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Surgery for metastatic pancreatic neuroendocrine tumors: a narrative review

Hepatobiliary Surgery and Nutrition 2023年第1期12卷 69-83页

作者： Jelani K.Williams Jason l.schwarz Xavier M.Keutgen Division of General Surgery and Surgical Oncology Department of SurgeryUniversity of Chicago MedicineChicagoILUSA

Background and Objective:Pancreatic neuroendocrine tumors(PanNETs)are derived from the islet cells of the pancreas and have been increasing in *** of these tumors are nonfunctional although some can secrete hormones and lead to hormone-specific clinical *** is the mainstay of treatment for localized tumors,however,surgical resection is controversial in metastatic *** narrative review seeks to summarize the current literature surrounding surgery,specifically in the controversial area of metastatic PanNETs,review current treatment paradigms,and understand the benefits of surgery in this group of ***:Authors searched PubMed using the terms“surgery pancreatic neuroendocrine tumor”,“metastatic neuroendocrine tumor”,and“liver debulking neuroendocrine tumor”from January 1990 to June *** English language publications were *** Content and Findings:There is no consensus among the leading specialty organizations regarding surgery for metastatic *** considering surgery for metastatic PanNETs,tumor grade and morphology,location of the primary tumor,extra-hepatic or extra-abdominal disease,as well as liver tumor burden and metastatic distribution should be *** the liver is the most common site of metastasis and liver failure is the most common cause of death in patients with hepatic metastases,attention is centered here on debulking and other ablative *** transplantation is rarely used for hepatic metastases but could be beneficial in a small subset of *** studies have demonstrated improvement in survival and symptoms after surgery for metastatic disease,but the lack of prospective randomized control trials significantly limits analysis of surgical benefits in patients with metastatic ***:Surgery is the standard of care for localized PanNETs,while it remains controversial in metastatic *** studies have shown a survival and symptomatic be

关键词： Pancreatic neuroendocrine tumors(PanNETs) liver tumor burden hepatic metastasis liver debulking DOTATATE

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Prospective cohort study on facial profile changes in infants with Robin sequence and healthy controls

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World Journal of Pediatrics 2024年第6期20卷 581-589页

作者： Cornelia Wiechers Julian Sowula Karen Kreutzer Christoph E.schwarz Christina Weismann Michael Krimmel Christian F.Poets Bernd Koos Department of Neonatology Tuebingen University HospitalCalwerstrasse 772076 TuebingenGermany Center for Cleft lip Palate and Craniofacial MalformationsTuebingen University HospitalTuebingenGermany Department of Orthodontics Tuebingen University HospitalTuebingenGermany Department of Oral and Maxillofacial Surgery Tuebingen University HospitalTuebingenGermany

Background Various conservative and surgical approaches exist to treat Robin sequence(RS),but their effects on facial profile and mandibular catch-up growth are unclear.A functional treatment concept,used in our centre for 25 years,includes an individualized palatal plate with a velo-pharyngeal extension and intensive feeding *** We performed a prospective study to objectively describe facial profiles in infants with RS treated with the above *** with isolated RS were admitted to our tertiary perinatal and national referral centre for craniofacial malformations between May 2018 and Nov *** with RS received 3D-photographs during clinically indicated *** controls were recruited from Dec 2018 to Sep 2019 and received 3D-photographs every 3 *** digitally measured jaw index(JI),defined as alveolar overjet(O)x maxillary arch(U)/mandibular arch(l),and the soft tissue reference points A’-point,Nasion’,B’-point angle(ANB’),describing the relative position of maxilla to mandible,were *** mixed models were used to examine time trajectories in JI and ANB’.Results A total of 2073D images,obtained in 19 infants with RS and 32 controls,were *** and ANB’decreased over time in both groups[for JI−0.18(95%CI−0.25 to−0.10);for ANB’:−0.40°per month[(95%CI−0.48 to−0.32)]]but remained lower in controls[for JI−2.5(95%CI−3.2 to−1.8);for ANB’-1.7°(95%CI−2.4 to−1.0)].Also,the ANB’model showed a significant effect of the interaction term diagnosis x *** Based on longitudinal 3D images,we describe changes in objective parameters of facial profile in infants with and without RS during the first year of *** findings indicate catch-up growth in infants treated for RS.

关键词： Infant Mandibular catch-up growth Pre-epiglottic Baton Plate Robin sequence Three-dimensional photography

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钾通道Kv4.2亚单位在疼痛可塑性变化中起决定作用

钾通道Kv4.2亚单位在疼痛可塑性变化中起决定作用

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中华医学会疼痛学分会第六届年会

作者：胡慧娟 CARRASQUIllO,Y. KARIM,F JUNG,W.E NERBONNE,J.M schwarz,T.l GEREAU IV,R.W Department of Neuroscience Washington University Pain Center and Department of Anesthesiology Washington University School of Medicine St.LouisMO 63110 Children’s Hospital Department of Molecular Biology and Pharmacology Children’s Hospital Washington University Pain Center and Department of Anesthesiology

＜正＞目的:研究钾通道Kv4.2亚单位在疼痛可塑性变化中的作用。方法:采用膜片钳技术,免疫组化及基因剔除等分子生物学方法,脱察脊髓背角神经元A型钾通道的电生理学特性、分布及对神经兴奋性和疼痛行为的调节。结果:Kv4.2 α亚单位是脊...

＜正＞目的:研究钾通道Kv4.2亚单位在疼痛可塑性变化中的作用。方法:采用膜片钳技术,免疫组化及基因剔除等分子生物学方法,脱察脊髓背角神经元A型钾通道的电生理学特性、分布及对神经兴奋性和疼痛行为的调节。结果:Kv4.2 α亚单位是脊髓背角神经元A型钾通道的主要组成部分,也是神经兴奋性和疼痛行为的主

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胰腺术后患者死亡原因分析多中心队列研究(CARE研究)

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肝胆外科杂志 2021年第6期29卷 479-480页

作者： Beugniez C Sauvanet A Sulpice l Gaujoux S Turrini O Truant S schwarz l Piessen G Regimbeau JM Muscari F Adham M Pattou F Schneider l Clement G Delpero JR Pruvot FR Mehdi EA 崔笑(摘译) 薛鸿(摘译) 耿小平(审校) French-ACHBT Working Group 不详

虽然近年来胰腺手术技术取得了长足进步,但胰腺术后发生死亡的事件依然仍有发生.本研究分析了法国多个高流量胰腺外科中心2015年1月至2018年12月期间接受胰腺切除术90天内死亡的原因.共9个中心纳入研究患者3195例,术后90天内死亡140例,3... 详细信息

虽然近年来胰腺手术技术取得了长足进步,但胰腺术后发生死亡的事件依然仍有发生.本研究分析了法国多个高流量胰腺外科中心2015年1月至2018年12月期间接受胰腺切除术90天内死亡的原因.共9个中心纳入研究患者3195例,术后90天内死亡140例,39例患者因故排除,有效分析101例.30%的死亡是术前评估或术后管理不善导致,约10%是不恰当的术中决策所致.高龄、联合动脉切除,尤其是计划外手术切除,是死亡相关危险因素.

关键词：胰腺手术胰腺外科胰腺切除术术前评估死亡原因分析计划外相关危险因素术后管理

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CD137l,a driver of harmful inflammation in the nervous system

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Neural Regeneration Research 2023年第11期18卷 2387-2388页

作者： Hiu Yi Wong Amanda C.Y.Chan Anselm Mak Herbert schwarz Division of life Science State Key Laboratory of Molecular NeuroscienceMolecular Neuroscience CenterThe Hong Kong University of Science and TechnologyHong Kong Special Administrative RegionChina Hong Kong Center for Neurodegenerative Diseases Hong Kong Special Administrative RegionChina Division of Neurology University Medicine ClusterNational University HospitalSingapore Department of Medicine Yong Loo Lin School of MedicineNational University of SingaporeSingapore Division of Rheumatology University Medicine ClusterNational University Health SystemDepartment of MedicineYong Loo Lin School of MedicineNational Univesity of SingaporeSingapore Department of Physiology and Immunology ProgrammeYong Loo Lin School of MedicineNational University of SingaporeSingapore Integrative Sciences and Engineering Programme NUS Graduate SchoolNational University of SingaporeSingapore

CD137 (TNFRSF9,4-1BB) is a member of the tumor necrosis factor (TNF) receptor family and a potent costimulatory *** levels of CD137 are expressed on T cells upon ***137 signaling in T cells,either by cognate interaction with antigen-presenting cells (APC)or by agonistic anti-CD137 antibodies,strongly enhances proliferation,interferon-y secretion,and cytolytic activity of T ***,CD137 signaling is a main driver of cellular,type 1 helper T cells (Th1)and type 1 cytolytic T cells (Tc1) polarised immune responses.

关键词： CD137 CD137l inflammation

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Systemic Il-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

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Bone Research 2022年第4期10卷 826-837页

作者： Yugo Morita Motoo Saito Javier Rangel-Moreno Anthony M.Franchini John R.Owen John C.Martinez John l.Daiss Karen l.de Mesy Bentley Stephen l.Kates Edward M.schwarz Gowrishankar Muthukrishnan Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of Allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental Medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathology and laboratory Medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum Il-27 levels(20-fold higher,Plthy ***,Il-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(Ple of *** test this hypothesis,we evaluated *** osteomyelitis in WT and Il-27Rα^(−/−)mice with and without exogenous Il27 induction by intramuscular injection of rAAV-Il-27p28 or rAAV-GFP,*** found that Il-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by M0,M1 and M2 macrophages and osteoblasts but not by ***,exogenous Il-27p28(~2 ng·ml^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local Il-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in Il-27Rα^(−/−)mice compared with WT mice,suggesting that Il-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that Il-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of Il-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic Il-27 in osteomyelitis.

关键词： abscess protective immunity

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Development of high damage threshold laser-machined apodizers and gain filters for laser applications

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High Power laser Science and Engineering 2016年第3期4卷 113-119页

作者： Patrick Rambo Jens schwarz Mark Kimmel John l.Porter Sandia National laboratories

We have developed high damage threshold filters to modify the spatial profile of a high energy laser beam. The filters are formed by laser ablation of a transmissive window. The ablation sites constitute scattering centers which can be filtered in a subsequent spatial filter. By creating the filters in dielectric materials, we see an increased laser-induced damage threshold from previous filters created using ‘metal on glass' lithography.

关键词： apodization laser beam shaping laser micro-machining spatial filtering

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Suitability of Hermetia illucens larvae meal and fat in broiler diets:effects on animal performance,apparent ileal digestibility,gut histology,and microbial metabolites

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Journal of Animal Science and Biotechnology 2022年第5期13卷 1386-1401页

作者： Kristina Hartinger Katharina Froschl Marco Antonio Ebbing Barbara Bruschek-Pfleger Karl Schedle Christiane schwarz Martin Gierus Department of Agrobiotechnology Institute of Animal NutritionLivestock Productsand Nutrition PhysiologyUniversity of Natural Resources and Life SciencesViennaAustria

Background:The possibility of partially replacing soybean meal(SBM)with Hermetia illucens(HI)defatted larvae meal in broiler nutrition has frequently been *** sustainability reasons,however,the larvae fat produced during defatting should also be used and could be particularly beneficial regarding gut health due to its fatty acid *** evaluate the suitability of HI larvae as protein and fat source,a 2×3 factorial arrangement with two types of protein,***(S)or SBM and 15%of its crude protein replaced by HI larvae meal(l),and three levels of fat sources,namely 0(0 l),50%(50 l)or 100%HI larvae fat(100 l)at the expense of soybean oil was ***:In the starter phase,an interaction showed higher body weight(BW),average daily gain(ADG)and improved feed conversion ratio(FCR)if 50%or 100%HI larvae fat was fed with HI larvae ***,BW,ADG and FCR improved when feeding HI larvae meal as protein ***,we observed an increased average daily feed intake in the grower,finisher,and overall phase in the l groups and an improved FCR in 0 l compared to 50 l groups during the overall *** apparent ileal digestibility,HI larvae meal feeding increased dry matter,organic matter,and fat *** HI larvae meal as protein source decreased the concentrations of agmatine,spermidine,spermine and ammonia in the caecal digesta,whereas fat source affected agmatine with higher concentrations in 50 l compared to 0 l in the colonic *** contrast,caecal ethanolamine concentrations increased in HI larvae meal groups compared to *** butyric acid concentrations decreased with HI larvae meal *** interaction was found for the jejunal villus area,being higher in l+100 l compared to S+100 ***,l groups had greater villus ***:A partial replacement of SBM with HI larvae meal and soybean oil with HI larvae fat in broiler diets without impairing animal performance or gut health seems possible

关键词： Broiler chicken Hermetia illucens larvae fat larvae meal lauric acid Microbial metabolites Performance

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MyCTC chip:microfluidic-based drug screen with patient-derived tumour cells from liquid biopsies

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Microsystems & Nanoengineering 2022年第6期8卷 125-135页

作者： Fabienne D.Schwab Manuel C.Scheidmann lauren l.Ozimski AndréKling lucas Armbrecht Till Ryser Ilona Krol Karin Strittmatter Bich Doan Nguyen-Sträuli Francis Jacob AndréFedier Viola Heinzelmann-schwarz Andreas Wicki Petra S.Dittrich Nicola Aceto Department of Biomedicine Cancer Metastasis LaboratoryUniversity of BaselBaselSwitzerland Department of Gynaecologic Oncology University Hospital BaselBaselSwitzerland Department of Biology Swiss Federal Institute of Technology Zurich(ETH Zurich)ZurichSwitzerland Department of Biosystems Science and Engineering Swiss Federal Institute of Technology Zurich(ETH Zurich)BaselSwitzerland Department of Gynaecology University Hospital Zurich and University of ZurichZurichSwitzerland Department of Biomedicine Ovarian Cancer ResearchUniversity Hospital Basel and University of BaselBaselSwitzerland University of Zurich and University Hospital Zurich ZurichSwitzerland

Cancer patients with advanced disease are characterized by intrinsic challenges in predicting drug response patterns,often leading to ineffective *** clinical practice for treatment decision-making is commonly based on primary or secondary tumour biopsies,yet when disease progression accelerates,tissue biopsies are not performed on a regular *** is in this context that liquid biopsies may offer a unique window to uncover key vulnerabilities,providing valuable information about previously underappreciated treatment ***,we present MyCTC chip,a novel microfluidic device enabling the isolation,culture and drug susceptibility testing of cancer cells derived from liquid *** cell capture is achieved through a label-free,antigen-agnostic enrichment method,and it is followed by cultivation in dedicated conditions,allowing on-chip expansion of captured *** growth,cancer cells are then transferred to drug screen chambers located within the same device,where multiple compounds can be tested *** demonstrate MyCTC chip performance by means of spike-in experiments with patientderived breast circulating tumour cells,enabling>95%capture rates,as well as prospective processing of blood from breast cancer patients and ascites fluid from patients with ovarian,tubal and endometrial cancer,where sensitivity to specific chemotherapeutic agents was ***,we provide evidence that MyCTC chip may be used to identify personalized drug response patterns in patients with advanced metastatic disease and with limited treatment opportunities.

关键词： fluid transferred Together

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Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant *** infection with osseointegration in murine models of implant-associated osteomyelitis

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Bone Research 2023年第4期11卷 751-763页

作者： Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen l.de Mesy Bentley Ye Shu Yuting liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.schwarz Shuting Sun Chao Xie Center for Musculoskeletal Research University of Rochester Medical CenterRochesterNY 14642USA Department of Orthopaedics University of Rochester Medical CenterRochesterNY 14642USA Department of Pathology and Center for Advanced Research Technologies University of Rochester Medical CenterRochesterNY 14642USA BioVinc LLCPasadenaCA 91107USA Department of Chemistry University of Southern CaliforniaLos AngelesCA 90089USA Department of Pharmacology Pennsylvania State UniversityHersheyPA 17033USA Department of Chemistry University of RochesterRoche

Eradication of MRSA osteomyelitis requires elimination of distinct *** overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in *** we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300lAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BlI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+*** confirmed infection persisted in all groups except for mice treated with BCS or HBCS+*** revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and *** confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant *** results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm *** together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis.

关键词： implant infection overcome

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