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Implementation of soft microfingers for a hMSC aggregate manipulation system

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Microsystems & Nanoengineering 2016年第1期2卷 311-317页

作者： satoshi Konishi Shuhei Shimomura Shuhei Tajima Yasuhiko Tabata Department of Mechanical Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Graduate School of Science and Engineering Ritsumeikan University1-1-1 Noji-higashKusatsuShiga 525-8577Japan Institute for Frontier Medical Sciences Kyoto UniversityYoshida-shimoadachiSakyo-kuKyoto 606-8501Japan

This paper describes a pneumatic balloon actuator(PBA)composed of polydimethylsiloxane(PDMS)for cellular aggregate *** evaluated the ability of the microdevice to manipulate a tiny and sensitive cellular aggregate without causing serious *** used human mesenchymal stem cells(hMSCs)for the cellular *** describe the design,fabrication,characterization and operation of the soft microfingers to pinch and release a spherical hMSC aggregate(φ200μm),and we employed a PBA to serve as an artificial muscle to drive the microfingers.A design of the microfingers in terms of dimensions,generated force and contact conditions was *** designed dimensions of a single finger were 560μm×900μ*** summary,we demonstrate the utility of the surface modification of a fingertip for pinching and releasing a cellular aggregate and describe a manipulation system that was constructed to drive and control the *** implemented manipulation system,which is composed of microfingers and a positioning mechanism,was tested and verified in a series of operations.

关键词： cellular aggregate manipulation pinching releasing positioning pneumatic balloon actuator soft MEMS surface modification

Visualization of flashback in a premixed burner with swirling flow

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Science China(Technological Sciences) 2010年第1期53卷 40-45页

作者： satoshi TANIMURA Masaharu KOMIYAMA Kenichiro TAKEISHI Yuji IWASAKI Kiyonobu NAKAYAMA Mitsubishi Heavy Industries Ltd.2-1-1ShinhamaArai-choTakasagoHyogo676-0871Japan Department of Mechanical Engineering Osaka University2-1YamadaokaSuitaOsaka565-0871Japan

In this study,the measurement object is a flame propagating in a premixed burner with swirling flow in order to investigate unsteady flame behavior in a gas turbine *** flashback,the flame propagating upstream was visualized with a high-speed ***,we established the technique to measure the instantaneous flow fields of unburned fuel-air mixture in a swirling premixed burner using particle image velocimetry(PIV).As a result,the characteristics of flame behavior propagating upstream were *** it was found that a low velocity region existed in the vicinity of the flame *** relationship between low velocity region and flame behavior was discussed in detail.

关键词： gas turbine lean premixed combustion flashback particle image velocimetry

Biodegradability of four phthalic acid esters under anaerobic condition assessed using natural sediment

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Journal of Environmental Sciences 2006年第4期18卷 793-796页

作者： Ruttapol Lertsirisopon satoshi Soda Kazunari Sei Michihiko Ike Masanori Fuj ita Graduate School of Engineering Osaka University 2-1 Yamada-oka Suita Osaka Japan.

Biodegradability of di-n-butyl phthalate （DBP）, butylbenzyl phthalate （BBP）, di-ethylhexyl phthalate （DEHP）, and di-isononyl phthalate （DINP） under an anaerobic condition was evaluated using three natural sediment microcosms obtained from ponds in Osaka, which had not been significantly polluted by the chemicals. The degradabilities of the four phthalic acid esters（PAEs） were analyzed by a first-order kinetic model with a lag phase and ranked as DBP〉BBP〉〉DEHP〉DINP. The PAEs with shorter alkyl-chains, DBP and BBP, were degraded with quite short lag phases near to zero and short half-lives of a few days. The PAEs with longer alkyl-chains, DEHP and DINP, were degraded with lag phases of 5-30 d and the quite long half-lives of a couple of hundred days. Although no data was available on the anaerobic biodegradability of D1NP before this study, it was clarified that DINP can be degraded with slow degradation rates. The fact that all the three intact sediments were capable of biodegradation of the PAEs suggests that potential of anaerobic biodegradation of PAEs is widespread in the aquatic environment.

关键词： phthalic acid esters anaerobic biodegradation sediment first-order kinetics

Autoantibodies in primary biliary cirrhosis:Recent progress in research on the pathogenetic and clinical significance

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World Journal of Gastroenterology 2014年第10期20卷 2606-2612页

作者： satoshi Yamagiwa Hiroteru Kamimura Masaaki Takamura Yutaka Aoyagi Division of Gastroenterology and Hepatology Niigata University Graduate School of Medical and Dental Sciences Niigata 951-8510 Japan

Primary biliary cirrhosis(PBC)is a chronic progressive cholestatic liver disease characterized by immunemediated destruction of the small-and medium-sized intrahepatic bile ducts and the presence of antimitochondrial antibodies(AMA)in the *** are detected in over 90%of patients with PBC,whereas their prevalence in the general population is extremely low,varying from 0.16%to 1%.Previous studies have shown that the unique characteristics of biliary epithelial cells undergoing apoptosis may result in a highly direct and very specific immune response to mitochondrial ***,recent studies have demonstrated that serum from AMA-positive PBC patients is reactive with a number of xenobiotic modified E2 subunits of the pyruvate dehydrogenase complex,which is not observed in the serum of normal *** findings indicate that chemicals originating from the environment may be associated with a breakdown in the tolerance to mitochondrial *** it is currently generally accepted that AMA are the most specific serological markers of PBC,more than 60 au-toantibodies have been investigated in patients with PBC,and some have previously been considered specific to other autoimmune *** review covers the recent progress in research on the pathogenetic and clinical significance of important autoantibodies in *** the pathogenic role of those autoantibodies in PBC remains a priority of basic and clinical research.

关键词： Primary biliary cirrhosis Autoantibodies Anti-mitochondrial antibodies Anticentromere antibodies Anti-gp210 antibodies

Side-wall effect of runner casing on performance of Darrieus-type hydro turbine with inlet nozzle for extra-low head utilization

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Science China(Technological Sciences) 2010年第1期53卷 93-99页

作者： Kai SHIMOKAWA Akinori FURUKAWA Kusuo OKUMA Daisuke MATSUSHITA satoshi WATANABE Graduate School of Engineering Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan Department of Mechanical Engineering Kyushu UniversityMotooka 744Nishi-kuFukuoka819-0395Japan

A ducted Darrieus-type turbine has been proposed for hydropower utilization of extra-low head less than 2 *** the hydro turbine system,in general,might consist of an intake,runner casing section and a draft tube for higher efficiency operation,it was clarified in previous experiment that there was no need of the side-walls of runner casing section and a draft-tube for keeping the efficiency high in the case of duct with an inlet *** would yield a simplification of the structure of the turbine *** order to reconfirm this result for large-sized turbine with 560 mm×300 mm duct,instead of small-sized one with 400 mm×200 mm duct,the side-wall effect on turbine performance was experimentally investigated for three-or four-bladed *** the present paper,the experimental results are shown with considering flow behaviors in the runner section.

关键词： hydro turbine Darrieus-type runner duct side-wall effect turbine performance

Simultaneous removal of dissolved organic matter and bromide from drinking water source by anion exchange resins for controlling disinfection by-products

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Journal of Environmental Sciences 2014年第6期26卷 1294-1300页

作者： Athit Phetrak Jenyuk Lohwacharin Hiroshi Sakai Michio Murakami Kumiko Oguma satoshi Takizawa Department of Urban Engineering Graduate School of Engineering The University of Tokyo Institute of Industrial Science The University of Tokyo

Anion exchange resins （AERs） with different properties were evaluated for their ability to remove dissolved organic matter （DOM） and bromide, and to reduce disinfection by-product （DBP） formation potentials of water collected from a eutrophic surface water source in Japan. DOM and bromide were simultaneously removed by all selected AERs in batch adsorption experiments. A polyacrylic magnetic ion exchange resin （MIEX） showed faster dissolved organic carbon （DOC） removal than other AERs because it had the smallest resin bead size. Aromatic DOM fractions with molecular weight larger than 1600 Da and fluorescent organic fractions of fulvic acid- and humic acid-like compounds were efficiently removed by all AERs. Polystyrene AERs were more effective in bromide removal than polyacrylic AERs. This result implied that the properties of AERs, i.e. material and resin size, influenced not only DOM removal but also bromide removal efficiency, MIEX showed significant chlorinated DBP removal because it had the highest DOC removal within 30 rain, whereas polystyrene AERs efficiently removed brominated DBPs, especially brominated trihalomethane species. The results suggested that, depending on source water DOM and bromide concentration, selecting a suitable AER is a key factor in effective control of chlorinated and brominated DBPs in drinking water.

关键词： adsorption dissolved organic carbon drinking water treatment ion exchange

Structural and optical properties of nanostructured copper sulfide semiconductor synthesized in an industrial mill

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Frontiers of Chemical Science and Engineering 2019年第1期13卷 164-170页

作者： Marcela Achimovicova Erika Dutkova Erika Tothova Zdenka Bujnakova Jaroslav Briancin satoshi Kitazono Institute of Mineral and Waste Processing Waste Disposal and Geomechanics Clausthal University of Technology Clausthal 38678 Germany Institute of Geotechnics Slovak Academy of Sciences Kosice 04001 Slovakia Nakase Refinery Nihon Seiko Co. Ltd. Yabu-shi Hyogo 667-1111 Japan

Chalcogenide nanostructured semiconductor, copper sulfide (CuS) was prepared from copper and sulfur powders in stoichiometric ratio by a simple, fast, and convenient one-step mechanochemical synthesis after 40 min of milling in an industrial eccentric vibratory mill. The kinetics of the mechanochemical synthesis and the influence of the physical properties of two Cu powder precursor types on the kinetics were studied. The crystal structure, physical properties, and morphology of the product were characterized by X-ray diffraction (XRD), the specific surface area measurements, particle size distribution and scanning electron microscopy. The XRD analysis confirmed the hexagonal crystal structure of the product-CuS (covellite) with the average size of the crystallites 11 nm. The scanning electron microscopy analysis has revealed that the agglomerated grains have a plate-like structure composed of CuS nanoparticles. The thermal analysis was performed to investigate the thermal stability of the mechanochemically synthesized CuS. The optical properties were studied using UV-Vis and photoluminescence spectroscopy. The determined optical band gap energy 1.80 eV responds to the value of the bulk CuS, because of agglomerated nanoparticles. In addition, a mechanism of CuS mechanochemical reaction was proposed, and the verification of CuS commercial production was performed.

关键词： copper sulfide industrial mechanochemical synthesis thermal analysis optical properties

Thermal cycling creep properties of a directionally solidified superalloy DZ125

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Journal of Materials Science & Technology 2022年第9期104卷 269-284页

作者： Wenrui An satoshi Utada Xiaotong Guo Stoichko Antonov Weiwei Zheng Jonathan Cormier Qiang Feng Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and MaterialsUniversity of Science and Technology BeijingBeijing 100083China Institut Pprime UPR CNRS 3346Department of Physics and Mechanics of MaterialsISAE-ENSMABP4010986961 Futuroscope Chasseneuil CedexFrance China Electronic Product Reliability and Environmental Testing Research Institute Guangzhou 510610China Department of Microstructure Physics and Alloy Design Max-Planck-Institut für Eisenforschung GmbHDüsseldorf 40237Germany

Aero-engine turbine blades may suffer overheating during service,which can result in severe microstructural and mechanical degradation within tens of *** this study,the thermal cycling creep under(950℃/15 min+1100℃/1 min)-100 MPa was performed on a directionally solidified superalloy,*** effects of overheating and thermal cycling on the creep properties were evaluated in terms of creep behavior and microstructural evolution against isothermally crept specimens under 950℃/100 MPa,950℃/270 MPa,and 1100℃/100 *** results indicated that the thermal cycling creep life was reduced dramatically compared to the isothermal creep under 950℃/100 *** plastic creep deformation mainly occurred during the overheating stage during the thermal cycling *** thermal cycling creep curve exhibited three stages,similar to the 1100℃isothermal creep,but its minimum creep rate occurred at a lower creep *** overheating events caused severe microstructural degradation,such as substantial dissolution ofγ'phase,earlier formation of raftedγ'microstructure,widening of theγchannels,and instability of the interfacial dislocation *** microstructural degradation was the main reason for the dramatic decrease in thermal cycling creep life,as the thermal cycling promoted more dislocations to cut intoγ'phase and more cracks to initiate at grain boundaries,carbides,and residual eutectic *** study underlines the importance of evaluating the thermal cycling creep properties of superalloys to be used as turbine blades and provides insights into the effect of thermal cycling on directionally solidified superalloys for component design.

关键词： Directional solidified superalloy Thermal cycling creep Overheating Creep properties Microstructural degradation

Preservation and management of a World Heritage site Tajima Yahei Sericulture Farm and its buffer zone

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Built Heritage 2020年第3期4卷 1-17页

作者： Sweet Yee Cheng satoshi Ono Graduate School of Urban Innovation Yokohama National University79-5 TokiwadaiHodogaya WardYokohamaKanagawa 240-8501Japan

Tajima Yahei Sericulture Farm,one of the four components of the UNESCO World Heritage Site Tomioka Silk Mill and Related Sites inscribed in 2014,was the starting point for advancements in sericulture farmhouses,emphasizing the importance of *** Yahei’s experimentation surrounding the ideal space to breed silkworms,a new sericulture theory was invented,and a sericulture farmhouse architecture was *** the purpose of preserving this cultural heritage for future generations,it is important to understand the idea that led to the cultural and industrial advancement of the village of Shimamura and to revise the preservation plans prepared by *** paper will discuss the development of the sericulture theory,seiryō-iku theory,and the formation of a sericulture farmhouse architecture;describe the adaptation of former sericulture farmhouses and the surrounding landscapes in terms of the industry and environment;outline the plans and efforts for the preservation and revitalization of Tajima Yahei Sericulture Farm,its surrounding area and its underlying issues;and propose a direction for future preservation plans.

关键词： Preservation Revitalization Theory Management Planning Sericulture UNESCO world heritage Heritage buildings