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流程工业 2020年第12期 28-29页

作者： Christian schmitt Kyocera公司

利用废气洗涤清除顺势疗法生产矿物盐时产生的刺激性气体——通过湿式化学工艺技术生产顺势疗法所需的矿物盐时,会产生刺激性很强的酸性气体。废气洗涤器的安装使用有助于制药企业确保职工在工作环境下的人身安全,以及使职工免受有害气... 详细信息

利用废气洗涤清除顺势疗法生产矿物盐时产生的刺激性气体——通过湿式化学工艺技术生产顺势疗法所需的矿物盐时,会产生刺激性很强的酸性气体。废气洗涤器的安装使用有助于制药企业确保职工在工作环境下的人身安全,以及使职工免受有害气体的侵害。

关键词：刺激性气体制药企业顺势疗法矿物盐酸性气体有害气体工艺技术人身安全

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Development and Application of Dual UniValve System Based on a GDI Engine with SI/HCCI Dual Combustion Modes

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Development and Application of Dual UniValve System Based on...

Genomic Analyses Yield Markers for Identifying Agronomically Important Genes in Potato

2015中国汽车工程学会年会

作者： Yintong Liu Stephan schmitt Karsten Grimm Michael Breuer Liguang Li Jun Deng Tongji University

A full-variable-valvetrain prototype named Dual UniValve System has been developed for a GDI engine with SI/HCCI dual combustion modes,improving the fuel economy and emission perfonnance under some of part and low load *** on the dynamic perfonnance test,reliability of Dual UniValve System has been *** addition,under the NEDC condition,UniValve system can optimize the friction loss *** switching response time between valvelifts of Omm to 8mm is only 0.16s,which provides a fast response for transient ***,in the engine test with Dual UniValve System,SI/HCCI combustion mode switching has been also achieved with a fast speed,which increased indicated efficiency by 10%and reduced NO emissions by 99%.

关键词： variable-valve-actuation CVVL SI/HCCI mode switching

来源： cnki会议评论

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Molecular Plant 2018年第3期11卷 473-484页

作者： Yangping Li Christophe Colleoni Junjie Zhang Qiqi Liang Yufeng Hu Holly Ruess Reinhard Simon Yinghong Liu Hanmei Liu Guowu Yu Eric schmitt Ghloe Ponitzki Guangjian Liu Huanhuan Huang Feilong Zhan Lin Chen Yubi Huang David Spooner Binquan Huang College of Agronomy Sichuan Agricultural University Chengdu China Joint International Research Laboratory of Crop Resources and Genetic Improvement of Ministry of Education Sichuan Agricultural University Chengc)u China University of Lille CNRS UMR 8576-UGSF Lille France College of Life Science Sichuan Agricultural University Chengdu China Novogene Bioinformatics Institute Beijing China Vegetable Crops Research Unit USDA-Agricultural Research Service Department of Horticulture University of Wisconsin Madison Wl USA Integrated IT and Computational Research Unit International Potato Center Lima Peru Maize Research Institute Sichuan Agricultural University Chengdu China University of Lille CNRS UMR 8198 Evo Eco-Paleo Lille France Department of Plant Sciences University of Oxford Oxford UK These authors contributed equally to this article.

Wild potato species have substantial phenotypic and physiological diversity. Here, we report a comprehen- sive assessment of wild and cultivated potato species based on genomic analyses of 201 accessions of Solanum section Petota. We sequenced the genomes of these 201 accessions and identified 6 487 006 high-quality single nucleotide polymorphisms （SNPs） from 167 accessions in clade 4 of Solanum section Petota, including 146 wild and 21 cultivated diploid potato accessions with a broad geographic distribution. Genome-wide genetic variation analysis showed that the diversity of wild potatoes is higher than that of cultivated potatoes, and much higher genetic diversity in the agronomically important disease resistance genes was observed in wild potatoes. Furthermore, by exploiting information about known quantitative trait loci （QTL）, we identified 609 genes under selection, including those correlated with the loss of bitterness in tubers and those involved in tuberization, two major domesticated traits of potato. Phylogenetic analyses revealed a north-south division of all species in clade 4, not just those in the S. brevicaule complex, and further supported So candolleanum as the progenitor of cultivated potato and the monophyletic origin of cultivated potato in southern Peru. In addition, we analyzed the genome of S. candolleanum and identified 529 genes lost in cultivated potato. Collectively, the molecular markers generated in this study provide a valuable resource for the identification of agronomicaUy important genes useful for potato breeding.

关键词： potato Solanum section Petota genetic diversity molecular marker domestication phylogeny

Sporadic versus hereditary gastrinomas of the duodenum and pancreas: Distinct clinico-pathological and epidemiological features

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World Journal of Gastroenterology 2006年第34期12卷 5440-5446页

作者： Martin Anlauf Nele Garbrecht Tobias Henopp Anja schmitt Regina Schlenger Andreas Raffel Markus Krausch Oliver Gimm Claus F Eisenberger Wolfram T Knoefel Henning Dralle Paul Komminoth Philipp U Heitz Aurel Perren Günter Klppel Department of Pathology Universityof Kiel Germany Department of Pathology University of Zürich Switzerland Department of Pathology Universityof Kiel Germany Department of Forensic Medicine Universityof Kiel Germany Department of General Visceral andPediatric Surgery University of Düsseldorf Germany Department of General andVisceral Surgery University of Halle-Wittenberg Germany

Gastrinomas are defined as gastrin secreting tumors that are associated with Zollinger-Ellison syndrome （ZES）. ZES is characterized by elevated fasting gastrin serum levels, positive secretin stimulation test and clinical symptoms such as recurrent peptic ulcer disease, gastroesophageal reflux disease and occasional diarrhea. Genetically, nonhereditary （sporadic） gastrinomas are distinguished from hereditary gastrinomas, which are associated with multiple endocrine neoplasia type 1 （MEN1） syndrome. In general, duodenal gastrinomas are small and solitary if they are sporadic and multiple as well as hereditary. The sporadic gastrinomas occur in the duodenum or in the pancreas while the hereditary gastrinomas almost all occur in the duodenum. Our series of 77 sporadic duodenal neuroendocrine tumors （NETs） includes 18 patients （23.4%） with gastrinomas and ZES. Of 535 sporadic NETs in the pancreas collected from the NET archives of the departments of pathology in Zürich, Switzerland, and Kiel, Germany, 24 patients （4.5%） suffered from sporadic pancreatic gastrinomas and ZES. These NETs have to be distinguished from tumors with immunohistochemical positivity for gastrin but without evidence of ZES. An additional 19 patients suffered from MEN1 and ZES. These patients showed exclusively duodenal gastrinomas, but not pancreatic gastrinomas. The prognosis of sporadic and MEN1- associated duodenal gastrinomas is better than that of pancreatic gastrinomas, since they progress slowly to liver metastasis. In summary, sporadic and MEN1- associated gastrinomas in the duodenum and pancreas show different clinico-pathological and genetic features. The incidence of sporadic duodenal gastrin-producing tumors is increasing, possibly due to optimized diagnostic procedures. In contrast, pancreatic MEN1- associated gastrinomas seem to be extremely rare. A considerable subset of tumors with immunohistochemical expression of gastrin but without evidence of ZES should be designated as functio

关键词： Endocrine tumor Gastrinoma Multiple endocrine neoplasia type 1 Precursor lesion Zollinger-Ellison syndrome

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现代实用德语语法

1992年

作者：德赖耶尔·施密特(Dreyer schmitt)原

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法兰克福大学威斯腾特校区设计谈

城乡建设 2017年第6期 74-77页

作者： Jakob schmitt 高磊

法兰克福大学始建于1914年,是德国的第三大校园大学,座落于美丽的美茵河畔,是一所基金会大学,约有48000名学生。由于大学不断扩大,原本位于博肯海姆的校园很快被分散成若干校区。医学院位于尼德拉德校区,自然科学院位于理特堡校区,而体... 详细信息

法兰克福大学始建于1914年,是德国的第三大校园大学,座落于美丽的美茵河畔,是一所基金会大学,约有48000名学生。由于大学不断扩大,原本位于博肯海姆的校园很快被分散成若干校区。医学院位于尼德拉德校区,自然科学院位于理特堡校区,而体育学院位于金海姆校区。在德国统一且

关键词：威斯法本 IG 大厦图书馆建筑物建筑师美术家特校

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材料为食品工业设备而变的塑料产品

现代制造 2013年第46期 32-33页

作者： Ralf schmitt-Kling

法规的重要变化也要求食品工业领域中与食品接触的塑料产品随之而变。这些变化并不是它们的性能发生了变化,而是在食品工业领域巾所使用的塑料容器的存储、使用、跟踪追述和标签方面发生了变化。由此,塑料没备生产企业和塑料设备用户在...

法规的重要变化也要求食品工业领域中与食品接触的塑料产品随之而变。这些变化并不是它们的性能发生了变化,而是在食品工业领域巾所使用的塑料容器的存储、使用、跟踪追述和标签方面发生了变化。由此,塑料没备生产企业和塑料设备用户在执行新规定时将会更加顺利。

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土壤提取液中酰基高丝氨酸内酯的气相色谱-质谱检测方法优化

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土壤学报 2015年第1期52卷 95-103页

作者：生弘杰宋洋卞永荣柳广霞蒋新 P.schmitt-Kopplin 王芳土壤与农业可持续发展国家重点实验室(中国科学院南京土壤研究所) 南京210008 中国科学院大学北京100049 Department of Bio Geo Chemistry and Analytics Helmholtz Zentrum MünchenGerman Research Center for Environmental Health

建立并优化了利用气相色谱-质谱（Gas chromatography-mass spectrometry,GC-MS）检测酰基高丝氨酸内酯（Acyl-homoserine lactones,AHLs）的分析方法。通过优化升温程序,采用选择离子检测（m/z 143）,可同时检测7种AHLs（C4、C6、C7、C8、C10、C12和C14）,检出限分别为1.50、2.00、1.50、2.00、2.00、2.50和2.50μg l-1,在2.0 mg l-1浓度范围内均呈线性关系（R2〉0.997）。加标回收率实验表明,采用乙酸乙酯萃取,水中7种AHLs的回收率均在54%~97%之间;不同比例的土水体系中,砖红壤和黄棕壤提取液中AHLs的回收率均在56%~108%之间。不同介质中AHLs回收率与其Log P值（P：AHLs在正丁醇和水溶液中的分配比）及水溶解度对数均显著相关,表明采用乙酸乙酯萃取水和土壤提取液中的AHLs时,回收率主要与AHLs的Log P值和水溶解度有关。采用该方法对土壤提取液中AHLs进行测定发现砖红壤和黄棕壤提取液中7种AHLs的浓度分别为3.8~8.7μg l-1和4.2~9.8μg l-1。因此,不仅对于水溶液,土壤提取液等复杂介质中的AHLs也可以采用乙酸乙酯萃取后GC-MS进行分析测定。

关键词：信号分子萃取回收率气相色谱-质谱土壤提取液

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Partial external biliary diversion in bile salt export pump deficiency: Association between outcome and mutation

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World Journal of Gastroenterology 2017年第29期23卷 5295-5303页

作者： Philipp Ellinger Jan Stindt Carola Droge Katharina Sattler Claudia Stross Stefanie Kluge Diran Herebian Sander HJ Smits Martin Burdelski Sebastian Schulz-Jürgensen Antje Ballauff Jan Schulte am Esch Ertan Mayatepek Dieter Haussinger Ralf Kubitz Lutz schmitt In-stitute of Biochemistry Hein-rich-Hein-e-Un-iversity Düsseldorf Medical Faculty Departmen-t of Gastroen-terology Hepatology an-d In-fectious Diseases Hein-rich-Hein-e-Un-iversity Düsseldorf Departmen-t of Gen-eral Pediatrics Neon-atology an-d Pediatric Cardiology Medical Faculty Hein-rich-Hein-e-Un-iversity Düsseldorf Departmen-t of Paediatrics Un-iversity Hospital Schleswig Holstein- Departmen-t of Paediatrics Helios Clin-ic Departmen-t of Gen-eral Surgery Hein-rich-Hein-e-Un-iversity

To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency. METHODSMutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization. Bile acid profiles of patient and control bile samples were generated by ultra-performance liquid chromatography-tandem mass spectrometry. Wild-type and mutant BSEP transport of [3H]-labeled taurocholate (TC) and taurochenodeoxycholate (TCDC) was assessed by vesicular transport assays. RESULTSA girl (at 2 mo) presented with pruritus, jaundice and elevated serum bile salts (BS). PEBD stabilized liver function and prevented liver transplantation. She was heterozygous for the BSEP deletion p.T919del and the nonsense mutation p.R1235X. At the age of 17 years relative amounts of conjugated BS in her bile were normal, while total BS were less than 3% as compared to controls. An unrelated boy (age 1.5 years) presenting with severe pruritus and elevated serum BS was heterozygous for the same nonsense and another missense mutation, p.G1032R. PEBD failed to alleviate pruritus, eventually necessitating liver transplantation. BS concentration in bile was about 5% of controls. BS were mainly unconjugated with an unusual low amount of chenodeoxycholate derivatives (< 5%). The patients’ native liver biopsies showed canalicular BSEP expression. Both BSEP p.T919del and p.G1032R were localized in the plasma membrane in HEK293 cells. In vitro transport assays showed drastic reduction of transport by both mutations. Using purified recombinant BSEP as quantifiable reference, per-molecule transport rates for TC and TCDC were determined to be 3 and 2 BS molecu

关键词： Familial intrahepatic cholestasis type 2 Partial external biliary diversion Bile salt export pump ATP binding cassette transporter Intrahepatic cholestasis

2017香槟产区英法市场失利,出货量低于预期

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新食品 2018年第6期 30-31页

作者： Patrick schmitt Vivian(译) 不详

2017年香槟产区出货量低于预期近日,香槟产区发布了2017年香槟出货量,数据显示:2017年香槟产区总出货量为3.073亿瓶,远低于之前香槟委员会的预估数量。由于2017年10月的出货量要高于2016年同期,因此香槟委员会预估该产区2017年的全球总... 详细信息

2017年香槟产区出货量低于预期近日,香槟产区发布了2017年香槟出货量,数据显示:2017年香槟产区总出货量为3.073亿瓶,远低于之前香槟委员会的预估数量。由于2017年10月的出货量要高于2016年同期,因此香槟委员会预估该产区2017年的全球总出货量至少在3.12亿瓶,然而在2017年的最后两个月里,香槟市场却表现得令人失望。

关键词：数据显示英法低于预期出货量香槟市场产区