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北京中关村鼎好电子大厦升级改造项目中国北京市海淀区

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世界建筑导报 2023年第S2期38卷 52-53页

作者：森井直树龟井聪无 Zhen Jia Yao(摄) Tian Fangfang(摄) 不详维拓设计 ZHANGJIN PHOTOGRAPHY

开创脱碳社会的增值改造鼎好大厦位于被称为“中国硅谷”的北京市中关村,分别建成于2003年和2008年,是一个由商业和办公构成、建筑面积约20万㎡的综合设施,本次的项目便是对其进行升级改造。除了将曾经作为电子元件市场的用途转变为需... 详细信息

开创脱碳社会的增值改造鼎好大厦位于被称为“中国硅谷”的北京市中关村,分别建成于2003年和2008年,是一个由商业和办公构成、建筑面积约20万㎡的综合设施,本次的项目便是对其进行升级改造。除了将曾经作为电子元件市场的用途转变为需求日益增长的办公功能外,还使其作为高端办公楼焕然新生。针对本次更新改造,我们抛弃“拆旧造新”的城市更新方式,通过利用现有结构体将建筑从商业用途改为办公用途,并重新配置楼面进行结构体的改造。此外,还通过更换整个建筑外装实现建筑外观的全面翻新。

关键词：建筑外观城市更新中国硅谷商业用途更新改造北京市海淀区综合设施现有结构

Genetic and environmental determinants of risk for cholangiocarcinoma in Thailand

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World Journal of Gastrointestinal Pathophysiology 2014年第4期5卷 570-578页

作者： Masanao Miwa satoshi Honjo Gyokukou You Masakazu Tanaka Kazuhiko Uchida Petcharin Srivatanakul Thiravud Khuhaprema Watcharin Loilome Anchalee Techasen Chaisiri Wongkham Temduang Limpaiboon Puangrat Yongvanit Sopit Wongkham Nagahama Institute of BioScience and Technology Nagahama Shiga 526-0829 Japan Department of Biochemistry and Molecular Oncology Institute of Basic Medical Sciences University of Tsukuba Tsukuba Ibaraki 305-8575 Japan Department of Pediatrics National Hospital Organization Fukuoka National Hospital Fukuoka 811-1394 Japan Department of Microbiology Faculty of Medicine Kansai Medical University Hirakata City Osaka 573-1010 Japan Cancer Control Unit National Cancer Institute Department of Biochemistry and Liver Fluke and Cholangiocarcinoma Research Center Faculty of Medicine Khon Kaen University Faculty of Associated Medical Sciences Khon Kaen University

Cholangiocarcinoma(CCA) is a difficult cancer to diagnose in the early stage and to treat by curative resec-tion. The incidence of CCA in the northeast of Thailand is the highest in the world. To make progress in detecting a high risk group and in the prevention and detection of CCA, we have been analyzing the risk factors for CCA. Although liver fluke infection is known to be a risk factor, there are patients who are not infected with the liver fluke and not all people infected with the liver fluke will suffer from the disease. Therefore, it is of the utmost importance to analyze the risk factors and the mechanism to prevent the disease and also to detect the disease in its early stage to save patients' lives. Through collaboration among Thai and Japanese researchers, we analyzed the genetic and environmental determinants of risks for CCA. Also, we have been trying to develop methods to detect the disease in a non-invasive way. Without repeating findings reported in various reviews on CCA, we will first discuss the environmental and genetic determinants of the risks for CCA. Second, we will discuss the properties of CCA, including the etiological agents and the mechanism of cholangiocarcinogenesis, and finally, we will discuss future approaches to prevent and cure CCA from the standpoint of evidence-based medicine. We will discuss these points by including the data from our laboratories. We would like to emphasize the importance of the genetic data, especially whole genome approaches, to understand the properties of CCA, to find a high risk population for CCA and to develop effective preventative methods to stop the carcinogenic steps toward CCA in the near future. In addition, it is of the upmost importance to develop a non-invasive, specific and sensitive method to detect CCA in its early stage for the application of modern medical approaches to help patients with CCA.

关键词： Alcohol drinking Cholangiocarcinoma DNA polymorphism Glutathione S transferase 8-oxoguanine glycosylase 1 Liver fluke Opisthorchis viverrini Thailand

Delayed perforation after endoscopic submucosal dissection for early gastric cancer: Clinical features and treatment

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World Journal of Gastrointestinal Endoscopy 2016年第8期8卷 368-373页

作者： Takafumi Yano satoshi Tanabe Kenji Ishido Mizutomo Azuma Takuya Wada Mizuto Suzuki Natsuko Kawanishi Sakiko Yamane Tohru Sasaki Chikatoshi Katada Tetsuo Mikami Natsuya Katada Wasaburo Koizumi Department of Gastroenterology Kitasato University School of Medicine Research and Development Center for New Frontiers Kitasato University School of Medicine Department of Pathology Toho University School of Medicine Department of Surgery Kitasato University School of Medicine

Perforation is an important procedural complication of endoscopic submucosal dissection(ESD) for early gastric cancer. Although the incidence of delayed perforation after ESD is low, extreme caution is necessary because many cases require surgical intervention. Among 1984 lesions of early gastric cancer treated in our hospital by ESD in 1588 patients from September 2002 through March 2015, delayed perforation developed in 4 patients(4 lesions, 0.25%). A diagnosis of delayed perforation requires prompt action, including surgical intervention when required.

关键词： Endoscopic submucosal dissection Early gastric cancer Delayed perforation

13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

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13q31.1位点与欧洲人群非综合征型唇腭裂相关性研究

Podocyte loss and albuminuria of KK-Ay mouse: A spontaneous animal model for human type 2 diabetic nephropathy

2015中国遗传学会大会

作者：贾仲林 Elizabeth J.Leslie Margaret E.Cooper Azeez Butali Jennifer Standley Jennifer Rigdon satoshi Suzukil Ayana Gongorjav T.Enkhtur Shonkhuuz Nagato Natsume 石冰 Mary L.Marazita Jeffrey C.Murray 四川大学华西口腔医学院口腔疾病国家重点实验室 Department of Pediatrics University of Iowa 四川大学华西口腔医院唇腭裂外科 Center for Craniofacial and Dental Genetics Department of Oral BiologySchool of Dental MedicineUniversity of Pittsburgh Department of Oral Pathology Radiologyand MedicineCollege of DentistryUniversity of Iowa Divisionof Research and Treatment for Oral and Maxillofacial Congenital Anomalies School of DentistryAichi-Gakuin University

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验... 详细信息

全基因组关联研究已成功地发现了十几个位点与唇腭裂的发生相关。然而,这些信号可能只与特定人群相关联,需要在其他人群进行反复验证以发现真正致病SNP位点。我们在来自欧洲(美国和丹麦)、亚洲(日本和蒙古)人群的946个家系(3436个人)验证唇腭裂全基因组关联研究Meta分析发现的6个显著相关的位点:rs742071(1p36),rs7590268(2p21),rs7632427(3p11.1),rs12543318(8q21.3),rs8001641(13q31.1)和rs7179658(15q22.2);同时对来自美国,蒙古,和菲律宾三个人群的713个病例,438个正常对照及485个核心家系在SPRY2基因下游200Kb的三个非编码保守区进行直接测序。我们发现rs8001641位点显著与欧洲人群非综合征型唇裂伴腭裂的发生相关((p=4 x 10-5,ORtransmission=1.86和95%CI:1.38-2.52)。我们还在亚洲和欧洲的病例中发现了一些位于保守区域的遗传变异,它们可帮助定位与唇腭裂发生风险相关的常见遗传变异。这项研究进一步证实了先前报道的rs8001641和欧洲人群唇腭裂之间的关联。

关键词：全基因组关联研究非综合征型口面裂

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Efficacy and safety of endoscopic submucosal dissection under general anesthesia

Journal of Diabetes Mellitus（糖尿病） 2012年第3期

作者： Yuji Ishikawa Takamichi Ito Mitsuo Tanimoto Shinji Hagiwara Masako Furukawa Saori Yamaguchi Keisuke Omote Katsuhiko Asanuma Tomohito Gohda Yoshio Shimizu Kazuhiko Funabiki satoshi Horikoshi Yasuhiko Tomino

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World Journal of Gastrointestinal Endoscopy 2016年第13期8卷 466-471页

作者： Kanefumi Yamashita Hironari Shiwaku Toshihiro Ohmiya Hideki Shimaoka Hiroki Okada Ryo Nakashima Richiko Beppu Daisuke Kato Takamitsu Sasaki Seiichiro Hoshino satoshi Nimura Ken Yamaura Yuichi Yamashita Department of Gastroenterological Surgery Fukuoka University Faculty of Medicine Department of Pathology Fukuoka University Faculty of Medicine Department of Anesthesiology Fukuoka University Faculty of Medicine

AIM: To evaluate the efficacy and safety of endoscopic submucosal dissection(ESD) under general ***: From January 2011 to July 2014, 206 consecutive patients had undergone ESD under general anesthesia for neoplasms of the stomach, esophagus, and colorectum were enrolled in this retrospective study. The efficacy and safety of ESD under general anesthesia were ***: The en bloc resection rate of esophageal, gastric, and colorectal lesions was 100.0%, 98.3%, and 96.1%, respectively. The complication rate of perforationand bleeding were 0.0% and 0.0% in esophageal ESD, 1.7% and 1.7% in gastric ESD, and 3.9% and 2.0% in colorectal ESD, respectively. No cases of aspiration pneumonia were observed. All complications were managed by conservative treatment, with no surgical intervention ***: With the cooperation of an anesthesiologist, ESD under general anesthesia appears to be a useful method, decreasing the risk of complications.

关键词： Complication Endoscopic submucosal dissection General anesthesia Conscious sedation

福建沿海铝质A型花岗岩的地球化学及岩石成因

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地球化学 2000年第4期29卷 313-321页

作者：邱检生王德滋蟹泽聪史 BrentI A McInnes 南京大学成矿作用国家重点实验室南京大学地球科学系江苏南京210093 南京大学地球科学系日本东北大学理学院矿物岩石矿床研究所 CSIRODivisionofExplorationandMining

:以乌山、金刚山和新村三个典型岩体为例 ,系统研究了福建沿海铝质A型花岗岩的地质和地球化学特征。研究结果表明 ,铝质A型花岗岩常含有锰铝榴石、富锰白云母等特征的富铝矿物 ,化学成分上相对富铝 ,为一套准铝到弱过铝的岩石组合 ,并... 详细信息

:以乌山、金刚山和新村三个典型岩体为例 ,系统研究了福建沿海铝质A型花岗岩的地质和地球化学特征。研究结果表明 ,铝质A型花岗岩常含有锰铝榴石、富锰白云母等特征的富铝矿物 ,化学成分上相对富铝 ,为一套准铝到弱过铝的岩石组合 ,并具有贫磷、贫钛 ,氧化指数较低等特征。与碱性花岗岩相比 ,其Nb、Ta、Zr、Hf、Ga、Y和Zn等元素的含量及稀土总量和Ga/Al比值均偏低 ,但轻、重稀土的分馏程度(尤其是重稀土的分馏程度)较高。两类岩石具有相似的稀土和微量元素分布模式 ,并具有相似的钕同位素组成 ,εNd (t)值分别变化于 -4 28～ -6 12和 -3 45～ -5 21之间 ,表明两者具有相似的岩浆源区 ,均为壳幔物质混熔的产物。根据对两类岩石矿物组合及地球化学特征的综合分析 ,推测岩浆体系中F。

关键词：铝质A型花岗岩地球化学岩石成因论

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促进脊髓损伤修复的天然药物筛选

中国实验方剂学杂志 2012年第12期18卷 246-248页

作者：王晓华朱华紺野胜英东田千寻数马恒平久保山友晴宫永贤成都中医药大学成都610075 广西中医学院南宁530001 日本富山大学和汉医药学综合研究所

目的:从天然药物中筛选促进大脑皮质神经元轴突增长的药物。方法:采用系统溶剂提取法得到不同部位的人参、刺五加、黄芪提取液。从大鼠胚胎(SD大鼠,妊娠17 d)的大脑皮质分离神经细胞原代培养;应用磷酸化神经丝H(pNF-H)抗体(轴突的标记)... 详细信息

目的:从天然药物中筛选促进大脑皮质神经元轴突增长的药物。方法:采用系统溶剂提取法得到不同部位的人参、刺五加、黄芪提取液。从大鼠胚胎(SD大鼠,妊娠17 d)的大脑皮质分离神经细胞原代培养;应用磷酸化神经丝H(pNF-H)抗体(轴突的标记)和微管相关蛋白2(MAP2a&2b)抗体(树突的标记)进行免疫染色;采用显微摄影技术及图像分析技术,测量神经细胞轴突和树突的长度。结果:人参醇提液1 mg.L-1可促进大脑皮质神经细胞轴突增长(P<0.05);刺五加水提取液1 mg.L-1在大脑皮质神经细胞轴突增长方面有效(P<0.05);从刺五加水提取液中再次分得乙酸乙酯、正丁醇和水部分,其中1 mg.L-1正丁醇部位和水部位显示出促进轴突增长的作用(P<0.05)。结论:人参的醇提取液和刺五加的正丁醇部位及水部位可能具有潜在的促进脊髓损伤修复的作用。

关键词：人参黄芪刺五加脊髓损伤原代培养

量子点复合微球的活体荧光和化学发光双模式成像

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中国医疗设备 2017年第4期32卷 26-29页

作者：叶一王国武王莉萍和田智之王瑾晔上海交通大学生物医学工程学院上海200240 日本理化学研究所先进光子学中心

为了探索荧光/化学发光双模式成像方法用于可降解生物材料研究的可行性,将载有量子点的可降解高分子微球(量子点复合微球)植入小鼠背部皮下,利用美国Caliper定量荧光和生物发光成像系统IVIS Lumina II观察不同时间点植入部位的荧光强度... 详细信息

为了探索荧光/化学发光双模式成像方法用于可降解生物材料研究的可行性,将载有量子点的可降解高分子微球(量子点复合微球)植入小鼠背部皮下,利用美国Caliper定量荧光和生物发光成像系统IVIS Lumina II观察不同时间点植入部位的荧光强度和L-012介导的化学发光强度的变化。结果显示:30 mg量子点复合微球植入28 d时,仍能检测到荧光信号。L-012介导的化学发光强度随时间逐渐减弱,第28 d时,量子点复合微球处仍存在微弱的化学发光。

关键词：量子点复合微球活体荧光成像活性氧化学发光