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Open Journal of Genetics 2013年第3期3卷 216-223页

作者： Sharon M. Lutz Sunita Sharma John E. Hokanson scott weiss Benjamin Raby Christoph Lange Department of Biostatistics Harvard School of Public Health Boston USA Department of Epidemiology University of Colorado at Denver Aurora USA Institute for Genomic Mathematics University of Bonn Bonn Germany The Channing Division of Network Medicine Department of Medicine Bringham and Women’s Hospital Boston USA

In genetic association studies of complex diseases, endo-phenotypes such as expression profiles, epigenetic data, or clinical intermediate-phenotypes provide insight to understand the underlying biological path of the disease. In such situations, in order to establish the path from the gene to the disease, we have to decide whether the gene acts on the disease phenotype primarily through a specific endo-phenotype or whether the gene influences the disease through an unidentified path which is characterized by different intermediate phenotypes. Here, we address the question that a genetic locus, given its effect on an endo-phenotype, influences the trait of interest primarily through the path of the endo-phenotype. We propose a Bayesian approach that can evaluate the genetic association between the genetic locus and the phenotype of interest in the presence of the genetic effect on the endo-phenotype. Using simulation studies, we verify that our approach has the desired properties and compare this approach with a mediation approach. The proposed Bayesian approach is illustrated by an application to genome-wide association study for childhood asthma (CAMP) that contains expression profiles.

关键词： Expression Profiles Endo-Phenotypes Genetic Association Studies Bayesian Hierarchal Model Pathway Mediation

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柴油机用高性能铸铝活塞

汽车制造业 2011年第11期 70-71,73页

作者： Simon Reichstein Rainer weiss scott Kenningley Klaus Lades Frank Doernenburg 辉门公司

本文介绍了一种用于铸造活塞的全新的过共品铝合金，改进的活塞铸造工艺以及先进的金属重熔技术。

关键词：铸铝活塞性能机用柴油铸造工艺铝合金

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既是大厨又是洗碗工的CEO

风流一代 2018年第12期 11-11页

作者： scott weiss Hotmail A16Z

在一家创业公司中总会有很多工作要做,CEO通常既是大厨又是洗碗工,但是应该如何有成效地分配时间的问题持续困扰着我。'今天该做些什么呢?'每当一轮融资结束后,我便产生这种感觉。我曾经积极地接触其他CEO和创业导师,最常问的一个问题... 详细信息

在一家创业公司中总会有很多工作要做,CEO通常既是大厨又是洗碗工,但是应该如何有成效地分配时间的问题持续困扰着我。'今天该做些什么呢?'每当一轮融资结束后,我便产生这种感觉。我曾经积极地接触其他CEO和创业导师,最常问的一个问题是:'嘿,回想一下。

关键词： CEO 洗碗工

The viscosity at the glass transition of a liquid lubricant

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Friction 2019年第1期7卷 86-91页

作者： scott BAIR Center for High-Pressure Rheology George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology

In the classical study of elastohydrodynamic lubrication(EHL) which does not employ real, measurable viscosity in analysis, the possibility of a glass transition has not been considered in many years. Indeed, the two rheological assumptions of classical EHL, the Newtonian inlet and the equivalence of a traction curve to a flow curve, would not have persisted so long had the pressure dependence of the viscosity been accurately stated. With the recent appearance of viscosity obtained from viscometers in EHL analysis, the possibility of a glass transition in the contact should be reexamined, especially for the fragile traction fluids. This article employs published data for a synthetic cycloaliphatic hydrocarbon to estimate the glass transition viscosity so that, when using real viscosities in EHL simulations, the state of the liquid may be assessed. Far into the glassy state the liquid should be treated as an elastic solid with a yield stress.

关键词： elastohydrodynamic lubrication glass transition high pressure viscosity EHL friction

Searching for new ferroelectrics and multiferroics: A user’s point of view

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npj Computational Materials 2015年第1期1卷 47-55页

作者： JF scott School of Chemistry and School of Physics St Andrews UniversitySt AndrewsFifeScotland

A perspective on computational studies of ferroelectrics and multiferroics is given that emphasises what has yet to be done,along with some subtleties in previously studied *** with the extensive data-mining studies of Abrahams and more recently,Rabe,a survey is given of magnetostrictive effects in antiferromagnetic antiferroelectrics(after Toledano and Toledano),which has an nonmagnetic analogy in the antiferroelectric phase of tris-sarcosine calcium chloride and a reminder of the unusual spin–phonon coupling of Holden et *** systems such as KCoF3 and *** is also paid to field-temperature phase diagrams,finite non-periodic boundary conditions,and processing-dependent structures.

关键词： analogy ferroelectric phonon

Investigation on Liquid Holdup in Vertical Zero Net-Liquid Flow

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Chinese Journal of Chemical Engineering 2001年第3期9卷 284-290页

作者：刘磊 StuartL.scott NationalLab0ratoryofMultiphaseFlowinPowerEngineering Xi＇anJiaotongUniversityXi＇an710049China DepartmentofPetroleumEngineering TexasA＆MUniversityCollegeStationTX77843-3116U.S.A

Zero net-liquid flow (ZNLF) is a special case of upward gas-liquid two-phase flow. It is a phenomenon observed as a gas-liquid mixture flows in a conduit but the net liquid flow rate is zero. Investigation on the liquid holdup of ZNLF is conducted in a vertical ten-meter tube with diameter of 76 mm, both for Newtonian and nonNewtonian fluids. The gas phase is air. The Newtonian fluid is water and the non-Newtonian fluids are water-based guar gel solutions. The correlations developed for predicting liquid holdup on the basis of Lockhart-Martinelli parameter are not suitable to ZNLF. A constitutive correlation for the liquid holdup of vertical ZNLF was put forward by using the mass balance. It is found that the liquid holdup in ZNLF is dependent on both the gas flow rate and the flow distribution coefficient.

关键词： gas-liquid flow two-phase flow complex flow liquid holdup Newtonian fluid non-Newtonian fluid

Numerical Study on the Influence Mechanism of Inlet Distortion on the Stall Margin in a Transonic Axial Rotor

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Journal of Thermal Science 2012年第3期21卷 209-214页

作者： scott C.Morris Hessert Laboratory Department of Mechanical and Aerospace EngineeringUniversity of Notre Dame

A numerical study is conducted to investigate the influence of inlet flow condition on tip leakage flow (TLF) and stall margin in a transonic axial rotor.A commercial software package FLUENT,is used in the *** rotor investigated in this paper is ND_TAC rotor,which is the rotor of one-stage transonic compressor in the University of Notre *** varied inlet flow conditions are *** inlet boundary condition with hub distortion provides higher axial velocity for the incoming flow near tip region than that for the clean inflow,while the incoming main flow possesses lower axial velocity near the tip region at tip distortion inlet boundary *** the total pressure ratio curves for the three inlet flow conditions,it is found that the hub dis-torted inlet boundary condition improves the stall margin,while the tip distorted inlet boundary condition dete-riorates compressor *** axial location of interface between tip leakage flow (TLF) and incoming main flow (MF) in the tip gap and the axial momentum ratio of TLF to MF are further *** is demonstrated that the axial momentum balance is the mechanism for interface *** hub distorted inflow could de-crease the axial momentum ratio,suppress the movement of the interface between TLF and MF towards blade leading edge plane and thus enhance compressor stability.

关键词： Inlet distortion tip leakage flow stall margin axial momentum balance

Drug induced acute pancreatitis: Does it exist?

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World Journal of Gastroenterology 2014年第44期20卷 16529-16534页

作者： scott Tenner Division of Gastroenterology Department of Medicine State University of New York Downstate Medical Center State University of New York

As the incidence of acute pancreatitis continues to rise, establishing the etiology in order to prevent recurrence is important. Although the etiology of acute pancreatitis is not difficult in the majority of patients, almost a quarter of patients are initially labeled as having idiopathic acute pancreatitis. When confronted with a patient with acute pancreatitis and no clear etiology defined as an absence alcoholism, gallstones(ultrasound and/or MRI), a normal triglyceride level, and absence of tumor, it often appears reasonable to consider a drug as the cause of acute pancreatitis. Over 100 drugs have been implicated by case reports as causing acute pancreatitis. While some of these case reports are well written, many case reports represent poorly written experiences of the clinician simply implicating a drug without a careful evaluation. Over-reliance on case reports while ignoring randomized clinical trials and large pharmacoepidemiologic surveys has led to confusion about drug induced acute pancreatitis. This review will explain that drug induced acute pancreatitis does occur, but it is rare, and over diagnosis leads to misconceptions about the disease resulting in inappropriate patient care, increased litigation and a failure to address the true entity: idiopathic acute pancreatitis.

关键词： Drug induced acute pancreatitis Idiopathic acute pancreatitis

LIVING IN HARMONY WITH NATURE

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Journal of Green Building 2015年第3期10卷 28-46页

作者： scott Simons scott Simons Architects Portland ME 04101 USA

Mount Desert Island is one of the most beautiful places in New *** in the middle of Penobscot Bay in Maine,which is home to Acadia National Park,one of the most visited parks in the National Park *** landscape is classic Maine,with evergreen trees clinging to a rocky *** the past 150 years it has been a summer retreat for many,including the Rockefellers who helped create the carriage trails in the Park,and home to the infamous“cottages”of the wealthy that came to the Island starting in the second half of the nineteenth century to escape the hot summer temperatures of the *** was on this island,in this historic setting,that Pondicherry was *** a love of this unique place and a desire to find a way to live here in harmony with the natural setting,the owners sought out scott Simons Architects to help them design a unique house,one that would combine aesthetic beauty and ultra high environmental *** were looking to create a new way of living on Mount Desert *** appreciated the natural beauty of the Island and loved to hike in Acadia National *** wanted to design a house that was in harmony with the Park surroundings *** large cottages of Northeast Harbor where their family had vacationed for over a *** years of searching they found and purchased a piece of property on a glacial pond along the edge of the Park *** imagined a house that would respect the natural setting and features of the site,and used phrases like“simple,clean lines”,“human scale”,“lots of natural light”,“all natural materials”,and“timeless quality”to describe what they were looking *** initial goal was to have a high performance house that did not consume a lot of *** husband was on the board of a national environmental organization,and he managed the family forestry business in northern *** was in contact with a lot of people who were talking about how to preserve the environment and wante

关键词： Net-zero energy house LEED Platinum natural setting net-positive energy

Some non-trivial Kazhdan-Lusztig coefficients of an affine Weyl group of type _n

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Science China Mathematics 2010年第8期53卷 1919-1930页

作者： scott Leonard Department of Mathematics University of Virginia

In this paper we show that the leading coeficient μ(y,w) of some Kazhdan-Lusztig polynomials Py,w with y,w in an affine Weyl group of type n is n + *** fact has some consequences on the dimension of first extension... 详细信息

关键词： Kazhdan-Lusztig coeficient Kazhdan-Lusztig polynomial first extension group