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Xanthogranulomatous cholecystitis:Difficulty in differentiating from gallbladder cancer

World Journal of Gastroenterology 2015年第35期21卷 10166-10173页

作者： Hideki Suzuki satoshi wada Kenichiro Araki Norio Kubo Akira Watanabe Mariko Tsukagoshi Hiroyuki Kuwano Department of General Surgical Science (Surgery I) Gunma University Graduate School of Medicine Gunma University

AIM: To compare cases of xanthogranulomatous cholecystitis(XGC) and advanced gallbladder cancer and discuss the differential diagnoses and surgical ***: From April 2000 to December 2013, 6 XGC patients received extended surgical resections. During the same period, 16 patients were proven to have gallbladder(GB) cancer, according to extended surgical resection. Subjects chosen for analysis in this study were restricted to cases of XGC with indistinct borders with the liver as it is often difficult to distinguish these patients from those with advanced GB cancer. We compared the clinical features and computed tomography findings between XGC and advanced GB cancer. The following clinical features were retrospectively assessed: age, gender, symptoms, and tumor markers. As albumin and the neutrophil/lymphocyte ratio(NLR) are prognostic in several cancers, we compared serum albumin levels and the NLR between the two groups. The computerized tomography findings were used to compare the two diseases, determine the coexistence of gallstones, the pattern of GB thickening(focal or diffuse), the presence of a hypoattenuated intramural nodule, and continuity of the mucosal ***: Based on the preoperative image findings, we suspected GB carcinoma in all cases includingXGC in this series. In addition, by pathological examination, we found that the group of patients with XGC developed inflammatory disease after surgery. Patients with XGC tended to have abdominal pain(4/6, 67%). However, there was no significant difference in clinical symptoms, including fever, between the two groups. Serum albumin and NLR were also similar in the two groups. Serum tumor markers, such as carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9), tended to increase in patients with GB cancer. However, no significant differences in tumor markers were identified. On the other hand, gallstones were more frequently observed in patients with XGC(5/6, 83%) than in patients wit

关键词： Xanthogranulomatous cholecystitis Advanced gallbla

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Enhanced piezoelectric properties of (Ba_(0.3)Bi_(0.7))(Mg_(0.05)Fe_(0.6)Ti_(0.35))O_(3) piezoelectric ceramics with high Curie temperature

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Journal of Advanced Dielectrics 2014年第1期4卷 81-86页

作者： Ichiro Fujii Ryuta Mitsui Kouichi Nakashima satoshi wada Interdisciplinary Graduate School of Medical and Engineering University of Yamanashi Kofu 400-8510Japan

(Ba_(0.3)Bi_(0.7))(Mg_(0.05)Fe_(0.6)Ti_(0.35))O_(3) ceramics were either doped with vanadium or sintered in calcined powder with the same *** to an undoped ceramic sintered without the calcined powder,both ceramics showed reduced leakage current densities(lower than 1×10^(-7) A/cm^(2))and absence of dielectric relaxation behaviors observed in frequency-and temperaturedependent dielectric *** Curie temperatures of both samples were higher than 460℃.The maximum field-induced strain over the applied field,S_(max)/E_(max),of 366 pm/V of the undoped ceramic sintered without the calcined powder increased to 455 and 799 pm/V for the V-doped ceramics and the ceramics sintered with the calcined powder,*** increase was related to a reduced concentration of bismuth vacancy-oxygen vacancy defect dipoles.

关键词： Piezoelectrics domain structure lead-free high Curie temperature dopant.

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量子点复合微球的活体荧光和化学发光双模式成像

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中国医疗设备 2017年第4期32卷 26-29页

作者：叶一王国武王莉萍和田智之王瑾晔上海交通大学生物医学工程学院上海200240 日本理化学研究所先进光子学中心

为了探索荧光/化学发光双模式成像方法用于可降解生物材料研究的可行性,将载有量子点的可降解高分子微球(量子点复合微球)植入小鼠背部皮下,利用美国Caliper定量荧光和生物发光成像系统IVIS Lumina II观察不同时间点植入部位的荧光强度... 详细信息

为了探索荧光/化学发光双模式成像方法用于可降解生物材料研究的可行性,将载有量子点的可降解高分子微球(量子点复合微球)植入小鼠背部皮下,利用美国Caliper定量荧光和生物发光成像系统IVIS Lumina II观察不同时间点植入部位的荧光强度和L-012介导的化学发光强度的变化。结果显示:30 mg量子点复合微球植入28 d时,仍能检测到荧光信号。L-012介导的化学发光强度随时间逐渐减弱,第28 d时,量子点复合微球处仍存在微弱的化学发光。

关键词：量子点复合微球活体荧光成像活性氧化学发光

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A Non-scan DFT Method at RTL Based on Fixed-control Testability to Achieve 100%Fault Efficiency

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湖南大学学报（自然科学版） 2000年第S2期27卷 61-77页

作者： satoshi Ohtake Shintaro Nagai Hiroki wada Hideo Fujiwara Graduate School of Information Science Nara Institute of Science and Technology 8916-5TakayamaIkomaNara 630-0101Japan

This paper proposes a non-scan design-for-testability method for register-transfer level circuits where a circuit consists of a controller and a data path. It achieves complete fault efficiency with low hardware overh... 详细信息

关键词： Non-Scan Testable Design RTL Circuit

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Inverted Meckel's diverticulum preoperatively diagnosed using double-balloon enteroscopy

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World Journal of Gastroenterology 2016年第17期22卷 4416-4420页

作者： Kosuke Takagaki satoshi Osawa Tatsuhiro Ito Moriya Iwaizumi Yasushi Hamaya Hiroe Tsukui Takahisa Furuta Hidetoshi wada satoshi Baba Ken Sugimoto First Department of Medicine Hamamatsu University School of Medicine Department of Endoscopic and Photodynamic Medicine Hamamatsu University School of Medicine Department of Diagnostic Pathology Hamamatsu University School of Medicine Center for Clinical Research Hamamatsu University School of Medicine First Department of Surgery Hamamatsu University School of Medicine

An inverted Meckel’s diverticulum is a rare gastrointestinal congenital anomaly that is difficult to diagnose prior to surgery and presents with anemia, abdominal pain, or intussusception. Here, we report the case of 57-year-old men with an inverted Meckel’s diverticulum, who was preoperatively diagnosed using double-balloon enteroscopy. He had repeatedly experienced epigastric pain for 2 mo. Ultrasonography and computed tomography showed intestinal wall thickening in the pelvis. Double-balloon enteroscopy via the anal route was performed for further examination, which demonstrated an approximately 8-cm, sausage-shaped, submucosal tumor located approximately 80 cm proximal to the ileocecal valve. A small depressed erosion was observed at the tip of this lesion. Forceps biopsy revealed heterotopic gastric mucosa. Thus, the patient was diagnosed with an inverted Meckel’s diverticulum, and single-incision laparoscopic surgery was performed. This case suggests that an inverted Meckel’s diverticulum should be considered as a differential diagnosis for a submucosal tumor in the ileum. Balloon-assisted enteroscopy with forceps biopsy facilitate a precise diagnosis of this condition.

关键词： Inverted Meckel’ s diverticulum Double-balloon enteroscopy Small bowel tumor Epigastric pain Heterotopic gastric mucosa

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Huge capacity spacial division multiplexing transmission and integrated optical switching technologies(Invited Paper)

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Chinese Optics Letters 2016年第12期14卷 12-16页

作者： Naoya wada Ben J.Puttnam Ruben S.Luis Werner Klaus Jun Sakaguchi Jose M.D.Mendinueta Yoshinari Awaji satoshi Shinada Hideaki Furukawa National Institute of Information and Communications Technology Tokyo 184-8795 Japan

We review the research and development of beyond Pb/s capacity space-division-multiplexed transmission technology using multi-core optical fibers for satisfying the ever-increasing traffic demand. Moreover, we present an optical packet and circuit integrated network technology to improve switching capacity and flexibility in network nodes for the rapid traffic fluctuation and the data service diversification.

关键词： switching multiplexing satisfying fluctuation traffic packet frames transmit throughput overhead

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DOG1 is useful for diagnosis of KIT-negative gastrointestinal stromal tumor of stomach

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World Journal of Gastroenterology 2013年第47期19卷 9133-9136页

作者： Takuya wada satoshi Tanabe Kenji Ishido Katsuhiko Higuchi Tohru Sasaki Chikatoshi Katada Mizutomo Azuma Akira Naruke Myunguchul Kim Wasaburo Koizumi Tetsuo Mikami Department of Gastroenterology Kitasato University East HospitalKanagawa 252-0380Japan Department of Pathology Kitasato University East HospitalKanagawa 252-0380Japan

Approximately 80%-95%of gastrointestinal stromal tumors(GISTs)show positive staining for KIT,while the other 5%-20%show negative *** the tumor is negative for KIT,but is positive for CD34,a histological diagnosis is ***,if the tumor is negative for KIT,CD34,S-100,and SMA,a definitive diagnosis is often ***,Discovered on GIST-1(DOG1)has received considerable attention as a useful molecule for the diagnosis of ***1,a membrane channel protein,is known to be overexpressed in *** the sensitivity and specificity of DOG1 are higher than those of KIT,positive staining for DOG1has been reported,even in KIT-negative *** GISTs most commonly arise in the stomach and are mainly characterized by epithelioid features *** describe our experience with a rare case of a KIT-negative GIST of the stomach that was diagnosed by positive immunohistochemical staining for DOG1 in a patient who presented with severe *** findings suggest that immunohistochemical staining for DOG1,in addition to gene analysis,is useful for the diagnosis of KIT-negative tumors that are suspected to be GISTs.

关键词： KIT negative Gastrointestinal stromal tumors Discovered on gastrointestinal stromal tumor-1 Platelet-derived growth factor receptor alpha

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Myosin Heavy Chain Expression and Oxidative Modifications in Diabetic Rat Hearts

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Open Journal of Applied Sciences 2012年第4期2卷 248-256页

作者： Mai Kuratani Keita Kanzaki Noriyuki Yanaka satoshi Matsunaga Masanobu wada Faculty of Education and Culture Miyazaki University Miyazaki Japan Faculty of Food Culture Kurashiki-Sakuyo University Okayama Japan Graduate School of Biosphere Science Hiroshima University Hiroshima Japan Graduate School of Integrated Arts and Sciences Hiroshima University Hiroshima Japan

In this study, we tested the hypotheses that 1) diabetes-induced disturbances in cardiac my-ATPase activity would be attributed to not only myosin heavy chain (MHC) isoform transitions, but also reduced amounts in MHC protein;and 2) if diabetes results in declines in the MHC protein content, this change would relate to oxidative damage to MHC. Diabetes was induced by a single intraperitoneal injection of streptozotocin. After 6 weeks of injection, the left ventricles were excised for mechanical and biochemical analyses. Peak twitch tension and the rate of force development in papillary muscles were decreased by 23.4% and 34.1%, respectively. A 33.5% reduction in myofibrillar ATPase activity occurred in conjunction with a 9.5% decrease in MHC protein as well as MHC isoform transitions towards a slower phenotype. The decreased MHC content was not accompanied by elevations in carbonyl groups present in MHC. Whole muscle analyses indicated that the contents of malondialdehyde and reduced glutathione were elevated. These results suggest that decreases in the MHC content may be associated, at least in part, with a diabetes-related inactivation of cardiac my-ATPase and may not be due to accumulation of oxidative damage to protein.

关键词： Myofibrillar ATPase Reactive Oxygen Species Protein Degradation Isomyosin

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The Efficacy of Microcurrent Therapy on Eccentric Contraction-Induced Muscle Damage in Rat Fast-Twitch Skeletal Muscle

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Open Journal of Applied Sciences 2018年第3期8卷 89-102页

作者： Yosuke Hiroshige Daiki Watanabe Chihiro Aibara Keita Kanzaki satoshi Matsunaga Masanobu wada Department of Physical Education Faculty of Physical Education International Pacific University Okayama-shi Japan Graduate School of Integrated Arts and Sciences Hiroshima University Higashihiroshima-shi Japan Research Fellow of Japan Society for the Promotion of Science Department of Clinical Nutrition Faculty of Health Science and Technology Kawasaki University of Medical Welfare Kurashiki-shi Japan Faculty of Education University of Miyazaki Miyazaki-shi Japan

Microcurrent (MC) therapy, in which a very small electric current is applied to the body, has widely been used to promote tissue healing and relieve symptoms. The aim of this study was to examine the effect of MC treatment on eccentric contraction (ECC)-induced muscle damage in rat fast-twitch skeletal muscles. Tibialis anterior muscles underwent 200 repeated ECCs in situ and were then stimulated (25 μA, 0.3 Hz) for 20 min (MC treatment). MC treatment was performed immediately after ECC and during a recovery period of 3 days (a total of 4 times). Three days after ECC, the muscles were excised and used for measure of force output and for biochemical analyses. In MC-treated muscles, tetanic forces at 20 Hz and 100 Hz were partially and fully restored, respectively, whereas in non-treated muscles, both forces remained depressed. Biochemical analyses revealed that MC treatment partially or completely inhibited ECC-induced reductions: in 1) the Ca2+-release function of sarcoplasmic reticulum (SR), 2) proteolysis of ryanodine receptor, a Ca2+ release channel of SR, and 3) myosin ATPase activity. On the other hand, MC treatment was unable to lessen increases in the activity of calpain, a cytosolic, Ca2+-activated neutral protease. These results indicate that MC treatment results in beneficial effects, such as restoration of muscle performance following ECC, although the precise mechanisms are still unknown at this time.

关键词： Ryanodine Receptor Sarcoplasmic Reticulum SERCA Myosin ATPase

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Effect of Dietary Nitrate on Force Production and Sarcoplasmic Reticulum Ca<sup>2+</sup>Handling in Rat Fast-Twitch Muscles Following Eccentric Contraction

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Open Journal of Applied Sciences 2018年第12期8卷 607-618页

作者： satoshi Matsunaga Chihiro Aibara Daiki Watanabe Keita Kanzaki Yurie Morizaki Sumiko Matsunaga-Futatsuki Masanobu wada Faculty of Education University of Miyazaki Miyazaki Japan Graduate School of Integrated Arts and Sciences Hiroshima University Higashi-Hiroshima Japan Department of Engineering Science University of Electro-Communications Chofu Japan Faculty of Health Science and Technology Kawasaki University of Medical Welfare Kurashiki Japan Department of Communication and Liberal Arts Minami Kyushu Junior College Miyazaki Japan

Impaired excitation-contraction coupling occurs in eccentric contraction (ECC)-induced damaged muscles. It has been suggested that sarcoplasmic reticulum (SR) is susceptible to damage in the overstretched regions possibly marking the basis of excitation-contraction coupling damage. Recent studies have shown that dietary nitrate supplementation enhances SR function in fast-twitch muscles. In this study, we aimed to investigate whether dietary nitrate supplementation can alleviate a decline in muscle contractile properties and SR function following ECC. To this end, force production, Ca2+ uptake, Ca2+ release, and Ca2+-ATPase activity of the SR were examined in rat fast-twitch muscles immediately following ECC for 200 repetitions. In comparison with contralateral resting muscles, nitrate supplementation for up to 3 days resulted in an obvious decline in force production. However, there were no differences in terms of force production between 6-day nitrate-treated and contralateral muscles. Similar to the observations regarding force production, the SR Ca2+ release rate changed from an obvious decrease following the 0- and 3-day dietary nitrate supplementation to no difference following the 6-day nitrate supplementation. In contrast, ECC decreased the Ca2+-ATPase activity and Ca2+ uptake rate, irrespective of the period of dietary nitrate supplementation. Overall, these results indicate that dietary nitrate supplementation can alleviate ECC-related decreases in force production mediated through inhibited reductions in the SR Ca2+ release function.

关键词： Supplementation Ca2+-ATPase Activity Ca2+ Uptake Ca2+ Release

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