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An Invasive Succulent Plant (Kalanchoe daigremontiana) Influences Soil Carbon and Nitrogen Mineralization in a Neotropical Semiarid Zone

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Pedosphere 2018年第4期28卷 632-643页

作者： Ileana HERRERA Jose R. FERRER-PARIS Diana BENZO saul FLORES Belkis GARCIA Jafet M. NASSAR Ecuela de Ciencias Ambientales Universidad Espiritu Santo Guayaquil 091650 (Ecuador) Centro de Ecologla Instituto Venezolano de Investigaciones Cientificas (IVIC) Caracas 1020 (Venezuela) Centro de Estudios Botdnieos y Agroforestales Instituto Venezolano de Investigaeiones Cientificas Maracaibo 4005 (Venezuela)

It has long been recognized that plant invasions may alter carbon （C） and nitrogen （N） cycles, but the direction and magnitude of such alterations have been rarely quantified. In this study, we quantified the effects caused by the invasion of a noxious exotic plant, Kalanchoe daigrernontiana （Crassulaceae）, on C and N mineralization and enzymatic and microbial activities in the soil of a semiarid locality in Venezuela. We compared soil parameters associated with these processes （C and N mineralization time and the cumulative values, fluorescein diacetate hydrolytic activity, and activities of dehydrogenase, β-glucosidase, glucosaminidase, and urease） between invaded and adjacent non-invaded sites. In addition, correlations among these parameters and the soil physical-chemical properties were also examined to determine if a positive feedback exists between nutrient availability and K. daigremontiana invasion. Overall, our results showed that C mineralization and transformation of organic compounds to NH4^＋ were favored at sites colonized by K. daigrernontiana. With this species, we found the highest cumulative amounts of NH4^＋-N and C and the lowest mineralization time. These results could be explained by higher activities of urease and glueosaminidase in soils under the influence of K. daigremontiana. In addition, higher amounts of organic matter and moisture content in invaded soils might favor C and N mineralization. In conclusion, invasion of Neotropical semiarid zones by K. daigrernontiana may influence the chemical and biological properties of the soils covered by this species, increasing nutrient bioavailability, which, in time, can facilitate the invasion process.

关键词： Akaike Information Criterion C and N pools enzymatic activity NH4^+-N NO3^--N nutrient availability plant invasion

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Screening for self-renewal factors by a combination of mRNA and CGH microarray in human embryonic stem cells

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Frontiers in Biology 2010年第5期5卷 431-438页

作者： Lei XIAO Lixiazi HE saul J.SHARKIS Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Johns Hopkins University School of MedicineBaltimoreMD 21231USA Laboratory of Molecular Cell Biology Institute of Biochemistry and Cell BiologyShanghai Institutes for Biological SciencesChinese Academy of SciencesShanghai 200031China

Human embryonic stem cells(hESCs)undergo self-renewal while maintaining ***,the molecular mechanism that demonstrates how these cells maintain their undifferentiated state and how they self-renew is poorly ***,we characterized an aneuploidy H1 hESC subline(named H1T)using karyotyping and comparative genomic hybridization(CGH)*** the H1T hESC line displays a self-renewal advantage while maintaining an undiffer-entiated state,we speculated that the expression patterns of speciﬁc genes which are related to pluripotency or differentiation were altered;therefore,we attempted to screen for molecules that are propitious for maintenance of stemness by performing a combination of mRNA and CGH microarray analysis which compared the aneuploidy H1T hESC subline versus the euploid H1 hESC *** is discovered that some genes are up-regulated in H1T hESC subline such as TBX2 and Wnt3,while some are downregulated,for example,Fbxo7 and ***ﬁndings should fascilitate the study of the complex signaling network which maintains hESC pluripotency and function.

关键词： self-renewal mRNA microarray comparative genomic hybridization(CGH)microarray

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Marked elevation of B-type natriuretic peptide in patients with heart failure and preserved ejection fraction

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The Journal of Biomedical Research 2014年第4期28卷 255-261页

作者： Samuel Tate Andrea Griem Blythe Durbin-Johnson Clifton Watt saul Schaefer Department of Internal Medicine Division of Cardiovascular MedicineUniversity of California DavisDavisCAUSA Department of Public Health Sciences Division of BiostatisticsUniversity of California DavisDavisCAUSA Cardiology Section Department of Veteran AffairsNorthern California Health Care SystemMatherCAUSA

Marked elevations of B-type natriuretic peptide （BNP） are not generally seen in patients with heart failure and preserved ejection fraction （HFpEF）. The objective of this study was to examine the clinical and laboratory characteristics of a large cohort of patients with HFpEF and markedly elevated BNP. A retrospective examination of 421 inpatients at a university hospital admitted with a diagnosis of HFpEF was performed. Clinical and echocardiographic data in 4 groups of patients with levels of BNP ≤ 100 pg/mL, 100-400 pg/mL, 400-1,000 pg/mL and 〉 1,000 pg/mL were compared. Patients with HFpEF and BNP 〉 1,000 pg/mL （28% of the population） were characterized by impaired renal function and greater use of anti-hypertensive medications. A subset of these patients with BNP 〉 1,000 pg/mL had normal renal function （21%） and were significantly older, more frequently female, and tended to have lower ejection fractions. Conversely, patients with HFpEF and BNP ≤100 pg/mL were younger and had preserved renal function. BNP was inversely related to the likelihood of subsequent admission for heart failure, but not to myocardial infarction or death. In conclusion： BNP 〉 1,000 pg/mL is seen in almost 1/3 of patients hospitalized with HFpEF. This elevation of BNP often reflects impaired renal function, but can also be seen in patients with preserved renal function but relatively impaired systolic function.

关键词： B-type natriuretic peptide diastolic heart failure chronic kidney disease

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Structure and magnetostructural correlation of ferrimagnetic meso-tetraphenylporphinatomanganese(Ⅲ) dimethyl- N,N′-dicyanoquinone diiminide, [MnTPP]^+[Me_2DCNQI]^(.-)

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Science China Chemistry 2012年第6期55卷 987-996页

作者： Jordan L. Arthur saul H. Lapidus Peter W. Stephens Joel S. Miller Department of Chemistry University of Utah Salt Lake City Utah 84112-0850 USA Department of Physics & Astronomy Stony Brook University Stony Brook NY 11794-3800 USA Photon Sciences Directorate Brookhaven National Laboratory Upton NY 11973 USA

The structure [MnmTPP][Me2DCNQI] （TPP = tetraphenylporphinato; Me2DCNQI = 2,5-dimethyl-N,N＇-dicyanoquinonediimine） has been determined from X-ray powder diffraction data. The nonsolvated structure is composed of linear （I-D） chains of alternating [MnmTPP]＋ and ta-[MezDCNQI]＇- with intrachain Mn...Mn separations of 12.83 A, and a Mn-NDcNQI distance of 2.18A. The dihedral angle between the mean Mn（N4）xpp and [MezDCNQI]＇-planes, and the Mn-（N-C）ocNQ1 angle are 84.18° and 143.6°, respectively. [MnInTpP][MezDCNQI] has a Tc of 4.3 K from the 10 Hz x（T） data, 2-K coercivity of 5,600 Oe, and 6,300 emuOe/mol remnant magnetization that are reduced from that observed for related materials, and their in- clusion extends the magnetostructural correlation between the intrachain coupling and both the dihedral angle between the mean Mn（N4）xPp and [TCNE]＇-（TCNE --- tetracyanoethylene） planes and Mn-（N-C）Tcr angles. This is in accord with the in- trachain coupling arising from the overlap of the Mnm dz2-1ike singly occupied molecular orbital （SOMO） and the z component of the [TCNE]- π＊（π2＊） SOMO, which increases with decreasing dihedral angle between the mean Mn（N4）xep and [TCNE]＇- planes and Mn-（N-C）TcNE angle.

关键词： metalloporphyrin magnetic ordering ferrimagnet crystal structure

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Coexistent alcohol-related cirrhosis and chronic pancreatitis have a comparable phenotype to either disease alone:A comparative retrospective analysis

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World Journal of Hepatology 2023年第3期15卷 431-440页

作者： Michael Lu Yujie Sun Robert Feldman Melissa saul Andrew Althouse Gavin Arteel Dhiraj Yadav Department of Medicine University of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Medicine Center for Research on Health Care DataPittsburghPA 15213United States Division of Gastroenterology Hepatologyand NutritionUniversity of Pittsburgh Medical CenterPittsburghPA 15213United States Department of Medicine Division of GastroenterologyHepatology and NutritionUniversity of Pittsburgh Medical CenterPittsburghPA 15213United States

BACKGROUND Alcohol use disorder is a prevalent disease in the United *** is a well-demonstrated cause of recurrent and long-standing liver and pancreatic injury which can lead to alcohol-related liver cirrhosis(ALC)and chronic pancreatitis(ACP).ALC and ACP are associated with significant healthcare utilization,cost burden,and *** prevalence of coexistent disease(CD)ranges widely in the literature and the intersection between ALC and ACP is inconsistently *** such,the clinical profile of coexistent ALC and ACP remains poorly *** hypothesized that patients with CD have a worse phenotype when compared to single organ *** To compare the clinical profile and outcomes of patients with CD from those with ALC or ACP *** In this retrospective comparative analysis,we reviewed international classi-fication of disease 9/10 codes and electronic health records of adult patients with verified ALC Only(n=135),ACP Only(n=87),and CD(n=133)who received care at UPMC Presbyterian-Shadyside *** was defined by histology,imaging or clinical evidence of cirrhosis or hepatic *** was defined by imaging findings of pancreatic calcifications,moderate-severe pancreatic duct dilatation,irregularity or *** compared demographics,pertinent clinical variables,healthcare utilization,and mortality for patients with CD with those who had single organ *** Compared to CD or ACP Only,patients with ALC Only were more likely to be older,Caucasian,have higher body mass index,and Hepatitis B or C *** patients(vs ALC Only)were less likely to have imaging evidence of cirrhosis and portal hypertension despite possessing similar MELD-Na and Child C scores at the most recent *** patients(vs ACP Only)were less likely to have acute or recurrent acute pancreatitis,diabetes mellitus,insulin use,oral pancreatic enzyme therapy,and need for endoscopic therapy or pancreatic *** number of hospitalizati

关键词： Alcohol Cirrhosis Chronic pancreatitis Overlap Phenotype

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伊曲康唑治疗常见的皮肤真菌感染：固定治疗方案

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临床皮肤科杂志 1993年第A60期22卷 53-54页

作者： saul,A 颜艳

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CONTROL OF ANGIOGENESIS BY INHIBITOR OF PHOSPHOLIPASE A_2

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Chinese Medical Sciences Journal 2004年第1期19卷 6-12页

作者：陈文明李利红朱嘉芷刘晋玮 Soria Jeannette Soria Claudine Yedgar saul Beijing Chaoyang Hospital Capital University of Medical Sciences Hotel Dieu Laboratoire Difema Faculte de Medecine et de Phamacie Hadassah Hospital

Objective To investigate the potential effects of angiogenic process by secretory phospholipase A2 (sPLA2)inhibitor-HyPE(linking N-derivatized phosphatidyl-ethanolamine to hyaluronic acid)on human bone marrow endothelial cell line(HBME-1). Methods In order to examine the suppressing effects of HyPE on HBME-1 proliferation, migration, and capillary-like tube formation, HBME-1 were activated by angiogenic factor, specifically by basic fibroblast growth factor(b-FGF), vascular endothelial growth factor(VEGF),and oncostatin M(OSM)(at a final concentration of 25, 20, and 2.5 ng/mL, respectively), then HBME-1 proliferation, migration, and tube forma-tion were studied in the absence or presence of HyPE. HBME-1 tube formation was specially analyzed in fibrin gel. Results HyPE effectively inhibited HBME-1 proliferation and migration as a dose-dependent manner, whatever HBME-1 were grown in the control culture medium or stimulated with b-FGF, VEGF, or OSM. In fibrin, the formations of HBME-1 derived tube-like structures were enhanced by all angiogenic factors, but these were strongly suppressed by HyPE. Conclusions The results support the involvement of sPLA2 in angiogenesis. It is proposed that sPLA2 inhibitor introduces a novel approach in the control of cancer development.

关键词： angiogenesis phospholipase A_2 inhibitor endothelial cell line

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Vulnerability and Resilience to Stress and Immune and Neuroendocrine Function in Portuguese Subjects with Psychic Anomaly (Anxiety and Depression)

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Open Journal of Psychiatry 2015年第4期5卷 362-373页

作者： Eduardo Goncalves saul Neves de Jesus Department of Psychiatry and Mental Health of Hospital Center of Algarve Faro Portugal Department of Psychology of Faculty of Social and Human Sciences of University of Algarve Faro Portugal

The present study aimed to investigate the impact of chronic psychosocial stress and resilience, including at a biological level (immune and neuroendocrine function) in Portuguese citizens with psychic anomaly/mental disorder. The sample aggregated 69 participants. It has been used the following psychometric instruments: 21-item depression, anxiety and stress scales (DASS-21), in the Portuguese validated version;measuring state resilience (MSR), in the Portuguese validated version;the Portuguese scale of 23 questions on vulnerability to stress. Serum levels of cortisol, dehydroepiandrosterone sulfate, antibodies anti-viral capsid antigen of Epstein-Barr virus, triglycerides, high density lipoprotein-cholesterol and body mass index have been measured. It has been concluded that factors of vulnerability to stress and chronic stress, of social nature (lack of social support, adverse living conditions), correlate positively with depression, anxiety and stress, and, through alostatic load, are involved in a greater propensity for immune and neuroendocrine dysfunction in this population.

关键词： Vulnerability to Stress Stress Coping Resilience Alostatic Load Anxiety Depression Cortisol Dehydroepiandrosterone Epstein-Barr Virus Triglycerides High Density Lipoprotein-Cholesterol Body Mass Index

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关于减重,团队干预可能比一对一干预更有效

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英国医学杂志中文版 2022年第3期25卷 172-173页

作者： Helen saul Deniz Gursul 徐静(译) NIHR Centre for Engagement and Dissemination TwickenhamUK 中华心血管病杂志编辑部

研究Abbott S,Smith E,Tighe B,Lycett *** versus one-to-one multi-component lifestyle interventions for weight management:a systematic review and meta-analysis of randomised controlled trials.J Hum Nutr Diet 2021;34:485-93.研究背景在英国,约1/4的人患有肥胖症。肥胖会增加某些疾病的患病风险,如糖尿病、心脏病、卒中及一些癌症。肥胖缩短预期寿命、影响患者生存质量,并且显著增加英国国家健康体系(NHS)和社会的经济负担。

关键词：患病风险肥胖症预期寿命

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First report of L1014F kdr mutation in Culex quinquefasciatus in Mexico

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Insect Science 2016年第6期23卷 829-834页

作者： Gustavo Ponce Iram P. Sanchez Selene M. Garcia Jose M. Torrado saul Lozano-Fuentes Beatriz Lopez-Monroy Adriana E. Flores Facultad de Ciencias Biologicas Universidad Autonoma de Nuevo Leon A v. Universidad sin Cd. Universitaria San Nicolas de los GarzaN.L. 66455 Mexico Department of Microbiology Immunology and Pathology Colorado State University Fort Collins CO USA

The L1014F mutation in the voltage-sodium channel gene has been associated with resistance to DDT and pyrethroids in various arthropod species including mosquitoes. We determined the frequency of the L1014F kdr mutation in 16 field populations of Culex quinquefasciatus from Northeastern Mexico collected between 2008 and 2013. The L1014F was present in all populations analyzed with the lowest frequency （3.33%） corresponding to the population from Monclova collected in 2012, and the highest frequency （63.63%） from the Monterrey population collected in 2012. The presence of a kdr mutation in populations of Cx. quinquefasciatus from northeastern Mexico provides evidence ofpyrethroid resistance. This requires a special attention, considering that pyrethroid-based insecticides are commonly used in vector-control campaigns, especially against Aedes aegypti （L.）.

关键词： Culex quinquefasciatus insecticide resistance kdr L 1014F mutation

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