检索结果-南通市图书馆

A review of age-old antimalarial drug to combat malaria:efficacy upgradation by nanotechnology based drug delivery

Asian Pacific Journal of Tropical Medicine 2014年第9期7卷 673-679页

作者： satyajit tripathy Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar UniversityMidnapore-721102West BengalIndia

Malaria is uncontrolled burden in the world till *** of different efforts to develop antimalarial drug for decades,any anti-malarial drug can able to eradicate completely till *** anti-malarial substances are practically ineffectual because of their physicochemical limitations,cytotoxicity,chemical instability and degradation,and limited activities against intracellular *** into consideration,the amount of research is going to conduct in the field of nanoparticle based drug delivery systems,lead to new ways of improving the treatment of infectious *** study has focused on the progress and advancement of research on nanotechnology based drug delivery to eradicate the *** like to focus the efficacy of nanotechnology based drug application for the opening out of novel chemotherapeutics in laboratory research,which may show the way to better use with age-old antimalarial drug and may draw the attention of pharmaceutical industries for the improvement and designing of effective anti-malarial drugs in future.

关键词： Nanotechnology Age-old drug Drug efficacy Antimalaria Nanomedicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nano chloroquine delivery against Plasmodium berghei NK65 induced programmed cell death in spleen

引用

Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 540-546页

作者： satyajit tripathy Sourav Chattopadhyay Sandeep Kr.Dash Motlalepula G.Matsabisa Somenath Roy Immunology and Microbiology Laboratory Department of Human Physiology with Community HealthVidyasagar University Department of Pharmacology University of the Free State B.S.B.E.Indian Institute of Technology University of Gour Banga

Objective:To compare the protective effects of chitosan-trypolyphosphate(CS-TPP) nanoparticle conjugated chloroquine(CQ) with effect of CQ alone on the reversal of splenic damages and induction of ***:Different researches have been carried out to explore the potential role of chitosan based drug delivery system against parasitic *** successive Plasmodium berghei NK65 parasiste infection by intraperitoneal injection in Swiss mice and subsequent parasite development,the ROS generation,anti-apoptotic and pro apoptotic protein levels in spleen were *** analyze caspases,flow cytometry study was performed with annexin 桋-FITC and with PI ***:The results revealed that ROS mediated caspase 3 and 9 activation and the induction of apoptosis occurred during the parasitic ***,CS-TPP conjugated CQ was relatively better in reversing the splenic damage compared with similar effects of CQ ***:This study indicates that Plasmodium berghei NK65 induces apoptosis in the *** study further shows that CS-TPP nanoparticles conjugation with CQ have positive influence on the recovery of damaged host's system towards maintenance of normal homeostasis,and this is shown to be selective to CS-TPP conjugated CQ treated animals only.

关键词： Splenocyte Apoptosis Nano chloroquine Plasmodium berghei Chitosan

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：