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Normalization of Serum Alkaline Phosphatase in Primary Sclerosing Cholangitis Associated with Ulcerative Colitis

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Health 2014年第10期6卷 969-974页

作者： Mitsuro Chiba Hidehiko Tsuda satoko Tsuda Masafumi Komatsu Yasuo Horie Hirohide Ohnishi Depatment of Gastroenterology Akita University School of Medicine Akita Japan Division of Gastroenterology Akita City Hospital Akita Japan Division of Gastroenterology Akita Kumiai General Hospital Akita Japan

Primary sclerosing cholangitis (PSC) is commonly associated with ulcerative colitis (UC). PSC progresses independently of UC ultimately resulting in liver failure. There is no established medical treatment to improve the natural course of PSC. Normalization of serum alkaline phosphatase (ALP) in early stage might delay the progress of PSC. A 20-year-old female, had a sudden attack of right hypochondralgia with high fever and abnormal liver function tests without elevation of bilirubin: ALP 478 IU/L, aspartate aminotransferase 360 IU/L, alanine aminotransferase 174 IU/L. Abnormal liver function tests returned to normal after the attacks. Morphological examinations initially indicated then confirmed a diagnosis of PSC. One month after displaying PSC symptoms administration of ursodeoxycholic acid was initiated. Similar attacks of cholangitis were repeated several times over the following two years. Even in the absence of these attacks, she always suffered postprandial hypochondralgia. There was no acute cholangitis in the year prior to the last hospitalization due to abdominal pain and bloody diarrhea. Findings were consistent with UC in the form of entire colitis. Sulfasalazine, metronidazole and semi-vegetarian diet (SVD) were initiated. Metronidazole is routinely used in inflammatory bowel disease (IBD) in our practice with the expectation of elimination of any potentially pathogenic bacteria. SVD was designed for IBD hoping to increase beneficial bacteria. A remission of UC was ascertained during hospitalization. Elevated ALP, in the absence of clinical cholangitis, was decreased to normal after the therapy for UC.

关键词： Primary Sclerosing Cholangitis Ulcerative Colitis Alkaline Phosphatase Metronidazole Vegetarian Diet

Salivary Alpha-Amylase Reactivity under Psycho-Physiological Stress. A Nonverbal Communication Measurement Tool?

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Journal of Behavioral and Brain Science 2011年第1期1卷 12-15页

作者： Takuji Inagaki Masa Ieda satoko Yamashita Tsuyoshi Miyaoka Jun Horiguchi 不详

Previous studies have shown that changes in salivary alpha-amylase (sAA) levels are dependent on psychosocial stress stimulation and reflect the activity of the sympathetic nervous system. sAA measurement can be performed easily and quickly;therefore, it may be useful for evaluating psychosocial or physical stress. The aim of this preliminary study was to examine the use of sAA measurements as objective indicators of psychological and physiological stress levels by examining sAA changes in volunteers subjected to conditions similar to those suffered by children with severe motor and intellectual disabilities and cerebral paralysis. Twelve healthy volunteers were required to not move or speak, as is found in patients suffering from total paralysis, for 30 min. Saliva samples were taken at three points, and sAA activity was measured using a hand-held monitor before the test, immediately after the test, and 10 min after the test. In the present study, a marked increase in sAA activity due to physiological stress and a rapid return to the baseline level were observed. Many subjects felt bodily pain and psychotic discomfort. This measurement method is useful for evaluating stress in children with severe motor and intellectual disabilities, who can not fully express their emotions or communicate with their caregivers.

关键词： Nonverbal Communication Psychological Stress Physiological Stress Salivary Alpha-Amylase Severe Motor and Intellectual Disabilities

A Case of Huge Fibroma in the Palate

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Open Journal of Clinical Diagnostics 2018年第4期8卷 52-59页

作者： Sayaka Yoshiba Koki Takamatsu Shinsuke Nakamura Junichiro Chikuda Naoko kawachi Tatsuo Shirota Department of Dental and Oral Surgery Showa University Northern Yokohama Hospital Tokyo Japan Department of Oral and Maxillofacial Surgery Showa University School of Dentistry Tokyo Japan Department of Dental and Oral Surgery Health Park Clinic Gunma Japan

Fibroma-like lesions occur with relatively high frequency in oral soft tissues, but represent reactive proliferation against chronic irritation. True fibromas are rare. Tumor size is often seen to range from the mass of a red bean to a soybean. We encountered a case of huge fibroma in the palate with a long history of more than 30 years. The patient was a 60-year-old man who became aware of a tumor in the right palate about 30 years earlier. The mass had tended to increase in size in recent years, and was introduced to our department for the first visit. As an intraoral finding, a pedicled mass measuring 29 × 27 mm was found in the right palate. We also considered the possibility of verrucous carcinoma, and performed biopsy, obtaining a diagnosis of fibroma. Right palatectomy was performed under general anesthesia in October 2016. We performed immunohistochemical examination of the surgical specimen, obtaining a definitive diagnosis of fibroma. As of 1 year postoperatively, no recurrence has been identified and the course has been good.

关键词： Huge Fibroma Immunohistological Examination

Development of peptide inhibitors of HIV transmission

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Bioactive Materials 2016年第2期1卷 109-121页

作者： Siyu Shi Peter K.Nguyen Henry J.Cabral Ramon Diez-Barroso Paul J.Derry satoko M.Kanahara Vivek A.Kumar Department of Chemistry Rice UniversityHoustonTX 77030USA Baylor College of Medicine HoustonTX 77030USA Community Healthcare Network New YorkNY 10010USA Department of Biomedical Engineering New Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102USA Department of Chemical Biological and Pharmaceutical EngineeringNew Jersey Institute of TechnologyUniversity HeightsNewarkNJ 07102USA

Treatment of HIV has long faced the challenge of high mutation rates leading to rapid development of resistance,with ongoing need to develop new methods to effectively fight the ***,early HIV medications were designed to inhibit RNA replication and protein production through small molecular *** based therapeutics are a versatile,promising field in HIV therapy,which continues to develop as we expand our understanding of key protein-protein interactions that occur in HIV replication and *** review begins with an introduction to HIV,followed by the biological basis of disease,current clinical management of the disease,therapeutics on the market,and finally potential avenues for improved drug development.

关键词： HIV HIV treatment Drug development Peptide therapeutic Peptide inhibitor

Low-Molecular-Weight Heparin and Protamine-Based Polyelectrolyte Nano Complexes for Protein Delivery (A Review Articles)

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Journal of Biomaterials and Nanobiotechnology 2011年第5期2卷 500-509页

作者： Masayuki Ishihara satoko Kishimoto Megumi Takikawa Yasutaka Mori Shingo Nakamura Masanori Fujita 不详

We produced low-molecular-weight heparin/protamine micro (nano) particles (LMW-H/P MPs·NPs) as a carrier for heparin-binding growth factors (GFs), such as fibroblast growth factor (FGF)-2 and various GFs in platelet-rich plasma (PRP). A mixture of LMW-H (MW: approximately 5000 Da, 6.4 mg/ml) and protamine (MW: approximately 3000 Da, 10 mg/ml) at a ratio of 7:3 (vol:vol) yields a dispersion of micro (nano) particles (200 nm - 3 μm in diameter). The diluted LMW-H solution in saline (0.32 mg/ml) mixed with diluted protamine (0.5 mg/ml) at a ratio at 7:3 (vol:vol) resulted in soluble nanoparticles (approximately 100 nm in diameter). The generated NPs could be then stabilized by adding 2 mg/ml dextran (MW: 178-217 kDa) and remained soluble after lyophilization of dialyzed LMW-H /P NPs solution. The LMW-H/P MPs·NPs adsorb GFs, control their release, protect GFs and activate their biological activities. Furthermore, administration of GFs-containing F/P MPs·NPs exhibited significantly higher inductions of vascularization and fibrous tissue formation in vivo than GFs alone. LMW-H/P MPs·NPs can also efficiently bind to tissue culture plates and retain the binding of GFs. The LMW-H/P MPs·NP-coated matrix with various GFs or cytokines provided novel biomaterials that could control cellular activity such as proliferation and differentiation. Thus, LMW-H/P MPs·NPs are an excellent carrier for GFs and are a functional coating matrix for various kinds of cell cultures.

关键词： Polyelectrolyte Complexes Nanoparticles Heparin-Binding Growth Factors Platelet-Rich Plasma Drug Delivery

Factors Affecting Children’s Cholesterol Levels with a View to Prevent Cardiovascular Disease—The Unique Benefits of Health Screening at the Elementary School

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Health 2017年第1期9卷 172-188页

作者： Akihiro Kihara Hiromi Kawasaki satoko Yamasaki Mika Nishiyama Md. Moshiur Rahman Graduate School of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Institute of Biomedical & Health Sciences Hiroshima University Hiroshima Japan Department of Welfare Hiroshima Bunkyo Women’s University Hiroshima Japan

Background: The prevention of cardiovascular disease (CVD) can substantially contribute to reducing the mortality rate across countries. The level of interest in cholesterol among experts increases when the subjects are elderly and obese individuals. However, specialists do not recommend that children should receive the cholesterol test. The objective of this study was to investigate the distribution of cholesterol levels among the children of public school and their parents’ lifestyles that are associated with cholesterol levels, and to assess the need for and utility of cholesterol testing in school settings. Methods: The study investigated a group of 226 fourth-grade public school children aged between 9 and 10 years and guardians in Akitakatacity of Hiroshima Prefecture, Japan. Multiple regression analyses were performed with the logarithmic value of cholesterol levels as a response variable, awareness about lifestyles and health of children as an explanatory variable, and child’s sex and body mass index (BMI) as moderating variables. Using questionnaires about lifestyles, the step-down procedure was applied in multiple regression analyses to narrow down relevant lifestyle variables. Results: The percentage of children with the high total cholesterol (TC) value was about 15 and with low-density lipoprotein (LDL) cholesterol value was about 10. Children with low high-density lipoprotein (HDL) cholesterol value were 5%. Treatment was not required according to the comprehensive assessment. Cholesterol levels were associated with the situation of the children and their guardians as follows, guardian need to consider the food, and child has the correct knowledge about food like how to eat snacks. Conclusions: Children had poor cholesterol levels. From childhood, along with the parents, there is a need to learn about appropriate level of cholesterol for CVD prevention.

关键词： Children’s Lifestyle-Related Disease Cardiovascular Disease Health Promotion for Family School Health

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大鼠小肠—辅助性肝脏联合移植的实验研究

中华器官移植杂志 2004年第6期25卷 351-353页

作者：陈雨信寿楠海徐克森 Watanabe Y kawachi K 山东大学齐鲁医院普外科济南250012 Department of Surgery Second Ehime University Japan

目的　研究小肠—辅助性肝脏联合移植的可行性以及移植后的肝脏增生。方法　供、受者均为Lewis大鼠 ,分为移植组和对照组。移植组 :切取供者小肠和 6 0 %肝脏 ;切除受者小肠 ;然后将移植物植入受者。移植物血液供应通过连自移植物的腹... 详细信息

目的　研究小肠—辅助性肝脏联合移植的可行性以及移植后的肝脏增生。方法　供、受者均为Lewis大鼠 ,分为移植组和对照组。移植组 :切取供者小肠和 6 0 %肝脏 ;切除受者小肠 ;然后将移植物植入受者。移植物血液供应通过连自移植物的腹主动脉和受者腹主动脉端侧吻合 ,静脉回流通过移植物的肝下下腔静脉和受者左、右肾静脉之间的下腔静脉端侧吻合。对照组 :单行剖腹探查 ;观察 1 8个月后处死。分别测量两组的肝脏重量 ,检测肝功能、肝脏和小肠的组织学改变。结果　移植组受者自身肝脏未见增生 ,移植肝脏明显增生 ;受者的肝脏 /体重比明显升高。移植组和对照组体重、肝脏功能检查、肝脏和小肠的组织学差异不显著。移植组受者自身肝脏、移植肝脏及对照组肝脏肝细胞的凋亡指数差异无显著性。移植组受者自身肝脏肝细胞增殖指数较移植肝脏及对照组肝脏肝细胞的增殖指数明显降低。结论　小肠—辅助性肝脏联合移植是可行的 ;辅助性肝移植可以提高肝脏 /体重比。

关键词：肝脏小肠受者对照组联合移植移植物移植肝辅助性结论差异

亚洲远程教育的现状与未来发展前景——第22届亚洲开放大学协会(AAOU)年会综述(英文)

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开放教育研究 2008年第6期14卷 98-103页

作者：保罗.川内北京师范大学北京100875

2008年10月14日至16日,第22届亚洲开放大学协会(AAOU)年会在天津召开,本次年会由天津广播电视大学承办。本届年会共有七个主题演讲,这些主题演讲建议和主张我们在建构和运行亚洲乃至世界范围内的开放与远程教育过程中所面临的重大变革... 详细信息

2008年10月14日至16日,第22届亚洲开放大学协会(AAOU)年会在天津召开,本次年会由天津广播电视大学承办。本届年会共有七个主题演讲,这些主题演讲建议和主张我们在建构和运行亚洲乃至世界范围内的开放与远程教育过程中所面临的重大变革。从中可得出五点结论:①为了质量保证,考试应外包给一些跨机构的考试和认证机构;②开放教育资源应该是免费的,而且更容易为全球所获取;③获取远程教育的途径必须更加灵活,以应付不断变化的人口统计数据和预期增长的年长的、身体受损的学生数量;④在课程设计中不应只提供给学生二手信息,而要成为学生学习经验的主要来源;⑤AAOU应该做更多的工作,以促进学生、教师和课程的跨文化交流。第一和第二点一起是指为每个学生提供尽可能多的可付得起的高质量教育机会;第三点提醒我们采用ISO标准;而第四和第五点涉及到的是AAOU的核心内容:即亚洲所有国家和地区唯一的共同特征是多样性,而这种多样性不仅在于会议的丰富和价值,也在于我们的教师和学生。

关键词：年会综述开放大学远程教育亚洲协会天津广播电视大学学生数量现状

Assessment of Japanese healthy children’s nutritional status using Waterlow classification

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Health 2012年第11期4卷 1036-1040页

作者： Yukie Higashiyama Masaru Kubota satoko Oshima Marie Mibu Yuka Yasui Ayako Nagai Department of Human Life and Environment Nara Women’s University Nara Japan Department of Human Life and Environment Nara Women’s University Nara Japan

Malnutrition is associated with an increased risk of morbidity and mortality, and may case an undesirable effect on the growth and development in children. There have been several reports about the prevalence of malnutrition in hospitalized children, but reports about malnutrition in a large number of healthy children are quite limited. The aim of this study was to evaluate the prevalence of likelihood of malnutrition in Japanese healthy children. We retrospectively reviewed data of height and weight at a regular health check in 7517 healthy children (age 3 - 17;3747 boys, 3770 girls) during 2008 and 2010 in Nara city, Japan. The data were evaluated using Waterlow classification, i.e., weight-for-height (W/H) and height-for-age (H/A). The prevalence of under-nutrition, as estimated by the values of W/H less than 90% and H/A less than 95%, were 20.1% and 8.3%, respectively, and this prevalence of malnutrition risk tended to vary substantially with age. The peak levels of the prevalence were found to be at around 12 years old for both sexes in W/H, and at around 11 years old for boys and at around 10 years old for girls in H/A. We have clearly demonstrated the existence of certain percentages of the likelihood of malnutrition at different ages in healthy children. These findings suggest that when we want to evaluate the nutritional status using Waterlow classification in hospitalized children, we should be careful by taking such reference values into account.

关键词： Healthy Children Malnutrition Nutritional Assessment Waterlow Classification