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Urinary hepcidin is potentially a marker of systemic infection rather than inflammation,in the setting of preserved renal function

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Urinary hepcidin is potentially a marker of systemic infecti...

Bioassays to assess drug effects to cells of the microvascular system

国际全身性感染论坛-2011北京

作者： NJ Glassford AG schneider G Eastwood L peck H Young m Westerman V Ostland R Bellomo Department of Intensive Care Austin HospitalVICAustralia

＜正＞Introduction Urinary proteomics have recently identified hepcidin,a key regulator of iron homeostasis,as a potential marker of tubular stress [1].It appears to be released in response to situations that predispo...

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Bioassays to assess drug effects to cells of the microvascul...

A phase 1b randomized clinical trial of CT1812 to measure Aβoligomer displacement in Alzheimer’s disease using an indwelling CSF catheter

2000上海科技论坛BIO-X研讨会暨中德医学生物物理和上海流变学研讨会

作者： O.Stache J.Ziemer G.schneider N.muecke G.m.Artmann Department of Cell Biophysics Fachhochschule Aachen-JuelichGensterweg 152428Germany

pharmacology performed on isolated cells relates the agent concentration to its biological effect and istherefore a valuable tool to study the complex mechanisms of drug effects on living system. Resultsontained with bioassays can be extremely useful When assessing the actively if natural compounds as thoseused in Chinese traditional medicine. In this context,we would like to introduce three examples of newbioassays:

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Translational Neurodegeneration 2023年第1期12卷 568-571页

作者： Kelsie m.LaBarbera Yvette I.Sheline Nicholas J.Izzo Carla m.Yuede Lora Waybright Raymond Yurko Hannah m.Edwards Woodrow D.Gardiner Kaj Blennow Henrik Zetterberg Anne Börjesson-Hanson Roger morgan Charles S.Davis Robert J.Guttendorf Lon S.schneider Steven DeKosky Harry LeVine III michael Grundman Anthony O.Caggiano John R.Cirrito Susan m.Catalano mary E.Hamby Cognition Therapeutics Inc. PittsburghPAUSA University of pennsylvania PhiladelphiaUSA Washington University St.LouisUSA University of Gothenburg MölndalSweden Department of psychiatry and Neurochemistry Institute of Neuroscience and PhysiologyThe Sahlgrenska Academy at the University of GothenburgMölndalSweden Clinical Neurochemistry Laboratory Sahlgrenska University HospitalMölndalSweden Department of Neurodegenerative Disease UCL Institute of NeurologyQueen SquareLondonUK UK Dementia Research Institute at UCL LondonUK Hong Kong Center for Neurodegenerative Diseases Clear Water BayHong KongChina Wisconsin Alzheimer’s Disease Research Center University of Wisconsin School of Medicine and Public HealthUniversity of Wisconsin-MadisonMadisonWIUSA Karolinska University Hospital StockholmSweden medSurgpI LLCRaleighNCUSA CSD Biostatistics Inc.Oro ValleyAZUSA Aclairo pharmaceutical Development Group IncViennaVAUSA Keck School of medicine of USC Los AngelesCAUSA mcKnight Brain Institute University of FloridaGainesvilleFLUSA Sanders-Brown Center on Aging University of KentuckyLexingtonKYUSA Global R&D partners LLCSan DiegoCAUSA Department of Neurosciences University of CaliforniaSan DiegoUSA

Trial Registration:may 11th,2018 *** Identifier:NCT03522129 https://clini caltr ***/ct2/show/*** therapies for Alzheimer’s disease(AD)target a wide range of mechanisms,yet promising dis-ease-modifying therapies remain a huge unmet *** evidence indicates that the oligomeric form of amyloid-beta(Aβ)is a toxic species contributing to AD through synaptic damage and neuronal toxicity[1].

关键词： Alzheimer Aβ damage

Evolving technologies for growing,imaging and analyzing 3D root system architecture of crop plants

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Journal of Integrative plant Biology 2016年第3期58卷 230-241页

作者： miguel A.pieros Brandon G.Larson Jon E.Shaff David J.schneider Alexandre Xavier Falcao Lixing Yuan Randy T.Clark Eric J.Craft Tyler W.Davis pierre-Luc pradier Nathanael m.Shaw Ithipong Assaranurak Susan R.mc Couch Craig Sturrock malcolm Bennett Leon V.Kochian USDA-ARS Robert Holley Center for Agriculture and Health538 Tower RoadIthacaNY 14580USA Department of Information Systems Institute of ComputingUniversity of CampinasAv.Albert Einstein1251CEP 13083-852CampinasSPBrazil Department of plant Nutrition China Agricultural UniversityBeijing 100193China Department of plant Breeding and Genetics Cornell UniversityIthacaNY 14853USA Centre for plant Integrative Biology School of BiosciencesUniversity of NottinghamSutton BoningtonLE12 5RDUK College of Science King Saud UniversityRiyadh 11451Kingdom of Saudi Arabia

A plant＇s ability to maintain or improve its yield under limiting conditions,such as nutrient de ficiency or drought,can be strongly in fluenced by root system architecture（RSA）,the three-dimensional distribution of the different root types in the soil. The ability to image,track and quantify these root system attributes in a dynamic fashion is a useful tool in assessing desirable genetic and physiological root traits. Recent advances in imaging technology and phenotyping software have resulted in substantive progress in describing and quantifying RSA. We have designed a hydroponic growth system which retains the three-dimensional RSA of the plant root system,while allowing for aeration,solution replenishment and the imposition of nutrient treatments,as well as high-quality imaging of the root system. The simplicity and flexibility of the system allows for modi fications tailored to the RSA of different crop species and improved throughput. This paper details the recent improvements and innovations in our root growth and imaging system which allows for greater image sensitivity（detection of fine roots and other root details）,higher ef ficiency,and a broad array of growing conditions for plants that more closely mimic those found under field conditions.

关键词： Abiotic stress digital root phenotyping mineral nutrition root system architecture

美金刚对接受多奈哌齐治疗阿尔茨海默病患者的行为效应

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世界核心医学期刊文摘(神经病学分册) 2006年第12期 12-13页

作者： Cummings J.L. schneider E. Tariot p.N. Graham S.m. 郭俊 Dr.Reed Neurological Research Center UCLABox 951769710 Westwood PlazaLos AngelesCA90095-1769United States

OBJECTIVE:To investigate the behavioral effects of memantine in moderate to severe Alzheimer disease(AD).mETHODS:The authors conducted a hypothesis-generating,exploratory analysis of a 24-week,double-blind,placebo-controlled trial comparing memantine(20 mg/day)with placebo in subjects with moderate to severe AD on stable donepezil *** employed the Neuropsychiatric Inventory(NpI;12-item),administered at baseline,week 12,and week 24,to assess the effects of memantine on ***,cognitive,and functional measures were collected and relationships between these assessments and changes in behavior were *** intent-to-treat population was examined using last-observation-carried-forward and observed-cases ***:patients treated with memantine had significantly lower NpI total scores than patients treated with *** of the 12 NpI domains revealed significant effects in favor of memantine on agitation/aggression,eating/appetite,and irritability/*** patients who exhibited agitation/aggression at baseline,those treated with memantine showed significant reduction of symptoms compared with placebo-treated ***-treated patients without agitation/aggression at baseline evidenced significantly less emergence of this symptom compared with similar patients receiving *** of patients receiving memantine registered significantly less agitation-related *** were significant relationships between the NpI and the global rating scale and performance of activities of daily living,but not between changes in the NpI and ***:Treatment with memantine reduced agitation/aggression,irritability,and appetite/eating *** reduced agitation/aggression in patients who were agitated at baseline and delayed its emergence in those who were free of agitation at baseline.

关键词：多奈哌齐攻击行为侵犯行为阿尔茨海默病美金刚患者行为效应

与橄榄岩矿物平衡的流体:地幔交代作用的含意

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地球与环境 1988年第5期 52-58页

作者： m.E.schneider ,D.H.Eggler ,林兵中国地质大学武汉

金云母橄榄岩实验1.实验结果表3列出了金云母橄榄岩组合的实验结果。这些实验是在1080—1100℃下进行的,这一温度正好在所研究的岩石组合的熔融温度之下。与金云母-顽火辉石-镁橄榄石平衡的流

关键词：流体橄榄岩超基性岩金云母矿物

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涡流问题的有限元—边界积分耦合公式

电炉 1990年第2期 45-50页

作者： S.J.Salon J.m.schneider 杨琦西安电子科技大学

本文提出了一种基于磁矢位的二维涡流问题求解方法。使用这种方法时,可将问题的任一求解域视为有限元区或边界积分区。这些数据通过一个交互图式的预处理程序完成,该程序能自动产生边界单元和有限单元。文中给出了一些实例。

关键词：二维涡流有限元法电磁场计算

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内分泌性眼眶病的磁共振诊断

放射学实践 1991年第4期6卷 181-185页

作者： N.Hosten Ch.Schubert m.Cordes R.schneider R.Felix 储凤梧 Radiologische Klinik und poliklinik des Universit tsklinikums Rudolf Virchow/Charlottenburg der Freien Universit t Berlin 上海第六人民医院

磁共振断层摄影应用的指征范围随着经验的不断增加而扩大.这是对CT检查的重要补充,它能对组织进行鉴别.内分泌性眼眶病就是一个例证.

关键词：内分泌性眼眶病磁共振成象诊断

Unsteady boundary layers on flapping wings

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Unsteady boundary layers on flapping wings