Park Min Suk Shim Kang Moo Huh Yong-yeon Cho Joo Young Lee Hye Suk Lee Han chang Kang Department of Pharmacy Integrated Research Institute of Pharmaceutical Sciences and BK21 PLUS Team for Creative Leader Program for Pharmacomics-based Future Pharmacy College of Pharmacy The Catholic University of Korea Division of Bioengineering Incheon National University Department of Polymer Science and Engineering Chungnam National University

mitochondrial-targeting moieties to anticancer drugs, antioxidants and sensor molecules. Among them, the most widely applied mitochondrial targeting moiety is triphenylphosphonium(TPP), which is a delocalized cationic lipid that readily accumulates and penetrates through the mitochondrial membrane due to the highly negative mitochondrial membrane potential. Other moieties, including short peptides,dequalinium, guanidine, rhodamine, and F16, are also known to be promising mitochondrial targeting agents. Direct conjugation of mitochondrial targeting moieties to anticancer drugs, antioxidants and sensors results in increased cytotoxicity, anti-oxidizing activity and sensing activity, respectively,compared with their non-targeting counterparts, especially in drug-resistant cells. Although many mitochondria-targeted anticancer drug conjugates have been investigated in vitro and in vivo, further clinical studies are still needed. On the other hand, several mitochondria-targeting antioxidants have been analyzed in clinical phases I, II and III trials, and one conjugate has been approved for treating eye disease in Russia. There are numerous ongoing studies of mitochondria-targeted sensors.

关键词： Anticancer agents Antioxidants Direct conjugation Mitochondria-targeting sensing agents