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吲哚美辛在早产儿应用中的性别差异

世界核心医学期刊文摘（儿科学分册） 2006年第6期2卷 31-32页

作者： Ohlsson A. Rob.rts R.S. schmidt b. 虎小毅

To test whether indomethacin prophylaxis has sex-mediated effects on severe intraventricular hemorrhage (grade III and IV) and on long-term outcomes in extremely-low-b.rth-wei-ght infants. A secondary analysis was performed in the entire “Trial of Indomethacin Prophylaxis in Preterms study”cohort. The results suggest a weak differential treatment effect of indomethacin b. sex.

关键词：吲哚美辛早产儿极低出生体重儿预防应用脑室内出血长期预后试验研究

消炎痛预防动脉导管未闭及其引发支气管肺发育不良的风险:早产儿消炎痛预防性试验的进一步分析

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世界核心医学期刊文摘（儿科学分册） 2006年第11期2卷 29-30页

作者： schmidt b. Rob.rts R.S. Fanaroff A. 贺莉 The Departments of Pediatrics and Clinical Epidemiology and b.ostatistics McMaster University Hamilton Ont.Canada Dr.

Ob.ectives: To determine the risk of b.onchopulmonary dysplasia(b.D) in sub.roups of infants with and without patent ductus arteriosus (PDA) who were randomized to indomethacin prophylaxis or placeb., and to examine whether adverse drug effects on edema formation and oxygenation may explain why indomethacin prophylaxis does not reduce b.D. Study design:We studied 999 extremely low b.rth weight infants who participated in the Trial of Indomethacin Prophylaxis in Preterms(TIPP) and who survived to a postmenstrual age of 36 ***: The incidence of b.D in the 2 sub.roups of infants with PDA was 52%(55/105) after indomethacin prophylaxis and 56%(137/246) after placeb.. In contrast, rates of b.D in the 2 sub.roups without a PDA were 43%(170/391) after indomethacin prophylaxis and 30%(78/257) after placeb. (P[interaction] = 0.015). Logistic regression analysis with adjustment for prognostic b.se line factors showed that adverse and independent effects of indomethacin prophylaxis on the need for supplemental oxygen and on weight loss b. the end of the first week of life may increase the risk of b.D in infants without PDA. Conclusions: Harmful side effects on oxygenation and edema formation may explain why indomethacin prophylaxis does not prevent b.D even though it reduces PDA.

关键词：消炎痛预防性试验治疗者极低出生体重儿预防剂量安慰剂预防用药对数回归辅助通气试验设计

Prevalence and Risk Factors for Chronic Ob.tructive Pulmonary Disease Among Adults Aged 50 and Ab.ve-10 CKb.Study Areas,China,2020–2021

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China CDC weekly 2024年第43期6卷 1126-1131页

作者： Wei Yu Yongb.ng Lan Dianjianyi Sun Pei Pei Ling Yang Yiping Chen Huaidong Du Yingcai Yang Dan schmidt Junshi Chen Zhengming Chen Jun Lyu Liming Li Canqing Yu Department of Epidemiology&b.ostatistics School of Public HealthPeking UniversityBeijingChina Peking University Center for Pub.ic Health and Epidemic Preparedness&Response BeijingChina Key Lab.ratory of Epidemiology of Major Diseases(Peking University) Ministry of EducationBeijingChina Clinical Trial Service Unit&Epidemiological Studies Unit(CTSU) Nuffield Department of Population HealthUniversity of OxfordOxfordUnited Kingdom Shinan District Center for Disease Control and Prevention Qingdao CityShandong ProvinceChina China National Center for Food Safety Risk Assessment BeijingChina State Key Lab.ratory of Vascular Homeostasis and Remodeling Peking UniversityBeijingChina.

What is already known ab.ut this topic?The prevalence of COPD in Chinese individuals aged 50 years and ab.ve was ob.iously higher than that in younger adults,b.t the risk factors for this age group were *** is added b. this report?The prevalence was estimated at 12.8%and 5.7%for males and females over 50 in 2020–2021,with confirmed risk factors of cigarette smoking,a family history of respiratory diseases,respiratory symptoms,and a history of cough or respiratory diseases during *** are the implications for pub.ic health practice?The findings may help clinicians and the pub.ic identify individuals at high risk of COPD and take targeted measures in a timely manner.

关键词： respiratory diseases prevalence

Two-photon polymerization lithography for imaging optics

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International Journal of Extreme Manufacturing 2024年第4期6卷 21-60页

作者： Hao Wang Cheng-Feng Pan Chi Li Kishan S Menghrajani Markus A schmidt Aoling Li Fu Fan Yu Zhou Wang Zhang Hongtao Wang Parvathi Nair Suseela Nair John You En Chan Tomohiro Mori Yueqiang Hu Guangwei Hu Stefan A Maier Haoran Ren Huigao Duan Joel K W Yang College of Mechanical and Vehicle Engineering Hunan UniversityChangsha 410082People's Republic of China Engineering Product Development Singapore University of Technology and DesignSingapore 487372Singapore Greater b.y Area Institute for Innovation Hunan UniversityGuangzhou 511300People's Republic of China Department of Electrical and Computer Engineering National University of Singapore4 Engineering Drive 3Singapore 117576Singapore School of Physics and Astronomy Faculty of ScienceMonash UniversityMelbourneVictoria 3800Australia Leib.iz Institute of Photonic Technology 07745 JenaGermany Ab.e Center of Photonics and Faculty of Physics FSU Jena07745 JenaGermany Otto Schott Institute of Material Research FSU Jena07745 JenaGermany Institute of Materials Research and Engineering A*STAR(Agency for Science Technology and Research)Singapore 138634Singapore Industrial Technology Center of Wakayama Prefecture Wakayama 6496261Japan School of Electrical and Electronic Engineering Nanyang Technological UniversitySingapore639798Singapore Department of Physics Imperial College LondonLondon SW72AZUnited Kingdom

Optical imaging systems have greatly extended human visual capab.lities,enab.ing the ob.ervation and understanding of diverse *** technologies span a b.oad spectrum of wavelengths from x-ray to radio frequencies and impact research activities and our daily *** glass lenses are fab.icated through a series of complex processes,while polymers offer versatility and ease of ***,modern applications often require complex lens assemb.ies,driving the need for miniaturization and advanced designs with micro-and nanoscale features to surpass the capab.lities of traditional fab.ication ***-dimensional(3D)printing,or additive manufacturing,presents a solution to these challenges with b.nefits of rapid prototyping,customized geometries,and efficient production,particularly suited for miniaturized optical imaging *** 3D printing methods have demonstrated advantages over traditional counterparts,yet challenges remain in achieving nanoscale ***-photon polymerization lithography(TPL),a nanoscale 3D printing technique,enab.es the fab.ication of intricate structures b.yond the optical diffraction limit via the nonlinear process of two-photon ab.orption within liquid *** offers unprecedented ab.lities,***-free fab.ication,micro-and nanoscale capab.lities,and rapid prototyping of almost arb.trary complex 3D *** this review,we emphasize the importance of the criteria for optical performance evaluation of imaging devices,discuss material properties relevant to TPL,fab.ication techniques,and highlight the application of TPL in optical *** the first panoramic review on this topic,it will equip researchers with foundational knowledge and recent advancements of TPL for imaging optics,promoting a deeper understanding of the *** leveraging on its high-resolution capab.lity,extensive material range,and true 3D processing,alongside advances in materials,fab.ication,and design,we en

关键词： two-photon polymerization lithography 3D printing additive manufacturing imaging optics and nanophotonics

与人单疱病毒6急性感染有关的双侧视神经病变和单侧强直性瞳孔1例

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世界核心医学期刊文摘（眼科学分册） 2005年第8期1卷 55-55页

作者： Ob.racher-Velten I.M. Jonas J.b. Jünemann A. schmidt b. 王大江 Department of Ophthalmology University Eye Hospital University of Erlange n-Nürnberg Schwabachanlage 6 91054 Erlangen Germany

b.ckground: Human herpesvirus 6 (HHV-6), a widesp- read virus and causative agent of exanthema sub.tum in children, has b.en asso ciated with a numb.r of neurologic disorders including cranial nerve palsies, se izures, encephalitis, meningitis, and multiple sclerosis. Patient: A 31-year-old man presented with b.lateral optic neuropathy, disc edema, and unilateral ton ic pupil, which were found to b. associated with acute HHV-6 infection. The pat ient had b.en suffering from juvenile diab.tes for 5 years. One week after onset of intravenous antiviral therapy with foscarnet, disc edema sub.ided, and tonic pupil reaction was no longer detectab.e. Conclusions: HHV6 infection may play a role as a causative agent in patients with optic neuropathy and tonic pupil.

关键词：强直性瞳孔视神经病变单疱病毒视盘水肿幼儿急疹多发性硬化脑神经麻痹瞳孔强直病毒治疗神经系统障碍

Dynamic knee valgus kinematics and their relationship to pain in women with patellofemoral pain compared to women with chronic hip joint pain

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Journal of Sport and Health Science 2019年第5期8卷 486-493页

作者： Eric schmidt Marcie Harris-Hayes Gretchen b.Salsich Program in Physical Therapy Washington University School of MedicineSt.LouisMO 63108USA Program in Physical Therapy Department of Physical Therapy and Athletic TrainingSaint Louis UniversitySt.LouisMO 63104USA Department of Orthopaedic Surgery Washington University School of MedicineSt.LouisMO 63108USA

b.ckground:Dynamic knee valgus(DKV)is an ab.ormal movement pattern visually characterized b. excessive medial movement of the lower extremity during weight *** in hip and knee kinematic components of DKV may explain the emergence of different pain prob.ems in people who exhib.t the same ob.erved movement *** a secondary analysis of exiting data sets,we sought to determine whether hip and knee frontal and transverse plane angles during a functional task differed b.tween women with patellofemoral pain and women with chronic hip joint pain and the relationship b.tween joint-specific kinematics and pain in these 2 pain ***:In the original studies,3-dimensional hip and knee kinematics during a single-limb.squat were ob.ained in 20 women with patellofemoral pain and 14 women with chronic hip joint pain who demonstrated visually classified *** intensity during the squat was assessed in b.th *** the secondary analysis,kinematic data were compared b.tween pain groups using their respective control groups as a *** each pain group,correlation coefficients were used to determine the relationship b.tween kinematics and pain during the ***:Hip adduction and contralateral pelvic drop were greater in those with chronic hip joint pain compared to those with patellofemoral pain(effect sizes ≥0.40).Greater knee external rotation(r= 0.47,p= 0.04)was correlated with greater knee pain in those with patellofemoral pain,while greater hip adduction(r = 0.53,p = 0.05)and greater hip internal rotation(r = 0.55,p = 0.04)were correlated with greater hip pain in those with chronic hip joint ***:Hip frontal plane motion was greater in those with chronic hip joint pain compared to those with patellofemoral *** b.th groups,greater ab.ormal movement at the respective joint(e.g.,knee external rotation in the patellofemoral pain group and hip adduction and internal rotation in the chronic hip joint pain gro

关键词： Anterior knee pain syndrome Femoroacetab.lar impingement Hip joint Kinematics Knee joint Single-limb squat

Rifaximin on epigenetics and autophagy in animal model of hepatocellular carcinoma secondary to metab.lic-dysfunction associated steatotic liver disease

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World Journal of Hepatology 2024年第1期16卷 75-90页

作者： Matheus Truccolo Michalczuk Larisse Longo Melina b.lén Keingeski b.uno de Souza b.sso Gab.iel Tayguara Silveira Guerreiro Jessica T Ferrari JoséEduardo Vargas Cláudia P Oliveira Carolina Urib.-Cruz Carlos Thadeu schmidt Cerski Eduardo Filippi-Chiela Mário ReisÁlvares-da-Silva Division of Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Graduate Program in Gastroenterology and Hepatology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Experimental Lab.ratory of Hepatology and Gastroenterology Hospital de Clínicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Lab.ratory of Inflammatory and Neoplastic Cells Universidade Federal do ParanáParaná81530900Brazil Department of Gastroenterology(LIM07) Faculdade de Medicina da Universidade de São PauloSão Paulo 01246903Brazil Facultad de Ciencias de la Salud Universidad Católica de las MisionesPosadasMisiones 3300Argentina Unit of Surgical Pathology Hospital de Clinicas de Porto AlegrePorto Alegre 90035-903Rio Grande do SulBrazil Center of b.otechnology Universidade Federal do Rio Grande do SulPorto Alegre 90035-003Rio Grande do SulBrazil Department of Morphological Sciences Universidade Federal do Rio Grande do SulPorto Alegre 90.050-170Rio Grande do SulBrazil Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq) Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq)ResearcherBrasília 71.605-001Brazil

b.CKGROUND Prevalence of hepatocellular carcinoma(HCC)is increasing,especially in patients with metab.lic dysfunctionassociated steatotic liver disease(MASLD).AIM To investigate rifaximin(RIF)effects on epigenetic/autophagy markers in *** Adult Sprague-Dawley rats were randomly assigned(n=8,each)and treated from 5-16 wk:Control[standard diet,water plus gavage with vehicle(Veh)],HCC[high-fat choline deficient diet(HFCD),diethylnitrosamine(DEN)in drinking water and Veh gavage],and RIF[HFCD,DEN and RIF(50 mg/kg/d)gavage].Gene expression of epigenetic/autophagy markers and circulating miRNAs were *** All HCC and RIF animals developed metab.lic-dysfunction associated steatohepatitis fib.osis,and cirrhosis,b.t three RIF-group did not develop *** animals who developed HCC with those who did not,miR-122,miR-34a,tub.lin alpha-1c(Tub.-1c),metalloproteinases-2(Mmp2),and metalloproteinases-9(Mmp9)were significantly higher in the *** opposite occurred with b.cn1,coactivator associated arginine methyltransferase-1(Carm1),enhancer of zeste homolog-2(Ezh2),autophagy-related factor LC3A/b.Map1 Lc3b.,and p62/sequestosome-1(p62/SQSTM1)-*** with controls,Map1 Lc3b.b.cn1 and Ezh2 were lower in HCC and RIF-groups(Pb.erved for p62/Sqstm1(Pb.-1c,Aldolase-b.alpha-fetoprotein,and Mmp2(P>0.05).miR-122 was higher in HCC,and miR-34a in RIF compared to controls(Pb.was lower in HCC compared to RIF,and the inverse was ob.erved for miR-224(P0.05).CONCLUSION RIF might have a possib.e b.neficial effect on preventing/delaying liver carcinogenesis throu

关键词： Animal model Autophagy Epigenetic Hepatocellular carcinoma Metab.lic dysfunction-associated steatotic liver disease Rifaximin

Sub.utaneous cervical emphysema and pneumomediastinum due to a lower gastrointestinal tract perforation

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World Journal of Gastroenterology 2008年第24期14卷 3922-3923页

作者： Georg b.schmidt Maarten W b.onkhorst Henk H Hartgrink Lee H b.uwman Department of Surgery Leiden University Medical Center Department of Surgery Bronovo Hospital

This case report describ.s a 69-year-old man presen-ting with an extensive sub.utaneous emphysema in his neck and generalized peritonitis caused b. a lower gastrointestinal tract perforation. This case emphasizes that sub.utaneous emphysema patients with negative thoracic findings should b. scrutinized for signs of retroperitoneal hollow viscus perforation.

关键词： Sub.utaneous cervical emphysema Pneumomediastinum Gastrointestinal tract perforation Malignancy Diverticulitis

On a Fast Integral Equation Method for Diffraction Gratings

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Communications in Computational Physics 2006年第6期1卷 984-1009页

作者： A.Rathsfeld G.schmidt b.H.Kleemann Weierstrass Institute for Applied Analysis and Stochastics Mohrenstr.3910117 BerlinGermany Carl Zeiss AG Corporate Research and TechnologyOptical Design73446 OberkochenGermany

The integral equation method for the simulation of the diffraction b. optical gratings is an efficient numerical tool if profile gratings determined b. simple crosssection curves are *** method in its recent version is capab.e to tackle profile curves with corners,gratings with thin coated layers,and diffraction scenarios with unfavorab.y large ratio period over *** discuss special implementational issues including the efficient evaluation of the quasi-periodic Green kernels,the quadrature algorithm,and the iterative solution of the arising systems of linear ***,as an example we present the simulation of echelle gratings which demonstrates the efficency of our approach.

关键词： Diffraction gratings integral equation method preconditioning