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血管紧张素II与去甲肾上腺素释放的相互作用及对心脏的影响

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世界核心医学期刊文摘（心脏病学分册） 2005年第11期1卷 56-57页

作者： schlaich m. P. Kaye D. m. Lambert E. 郝广华 Department of medicine IV University of Erlangen-NuernbergKrankenhausstraβe 12 91054 Erlangen Germany Dr.

Background: Angiotensin(Ang) II may enhance the influence of the sympathetic nervous system at various levels by facilitating norepinephrine(NE) release. We investigated whether such an interaction is evident in the human heart and whether it has an impact on left ventricular(LV) structure. methods and results: Ang I and Ang II concentrations were determined in arterial and coronary sinus(CS) plasma samples in a group of normotensive(n=10) and hypertensive(n=18) subjects. Total systemic and cardiac NE spillover was measured using isotope dilution methodology and LV structure by echocardiography. Arterial and CS concentrations of Ang I and Ang II were similar in both groups(Ang II CS, 5.8±4.0 versus 3.7±3.1 fmol/ml; P=not significant), as was the Ang II/ Ang I ratio(CS, 0.56±0.17 versus 0.54±0.22 fmol/fmol; P=not significant). Total systemic(223±145 versus 374±149 ng/min; Pmin; Pmass index(LVmI)(86.7±14.7 versus 117.2±19.4 g/m2; PmI correlated with cardiac NE spillover(r=0.47; PmI(r=-0.20; P=not significant). Arterial Ang II tended to correlate with total systemic NE spillover(r=0.34; P=0.081). When hypertensive subjects were divided into two groups with either high or low CS Ang II concentration, cardiac NE spillover and LVmI did not differ between the two groups. Conclusion: These findings suggest a growth-promoting effect of increased cardiac sympathetic tone on cardiomyocytes in hypertensive patients, but do not support the notion of a significant role of Ang II for norepinephrine release and LV hypertrophy in the hypertensive human heart.

关键词：血管紧张素去甲肾上腺素正常血压血浆样本质量指数交感神经系统左心室冠状窦同位素稀释法超声心动图

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家庭血压监测:澳大利亚专家共识说明

中华高血压杂志 2015年第8期23卷 708-708页

作者：罗雪琚叶鹏 Sharman JE Howes FS Head GA mcGrath XY Stowasser m schlaich m Glasziou P Nelson mR

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPm）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在... 详细信息

医生所测诊室血压可能获取到并无代表性的血压测量结果,从而影响对高血压的准确评估和治疗。家庭血压监测（home blood pressure monitoring,HBPm）是在医疗保健工作者指导下,在一定的时间内（比如7d）患者在家里自行测量血压（通常在早晨和晚间）。当患者不能进行24 h动态血压监测（ambulatory blood pressure monitoring，ABPm）时，HBPm则为诊治高血压提供了另一种方法。HBPm有良好的重复性，良好的耐受性，比较便宜，且对心血管病发病和死亡的预测均优于诊室血压。HBPm可结合诊室血压测量用来识别“白大衣性高血压”和“隐蔽性高血压”。HBPm平均血压≥135／85mmHg（1mmHg=0．133kPa）是高血压诊断的适合阈值。HBPm还有利于患者管理血压，增强药物治疗依从性，达到目标血压水平。该文建议，在合适情况下，应考虑将HBPm常规应用于高血压的临床管理中。

关键词：动态血压监测澳大利亚白大衣性高血压家庭药物治疗依从性专家血压测量患者管理

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高血压高危患者的去肾交感神经术治疗

中华高血压杂志 2020年第8期28卷 775-775页

作者：刘青(译) 刘莉(校) mahfoud F mancia G Schmieder R Narkiewicz K Ruilope L schlaich m Whitbourn R Zirlik A Zeller T Stawowy P Cohen SA Fahy m Bohm m 不详

去肾交感神经术(renal denervation,RDN)治疗难治性高血压的研究正在进行中,对于心血管病风险较高的患者来说,RDN可能是一种具有吸引力的治疗方法。确定基线心血管病风险是否会影响RDN的有效性非常重要。该项研究的目的是评估伴有各种... 详细信息

去肾交感神经术(renal denervation,RDN)治疗难治性高血压的研究正在进行中,对于心血管病风险较高的患者来说,RDN可能是一种具有吸引力的治疗方法。确定基线心血管病风险是否会影响RDN的有效性非常重要。该项研究的目的是评估伴有各种合并症的患者RDN后的血压降低和事件发生率,并验证RDN在这些高风险人群中有效且持久这一假设。

关键词：难治性高血压高风险人群去肾交感神经术高危患者心血管病风险血压降低事件发生率合并症

Neurogenesis dynamics in the olfactory bulb:deciphering circuitry organization, function, and adaptive plasticity

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Neural Regeneration Research 2025年第6期20卷 1565-1581页

作者： moawiah m.Naffaa Department of Psychology and Neuroscience Duke UniversityDurhamNCUSA Department of Cell Biology Duke University School of MedicineDurhamNCUSA

Adult neurogenesis persists after birth in the subventricular zone, with new neurons migrating to the granule cell layer and glomerular layers of the olfactory bulb, where they integrate into existing circuitry as inhibitory interneurons. The generation of these new neurons in the olfactory bulb supports both structural and functional plasticity, aiding in circuit remodeling triggered by memory and learning processes. However, the presence of these neurons, coupled with the cellular diversity within the olfactory bulb, presents an ongoing challenge in understanding its network organization and function. moreover,the continuous integration of new neurons in the olfactory bulb plays a pivotal role in regulating olfactory information processing. This adaptive process responds to changes in epithelial composition and contributes to the formation of olfactory memories by modulating cellular connectivity within the olfactory bulb and interacting intricately with higher-order brain regions. The role of adult neurogenesis in olfactory bulb functions remains a topic of debate. Nevertheless, the functionality of the olfactory bulb is intricately linked to the organization of granule cells around mitral and tufted cells. This organizational pattern significantly impacts output, network behavior, and synaptic plasticity, which are crucial for olfactory perception and memory. Additionally, this organization is further shaped by axon terminals originating from cortical and subcortical regions. Despite the crucial role of olfactory bulb in brain functions and behaviors related to olfaction, these complex and highly interconnected processes have not been comprehensively studied as a whole. Therefore, this manuscript aims to discuss our current understanding and explore how neural plasticity and olfactory neurogenesis contribute to enhancing the adaptability of the olfactory system. These mechanisms are thought to support olfactory learning and memory, potentially through increased

关键词： network adaptability neurogenesis neuronal communication olfactory bulb olfactory learning olfactory memory synaptic plasticity

mitochondria–cGAS–STING axis is a potential therapeutic target for senescence-dependent inflammaging-associated neurodegeneration

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Neural Regeneration Research 2025年第3期20卷 805-807页

作者： Josém.Izquierdo Centro de Biología molecular Severo Ochoa(CBm) Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid(CSIC-UAM)MadridSpain

The word “senescence” comes from the Latin senescens, meaning “to begin to age”, and is characterized by a long-lasting but reversible block in proliferation, resulting from stress-induced cell cycle arrest of pre... 详细信息

关键词： Latin potential lasting

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri J.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

Search for microglia-specific peptides:advances in the discovery toolbox

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Neural Regeneration Research 2025年第2期20卷 471-472页

作者： Ivan Sarabia Kyle m.Koss Department of Surgery University of ArizonaTucsonAZUSA

Uncontrolled and chronic inflammatory states in the central nervous system(CNS)are the hallmark of neurodegenerative pathology and every injury or stroke-related *** key mediators of these neuroinflammatory states are glial cells known as microglia,the resident immune cell at the core of the inflammatory event,and astroglia,which encapsulate inflammatory insults in proteoglycan-rich scar *** gliotic scar blocks significant portions of healthy axonal networking,preventing *** most neuroinflammation is exclusively based on the responses of said microglia,their phenotypes are suggested to follow those of macrophages;m1 and m2 are opposites of pro-and ***,microglial phenotypes have been identified to be on an inflammatory spectrum encompassing developmental,homeostatic,and reparative behaviors as opposed to their ability to affect devastating cell death cascades and scar tissue formation.

关键词： inflammation pathology death

SBL-JP-0004: A promising dual inhibitor of JAK2 and PI3KCD against gastric cancer

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Oncology research 2025年第1期33卷 235-243页

作者： Hassan m Otifi Department of Pathology College of Medicine King Khalid University Abha 62521 Saudi Arabia.

Background:Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions.methods:This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for evaluation.Results:SBL-JP-0004 exhibited a robust binding affinity for JAK2 and PI3KCD kinases, as evidenced by molecular docking scores and molecular dynamics simulations. Binding interactions and Gibbs binding free energy estimates confirmed stable and favorable interactions with target proteins. SBL-JP-0004 displayed an half-maximal inhibitory concentration (IC) value of 118.9 nm against JAK2 kinase and 200.9 nm against PI3KCD enzymes. SBL-JP-0004 exhibited potent inhibition of cell proliferation in KATOIII and SNU-5 cells, with half-maximal growth inhibitory concentration (GI) values of 250.8 and 516.3 nm, respectively. A significant elevation in the early phase apoptosis (28.53% in KATOIII cells and 26.85% in SNU-5 cells) and late phase apoptosis (17.37% in KATOIII cells and 10.05% in SNU-5 cells) were observed with SBL-JP-0004 treatment compared to 2.1% and 2.83% in their respective controls.Conclusion:The results highlight SBL-JP-0004 as a promising dual inhibitor targeting JAK2 and PI3KCD kinases for treating GC and warrant further preclinical and clinical investigations to validate its utility in clinical settings.

关键词： Dual inhibition Gastric cancer (GC) JAK2 molecular docking molecular dynamics simulation PI3KCD SBL-JP-0004

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超低剂量四联疗法治疗高血压的成本效益

中华高血压杂志 2023年第11期31卷 1085-1085页

作者： Atkins ER Chye A Lung T Nolde Jm Billot L Burke m Chalmers J Figtree GA Hay P Hillis GS Jansen S marschner S Neal B Nelson mR Reid Cm Usherwood T schlaich m Chow CK Rodgers A 刘青 (译) 练桂丽(审校) 不详

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验... 详细信息

确定含有厄贝沙坦37.5 mg、氨氯地平1.25 mg、吲达帕胺0.625 mg和比索洛尔2.5 mg的四药联用与厄贝沙坦150 mg相比,对于未经治疗或接受单药治疗的高血压患者的成本效益和成本效用。方法:研究者对四联超低剂量治疗高血压试验进行内部试验和建模经济评估。分析是预先计划的,并在试验期间获取药物和卫生服务的使用情况。

关键词：卫生服务成本效用成本效益超低剂量单药治疗厄贝沙坦四联疗法吲达帕胺