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Spontaneous resolution of a macroaneurysm on the optic disc

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International Journal of Ophthalmology(English edition) 2014年第1期7卷 179-180页

作者： Taku Toyama satoshi kato Yasuo Noda Atsuko Tsutsumi Department of Ophthalmology University of Tokyo Hospital7-3-1 HongoBunkyo-kuTokyo 113-8655Japan Tsutusmi Eye Clinic 2-22-8Kita-choNerima-kuTokyo 179-0081Japan

Dear Sir,Iam *** Toyama,from the Department of Ophthalmology,University of Japan.I write to present a case report of macroaneurysm on the optic disc.A 63-year-old woman had initially visited an eye clinic because she experienced anorthopia in her left eye.A macroaneurysm on the left optic disc was *** was referred to our hospital for a medical *** 61 years of age,she had undergone a laser photocoagulation treatment

关键词： RETINAL ARTERY-OCCLUSION

心血管状况与糖尿病视网膜血管内皮细胞的相关性（英文）

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国际眼科杂志 2017年第1期17卷 21-25页

作者： Galina Dimitrova satoshi kato Pariska bb.Sep.8^th综合医院眼科马其顿斯科普里1000 东京大学医院眼科日本东京市113-0033

糖尿病视网膜病变及其并发大血管病变表明两者之间致病存在相关性。血管内皮细胞是糖尿病血管损伤的主要部位。糖尿病视网膜病变能并发全身动脉硬化和改变血管内皮的功能及结构。在黄斑,动静脉交叉处和在筛板区视神经中的视网膜血管内... 详细信息

糖尿病视网膜病变及其并发大血管病变表明两者之间致病存在相关性。血管内皮细胞是糖尿病血管损伤的主要部位。糖尿病视网膜病变能并发全身动脉硬化和改变血管内皮的功能及结构。在黄斑,动静脉交叉处和在筛板区视神经中的视网膜血管内皮细胞不同与其余视网膜血管中内皮细胞。中央视网膜在视神经中动脉和静脉非常接近且共用同一外膜;因此,增加动脉壁的硬度和厚度可以影响该区域中的相邻中央视网膜静脉中的血流量。此外,小动脉床中的动脉硬化加剧与视网膜微血管扩张有关;这表明筛板中视网膜中央动脉压迫视网膜中央静脉的可能性,从而损害糖尿病患者视网膜中的小静脉流出。经观察发现糖尿病视网膜病变患者在后层流区的视网膜中央静脉中的血流量发生改变。在视网膜中央静脉中增加静水压可能在糖尿病视网膜病变的病情进展过程中起重要作用。这篇综述文章的主旨是强调这种常常被忽视的发病机制。

关键词：糖尿病视网膜病变微脉管心血管疾病视网膜中央动脉视网膜中央静脉内皮发病机理

Female Preponderance in the Discordant Association between Retinopathy and Nephropathy in Patients with Type 2 Diabetes Mellitus

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International Journal of Clinical Medicine 2011年第1期2卷 13-17页

作者： Satsuki Kawasaki Shinobu Satoh Osamu Hasegawa satoshi Morita satoshi kato Yasuo Terauchi 不详

Aim: To elucidate clinical features in patients with type 2 diabetes with advanced retinopathy but without nephropathy. Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes mellitus. Diabetic reti-nopathy was graded according to the International Clinical Classification of Diabetic Retinopathy as no diabetic reti-nopathy, mild or moderate non-proliferative diabetic retinopathy, severe non-proliferative diabetic retinopathy, and proliferative diabetic retinopathy. Diabetic nephropathy was classified into four stages of severity according to the Guideline Committee of the Japan Diabetes Society. Each patient was examined for retinopathy grade and nephropathy stage. Clinical features of patients with proliferative diabetic retinopathy were compared with regard to the four grades of diabetic nephropathy. Results: Fifty-two patients with type 2 diabetes (3.9% of the whole series of 1324 patients with type 2 diabetes and 25.7% of patients with proliferative diabetic retinopathy) had proliferative diabetic retinopathy without the presence of nephropathy. Multiple statistical analysis using a proportional odds model revealed that pa-tients with proliferative diabetic retinopathy without nephropathy had a significantly lower systolic blood pressure (p < 0.001) than those who did and were preponderantly female (p < 0.05). Conclusions: A possible susceptibility of dia-betic females to proliferative advanced retinopathy without nephropathy encourages further studies on the role of hor-mones and blood coagulation in the pathogensis of proliferative diabetic retinopathy.

关键词： Discordance Female Gender preponderance Hormone Nephropathy Pathogenesis Proliferative Retinopathy Risk factor Type 2 diabetes

激光诱导脉络膜视网膜静脉吻合术后玻璃体出血及纤维血管增生1例(英文)

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国际眼科杂志 2011年第5期11卷 765-766页

作者： Tomoyasu Shiraya satoshi kato Takashi Shigeeda Harumi Fukushima 东京大学医学研究生院眼科

目的:报告1例非缺血性中央视网膜静脉阻塞的患者实施激光诱导脉络膜视网膜静脉吻合术后出现玻璃体出血及纤维血管增生而进行玻璃体切割术。方法:病例报告。结果:患者,男,72岁,主诉左眼中央有一暗点,诊断为非缺血性中央视网膜静脉阻塞。... 详细信息

目的:报告1例非缺血性中央视网膜静脉阻塞的患者实施激光诱导脉络膜视网膜静脉吻合术后出现玻璃体出血及纤维血管增生而进行玻璃体切割术。方法:病例报告。结果:患者,男,72岁,主诉左眼中央有一暗点,诊断为非缺血性中央视网膜静脉阻塞。在其他医院实施激光诱导脉络膜视网膜静脉吻合术。术后患者左眼视力短暂恢复,但并发严重的玻璃体出血,遂来我院实施玻璃体切割术。结论:激光诱导脉络膜视网膜静脉吻合术有发生严重并发症的危险,要求临床医师慎重选择,特别是对于某些种族(比如日本),因为色素沉着可引起光凝过度反应。

关键词：膜静脉吻合术非缺血性中央视网膜静脉阻塞

No-touch isolation technique in emergency pancreaticoduodenectomy for neoplastic hemorrhage: Two case reports and review of literature

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1910-1917页

作者： Akihiro Cho satoshi Katagiri Masao Ota Shunsuke Onizawa Ryota Higuchi Toshiya Sugishita Yukiko Niwa Takeshi Ishita Toshihiko Mouri Akita kato Moe Iwata Division of Gastroenterological Surgery Tokyo Women’s Medical UniversityYachiyo Medical CenterChiba 276-8524Japan

BACKGROUND Emergency pancreaticoduodenectomy(EPD)is a rare event for complex periam-pullary *** intraoperative blood loss is correlated with poor post-operative *** SUMMARY Two patients underwent EPD using a no-touch isolation technique,in which all arteries supplying the pancreatic head region were ligated and divided before manipulation of the pancreatic head and *** operative times were 220 and 239 min,and the blood loss was 70 and 270 g,*** patients were discharged on the 14^(th) and 10^(th) postoperative day,***-two patients underwent EPD for the treatment of neoplastic *** mean operative time was 361.6 min,and the mean blood loss was 747.3 *** comp-lication rate was 37.5%.The in-hospital mortality rate was 9.38%.CONCLUSION The no-touch isolation technique is feasible,safe,and effective for reducing intraoperative blood loss in EPD.

关键词： No-touch isolation technique Pancreaticoduodenectomy Emergency pancre-aticoduodenectomy Neoplastic bleeding Superior mesenteric artery first approach Case report

手术期间血糖控制对糖尿病视网膜病变和黄斑病变的影响

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美国医学会眼科杂志（中文版） 2006年第4期18卷 254-255页

作者： Chikako Suto Sadao Hori satoshi kato Kanemitsu Muraoka Shigehiko Kitano 刘亮（译）

目的：评估手术期间血糖控制对糖尿病视网膜病变和黄斑病变进展的影响。

关键词：糖尿病视网膜病变黄斑病变血糖控制手术期间

Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

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Hepatobiliary & Pancreatic Diseases International 2017年第6期16卷 659-661页

作者： Hirotsugu Maruyama Kazunari Tominaga Kunihiro kato satoshi Sugimori Masatsugu Shiba Toshio Watanabe Yasuhiro Fujiwara Department of Gastroenterology Osaka City University Graduate School of Medicine 1-4-3 Asahimachi Abeno-ku Osaka 545-8585 Japan

To the Editor:Biliary drainage is most frequently performed among endoscopic procedures using pancreatobiliary endoscopy.A large-diameter metallic stent can significantly extend the patency period rather than a plastic stent for extrahepatic biliary stricture.;However,the optimal drainage for the hilar biliary obstruction is still controversial.

关键词： Safety and efficacy of transpapillary bridged bilateral side-by-side stenting for unresectable malignant hilar biliary obstruction

Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells

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World Journal of Gastroenterology 2008年第16期14卷 2511-2516页

作者： Akemi Imaoka Tatsuichiro Shima Kimitoshi kato Shigeaki Mizuno Toshiki Uehara satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki Yakult Central Institute for Microbiological Research Yaho Kunitachi Department of Gastroenterology and Hepatology Nihon University School of Medicine

AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of ***: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis.

关键词： Bifidobacterium Ulcerative colitis Anti-inflammatory Intedeukin-10 Interleukin-8

Vascular endothelial growth factor and angiopoietins regulate sinusoidal regeneration and remodeling after partial hepatectomy in rats

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World Journal of Gastroenterology 2005年第46期11卷 7254-7260页

作者： Hiroaki Shimizu Noboru Mitsuhashi Masayuki Ohtsuka Hiroshi Ito Fumio Kimura satoshi Ambiru Akira Togawa Hiroyuki Yoshidome Atsushi kato Masaru Miyazaki Department of General Surgery Graduate School of Medicine Chiba University Chiba 260-0856 Japan

AIM： To study the regulatory mechanisms of sinusoida regeneration after partial hepatectomy. METHODS： We invesldgated the expression of angiopoietin （Ang）-1, Ang-2, Tie-2, and vascular endothelial growth factor （VEGF） in regenerating liver tissue by quantitative reverse-transcription polymerase chain reaction （RT- PCR） using a LightCycler （Roche Diagnostics） and also immunohistochemical staining after 70% hepatectomy in rats. In the next step, we isolated liver cells （hepatocytes, sinusoidal endothelial cell （SEC）, Kupffer cell, and hepatic stellate cells （HSC）） from regenerating liver tissue by in situ collagenase perfusion and counterflow elutriation, to determine potential cellular sources of these angiogenic factors after hepatectomy. Proliferation and apoptosis of SECs were also evaluated by proliferating cell nuclear antigen （PCNA） staining and the terminal deoxynucleotidyl transferase d-uridine triphosphate nick end labeling （TUNEL） assay, respectively. RESULTS： VEGF mRNA expression increased with a peak at 72 h after hepatectomy, decreasing thereafter. The expression of Ang-1 mRNA was present at detectable levels before hepatectomy and increased slowly with a peak at 96 h. Meanwhile, Ang-2 mRNA was hardly detected before hepatectomy, but was remarkably induced at 120 and 144 h. In isolated cells, VEGF mRNA expression was found mainly in the hepatocyte fraction. Meanwhile, mRNA for Ang-1 and Ang-2 was found in the SEC and HSC fractions, but was more prominent in the latter. The PCNA labeling index of SECs increased slowly, reaching a peak at 72 h, whereas apoptotic SECs were detected between 120 h and 144 h. CONCLUSION： Ang-Tie system, together with VEGF, plays a critical role in regulating balance between SEC proliferation and apoptosis during sinusoidal regeneration after hepatectomy. However, the VEGF system plays a more important role in the early phase of sinusoidal regeneration than angiopoietin/Tie system.

关键词： Vascular endothelial cell growth factor Angiopoietin Sinusoidal endothelial cell Hepatectomy Liver regeneration