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Threefold Increase in the Number of Drug Resistant TB Cases after Introduction of Universal Drug Susceptibility Testing: Experiences from Two South India Districts

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Journal of Tuberculosis Research 2020年第2期8卷 42-52页

作者： Sanath Kumar Gurram Krishnamurthy Sharath Burugina Nagaraja Tanu Anand Karuna D. Sagili Cheluve Gowda Shailaja Basavaraj Poojar Srinath satyanarayana Department of Health and Family Tumkur District Karnataka India Department of Community Medicine ESIC Medical College and PGIMSR Bengaluru India Department of Community Medicine North Delhi Municipal Corporation Medical College Hindu Rao Hospital Delhi India Department of TB and Communicable Diseases the Union South East Asia Office New Delhi India Department of Community Medicine Sri Siddhartha Medical College Tumkur Karnataka India Department of Health and Family Belgaum District Karnataka India Department of Pharmacology Kasturba Medical College Mangalore Manipal Academy of Higher Education Manipal India The Union South East Asia Office New Delhi India

Background: In India, tuberculosis (TB) is a major public health problem, and the advent of drug resistance TB (DR-TB) has worsened the situation. The Revised National TB Control Programme (RNTCP) has introduced universal drug susceptibility testing (UDST) for all diagnosed TB cases in 2018. We conducted this study to know the advantage of implementing UDST when compared to selective testing existent in 2017 on key diagnostic cascade parameters and to identify the challenges in the implementation of UDST. Methods: The study was conducted in two districts of Karnataka, India during January 2017-December 2018. The quantitative part consisted of before-and-after design and the qualitative part consisted of descriptive design. Results: In 2017 (during selective testing/“before” period) out of the 2440 TB patients, 80 (3%) were diagnosed with Isoniazid and Rifampicin resistance patients;in contrast in 2018 (during UDST/“after” period) of the 5129 TB patients 258 (5%) were diagnosed with Isoniazid and Rifampicin resistance. However, the proportion of eligible patients tested for rifampicin resistance during the “after” period was 60% when compared to 100% during the “before” period and median turnaround time for testing was also longer during the “after” period when compared to the “before” period (32.5 days vs 27.5 days). Major reasons for these two gaps were found to be difficulties in collecting sputum specimens and transportation. Conclusion: The rollout of UDST has led to a three-fold increase in a number of DR-TB cases detected in the region. There is a need for the programme to increase the proportion tested for DST by increasing the laboratory capacity and address the challenges in sputum collection and transportation.

关键词： Operational Research Criteria C Line Probe Assay Universal Drug Susceptibility Testing Culture and Drug Susceptibility Testing

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Catalyst Free One-Pot Synthesis of Chromeno Quinolines and Their Antibacterial Activity

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Green and Sustainable Chemistry 2017年第2期7卷 141-151页

作者： Sruthi Vasamsetty Sunitha Medidi Satheesh Ampolu Ravi Kumar Majji Mastan Rao Kotupalli Chikurumilli China satyanarayana Annapurna Nowduri Paul Douglas Sanasi Department of Engineering Chemistry AU College of Engineering (A) Andhra University Visakhapatnam India SKR College for Women Rajamahendravaram India Department of Chemistry Dodoma University Dodoma Tanzania SKBR College Amalapuram India

An efficient greener one pot synthesis of dimethyl-dihydro-7H-chromeno[3, 2-h]quinolin-8(9H)-one derivatives has been synthesized through cyclization of aromatic aldehyde, dimidone and 8-hydroxy-quinoline through one-pot condensation method is described. The synthesized compounds are screened for further biological activities against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Bacillus subtilis, Bacillus using cut plate method and disc diffusion method.

关键词： Dimethyl-Dihydro-7H-Chromeno[3 2-h]Quinolin-8(9H)-One Derivatives Syn-thesis Biological Activity and One-Pot Condensation

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Patient Experience during Hospital Stay: A Pilot Survey

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Health 2016年第14期8卷 1518-1528页

作者： satyanarayana V. Sagi Cong Chen Kyaw Z. Htun Kalyani Puvanendrampillai Medhavi Ratnayake Joseph Ngwira Jeyanthy Rajkanna Samson O. Oyibo Department of General Medicine Peterborough City Hospital Peterborough UK

Introduction: Hospital inpatient care is provided to individuals who have a condition that requires them to stay in hospital. Patient experience is an important aspect of high-quality patient-centered care. Aim: With this pilot survey we aimed to obtain patient feedback on their experiences during their hospital stay, highlight areas of best practice and areas for improvement and provide a basis for a hospital-wide inpatient experience survey. Patients and Methods: Anonymous patient experience questionnaires were given to patients who were discharged from hospital during the month of May 2016. Patients were asked to answer 45 questions concerning their experience during hospital stay using the five-point Likert scale, and hand back the questionnaire before leaving the hospital. A suggestion box was provided for comments and suggestions for improvement. Results: Fifty-six questionnaires were handed out and 50 (from 27 males, 17 females and 6 patients who did not specify their gender) questionnaires were returned (89% response rate). Most of the responses fell within the “agree” to “strongly agree” range indicating a positive patient experience for most of the items addressed. Patients also provided useful comments and suggestions. Conclusion: Results of this survey indicate that patients generally had a positive experience during their hospital stay. This survey has revealed areas for improvement, and highlights the importance of patient experience when assessing a patient-centered service.

关键词： Patient Experience Inpatients Hospital Stay Patient-Centered Care

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Detection of Quarry Blasts in the Koyna-Warna Region, Western India

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Open Journal of Earthquake Research 2014年第4期3卷 162-169页

作者： D. Shashidhar K. Mallika N. Purnachandra Rao H. V. S. satyanarayana H. K. Gupta CSIR-National Geophysical Research Institute Hyderabad India

Koyna-Warna is a seismically active region, characterized by earthquakes triggered by loading of artificial water reservoirs. In this region quarrying is ongoing and sometimes the quarry blasts are confused with triggered seismic events. About 410 events around a known mining area were ob-served during January 2007-October 2013. In general the quarry blasts are carried out mostly during the day time. Based on this fact a well known method of [1] is implemented, which has the capability of detecting the areas of quarry blast activity. Also, discrimination of quarry blasts from earthquakes has been achieved by studying waveforms at key seismic stations located close to the quarrying area. Further, distinction is achieved through spectral analysis in the frequency band of 3 - 15 Hz. Ratio of day-time to night-time events, waveform pattern and spectral analysis approach confirm the presence of quarry blasts aligned south-east of the Warna reservoir.

关键词： Quarry Blasts Koyna Reservoir Seismicity Warna Frequency

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The role of auxin during early berry development in grapevine as revealed by transcript profiling from pollination to fruit set

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Horticulture Research 2021年第1期8卷 1924-1938页

作者： Francisca Godoy Nathalie Kuhn Mindy Muñoz German Marchandon satyanarayana Gouthu Laurent Deluc Serge Delrot Virginie Lauvergeat Patricio Arce-Johnson Departamento de Genetica Molecular y Microbiologia Facultad de Ciencias BiologicasPontificia Universidad Catolica de ChileAlameda 340SantiagoChile Facultad de Ciencias Agronomicas y de los Alimentos Pontificia Universidad Catolica de Valparaiso2340025 ValparaisoChile Department of Horticulture Oregon State UniversityCorvallisOR 97331USA UMR Ecophysiologie et Genomique Fonctionnelle de la Vigne ISVVUniversitéde BordeauxVillenave d´OrnonFrance

Auxin is a key phytohormone that modulates fruit formation in many fleshy fruits through the regulation of cell division and *** content rapidly increases after pollination and the manipulation in its levels may lead to the parthenocarpic *** Vitis vinifera L.,little is known about the early fruit development that encompasses from pollination to fruit ***/fertilization events trigger fruit formation,and auxin treatment mimics their effect in grape berry ***,the role of auxin in this process at the molecular level is not well *** elucidate the participation of auxin in grapevine fruit formation,morphological,reproductive,and molecular events from anthesis to fruit set were described in sequential days after *** RNA-seq analysis at four time points from anthesis to fruit set revealed that the highest percentage of genes induced/repressed within the hormone-related gene category were auxin-related *** profiling showed significant transcript variations in auxin signaling and homeostasis-related genes during the early fruit *** acetic acid and several auxin metabolites were present during this ***,application of an inhibitor of auxin action reduced cell number and the mesocarp diameter,similarly to unpollinated berries,further confirming the key role of auxin during early berry *** work sheds light into the molecular features of the initial fruit development and highlights the auxin participation during this stage in grapevine.

关键词： development. auxin fir

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A clinically relevant combination treatment with doxorubicin and cyclophosphamide does not induce hepatotoxicity in C57BL/6J mice

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Liver Research 2021年第4期5卷 239-242页

作者： satyanarayana R Pondugula Julia M Salamat Kodye L Abbott Patrick C Flannery Mohammed Majrashi Mohammed Almaghrabi Manoj Govindarajulu Sindhu Ramesh Maninder Sandey Suneel K Onterue Chen-Che J Huang Yoshimi Iwaki Kristina Gill Natasha Narayanan Edwin McElroy Darshini Desai Rishi Nadar Timothy Moore Muralikrishnan Dhanasekaran Department of Anatomy Physiology and PharmacologyCollege of Veterinary MedicineAuburn UniversityAuburnALUSA Department of Pharmacology Faculty of MedicineUniversity of JeddahJeddahSaudi Arabia Department of Drug Discovery and Development Harrison School of PharmacyAuburn UniversityAuburnALUSA Department of Pathobiology College of Veterinary MedicineAuburn UniversityAuburnALUSA Animal Biochemistry Division National Dairy Research InstituteICAR-National Dairy Research InstituteKarnalHaryanaIndia Department of Clinical Science College of Veterinary MedicineAuburn UniversityAuburnALUSA

Background and aims:Chronic exposure to chemotherapeutics can lead to severe adverse events including hepatotoxicity.A combination chemotherapy regimen of doxorubicin(DOX)and cyclophos-phamide(CPS)is employed in treatment of several cancers such as leukemia,lymphoma,and breast *** is not well understood whether a combination therapy with DOX and CPS can induce *** therefore sought to determine whether co-administration of DOX and CPS at their clini-cally relevant doses and frequency results in ***:Male C57BL/6J mice received one intraperitoneal injection of saline or DOX-2 mg/kg and CPS-50 mg/kg once a week for 4 *** the treatment period,liver histology and various serum bio-markers of hepatotoxicity were ***:Co-treatment with DOX and CPS did not alter the serum levels of alanine aminotransferase(ALT),alkaline phosphatase(ALP),bilirubin,albumin,globulin,or total ***,co-administration of DOX and CPS did not result in a noticeable change in liver ***,it was notable that the concomitant treatment with DOX and CPS resulted in a significant increase in serum levels of aspartate aminotransferase(AST).Elevated serum AST levels were also associated with increased serum creatinine kinase(CK)levels,suggesting that the elevated serum AST levels are likely due to muscle injury following the co-administration of DOX and ***:Taken together,our results,for the first time,suggest that co-administration of DOX and CPS,at their clinically relevant doses and frequency does not induce a significant hepatotoxicity in the mice.

关键词： Cyclophosphamide(CPS) Doxorubicin(DOX) Hepatotoxicity Liver injury Muscle injury

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A bio-chemical study on liver disorders among Jaundice patients from Coastal Andhra Pradesh,India

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海南医学院学报 2010年第2期16卷 161-164页

作者： M.Kiran Deedi D.S.R.S.Prakash V.S.Prabodh R.L.Nayak C.satyanarayana Department of Biochemistry GSL Medical UniversityRajahmundryAndhra Pradesh Department of Biotechnology Godavari Institute of Engineering and TechnologyRajahmundryAndhra Pradesh Department of Computer Sciences Jawaharlal Nehru Technological UniversityKakinadaAndhra Pradesh

Objective:To detect types of liver disorders through biochemical studies in coastal Andhra Pradesh,***:Serum level of bilirubin(total and direct),serum glutamate oxaloacetate transaminase(SGOT),serum glutamate pyruvate transaminase(SGPT)and alkaline phosphatase(ALP)were measured among the adult men and women from a South Indian *** methodologies were adopted during selection of study participants and collection and analysis of blood ***:It is observed that there is no difference in the levels of bilirubin(total and direct)and ALP in male and female *** is observed that there are significant differences in the levels of SGOT and *** recorded higher levels than ***:A considerable number of patients showed increased levels of total and direct bilirubin,SGOT,SGPY and *** higher levels of SGOT and SGPT among males might be due to their alcoholic habits and among men in this *** overall liver function abnormalities may be due to dietary habits,mal-absorption,nonalcoholic fatty liver,diabetes mellitus and contaminated drinking water.

关键词：肝脏血清肝功能谷氨酸草酰乙酸转氨酶

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Breeding and biotechnological efforts in Jatropha curcas *** sustainable yields

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Oil Crop Science 2021年第4期6卷 180-191页

作者： S.Arockiasamy Jyothirmayi Kumpatla Sainath Hadole Vijay Yepuri Manoj Patil Vineeta Shrivastava Chandrasekhara Rao Nagesh Kancharla Saakshi Jalali Alok Varshney Neeta Madan Sai Pothakani Vinod Nair Sridhar Peyyala Vishwnadharaju Mudunuri Ananthan Gopal Niranjan S.Kumar Jawahar Pachiyannan satyanarayana Seelamanthula J.V.Narasimham Makarand Phadke Anindya B Ajit Sapre Santanu Dasgupta Agronomy Division Reliance Technology GroupReliance Industries LtdGhansoliNavi Mumbai400701India Jatropha Breeding Station Reliance Industries LtdIDA-PeddapuramADB Road SamalkotaAndhra Pradesh533440India

Jatropha is a non-edible,important bioenergy plant,which can grow in marginalized *** seeds possess about 36%oil and this would be converted into biodiesel or *** provides an option for sustainable feed and fuel production due to its inherent qualities including hardy nature,drought tolerance and surviving with limited amount of water,tolerance to unfavorable conditions and excessive ***,heterozygosity,low productivity and poor understanding of its genome are the major impediments to elite line ***,classical breeding and advanced technological investments remain limited owing to long juvenile phase and breeding *** technologies that lead to identification of elite genotypes and development of high yielding elite Jatropha lines and effective methods of detoxification of seeds needs immediate *** tissue culture system,doubled haploids(DH)and genomic tools are increasingly made available to improve the seed yield and its oil quantity through the development of geminivirus disease resistant *** application of advanced,sequencing technologies has presented a repertoire of genomic information for this important yet orphan *** the present investigation,we highlight the achievements made in Jatropha towards development of high yielding,virus resistant elite lines and hybrids with yield potential ranging from 3 to 5 tons per hectare in a year,which is a first ever report in the *** also developed potential biotechnological tools such as genetic transformation,genome editing and next generation genomics tools including linkage maps and QTLs for accelerating breeding efforts through marker assisted *** of our concerted and continuous efforts during the past 15 years,we have overcome all the obstacles and developed high yielding,disease resistant hybrids/lines,advanced cultivation technologies with thorough knowledge on Agronomy of the Jatropha *** Jatropha cultivat

关键词： Breeding Hybrids Micropropagation Transformation Sequencing Mapping QTLs CRISPR

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Magnetic Nano Cobalt Ferrite Catalyzed Synthesis of 4H-Pyrano[3,2-h]quinoline Derivatives under Microwave Irradiation

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Green and Sustainable Chemistry 2016年第2期6卷 101-109页

作者： Swathi Bandaru Ravi K. Majji satyanarayana Bassa Pandu N. Chilla Ramesh Yellapragada Sruthi Vasamsetty Rajendra K. Jeldi Raghu B. Korupolu Paul D. Sanasi Department of Engineering Chemistry A. U. College of Engineering (A) Andhra University Visakhapatnam India

A microwave irradiated magnetically separable nano cobalt ferrite catalyzed green method for the synthesis of 4-phenyl-4H-pyrano[3,2-h]quinolin-2-amine and 2-amino-4-phenyl-4H-pyrano[3,2-h] quinoline-3-carbonitrile derivatives through cyclization of aromatic aldehyde, acetonitrile/malononitrile and 8-hydoxyquinoline is developed and presented in this paper. The cubic magnetic cobalt ferrite nano particles were synthesized by sol-gel citrate precursor method and characterized by FT-IR, XRD, SEM and TEM techniques and the structures of the synthesized pyranoquinoline derivatives were assigned by IR, MASS and 1H NMR techniques. The reaction is carried out in a domestic microwave oven with a heat-resistant microwave safe glass container with a lid.

关键词： Synthesis of 4H-Pyrano[3 2-h]quinoline Derivatives Microwave Irradiation Nano Cobalt Ferrite Catalyst

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CORBA Architecture for the Integration of Add-on Software in Automotive Systems

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通讯和计算机（中英文版） 2010年第10期7卷 45-51页

作者： Rajeshwari Hegde Kargal satyanarayana Gurumurthy Dept of Telecommunication Engineering BMS College of Engineering Bangalore 560019 India Dept of Electronics ＆ Communication University Visvesvaraya College of Engg Bangalore 560001 India

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