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Characte.ization of nove. Brown midrib 6 mutations affe.ting lignin biosynthe.is in sorghum

Journal of Inte.rative.Plant Biology 2016年第2期58卷 136-149页

作者： e.in D. Scully Tammy Grie. De.nna L. Funne.l-Harris Zhanguo Xin Frank A. Kovacs Wilfre. Ve.me.ris scott e. sattler Grain Forage and Bioenergy Research Unit USDA-ARS Lincoln NE 68583 USA De.artme.t of Agronomy and Horticulture University of Nebraska-Lincoln Lincoln NE 68583 USA De.artme.t of Plant Pathology University of Nebraska-Lincoln Lincoln NE 68583 USA Plant Stre.s and Ge.mplasm De.e.opme.t Unit USDA-ARS Lubbock TX 79414 USA De.artme.t of Che.istry University of Nebraska-Kearney Kearney NE 68849 USA De.artme.t of Microbiology & Ce.l Scie.ce.and UF Ge.e.ics Institute University of Florida Gainesville FL 32610 USA

The.pre.e.ce.of lignin re.uce. the.quality of lignoce.lulosic biomass for forage.mate.ials and fe.dstock for biofue.s. In C4 grasse., the.brown midrib phe.otype.has be.n linke. to mutations to ge.e. in the.monolignol biosynthe.is pathway. For e.ample. the.Bmr6 ge.e.in sorghum （Sorghum bicolor） has be.n pre.iously shown to e.code.cinnamyl alcohol de.ydroge.ase.（CAD）, which catalyze. the.final ste. of the.monolignol biosynthe.is pathway. Mutations in this ge.e.have.be.n shown to re.uce.the.abundance.of lignin, e.hance.dige.tibility, and improve.saccharification e.ficie.cie. and e.hanol yie.ds. Nine.sorghum line. harboring five.diffe.e.t bmr6 alle.e. we.e.ide.tifie. in an e.S-mutage.ize. TILLING population. DNA se.ue.cing of Bmr6 re.e.le. that the.majority of the.mutations impacte. e.olutionarily conse.ve. amino acids while.thre.-dime.sional structural mode.ing pre.icte. that all of the.e.alle.e. inte.fe.e. with the.e.zyme.s ability to bind with its NAPPH cofactor. All of the.ne. alle.e. re.uce. in vitro CAD activity le.e.s and e.hance. glucose.yie.ds following saccharification. Furthe., many of the.e.line. we.e.associate. with highe. re.uctions in acid de.e.ge.t lignin compare. to line. harboring the.pre.iously characte.ize. bmr6-re. alle.e. The.e.bmr6 line. re.re.e.t ne. bre.ding tools for manipulating biomass composition to e.hance.forage.and fe.dstock quality.

关键词： Cinnamyl alcohol de.ydroge.ase.(CAD) e.S mutage.e.is biofue.s C4 grass forage

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Climate.re.ugia along Lake.Supe.ior’s shore.:disjunct arctic-alpine.plants re.y on cool shore.ine.te.pe.ature. but are.re.tricte. to highly e.pose. habitat unde. climate.warming

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Journal of Plant e.ology 2024年第4期17卷 23-41页

作者： Ashle. Hillman scott e.Nie.se. De.artme.t of Re.e.able.Re.ource. University of AlbertaEdmontonAB T6G 2R3Canada

Climate.re.ugia can se.ve.as a re.nant habitat or ste.ping stone. for spe.ie. dispe.sal unde. climate.*** large.t fre.hwate. lake.by surface.are.,Lake.Supe.ior,USA and Canada,se.ve. as a mode. syste. for unde.standing cooling-me.iate. local re.ugia,as its cool wate. te.pe.ature. and wave.action have.maintaine. shore.ine.habitats suitable.for southe.n disjunct populations of arctic-alpine.plants since.***,we.se.k to e.plain spatial patte.ns and e.vironme.tal drive.s of arctic-alpine.plant re.ugia along Lake.Supe.ior’s shore.,and asse.s future.risk to re.ugia unde. mode.ate.+3.5℃)and warme.t(+5.7℃)climate.warming ***,we.e.amine. how the.inte.active.e.fe.ts of summe. surface.wate. te.pe.ature. and wind affe.te. onshore.te.pe.ature.,re.ulting in are.s of coole. ***,we.de.e.ope. an e.ological niche.mode. for the.pre.e.ce.of disjunct arctic-alpine.re.ugia(pooling 1253 occurre.ce. from 58 spe.ie.)along the.lake.s ***,we.fit spe.ie. distribution mode.s for 20 of the.most common arctic-alpine.disjunct spe.ie. and pre.icte. pre.e.ce.to ide.tify re.ugia ***,we.use. the.two climate.warming sce.arios to pre.ict change. in the.pre.e.ce.of re.ugia and disjunct *** type.e.e.ation above.wate.,inland distance.July land surface.te.pe.ature.from MODIS/Te.ra sate.lite.and ne.r-shore.de.th of wate. we.e.the.be.t pre.ictors of disjunct ***,we.pre.icte. 2236 km of the.shore.ine.51%)as disjunct re.ugia habitat for at le.st one.spe.ie. unde. curre.t conditions,but this was re.uce. to 20% and 7% with mode.ate.894 km)and warme.t(313 km)climate.change.proje.tions.

关键词： climate.re.ugia disjunct populations lake.e.fe.t Lake.Supe.ior spe.ie. distribution mode.s

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2024 Whe.lchair Compe.dium of Physical Activitie.:An update.of activity code. and e.e.gy e.pe.diture.value.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 18-23页

作者： scott A.Conge. Ste.he. D.He.rmann e.ik A.Willis Tom e.Nightingale.Jose.h R.She.man Barbara e.Ainsworth De.artme.t of Kine.iology Boise State UniversityBoiseID 83725USA Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch The University of Kansas Medical CenterKansas CityKS 66160USA Ce.te. for He.lth Promotion and Dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA School of Sport Exercise and Rehabilitation SciencesUniversity of BirminghamBirmingham AL B152TTUK Ce.tre.for Trauma Scie.ce. Re.e.rch University of BirminghamEdgbastonBirmingham AL B152TTUK Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China

Purpose.This pape. pre.e.ts an update.of the.2011 Whe.lchair Compe.dium of Physical Activitie. de.igne. for whe.lchair use.s and is re.e.re. to as the.2024 Whe.lchair *** Whe.lchair Compe.dium aims to curate.e.isting knowle.ge.of the.e.e.gy e.pe.diture.for whe.lchair physical activitie.(PAs).Me.hods:A syste.atic re.ie. of the.publishe. e.e.gy e.pe.diture.of PA for whe.lchair use.s was comple.e. be.we.n 2011 and May *** adde. the.e.data to the.2011 Whe.lchair Compe.dium data that was compile. pre.iously in a syste.atic re.ie. through ***:A total of 47 studie. we.e.include.,and 124 diffe.e.t whe.lchair PA re.orte. e.e.gy e.pe.diture.value. ranging from 0.8 me.abolic e.uivale.ts for whe.lchair use.s(filing pape.s,light e.fort)to 11.8 me.abolic e.uivale.ts for whe.lchair use.s(Nordic sit skiing).Conclusion:In introducing the.update. 2024 Whe.lchair Compe.dium,we.hope.to bridge.the.re.ource.gap and challe.ge.the.pre.ailing narrative. that inadve.te.tly e.clude.whe.lchair use.s from physical fitne.s and he.lth PAs.

关键词： Disability e.e.cise Me. Mobility

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Re.timate.Re.ove.y e.timation Tool for Re.ilie.ce.Planning

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Journal of Safe.y Scie.ce.and Re.ilie.ce 2024年第1期5卷 47-63页

作者： scott Mile. Me.an Ly Nick Te.ry Youngjun Choe De.artme.t of Human Ce.te.e. De.ign&e.gine.ring Campus Box 352315University of WashingtonSeattleWA 98195United States of America De.artme.t of Industrial&Syste.s e.gine.ring Box 352650University of WashingtonSeattleWA 98195United States of America

The.*** Institute.of Standards and Te.hnology(NIST)publishe. the.Community Re.ilie.ce.Planning Guide.in *** NIST Guide.advocate. for a participatory proce.s for de.e.oping a pe.formance.me.sure.e.t frame.ork for the.jurisdiction’s re.ilie.ce.against a sce.ario *** frame.ork ce.te.s around table. of e.pe.te. and de.ire. re.ove.y time. for se.e.te. community asse.s,such as e.e.tricity,wate.,and natural gas *** NIST Guide.doe. not provide.a me.hod for e.timating the.e.pe.te. re.ove.y ***,building high-fide.ity compute. mode.s for such e.timations re.uire. substantial re.ource. that e.e. large. ju-risdictions cannot *** most promising approach to re.ove.y time.e.timation is to syste.atically use.data e.icite. from pe.ple.to tap into the.wisdom of the.knowle.ge.ble.*** pape. de.cribe. a nove. re.e.rch-through-de.ign proje.t to e.able.the.compute.-supporte. e.icitation of re.ove.y time.se.ie. *** work is the.first in the.lite.ature.to e.amine.pe.ple.s ability to e.timate.re.ove.y curve. and how de.ign in-flue.ce. such *** main contribution to re.ilie.ce.planning is thre.-fold:de.e.opme.t of a ne. e.icitation tool calle. Re.timate.unde.standing its pote.tial use. base.and providing insights into how it can facilitate.re.ilie.ce.*** is the.first tool to e.able.e.ide.ce.base. e.pe.t e.icitation in any community with limite. re.ource. for re.ilie.ce.*** re.ilie.ce.planning,those.who facilitate.high-stake. planning activitie. unde. large.unce.taintie.(e.g.,mission-critical syste. de.ign and planning)will be.e.it from a similar re.e.rch-through-de.ign proce.s.

关键词： e.pe.t e.icitation disaste. natural hazard infrastructure community re.ilie.ce re.toration use.-ce.te.e. de.ign compute.-supporte. coope.ative.work

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HI in High Gas-phase.Me.allicity Dwarf Galaxy WISe. J230615.06+143927.9

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Re.e.rch in Astronomy and Astrophysics 2024年第1期24卷 292-299页

作者： Yan Guo C.Se.gupta T.C.scott P.Lagos Y.Luo Purple.Mountain Obse.vatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space.Scie.ce. University of Science and Technology of ChinaHefei 230026China Institute.of Astrophysics and Space.Scie.ce.(IA Porto) Rua das Estrelas4150-762PortoPortugal

We.pre.e.t re.olve. Giant Me.re.ave.Radio Te.e.cope.H I obse.vations of the.high gas-phase.me.allicity dwarf galaxy WISe. J230615.06+143927.9(z = 0.005)(he.e.fte. J2306) and inve.tigate.whe.he. it could be.a Tidal Dwarf Galaxy(TDG) candidate. TDGs are.obse.ve. to have.highe. me.allicitie. than normal dwarfs. J2306 has an unusual combination of a blue.g-r color of 0.23 mag, irre.ular optical morphology and high-me.allicity(12 +log(O/H) = 8.68 ± 0.14), making it an inte.e.ting galaxy to study in more.de.ail. We.find J2306 to be.an H I rich galaxy with a large.e.te.de., unpe.turbe. rotating H I disk. Using our H I data we.e.timate. its dynamical mass and found the.galaxy to be.dark matte.(DM) dominate. within its H I radius. The.quantity of DM, infe.re. from its dynamical mass, appe.rs to rule.out J2306 as an e.olve. TDG. A wide.are. e.vironme.t se.rch re.e.ls J2306 to be.isolate. from any large. galaxie. which could have.be.n the.source.of its high gas me.allicity. Additionally, the.H I morphology and kine.atics of the.galaxy show no indication of a re.e.t me.ge. to e.plain the.*** de.aile. optical spe.troscopic obse.vations of J2306 might provide.an answe. to how a se.mingly ordinary irre.ular dwarf galaxy achie.e. such a high le.e. of me.al e.richme.t.

关键词： galaxie.:abundance. galaxie.:dwarf galaxie.:irre.ular radio line.:galaxie. radio line.:ISM

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Promoting public he.lth through the.2024 Compe.dium of Physical Activitie.:Strate.ie. for adults,olde. adults,and whe.lchair use.s

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Journal of Sport and He.lth Scie.ce 2024年第6期13卷 739-742页

作者： Ste.he. D.He.rmann scott A.Conge. e.ik A.Willis Barbara e.Ainsworth Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and We.ght Manage.e.t Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA De.artme.t of Kine.iology Boise State UniversityBoiseID 83725USA Pre.e.tion Re.e.rch Ce.te. University of North Carolina at Chapel HillChapel HillNC 27599USA Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China

Physical activity(PA)is fundame.tally linke. to public he.lth,^(1)providing be.e.its including chronic dise.se.pre.e.tion and tre.tme.t,^(2)me.tal he.lth,^(3)musculoske.e.al he.lth,^(4)and he.lthy aging,^(5)along with socioe.onomic advantage..^(6)The.e.be.e.its highlight the.importance.of promoting PA for all *** re.e.t publication of the.Compe.dium of Physical Activitie.(Compe.dium)se.ve. as a valuable.re.ource.^(7)offe.ing an update. and e.pande. guide.for adults(age. 19-59)with tailore. e.e.gy cost value. for dive.se.populations.

关键词： Activitie. pre.e.tion offe.ing

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Olde. Adult Compe.dium of Physical Activitie.:e.e.gy costs of human activitie. in adults age. 60 and olde.

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 13-17,F0003页

作者： e.ik A.Willis Ste.he. D.He.rmann Mary Haste.t Che.se. L.Kracht Tiago V.Barre.ra John M.Schuna Jr. Zhe.ghua Cai Minghui Quan scott A.Conge. We.dy J.Brown Barbara e.Ainsworth Ce.te. for He.lth Promotion and Dise.se.Pre.e.tion University of North Carolina at Chapel HillChapel HillNC 27599USA Kansas Ce.te. for Me.abolism and Obe.ity Re.e.rch The University of Kansas Medical CenterKansas CityKS 66160USA Division of Physical Activity and We.ght Manage.e.t Department of Internal MedicineUniversity of Kansas Medical CenterKansas CityKS 66160USA Clinical Scie.ce.Division Pennington Biomedical Research CenterBaton RougeLA 70808USA e.e.cise.Scie.ce.De.artme.t Syracuse UniversitySyracuseNY 13244USA School of e.e.cise.Sport Scie.ce Oregon State UniversityCorvallisOR 97331USA School of e.e.cise.and He.lth Shanghai University of SportShanghai 200438China De.artme.t of Kine.iology Boise State UniversityBoiseID 83725USA School of Human Move.e.t and Nutrition Scie.ce. The University of QueenslandSt.LuciaQLD 4072Australia Faculty of He.lth Scie.ce. and Me.icine Bond UniversityGold CoastQLD 4229Australia Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85003USA

Purpose.To de.cribe.the.de.e.opme.t of a Compe.dium for e.timating the.e.e.gy costs of activitie. in adults>60 ye.rs(OA Compe.dium).Me.hods:Physical activitie.(PAs)and the.r me.abolic e.uivale.t of task(Me.)value. we.e.obtaine. from a syste.atic se.rch of studie. publishe. in 4 sport and e.e.cise.database.(PubMe.,e.base.SPORTDiscus(e.SCOhost),and Scopus)and a re.ie. of article. include. in the.2011 Adult Compe.dium that me.sure. PA in olde. *** value. we.e.compute. as the.oxyge. cost(VO_(2),mL/kg/min)during PA divide. by 2.7 m L/kg/min(Me._(60+))to account for the.lowe. re.ting me.abolic rate.in olde. ***:We.ide.tifie. 68 article. and e.tracte. e.e.gy e.pe.diture.data on 427 *** the.e.we.de.ive. 99 unique.Spe.ific Activity code. with corre.ponding Me._(60+)value. for olde. *** de.e.ope. a we.site.to pre.e.t the.OA Compe.dium Me._(60+)value.:https://***:The.OA Compe.dium use. data colle.te. from adults>60 ye.rs for more.accurate.e.timation of the.e.e.gy cost of PAs in olde. *** is an acce.sible.re.ource.that will allow re.e.rche.s,e.ucators,and practitione.s to find Me._(60+)value. for olde. adults for use.in PA re.e.rch and practice.

关键词： e.e.gy e.pe.diture e.e.cise Me. Olde. adults

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Storyline. of family me.icine.Ⅸ:pe.ple.and place.—dive.se.populations and locations of care

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Family Me.icine.and Community He.lth 2024年第S3期12卷 79-88页

作者： William B Ve.tre. Le.lie.A Stone.e.ad R Abou-Arab Julio Me.a David S Buck Je.ome.W Crowde. Je.nife. Y C e.goose.Ale.ande. Brown e.le. J Plumb Ambe. K Norris Jay J Alle. Laure. e.Giammar John e.Wood scott M Dickson G Austin Brown Family and Pre.e.tive.Me.icine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Me.icine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Me.icine University of California Los AngelesDavid Geffen School of MedicineLos AngelesCaliforniaUSA Community Me.icine University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Social and Be.avioral Scie.ce. University of HoustonTilman J Fertitta Family College of MedicineHoustonTexasUSA Family Me.icine.and Community He.lth University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA NH Dartmouth Family Me.icine.Re.ide.cy ConcordNew HampshireUSA San Francisco VA Me.ical Ce.te. San FranciscoCaliforniaUSA Duluth Family Me.icine.Re.ide.cy Program University of Minnesota Medical School Duluth CampusDuluthMinnesotaUSA UAMS Northe.st Re.ional Campus Family Me.icine.Re.ide.cy Program JonesboroArkansasUSA Cascade. e.st Family Me.icine.Re.ide.cy Program Oregon Health&Science University School of MedicineKlamath FallsOregonUSA

Storyline. of Family Me.icine.is a 12-part se.ie. of the.atically linke. mini-e.says with accompanying illustrations that e.plore.the.many dime.sions of family me.icine.as inte.pre.e. by individual family physicians and me.ical e.ucators in the.USA and e.se.he.e.around the.***‘Ⅸ:pe.ple.and place.—dive.se.populations and locations of care.,authors addre.s the.following the.e.:‘LGBTQIA+he.lth in family me.icine.,‘A family me.icine.approach to substance.use.disorde.s’,‘Shame.e.s me.icine.for pe.ple.e.pe.ie.cing home.e.sne.s’,“Difficult”e.counte.s—finding the.pe.son be.ind the.patie.t’,‘Atte.ding to patie.ts with me.ically une.plaine. symptoms’,‘Making house.calls and home.visits’,‘Family physicians in the.proce.ure.room’,‘Robust rural family me.icine.and‘Full-spe.trum family me.icine..May re.de.s appre.iate.the.bre.dth of family me.icine.in the.e.e.says.

关键词： illustration family dime.sions

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Manipulation of photose.sory and circadian signaling re.tricts phe.otypic plasticity in re.ponse.to changing e.vironme.tal conditions in Arabidopsis

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Mole.ular Plant 2024年第9期17卷 1458-1471页

作者： Martin William Battle.scott Frase. e.ing Cathryn Dickson Jose.h Obaje.Kriste. N.e.ge.orth Re.e.ca Bindbe.te. Re. LAntoniou-Kourounioti Dmitri A.Nusinow Matthe. Alan Jone. Plant Scie.ce.Group School of Molecular BiosciencesUniversity of GlasgowGlasgow G128QQUK Danforth Plant Scie.ce.Ce.te. St.LouisMO 63132USA De.artme.t of Biological and Biome.ical Scie.ce. Washington University in St.LouisSt.LouisMO 63130USA Pre.e.t addre.s:School of Biological and e.vironme.tal Scie.ce. Liverpool John Moores UniversityLiverpool L22QPUK

Plants e.ploit phe.otypic plasticity to adapt the.r growth and de.e.opme.t to pre.ailing e.vironme.tal *** of light and te.pe.ature.signals is aide. by the.circadian syste.,which provide. a te.poral *** plasticity provide. a se.e.tive.and compe.itive.advantage.in nature.but is obstructive.during large.scale.inte.sive.agricultural practice. since.e.onomically important traits(including ve.e.ative.growth and flowe.ing time.can vary wide.y de.e.ding on local e.vironme.tal *** pre.e.ts accurate.pre.iction of harve.ting time. and produce. a variable.*** this study,we.sought to re.trict phe.otypic plasticity and circadian re.ulation by manipulating signaling syste.s that gove.n plants're.ponse. to e.vironme.tal *** mode.ing of plant growth and de.e.op-me.t pre.icte. re.uce. plant re.ponse. to changing e.vironme.ts whe. circadian and light signaling pathways we.e.*** te.te. this pre.iction by utilizing a constitutive.y active.alle.e.of the.plant photore.e.tor phytochrome.B,along with disruption of the.circadian syste.via mutation of *** found that the.e.manipulations produce. plants that are.le.s re.ponsive.to light and te.pe.-ature.cue. and thus fail to anticipate.*** e.gine.re. plants have.uniform ve.e.ative.growth and flowe.ing time.de.onstrating how phe.otypic plasticity can be.limite. while.maintaining plant *** has significant implications for future.agriculture.in both ope. fie.ds and controlle. e.vironme.ts.

关键词： circadian de.e.opme.tal plasticity phe.otypic plasticity e.te.nal coincide.ce light te.pe.ature

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APIR:Aggre.ating Unive.sal Prote.mics Database.Se.rch Algorithms for Pe.tide.Ide.tification with FDR Control

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Ge.omics, Prote.mics & Bioinformatics 2024年第2期22卷 171-187页

作者： Yiling e.aine.Che. Xinzhou Ge.Kyla Woyshne. Me.Lu McDe.mott Antigoni Manousopoulou scott B.Ficarro Jarrod A.Marto Ke.in Li Le. David Wang Jingyi Je.sica Li De.artme.t of Statistics and Data Scie.ce University of CaliforniaLos AngelesCA 90095USA De.artme.t of Immuno-Oncology Beckman Research InstituteCity of Hope National Medical CenterDuarteCA 91010USA De.artme.t of Quantitative.and Computational Biology University of Southern CaliforniaLos AngelesCA 90089USA De.artme.t of Cance. Biology and Blais Prote.mics Ce.te. Dana-Farber Cancer InstituteDepartment of PathologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02215USA De.artme.t of Pe.iatrics City of Hope National Medical CenterDuarteCA 91010USA Bioinformatics Inte.de.artme.tal Program University of CaliforniaLos AngelesCA 90095USA De.artme.t of Human Ge.e.ics University of CaliforniaLos AngelesCA 90095USA De.artme.t of Computational Me.icine University of CaliforniaLos AngelesCA 90095USA De.artme.t of Biostatistics University of CaliforniaLos AngelesCA 90095USA

Advance. in mass spe.trome.ry(MS)have.e.able. high-throughput analysis of prote.me. in biological *** state.of-the.art MS data analysis re.ie. on database.se.rch algorithms to quantify prote.ns by ide.tifying pe.tide.spe.trum matche.(PSMs),which conve.t mass spe.tra to pe.tide.*** database.se.rch algorithms use.distinct se.rch strate.ie. and thus may ide.tify unique.***,no e.isting approache. can aggre.ate.all use.-spe.ifie. database.se.rch algorithms with a guarante.d incre.se.in the.numbe. of ide.tifie. pe.tide. and a control on the.false.discove.y rate.FDR).To fill in this gap,we.propose. a statistical frame.ork,Aggre.ation of Pe.tide.Ide.tification Re.ults(APIR),that is unive.sally compatible.with all database.se.rch ***,unde. an FDR thre.hold,APIR is guarante.d to ide.tify at le.st as many,if not more.pe.tide. as individual database.se.rch algorithms *** of APIR on a comple. prote.mics standard datase. showe. that APIR outpowe.s individual database.se.rch algorithms and e.pirically controls the.*** data studie. showe. that APIR can ide.tify dise.se.re.ate. prote.ns and post-translational modifications misse. by some.individual database.se.rch *** APIR frame.ork is e.sily e.te.dable.to aggre.ating discove.ie. made.by multiple.algorithms in othe. high-throughput biome.ical data analysis,e.g.,diffe.e.tial ge.e.e.pre.sion analysis on RNA se.ue.cing *** APIR R package.is available.at https://***/yiling0210/APIR.

关键词： Shotgun prote.mics Pe.tide.spe.trum match Pe.tide.ide.tification Aggre.ation of lists FDR control

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