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Particle elasticity influences polymeric artificial antigen presenting cell effectiveness in vivo via CD8+T cell activation,macrophage uptake,and the protein corona

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Nano Research 2024年第10期17卷 9052-9064页

作者： savannah E.Est-Witte Sydney R.Shannon Dennis H.Gong Kaitlyn G.Calabresi Jawaun J.Harris Kaitlyn Storm Edwin J.Yoo Ariel Isser Vivek P.Jani Natalie K.Livingston Mary O.Omotoso Kelly Rhodes Elana Ben-Akiva Randall A.Meyer Zoe T.Hsieh Simone Sidoli Stephany Y.Tzeng Jonathan P.Schneck Jordan J.Green Translational Tissue Engineering Center Institute for NanobiotechnologyDepartment of Biomedical EngineeringJohns Hopkins School of Medicine400 N BroadwayBaltimoreMD 21231USA Institute for Cell Engineering Department of PathologyJohns Hopkins School of Medicine733 N BroadwayBaltimoreMD 21205USA Department of Biochemistry Albert Einstein College of MedicineThe BronxNew York CityNY 10461USA

Adoptive cell therapy(ACT)is an immunotherapy strategy for cancer that has seen widespread clinical *** ACT,patient-derived lymphocytes are stimulated with the antigen of interest ex vivo,proliferated,then returned to the patient to initiate an antigen-specific antitumor *** effective,this process is resource-intensive and logistically impossible for many *** artificial antigen presenting cells(aAPCs)offer a potential“off-the-shelf”alternative to ex vivo *** particulate aAPCs perform well in vitro,they have had limited success in vivo due to poor bioavailability after *** to bioavailability include rapid clearance,unfavorable biodistribution,and inadequate interactions with CD8+T cells at sites of *** properties such as elasticity have been shown to vastly impact the bioavailability and particle-cell interactions,but this has yet to be investigated in the context of aAPCs for in vivo T-cell *** literature likewise indicates that biomaterial properties,especially elasticity,can modulate T-cell activation in *** the goal of creating a more biomimetic,next-generation particulate aAPC,we developed a poly(ethylene)glycol hydrogel particle platform with tunable elasticity to investigate the impact of elasticity on antigen-specific T cell activation for in vivo adoptive *** this knowledge,we were able to gain more precise control over in vivo T cell activation and investigate possible mechanisms including the effects of aAPC elasticity on T cell binding,macrophage uptake,and the protein corona.

关键词： adoptive cell therapy artificial antigen presenting cells particle drug delivery elasticity protein corona poly(ethylene glycol)

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哇！亲子英文玩出来

Cation engineering on lead iodide perovskites for stable and high-performance photovoltaic applications

作者：杨淑如 savannah

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作者： savannah Knoop.

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Journal of Energy Chemistry 2018年第4期27卷 1017-1039页

作者： Jue Gong Peijun Guo savannah E.Benjamin P.Gregory Van Patten Richard D.Schaller Tao Xu Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueLemontIL 60439USA Department of Chemistry Middle Tennessee State UniversityMurfreesboroTN 37132USA

Perovskite solar cells （PSCs） based on methylammonium lead iodide （CH3NH3PbI3） have shown unprecedentedly outstanding performance in the recent years. Nevertheless, due to the weak interaction between polar CH3NH3＋（MA＋） and inorganic PbI3 sublattices, CH3NH3PbI3 dramatically suffers from poor moisture stability, thermal decomposition and device hysteresis. As such, strong electrostatic interactions between cations and anionic frameworks are desired for synergistic improvements of the abovementioned issues. While replacements of I with Br and/or CI evidently widen optical bandgaps of perovskite materials, compositional modifications can solely be applied on cation components in order to preserve the broad absorption of solar spectrum. Herein, we review the current successful practices in achieving efficient, stable and minimally hysteretic PSCs with lead iodide perovskite systems that employ photoactive cesium lead iodide （CsPbI3）, formamidinium lead iodide （HC（NH2）2PbI3, or FAPbI3）, MA1-x y-zFAxCsyRbzPbI3 mixed-cation settings as well as two-dimensional butylammonium （C4H9NH3＋, or BA＋）/MA＋, polymeric ammonium （PEI＋）/MA＋ co-cation layered structures. Fundamental aspects behind the stabilization of perovskite phases α-CsPbi3, α-FAPbI3, mixed-cation MA1-x-y-zFAxCsyRb2PbI3 and crystallographic alignment of （BA）2（MA）3Pb4I13 for effective light absorption and charge transport will be discussed. This review will contribute to the continuous development of photovoltaic technology based on PSCs.

关键词： Solar energy conversion Perovskite solar cells Power conversion efficiency Optical bandgaps Device hysteresis Metastabte phases

Microglial process convergence on axonal segments in health and disease

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Neuroimmunology and Neuroinflammation 2020年第1期7卷 23-39页

作者： savannah D.Benusa Audrey D.Lafrenaye Department of Anatomy and Neurobiology Virginia Commonwealth UniversityRichmondVA 23298USA

Microglia dynamically interact with neurons influencing the development, structure, and function of neuronal networks. Recent studies suggest microglia may also influence neuronal activity by physically interacting with axonal domains responsible for action potential initiation and propagation. However, the nature of these microglial process interactions is not well understood. Microglial-axonal contacts are present early in development and persist through adulthood, implicating microglial interactions in the regulation of axonal integrity in both the developing and mature central nervous system. Moreover, changes in microglial-axonal contact have been described in disease states such as multiple sclerosis (MS) and traumatic brain injury (TBI). Depending on the disease state, there are increased associations with specific axonal segments. In MS, there is enhanced contact with the axon initial segment and node of Ranvier, while, in TBI, microglia alter interactions with axons at the site of injury, as well as at the axon initial segment. In this article, we review the interactions of microglial processes with axonal segments, analyzing their associations with various axonal domains and how these interactions may differ between MS and TBI. Furthermore, we discuss potential functional consequences and molecular mechanisms of these interactions and how these may differ among various types of microglial-axonal interactions.

关键词： Microglia multiple sclerosis traumatic brain injury microglia-axonal interactions

Feasibility study of minimally trained medical students using the Rural Obstetrical Ultrasound Triage Exam(ROUTE)in rural Panama

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World Journal of Emergency Medicine 2018年第3期9卷 216-222页

作者： Annasha Vyas Katherine Moran Joshua Livingston savannah Gonzales Marlene Torres Ali Duffens Carina Mireles Romo Gnevieve Mazza Briana Livingston Shadi Lahham John Christian Fox School of Medicine University of California IrvineIrvineCA 92697USA Department of Obstetrics and Gynecology University of California IrvineOrangeCA 92868USA Department of Emergency Medicine University of California IrvineOrangeCA 92868USA

BACKGROUND:Maternal and infant mortality rates reported in rural Panama are greater than those in urban *** del Toro is a region of Panama inhabited by indigenous people at greater risk for pregnancy-related complications and deaths due to geographic isolation and limited access to health *** ultrasound training programs have recently been implemented in low-resource settings to increase access to diagnostic *** goal of this study is to determine the feasibility of teaching firstyear medical students the Rural Obstetrical Ultrasound Triage Exam(ROUTE)to help identify pathology in pregnant women of the Bocas del Toro region of ***:Eight first-year medical students completed ROUTE training *** training,the students were compared to professional sonographers to evaluate their accuracy in performing the *** then performed the ROUTE in mobile clinics within Bocas del *** enrolled women pregnant in their 2nd or 3rd trimesters and measured biparietal diameter,head circumference,amniotic fluid index,fetal lie and placental *** abnormal measurement would be further analyzed by the lead physician for a potential hospital ***:A total of 60 women were enrolled in the *** women were detected as having a possible high-risk pregnancy and thus referred to a hospital for further ***:Based on our data,first-year medical students with additional training can use the ROUTE to identify complications in pregnancy using ultrasound in rural *** studies are required to determine the optimal amount of training required for proficiency.

关键词： Point of care ultrasound Ultrasound education Rural Panama Obstetrics ultrasound

Assessment of clinical dehydration using point of care ultrasound for pediatric patients in rural Panama

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World Journal of Emergency Medicine 2019年第1期10卷 46-50页

作者： Genevieve Mazza Carina Mireles Romo Marlene Torres Ali Duffens Annasha Vyas Katherine Moran Joshua Livingston savannah Gonzales Shadi Lahham Inna Shniter Maxwell Thompson John Christian Fox School of Medicine University of California Irvine Department of Emergency Medicine University of California Irvine

BACKGROUND: Dehydration and its associated symptoms are among the most common chief complaints of children in rural Panama. Previous studies have shown that intravascular volume correlates to the ratio of the diameters of the inferior vena cava(IVC) to the aorta(Ao). Our study aims to determine if medical students can detect pediatric dehydration using ultrasound on patients in rural Panama. METHODS: This was a prospective, observational study conducted in the Bocas del Toro region of rural Panama. Children between the ages of 1 to 15 years presenting with diarrhea, vomiting, or parasitic infection were enrolled in the study. Ultrasound measurements of the diameters of the IVC and abdominal aorta were taken to assess for dehydration. RESULTS: A total of 59 patients were enrolled in this study. Twenty-four patients were clinically diagnosed with dehydration and 35 were classified to have normal hydration status. Of the 24 patients with dehydration, half(n=12) of these patients had an IVC/Ao ratio below the American threshold of 0.8. Of the remaining asymptomatic subjects, about half(n=18) of these subjects also had an IVC/Ao ratio below the American threshold of ***: Our study did not support previous literature showing that the IVC/Ao ratio is lower in children with dehydration. It is possible that the American standard for evaluating clinical dehydration is not compatible with the rural pediatric populations of Panama.

关键词： Ultrasound Parasitic infection Panama Rural medicine Dehydration Medical education

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Biomedical and Environmental Sciences 1996年第4期9卷 380-385页

作者： G. UMA DEVI K. INDIRA G. R. V. BABU AND C. S. CHETTY (Dopartment of Zoology, S. V University, Tirupati-517 502 India Department of Medicine, Univ. Med Center, Jackson, MS 39216, USA, Department of Biology, savannah State University, savannah,GA 31404 Department of Zoology S. V. University Tirupati India.

Induced-acetaldehyde toxic effects on gluatathione [GSH] metabolism and sulfhydryl (SH) groups in liver and in brain of female albino rats with reference to age was *** total -SH groups were decreased whereas the specific activities of glutathione-S-transferase [GST] and glutathione peroxidase [GP0] were increased in acetaldehyde treated rats. However, the specific activity levels of glutathione reductase [GR] and Γ-glutamylcysteine synthetase [Γ-GCS] were decreased. In general, acetaldehyde indueed changes in the specific activities of the enzymes that increase with increasing age

关键词： SH Age-related Metabolic Effects of Acetaldehyde on Rats With Reference to Detoxification Enzymes and Sulfhydryl Groups

Effect of Acetaldehyde on Oxidoreductases in Tissues of Rats at Different Ages

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Biomedical and Environmental Sciences 1996年第4期9卷 430-436页

作者： G. UMA DEVI K. INDIRA G. R. V. BABU AND C. S. CHETTY (Department of Zoology, S. V University, Tirupati-517 502 India Department of Medicine, Univ. Med Center, Jackson, MS-39216,USA Department of Biology, savannah State University,savannah GA-31404, Department of Zoology S. V. University Tirupati India.

The toxicity of acetaldehyde and age related changes on oxidoreductases in the liver,brain, kidney, and musele of female albino rats (Wistar strain) were studied. The specific activities of lactate [LDH], isocitrate [ICDH (NAD/NADP)], succinate [SDH], malate [MDH], glutamate [GDH] and glucose-6-Phosphate [G-6-PDH] dehydrogenases were signifieantly inereased as a function of age. However, acetaldehyde treatment significantly inhibited oxidoreductases in the tissues of 21, 90 and 180 day old rats. Liver enzymes of young (21 days) rats exhibited greater sensitivity to acetaldehyde toxicity. Similar inhibition of oxidoreductases in brain and kidney of adult (180 days) rats treated with acetaldehyde was observed. LDH and GDH as compared to other enzymes studied showed higher susceptibility to acetaldehyde toxicity. The differential sensitivity of tissues and inhibition of oxidoreductases by acetaldehyde as a function of age could be attributed to hypoxic conditions, energy crisis, and mitochondrial structural changes. The results suggest that acetaldehyde affects oxidation of glucose via HMP shuni pathway, glycolytic pathway and Krebs cycle resulting in the impairment of carbohydrate metabolism

关键词： Effect of Acetaldehyde on Oxidoreductases in Tissues of Rats at Different Ages