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中华高血压杂志 2014年第4期22卷 398-398页

作者： Zhao Q Gu D Chen J Li J Cao J Lu F Guo D Wang R Shen J Chen CS Mills kT schwander k Rao DC He J 罗冬梅叶鹏

在盐敏感性遗传流行病学研究中，研究者曾观察到不同个体间对膳食钠钾干预和冷加压试验（coldpressortest，CPT）的血压反应存在差异。为了进一步验证先前的结论，该研究另选取695例患者重复该试验。方法：入选者先后接受低钠（51．3mmo... 详细信息

在盐敏感性遗传流行病学研究中，研究者曾观察到不同个体间对膳食钠钾干预和冷加压试验（coldpressortest，CPT）的血压反应存在差异。为了进一步验证先前的结论，该研究另选取695例患者重复该试验。方法：入选者先后接受低钠（51．3mmol／d），高钠（307．8mmol／d）和高钠钾（钠307．8mmol／d，

关键词：盐敏感性高血压冷加压试验血压反应钠钾北方农村干预膳食中国

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Prospective MRI Evaluation of the Incidence and Characterization of Fluid Collections and Other Postoperative Changes Seen in Transforaminal Lumbar Interbody Fusion Using Recombinant Human Morphogenetic Protein-2（rhBMP-2）

Prospective MRI Evaluation of the Incidence and Characteriza...

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第二届华东地区骨科学术大会暨山东省第九次骨科学术会议

作者：郑修军 James D schwander 王德春陈晓亮青岛大学医学院附属医院脊柱外科 From Twin Cites Spine Center Minneapolis MN USA Study Design. A prospective independent and nonblinded clinical study. 青岛大学医学院附属医院脊柱外科青岛大学医学院附属医院脊柱外科

＜正＞Objective To identify whether the use of rhBMP-2 is associated with an increased incidence of postop- erative fluid collections and inflammatory changes seen on MRI in patients who have a minimally invasive transforamial lumbar interbody fusion（TLIF）. In addition, to characterize the location of these changes and determine whether they result in clinical symptoms.

关键词： rhBMP-2 TLIF MRI fluid collection inflammatory change.

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Genome-Wide Linkage and Positional Association Analyses Identify Associations of Novel AFF3 and NTM Genes with Triglycerides:The GenSalt Study

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Journal of Genetics and Genomics 2015年第3期42卷 107-117页

作者： Changwei Li Lydia A.L.Bazzano Dabeeru C.Rao James E.Hixson Jiang He Dongfeng Gu Charles C.Gu Lawrence C.Shimmin Cashell E.Jaquish karen schwander De-Pei Liu Jianfeng Huang Fanghong Lu Jie Cao Shen Chong Xiangfeng Lu Tanika N.kelly Department of Epidemiology Tulane University School of Public Health and Tropical Medicine Department of Medicine Tulane University School of Medicine Division of Biostatistics Washington University School of Medicine Department of Epidemiology Human Genetics and Environmental SciencesUniversity of Texas School of Public Health State key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center of Cardiovascular DiseasesChinese Academy of Medical Sciences and Peking Union Medical College Division of Prevention and Population Sciences National HeartLungBlood Institute National Laboratory of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical College Institute of Basic Medicine Shandong Academy of Medical Sciences Department of Epidemiology and Biostatistics Nanjing Medical University School of Public Health

We conducted a genome-wide linkage scan and positional association study to identify genes and variants influencing blood lipid levels among participants of the Genetic Epidemiology Network of Salt-Sensitivity （GenSalt） study. The GenSalt study was conducted among 1906 participants from 633 Han Chinese families. Lipids were measured from overnight fasting blood samples using standard methods. Multipoint quantitative trait genome-wide linkage scans were performed on the high-density lipoprotein, low-density lipoprotein, and log- transformed triglyceride phenotypes. Using dense panels of single nucleotide polymorphisms （SNPs）, single-marker and gene-based association analyses were conducted to follow-up on promising linkage signals. Additive associations between each SNP and lipid phenotypes were tested using mixed linear regression models. Gene-based analyses were performed by combining P-values from single- marker analyses within each gene using the truncated product method （TPM）. Significant associations were assessed for replication among 777 Asian participants of the Multi-ethnic Study of Atherosclerosis （MESA）. Bonferroni correction was used to adjust for multiple testing. In the GenSalt study, suggestive linkage signals were identified at 2p11.2-2q12.1 [maximum multipoint LOD score （MML） = 2.18 at 2q11.2] and t lq24.3-11q25 （MML = 2.29 at 11q25） for the log-transformed triglyceride phenotype. Follow-up analyses of these two regions revealed gene-based associations of charged multivesicular body protein 3 （CHMP3）, ring finger protein 103 （RNF103）, AF4/FMR2 family, member 3 （AFF3）, and neurotrirnin （NTM） with triglycerides （P = 4 ×10^-4, 1.00 × 10^-5, 2.00 × 10^-5, and 1.00 × 10^-7, respectively）. Both the AFF3 and NTM triglyceride associations were replicated among MESA study participants（P = 1.00 × 10^-7 and 8.00× 10^-5, respectively）. Furthermore, NTM explained the linkage signal on chromosome 11, In conclusion, we identified novel genes associated with lipid

关键词： Lipids Linkage analysis Positional association analysis Gene-based analysis

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The Global Stratotype Section and Point （GSSP） for the base of the Holocene Series/Epoch （Quaternary System/Period） in the NGRIP ice core

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Episodes 2008年第2期31卷 264-267页

作者： Mike Walker Sigfus Johnsen Sune Olander Rasmussen Jorgen-Peder Steffensen Trevor Popp Philip Gibbard Wim Hoek John Lowe John Andrews Svante Bjorck Les Cwynar konrad Hughen Peter kershaw Bernd kromer Thomas Litt David J. Lowe Takeshi Nakagawa Rewi Newnham Jakob schwander Department of Archaeology and Anthropology University of Wales Lampeter Wales SA48 7ED UK. Centre for Ice and Climatel The Niels Bohr Institute University of Copenhagen Juliane Maries Vej 30 DK2100 Copenhagen Denmark. Stable Isotope Laboratory Institute of Arctic and Alpine Research University of Colorado Boulder Co 80302 USA. Department of Geography University of Cambridge Downing Place Cambridge CB2 3EN UK. Department-of Physical Geography University of Utrecht Heidelberglaan 2 3508 TC Utrecht The Netherlands. Department of Geography Royal Holloway University of London Egham Surrey TW20 0EX UK. Institute for Arctic and Alpine Research University of Colorado Campus Box 450 Boulder Co 80309 USA. GeoBiosphere Science Centre Quaternary Sciences Lund University S/51veg 12 SE-223 62 Lund Sweden. Department of Biology University of New Brunswick Fredericton New Brunswick Canada E3B 6E1. Department of Marine Chemistry and Geochemistry Woods Hole Oceanographic Institution Woods Hole MA 02543 USA. School of Geography and Environmental Science Monash University Victoria 3800 Australia. Heidelberg Academy of Sciences University of Heidelberg 1NF 229 D-69120 Heidelberg Germany. Institute for Palaeontology University of Bonn Nussallee 8 D-53115 Bonn Germany. Department of Earth and Ocean Sciences University of Waikato Private Bag 3105 Hamilton New Zealand. Department of Geography University of Newcastle Newcastle-upon-Tyne NE 1 7RU UK. School of Geography University of Plymouth Drake Circus Plymouth PIA 8AA UK. Climate and Environmental Physics Physics Institute University of Bern Sidlerstrasse 5 CH-3012 Bern Switzerland.

The Greenland ice core from NorthGRIP （NGRIP） contains a proxy climate record across the Pleistocene-Holocene boundary of unprecedented clarity and resolution. Analysis of an array of physical and chemical parameters within the ice enables the base of the Holocene, as reflected in the first signs of climatic warming at the end of the Younger Dryas/Greenland Stadial 1 cold phase, to be located with a high degree of precision.

关键词：地球全新世第四纪地质时代周期

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