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Hypofractionated stereotactic rad iotherapy alone without whole-brain irradiation for patien ts with solitary and oligo brain metastasis using noninvasive fixation of the skull

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癌症 2003年第7期22卷 744-744页

作者： Aoyama H Shirato H Onimaru R Kagei K Ikeda J Ishii N sawamura y Miyasaka K Department of Radiology Department of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of RadiologyDepartment of Radiology Hokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapanHokkaido University Graduate School of MedicineSapporoJapan

To evaluate the efficacy and toxicity of hypofractionated stereotactic radiotherapy(HSRT)using noninvasive fixation of the sk ull on solitary or oligo brain metastatic p atients as an alternative to stereotactic radiosurgery(SRS)using invasive *** subjects were 87patients who had 4or fewer brain meta stases(50solitary,37oligometastases).Treatment was conducted on 159meta stases by using a linac-based stereotactic system.T he median isocentric dose was 35Gy ***-brain irradiati on was not applied as an initial *** the salvage treatmen t of metachronous brain metastases,repeat HSRT or whole-brain irradiation was *** actuarial1-year local tumor control rate was 81%.Treatment-related complicatio ns were observed in 4patients in the e arly period(y achieved tumor control and survival equivalent to those of SRS reported i n the *** results suggested that HSRT could be an alternative for solitary or oligo br ain metastatic patients with less to xicity and less invasiveness compared to

关键词：脑肿瘤头颅无创固定法定向放射治疗病例报告

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Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)

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中国神经肿瘤杂志 2013年第1期11卷 21-21页

作者： Shibui S Narita y Mizusawa J Beppu T Ogasawara K sawamura y Kobayashi H Nishikawa R Mishima K Muragaki y Maruyama T Kuratsu J Nakamura H Kochi M Minamida y yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita y Nakazato y Sato A Fukuda H Nomura K Department of Neurosurgery and Neuro-Oncology National Cancer Center Hospital5-1-1 TsukijiChuo-kuTokyo 104-0045Japan

Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of *** therapy consists of resection with concomitant *** to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT *** study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + *** primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR ***: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in *** median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,*** median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,*** 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse ***: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM.

关键词：星形细胞母细胞随机试验放疗胶质变性化疗 MGMT

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角蛋白5的尾部区域1649碱基缺失突变的临床异质性:1个单纯型大疱性表皮松解症伴斑状色素沉着的日本家系

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世界核心医学期刊文摘（皮肤病学分册） 2005年第11期1卷 15-15页

作者： Horiguchi y. sawamura D. Mori R. 李政霄 Dr.Department of Dermatology Osaka Red Cross Hospital Fudegasaki-cho 5-30 Ten'noji-ku 543-8555 Osaka Japan

Twenty-five-and 22-y-old Japanese women, who are cousins, presented with distal skin fragility, widespread small, pigmented macules, and toenail deformity. Blisters occurred between the epidermis and the dermis with degeneration of the basal cells, suggesting epidermolysis bullosa simplex with mottled pigmentation (EBS-MP). Electron microscopy of the pigmented spots demonstrated vacuolization of basal cells as well as disturbed junctional structures and incontinence of pigmentation. Gene analysis resulted in detection of a heterozygous deletion of a guanine nucleotide in exon 9 at position 1649. P25L mutation was not detected in either case. It is possible that EBS-MP occurs not only based on the P25L mutation of the keratin 5 molecule, but also because of other types of mutations of epidermal keratin genes.

关键词：角蛋白基因色素沉着缺失突变异质性色素失禁色素性杂合缺失基底细胞空泡化泛发性

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