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Green tea——a new perspective of glaucoma prevention

International Journal of Ophthalmology(English edition) 2022年第5期15卷 747-752页

作者： Kornelijus Gasiunas saulius galgauskas Vilnius University Faculty of Medicine Vilnius 03101Lithuania Center of Eye Diseases Vilnius University Hospital Santaros KlinikosVilnius 08661Lithuania

AIM:To determine how green tea and catechins can affect intraocular pressure(IOP)***:Totally 43 young volunteers were included in the *** experiment was held between noon and 2 *** extracts—green tea and epigallocatechin gallate(EGCG,400 mg capsules)and placebo(400 mg capsules)were used in the *** were divided into three *** tea extract group(GT group)had 17 subjects,EGCG extract group 17 subjects,control(placebo)group 9 *** was measured with the Icare tonometer before and 30 min,1,1.5,2 h after the consumption of each extract and *** were analyzed using the IBM SPSS *** confidence level P<***:The most significant reduction of IOP from the beginning of the experiment was measured after 2 h in GT group(left 2.18±3.19 mm Hg,P=0.012;right 2.59±1.97 mm Hg,P<0.000)and after 1 h in EGCG extract group(left 2.41±2.98 mm Hg,P<0.004;right 1.94±1.98 mm Hg,P<0.001).In control group no significant changes were ***:People who have increased IOP or risk factors for glaucoma development,could benefit from drinking green tea or its concentrated extracts in moderate doses.

关键词： intraocular pressure glaucoma ocular hypertension tea catechin

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Rabbit models of dry eye disease: comparative analysis

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International Journal of Ophthalmology(English edition) 2023年第8期16卷 1177-1185页

作者： Vytautas Baranauskas Julija Daukantaitė saulius galgauskas Vilnius University Institute of Biochemistry Life Science CentreSauletekio av 7VilniusLT 10257Lithuania Vilnius University Faculty of Medicine M.K.Čiurlionio str.21VilniusLT 03101Lithuania

AIM:To report ocular changes in rabbits after the implementation of three different induction methods to create dry eye(DE)conditions and provides evidence of DErelated disease ***:Experimental methods were divided into 3 *** first model used involved triple injection of complete Freund’s adjuvant,50µL each,also called the meibomian gland dysfunction(MGD)*** the second model,DE conditions were created by the resection of nictitating membranes(NM),Harderian glands(HG),and main lacrimal glands(LG),also called the LGR *** third model involved the topical administration of benzalkonium chloride(BAK)0.1%*** Schirmer test,ocular surface staining with fluorescein,and tear breakup time tests were implemented before and after *** euthanasia,the ocular tissues were ***,conjunctiva,and meibomian glands were treated with periodic acid–Schiff(PAS)staining and haematoxylin–eosin ***:The MGD model triggered inflammation of meibomian *** detected changes in the lipid layer of the tear *** bilateral resection of NM,HG,and LG reduced the watering layer of the tear *** topical administration of BAK of 0.1%solution impacted the mucosal layer of the tear ***:Different changes are observed with different DE syndrome *** composition of the tear film differ depending on which part of the eye is *** studies need to be done to confirm whether an increased thickness of the cornea has any impact on the DE disease.

关键词： ocular surface lid inflammation keratitis tear deficiency rabbits dry eye disease

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Endothelial parameters in central and peripheral cornea in patients wearing contact lenses

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1768-1773页

作者： saulius galgauskas Justina Ignataviciute Zivile Vieversyte Rimvydas Asoklis Vilnius University Center of eye diseases Faculty of Medicine Vilnius University

AIM： To measure the parameters of endothelium in the central and peripheral parts of the cornea and evaluate the influence of wearing the hard and soft contact lenses on the mentioned ***： A specular microscope was used to measure the corneal endothelium parameters in both eyes of 139 Caucasians（a total of 278）. All participants were divided into three groups： soft lens wearers, hard lens wearers and a control group. Factors, such as age, smoking, types of lens material, duration of lens wear and lens air permeability were assessed to determine their impact on the morphometric parameters of the ***： A lower percentage of hexagon-like cells and higher cell variation than in other groups were determined in hard contact lens wearers. The difference in density of endotheliocytes between the groups was not observed. The measurements of the morphometric parameters in soft contact lens wearers did not depend neither on the duration of lens wear, nor on air permeability. The relation between the patients＇ age and the variation of endothelium parameters was determined in the group of hard contact lens ***： Wearing hard contact lenses provokes pleomorphism and polymegethism of the corneal endothelium, while soft contact lenses do not impact any parameters of the endothelium, most likely due to higher air permeability.

关键词： corneal endothelium morphometry endothelial changes contact lenses

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Comparison of intraocular pressure measurements with different contact tonometers in young healthy persons

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 76-80页

作者： saulius galgauskas rasa strupaite ernesta strelkauskaite rimvydas asoklis Center of Eye Diseases Vilnius University Vilnius LT-08661 Lithuania

AIM：To analyze the correlation of Goldmann applanation tonometer（GAT）,I-Care tonometer and Tono-Pen tonometer results in young healthy persons,and to investigate the influence of central corneal thickness（CCT）on intraocular pressure（IOP）measurements recorded with these tonometers.·M ETHODS：We conducted a pilot clinical study in 78eyes of 78 subjects aged 22-28 years old（44 women and34 men;mean age 23.8±1.19y）.IOP was measured using GAT,I-Care and Tono-Pen tonometers,followed by measurements of *** analysis was performed using SPSS 20.0.·RESULTS：The mean IOPs and standard deviation（±SD）for GAT,I-Care and Tono-Pen were 15.62±2.281 mm Hg,16.29±2.726 mm Hg and 16.32±2.393 mm Hg,*** mean CCT was 555.15±29.648μ*** positive correlations between GAT and I-Care,GAT and TonoPen,and I-Care and Tono-Pen tonometers were found（=0.867,〈0.001;=0.861,〈0.001;=0.915,〈0.001,respectively）.In comparison between devices,BlandAltman analysis showed a significant mean difference（MD）in the measurements by GAT and I-Care of-0.679 mm Hg and by GAT and Tono-Pen of-0.705 mm Hg（〈0.001）,but there was no significant difference between I-Care and Tono-Pe（〉0.05）.Both non-gold standard tonometers were affected by CCT;that is,both I-Care and Tono-Pen tonometer values were significantly higher with higher CCT means（〉555μm;MD=-1.282,〈0.001;MD=-0.949,〈0.001,respectively）compared with GAT.·CONCLUSION：Both I-Care and Tono-Pen tonometers overestimated IOP compared with the GAT *** the I-Care or Tono-Pen tonometer could be used instead of GAT because there was no significant difference between their *** CCT values（〉555μm）were associated with overestimated IOP values.

关键词： Goldmann tonometer I-Care tonometer Tono-Pen tonometer comeal thickness intraocular pressure

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