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Metformin reduces testosterone level in type 2 diabetes mellitus patients and its therapy by traditional medicine

Clinical Traditional Medicine and Pharmacology 2024年第4期5卷 19-26页

作者： Gorika Tomar Mitushi Singh Isha Sharma Anuj Nautiyal saurabh aggarwal Subhash Chandra Havagiray R.Chitme Cassio Rocha Medeiros Micheline de Azevedo Lima Lucia Raquel de Lima Henrique Douglas Melo Coutinho Bhavna Kumar Department of Pharmacy Practice School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Medicine Shri MahantIndiresh HospitalSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmaceutical Chemistry School of Pharmaceutical SciencesSGRR UniversityPatel NagarDehradun 248001UttarakhandIndia Department of Pharmacology and Toxicology Amity Institute of PharmacyAmity UniversitySector-125Noida 201313 UPGwaliorIndia CECAPE College Av.Padre Cícero3917-São JoséJuazeiro do Norte 63024-015CEBrazil Department of Molecular Biology Federal University of Paraiba-UFPBJoao Pessoa 58051-900ParaibaBrazil Department of Biological Chemistry Regional University of Cariri-URCACrato 63105-000CEBrazil Department of Pharmaceutics DIT UniversityDehradun 248009UttarakhandIndia

Background:Type 2 Diabetes Mellitus(T2DM)is a chronic metabolic disorder characterized by insulin resistance and ***,a commonly prescribed treatment for T2DM,is known for its effectiveness in improving glycemic *** studies suggest that metformin may also influence testosterone levels in male patients,a hormone crucial for male reproductive health,muscle mass maintenance,and overall quality of *** plants were traditionally used for influencing the testosterone level in the body which may be given as a therapy for the side–effects of metformin ***:To assess the impact of metformin treatment on testosterone levels in male patients with T2DM compared to non-diabetic males,and to evaluate the potential implications of traditional medical treatments in managing the consequences of reduced testosterone ***:This study is a prospective observational investigation conducted among a total of 60 patients,divided into two groups:30 males taking metformin as a hyperglycaemic agent with T2DM and 30 males without any diabetic *** study was be carried out in different outpatient department of Shri Mahant Indiresh Hospital,Patel Nagar,Dehradun to assess the level of testosterone in male patients with T2DM taking metformin and in non-Diabetic *** on these findings,potential traditional medicines methods for reducing testosterone levels were ***:It was demonstrated that male patients with T2DM undergoing metformin treatment exhibited significant reduction in testosterone serum levels compared to non-diabetic *** plants were examinedand,and clinical studies were conducted on *** was discovered that these plants have been effective in increasingtestosterone level,suggesting their potential use as therapy for ***:This study shows reduction in the testosterone levels,which may lead to low sex drives and induction of low testosterone induced erectile dy

关键词： Type 2 diabetes mellitus Testosterone Metformin Erectile dysfunction Hyperglycaemia

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An experimental study on optimizing parameters for sand consolidation with organic-inorganic silicate solutions

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Petroleum 2024年第3期10卷 483-493页

作者： saurabh Mishra Geetanjali Chauhan Keka Ojha Department of Energy Science and Technology Centre for Advanced StudiesLucknowIndia Department of Petroleum Engineering and Earth Sciences Indian Institute of Petroleum and EnergyVisakhapatnamIndia Department of Petroleum Engineering Indian Institute of Technology(ISM)DhanbadIndia

Sand production along with the oil/gas detrimentally affects the oil production rate,downhole&subsurface *** equipment and various chemicals like epoxy resin,furan resin,phenolic resin,*** used in the industry to reduce or eliminate this *** the present study,a blend of organic and inorganic silicates are used to consolidate loose sand in the presence and absence of crude oil using a core flooding *** effects of chemical concentration,pH,curing temperature and time,and the presence of residual oil on the consolidation treatment results such as compressive strength and permeability retention,were investigated and ***-IR and FE-SEM characterization techniques were employed to investigate the interaction between the chemical molecules and the sand *** current binding agent exhibited a viscosity of less than 6 cP at room temperature,which facilitates efficient pumping of binding agent into the desired formation through the well *** developed mixture demonstrated consolidation properties across all pH ***,during the experimental investigation,the curing time and temperature was carefully optimized at 12 h and 423.15K,respectively to achieve the highest compressive strength of 2021 psi while achieving the permeability retention of 64%.The current chemical system exhibited improved consolidation capacity and can be effectively utilized for sand consolidation treatment in high-temperature formations.

关键词： Chemical sand consolidation Rheology Compressive strength Permeability retention Silicate system Curing

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靶向抗肿瘤药物“市”不可挡

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中国处方药 2010年第6期9卷 50-51页

作者： saurabh aggarwal 石永进

靶向抗肿瘤药物市场持续快速增长,同时处于临床研究阶段的新药越来越多,给市场带来了更多的商机。

关键词：抗肿瘤药物靶向药物市场临床研究

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EPASAD:ellipsoid decision boundary based Process-Aware Stealthy Attack Detector

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Cybersecurity 2024年第3期7卷 32-48页

作者： Vikas Maurya Rachit Agarwal saurabh Kumar Sandeep Shukla Department of Computer Science and Engineering Indian Institute of Technology KanpurkanpurIndia Merkle Science BangaloreIndia

Due to the importance of Critical Infrastructure(Cl)in a nation's economy,they have been lucrative targets for cyber *** critical infrastructures are usually Cyber-Physical Systems such as power grids,water,and sewage treatment facilities,oil and gas pipelines,*** recent times,these systems have suffered from cyber attacks numer-ous *** have been developing cyber security solutions for Cls to avoid lasting *** to standard frameworks,cyber security based on identification,protection,detection,response,and recovery are at the core of these *** of an ongoing attack that escapes standard protection such as firewall,anti-virus,and host/network intrusion detection has gained importance as such attacks eventually affect the physical dynamics of the ***,anomaly detection in physical dynamics proves an effective means to implement *** is one example of anomaly detection in the sensor/actuator data,representing such systems physical *** present EPASAD,which improves the detection technique used in PASAD to detect these micro-stealthy attacks,as our experiments show that PASAD's spherical boundary-based detection fails to *** method EPASAD overcomes this by using Ellipsoid boundaries,thereby tightening the boundaries in various dimen-sions,whereas a spherical boundary treats all dimensions *** validate EPASAD using the dataset produced by the TE-process simulator and the C-town *** results show that EPASAD improves PASAD's average recall by 5.8%and 9.5%for the two datasets,respectively.

关键词： Intrusion detection system Critical infrastructure security Industrial control system Machine learning

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A hybrid machine learning approach based study of production forecasting and factors influencing the multiphase flow through surface chokes

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Petroleum 2024年第2期10卷 354-371页

作者： Waquar Kaleem saurabh Tewari Mrigya Fogat Dmitriy A.Martyushev Department of Industrial and Manufacturing Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Data Sciences Gyan Ganga Institute of Technology and SciencesJabalpur482002India Department of Petroleum and Geo-Engineering Rajiv Gandhi Institute of Petroleum Technology JaisBahadurpur229304India Department of Oil and Gas Technologies Perm National Research Polytechnic UniversityPerm614990Russia

Surface chokes are widely utilized equipment installed on wellheads to control hydrocarbon flow *** correlations have been suggested to model the multiphase flow of oil and gas via surface ***,substantial errors have been reported in empirical fitting models and correlations to estimate hydrocarbon flow because of the reservoir's heterogeneity,anisotropism,variance in reservoir fluid characteristics at diverse subsurface depths,which introduces complexity in production ***,the estimation of daily oil and gas production rates is still challenging for the petroleum ***,hybrid data-driven techniques have been reported to be effective for estimation problems in various aspects of the petroleum *** paper investigates hybrid ensemble data-driven approaches to forecast multiphase flow rates through the surface choke(*** generalization and voting architectures),followed by an assessment of the impact of input production control ***,machine learning models are also trained and tested individually on the production data of hydrocarbon wells located in North *** engineering has been properly applied to select the most suitable contributing control variables for daily production rate *** study provides a chronological explanation of the data analytics required for the interpretation of production *** test results reveal the estimation performance of the stacked generalization architecture has outperformed other significant paradigms considered for production forecasting.

关键词： Machine learning Tree-based methods Stacking ensemble Multiphase flow Data analytics Wellhead choke variables

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Barriers and drivers for sustainable public transportation in Indian context

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Green Energy and Intelligent Transportation 2024年第1期3卷 32-45页

作者： Gopi R Dev Vrat Pathak saurabh Pratap Lakshay Department of Mechanical Engineering Indian Institute of TechnologyVaranasiIndia

Rising negative externalities,including greenhouse gas emissions,climate change,and environmental pollution,shows the need for sustainable and environmentally friendly modes of *** zero-emission,environmentally friendly electric buses in public transportation systems can be an effective solution for both developing and developed countries,including *** the Indian government is making numerous efforts to promote electric buses in commercial and public transportation systems,it faces several formidable *** research objective is to analyze and evaluate the primary factors influencing the adoption and usage of electric buses in the Indian public transportation system,within the limited available resources.A survey questionnaire is prepared with several perceptual subjects for the key perceived *** empirical analysis using Structural Equation Modeling(SEM)is then performed to identify the critical *** result of this study demonstrates that the infrastructural barriers substantially impact the adoption and utilization of electric ***,the study provides critical insights and managerial implications for decision-makers.

关键词： Electric bus adoption Public transportation system Barriers Structural equation modelling Exploratory factor analysis Confirmatory factor analysis

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Role of endoscopic ultrasound-guided biliary drainage for palliation of malignant biliary obstruction

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2369-2373页

作者： Sahib Singh saurabh Chandan Antonio Facciorusso Department of Internal Medicine Sinai HospitalBaltimoreMD 21215United States Center for Interventional Endoscopy(CIE) Advent HealthOrlandoFL 32803United States Gastroenterology Unit Department of Medical and Surgical SciencesUniversity of FoggiaFoggia 71122Italy

Endoscopic ultrasound-guided biliary drainage(EUS-BD)directs bile flow into the digestive tract and has been mostly used in patients with malignant biliary obstruction(MBO)where endoscopic retrograde cholangiopancreatography-guided biliary drainage was unsuccessful or was not *** apposing metal stents(LAMS)are deployed during EUS-BD,with the newer electrocautery-enhanced LAMS reducing procedure time and complication rates due to the inbuilt cautery at the catheter ***-BD with electrocautery-enhanced LAMS has high technical and clinical success rates for palliation of MBO,with bleeding,cholangitis,and stent occlusion being the most common adverse *** studies have even suggested comparable efficacy between EUS-BD and endosc-opic retrograde cholangiopancreatography as the primary approach for distal *** this editorial,we commented on the article by Peng et al published in the recent issue of the World Journal of Gastrointestinal Surgery in 2024.

关键词： Endoscopic ultrasound Endoscopic ultrasound guided biliary drainage Cancer Pancreas Bile duct Endoscopy

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A Novel High-Efficiency Transaction Verification Scheme for Blockchain Systems

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Computer Modeling in Engineering & Sciences 2024年第5期139卷 1613-1633页

作者： Jingyu Zhang Pian Zhou Jin Wang Osama Alfarraj saurabh Singh Min Zhu School of Computer&Communication Engineering Changsha University of Science&TechnologyChangsha410015China Science and Technology on Information Systems Engineering Laboratory School of Systems EngineeringNational University of Defense TechnologyChangsha410073China Computer Science Department King Saud UniversityRiyadh11437Saudi Arabia Department of Artificial Intelligence and Big Data Woosong UniversityDaejeon34606South Korea College of Information Science and Technology Zhejiang Shuren UniversityHangzhou310015China

Blockchain can realize the reliable storage of a large amount of data that is chronologically related and verifiable within the *** technology has been widely used and has developed rapidly in big data systems across various *** increasing number of users are participating in application systems that use blockchain as their underlying *** the number of transactions and the capital involved in blockchain grow,ensuring information security becomes *** the verification of transactional information security and privacy has emerged as a critical ***-based verification methods can effectively eliminate the need for centralized third-party ***,the efficiency of nodes in storing and verifying blockchain data faces unprecedented *** address this issue,this paper introduces an efficient verification scheme for transaction ***,it presents a node evaluation module to estimate the activity level of user nodes participating in transactions,accompanied by a probabilistic analysis for all ***,this paper optimizes the conventional transaction organization form,introduces a heterogeneous Merkle tree storage structure,and designs algorithms for constructing these heterogeneous *** analyses and simulation experiments conclusively demonstrate the superior performance of this *** verifying the same number of transactions,the heterogeneous Merkle tree transmits less data and is more efficient than traditional *** findings indicate that the heterogeneous Merkle tree structure is suitable for various blockchain applications,including the Internet of *** scheme can markedly enhance the efficiency of information verification and bolster the security of distributed systems.

关键词： Blockchain architecture transaction verification information security heterogeneous Merkle tree distributed systems

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Digital-Twin Enabled Time Ahead Resource Allocation for Integrated Fiber-Wireless Connected Vehicular Network

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Journal of Communications and Information Networks 2024年第3期9卷 296-308页

作者： Akshita Gupta saurabh Jaiswal Martin Maier Vivek Ashok Bohara Anand Srivastava Wirocomm Research Group Department of Electronics&Communication EngineeringIndraprastha Institute of Information Technology Delhi(IIITD)New Delhi 110020India Department of Computer Science&Applied Mathematics Indraprastha Institute of Information Technology Delhi(IIITD)New Delhi 110020India Optical Zeitgeist Laboratory Institute National de la Recherche ScientifiqueMontreal H5A 1K6Canada

The digital twin(DT)is envisaged as a catalyst for pioneering ecosystems of service provision within an immersive environment born from the convergence of virtual and physical ***,DT could enhance the performance of edge-intelligent connected vehicular networks by allocating network resources efficiently based on the key performance indicators(KPIs)of vehicular data ***,this work addresses the key challenge of computation and spectrum resource allocation for vehicular *** allocate the optimal resource allocation,we subdivided the problem into:traffic classification,collective learning,and resource allocation *** order to do so,this paper concentrates on two crucial vehicular applications:brake application and lane-change *** utilize a random forest model to collectively learn vehicular data traffic in the upcoming time ***,a time-ahead resource allocation algorithm is proposed to improve the quality of service(QoS)by intelligently offloading vehicular data traffic to a DT-based integrated fiber-wireless(Fi-Wi)connected vehicular *** evaluate the performance of the resource allocation strategy in terms of resources required by the network alongside the packet loss *** was observed that there was a 44.74%increase in cost as the total computation resources increased from F=50 to 100 GHz,whereas the PLR of the network decreased by 71.43%.

关键词： connected vehicles digital twin edgeintelligence fiber-wireless machine learning resource allocation

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Overcoming the Challenges Encountered in the Performance Appraisal of Faculty Members

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Journal of Forensic Science and Medicine 2024年第2期10卷 152-154页

作者： saurabh RamBihariLal Shrivastava Ulfa Zora Yulia Putri Ayunigdyah Abhishek Joshi Deputy Director(Research and Development) Datta Meghe Institute of Higher Education and Research NagpurOff CampusDepartment of Community MedicineDatta Meghe Medical CollegeOff-campus Centre of Datta Meghe Institute of Higher Education and ResearchHingna RoadWanadongriNagpurMaharashtraIndia Department of Medical Education Faculty of MedicinePublic Health and NursingUniversitas Gadjah MadaYogyakartaIndonesia Department of Research and Education Dr.Yap Eye HospitalYogyakartaIndonesia Department of Community Medicine Jawaharlal Nehru Medical CollegeDatta Meghe Institute of Higher Education and ResearchSawangiWardhaMaharashtraIndia

Performance appraisal of teaching faculty who are involved in the act of delivery of medical education to prepare future doctors plays a pivotal role in measuring their competency level to train students,assessing the effectiveness in discharging their other roles,and acts as a motivating factor to continuously improvise and augment their knowledge and ***,the ground reality is that in most settings,this task is not acknowledged as an action for motivating a faculty member,but rather just an act of *** the identification of these challenges,we must look for remedial measures to overcome them to streamline and enhance the effectiveness of the performance appraisal *** conclusion,the performance appraisal of teaching faculty is an essential and indispensable ***,the success of performance appraisal,in terms of promoting professional development and organizational success,will depend a lot on the effective redressal of the existing challenges.

关键词： Faculty medical education performance appraisal

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