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雷公藤多苷对不可逆性肾小球硬化模型系膜损伤的抑制作用

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中国中药杂志 2005年第5期30卷 361-365页

作者：万毅刚孙伟清水不二雄顾刘宝铃木浩一唐泽环河内裕南京大学医学院附属鼓楼医院江苏南京210008 南京中医药大学附属医院肾科江苏南京210029 新潟大学大学院医歯学総合研究科附属肾研究施设分子病态学分野日本新潟9518510 江苏省老年医学研究所内分泌实验室江苏南京210008

目的观察雷公藤多苷(GTW)对不可逆性肾小球硬化模型系膜损伤的抑制作用,阐明其在体内延缓肾小球硬化的分子药理机制。方法运用2次注射单克隆抗体(mAb)1223的方法,建立大鼠不可逆性肾小球硬化模型,以经口灌胃GTW(50mg·kg-1BW)干预42d,... 详细信息

目的观察雷公藤多苷(GTW)对不可逆性肾小球硬化模型系膜损伤的抑制作用,阐明其在体内延缓肾小球硬化的分子药理机制。方法运用2次注射单克隆抗体(mAb)1223的方法,建立大鼠不可逆性肾小球硬化模型,以经口灌胃GTW(50mg·kg-1BW)干预42d,并设立对照组。比较24h尿蛋白排泄量(Upro)、肾功能(Scr,BUN)以及肾小球形态学(LM,IF)变化,并检测(RTPCR)模型鼠肾组织中I型胶原(collagentypeI)、转化生长因子(TGFβ)mRNA表达水平。结果GTW抑制肾小球硬化模型鼠Upro和系膜增殖。肾小球总细胞数GTW组(65.67±3.43),对照组(87.02±2.41),P<0.05;细胞外基质积分GTW组(1.20±0.06),对照组(2.77±0.23),P<0.05;α平滑肌肌动蛋白积分GTW组(1.75±0.33),对照组(2.62±0.15),P<0.05;I型胶原积分GTW组(1.68±0.31),对照组(2.06±0.24),P<0.05。GTW使肾小球硬化模型鼠肾组织中collagentypeI,TGFβmRNA表达水平下调53.5%和14.7%,与对照组比较,二者差异均有显著性(P<0.05)。结论GTW抑制肾小球硬化模型鼠Upro和系膜增殖的作用是通过减少细胞因子mRNA的表达来实现的。

关键词：肾小球硬化对照组雷公藤多苷 mRNA表达抑制作用 TGF-β Ⅰ型胶原模型不可逆性下调

Endoscopic retrieval of a gastric trichobezoar

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World Journal of Gastrointestinal Endoscopy 2011年第1期3卷 20-22页

作者： Hironori Konuma Kuangi Fu Takashi Morimoto Takayoshi Shimizu Yuko Izumi satoko Shiyanagi Masahiko Urao Akihisa Miyazaki Sumio Watanabe Department of Gastroenterology Juntendo Univerity Nerima Hospital Department of Pediatric Surgery Juntendo Univerity Nerima Hospital Department of Gastroenterology Juntendo University School of Medicine

A 9-year-old girl presented with a chief complaint of abdominal pain. Esophagogastroduodenal endoscopy (EGD) identifi ed a long and large gastric trichobezoar extending into the duodenum. We attempted endoscopic retrieval after informed consent was obtained from the patient's mother. Initially, a gasper with 5-prolongs, com monly used for retrieval of endoscopically excised poly ps, failed to remove the whole trichobezoar. When a net was used instead, it proved impossible to remove the trichobezoar completely. Therefore, we withdrew the scope from the mouth, leaving the net grasping the tri co bezoar firmly in the stomach. Subsequently, we were able to retrieve about 70% of the trichobezoar manually by grasping the snare part of the net directly. A second pass found no deep laceration or perforation endoscopically. The remaining trichobezoar was completely retrieved with the net. The procedure was completed within 15 min. The retrieved specimens were34 cm in length and 100 g in weight. The patient was discharged uneventfully 5 d thereafter. She was advised to visit a psychiatrist to avoid suffering from a relapse. Follow-up EGD showed no trichobezoar, and the patient' s frontal hair grew back.

关键词： Gastric bezoar Trichobezoar Endoscopic retrieval Grasper Retrieval net

江西鄱阳湖湖口水域船舶通行对长江江豚发声行为的影响

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水生生物学报 2012年第2期36卷 246-254页

作者：董首悦董黎君李松海木村里子赤松友成王克雄王丁中国科学院水生生物研究所武汉430072 中国科学院研究生院北京100049 日本京都大学信息学研究生院日本国立水产工学研究所

江西鄱阳湖是长江江豚(Neophocaena phocaenoides)的重要栖息地,湖中栖息着约400头江豚。多年的观察表明,船舶交通是鄱阳湖中江豚面临的重要威胁之一。为了评估船舶通行对长江江豚发声行为的影响,尤其是了解船舶通行期间及其前后江豚的... 详细信息

江西鄱阳湖是长江江豚(Neophocaena phocaenoides)的重要栖息地,湖中栖息着约400头江豚。多年的观察表明,船舶交通是鄱阳湖中江豚面临的重要威胁之一。为了评估船舶通行对长江江豚发声行为的影响,尤其是了解船舶通行期间及其前后江豚的发声和行为特征,作者于2007年6月27日—7月1日在江西鄱阳湖湖口水域采用固定被动声学系统,即安装在监测点(29°42′38″N,116°11′11″E)的一套水下声学数据记录系统,对周边通行船舶的水下噪声及江豚声纳信号脉冲事件进行了定点监测和记录,并对所记录的数据进行了定量和统计分析。在整个监测的109h中,声学记录仪共记录到船舶494艘,江豚声纳脉冲串信号13413个。船舶出现与江豚出现存在弱的负相关关系(r=0.029,N=6550,P0.05);当有船舶经过时,江豚的发声频次显著降低(Z=10.050,P0.05;Z=0.119,P>0.05);船舶通行之前和之后,江豚的发声频次、脉冲串持续时间、脉冲间间隔的差异性均不显著(χ2=5.255,P>0.05;χ2=3.511,P>0.05;χ2=5.155,P>0.05);在船舶经过时,江豚对游动方向没有明显的选择性(χ2=0.861,P>0.05)。基于分析结果推测,在狭窄水域中江豚躲避船舶干扰通常采取"临时性"策略,而非长距离逃避。由于鄱阳湖湖口水域水道相对狭窄,尽管研究的结果表明江豚对船舶有一定的敏感反应,但是在相对狭窄的水域中,江豚躲避船舶的行为难以充分表现。另外,江豚对该水域中高密度航行船舶的噪声可能存在一定的"适应性",导致当遭遇船舶时,江豚的声行为反应不十分强烈。因此,建议有必要在不同尺度的水体中采用声学数据记录仪继续开展类似的观察,以进一步了解江豚对船舶的行为响应,尤其是观察江豚躲避船舶的行为及发声特征。

关键词：长江江豚船舶通行发声行为固定声学系统鄱阳湖湖口

Meta-analysis of lymph node metastasis in Siewert type Ⅰ and Ⅱ T1 adenocarcinomas

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World Journal of Meta-Analysis 2016年第6期4卷 118-123页

作者： Hiroki Osumi Junko Fujisaki Masami Omae Tomoki Shimizu Toshiyuki Yoshio Akiyoshi Ishiyama Toshiaki Hirasawa Tomohiro Tsuchida Yorimasa Yamamoto Hiroshi kawachi Noriko Yamamoto Masahiro Igarashi Departments of Gastroenterology and Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research Departments of Pathology Cancer Institute Hospital Japanese Foundation for Cancer Research

AIM To evaluate the incidence of lymph node metastasis(LNM) and its risk factors in patients with Siewert type Ⅰ and type Ⅱ pT1 *** We enrolled 85 patients [69 men, 16 women; median age(range), 67(38-84) years] who had undergone esophagectomy or proximal gastrectomy for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas. Predictive risk factors of LNM included age, sex, location of the tumor center, confirmed Barrett's esophageal adenocarcinoma, tumor size, macroscopic tumor type, pathology, invasion depth, presence of ulceration, and lymphovascular invasion. Multivariate logistic regression analysis was used to identify factors predicting LNM. We also evaluated the frequencies of LNM for Siewert type Ⅰ and type Ⅱ pT1 adenocarcinomas in meta-data *** LNMs were found in 11 out of 85 patients(12.9%, 95%CI: 5.8-20.0). Only 1 of the 15 patients(6.6%, 95%CI: 0.0-19.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 10 ofthe 70 patients(14.2%, 95%CI: 6.0-22.4) with a final diagnosis of pT1b adenocarcinoma had positive LNM. Furthermore, only one of the 30 patients(3.3%, 95%CI: 0.0-9.7) with a tumor invasion depth within 500 μm from muscularis mucosae had positive LNM. Poor differentiation and lymphovascular invasion were independently associated with a risk of LNM. In meta-data analysis, 12 of the 355 patients(3.3%, 95%CI: 1.5-5.2) who had a final diagnosis of pT1a adenocarcinoma had a positive LNM, whereas 91 of the 438 patients(20.7%, 95%CI: 16.9-24.5) with a final diagnosis of pT1b adenocarcinoma had positive LNM. CONCLUSION We consider endoscopic submucosal dissection(ESD) is suitable for patients with Siewert type Ⅰ and type Ⅱ T1 a adenocarcinomas. For patients with T1b adenocarcinoma, especially invasion depth is within 500 μm from muscularis mucosae with no other risk factor for LNM, diagnostic ESD could be a treatment option according to the overall status of patients and the presence of comorbidities.

关键词： Siewert type Ⅰ and type Ⅱ adenocarcinomas Lymph node metastasis

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程序化降温保存血管内皮功能的研究

中国现代普通外科进展 2005年第3期8卷 144-145页

作者：刘毅徐克森河内宽治陈雨信寿楠海山东大学齐鲁医院普外科肝胆血管外科研究所山东济南250012 日本爱媛大学第二外科日本松山7910295

目的探讨程序化降温对体外大鼠血管内皮的影响。方法对大鼠腹主动脉进行0.7℃/min(新鲜血管组和常规方法组)及1℃/min(试验组)程序化降温,低温保存3个月后对比观察血管内皮形态和功能变化。结果试验组的平均收缩张力及非依赖性血管舒张... 详细信息

目的探讨程序化降温对体外大鼠血管内皮的影响。方法对大鼠腹主动脉进行0.7℃/min(新鲜血管组和常规方法组)及1℃/min(试验组)程序化降温,低温保存3个月后对比观察血管内皮形态和功能变化。结果试验组的平均收缩张力及非依赖性血管舒张均较常规组高(P0.05);光镜下试验组血管内皮细胞较常规组完整。结论改良的降温程序能够较好保持内皮的收缩功能以及非内皮依赖性舒张功能,但对内皮依赖性舒张功能效果欠佳。

关键词：低温保存内皮,血管大鼠,Wister

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胆囊癌中发现破骨细胞样巨细胞

世界核心医学期刊文摘（胃肠病学分册） 2006年第8期2卷 52-52页

作者： Akatsu T. Kameyama K. kawachi S. 郑世成(译) 王顺涛(校) Division of Diagnostic Pathology Keio University School of Medicine 35 Shinanomachi Shinjuku-ku Tokyo 160- 8582 Japan 不详

Extraskeletal tumors containing multinucleated, osteoclast-like giant cells (OGCs) are uncommon. These neoplasms are most frequently reported in the breast and pancreas. Recently, some authors have suggested that carcinomas containing OGCs may represent a distinct clinicopathological entity with a more favorable prognosis. Occurrence in the gallbladder is extremely rare, with only one previous case. We report here on an additional case of gallbladder carcinoma with an infiltrate of OGCs. A 72- year-old woman presented with postprandial abdominal pain and was found to have a mass in the body of the gallbladder with direct liver invasion. Histological examination showed an adenosquamous carcinoma with an infiltrate of benign OGCs. Immunohistochemical analysis demonstrated that the giant cells were of histiocytic origin. The patient survived for 6 years without evidence of recurrence. This case adds to a small body of literature on gallbladder carcinoma with OGCs. Further studies are required to clearly define the prognostic significance of these giant cells in gallbladder cancer and the differences between adenosquamous carcinoma with OGCs and other gallbladder carcinomas (such as adenocarcinoma and squamous cell carcinoma) with those cells.

关键词：破骨细胞样巨细胞胆囊癌临床病理学特征胰腺肿瘤免疫组化分析多核巨细胞组织学诊断餐后腹痛直接浸润组织细胞

Age is an independent adverse prognostic factor for overall survival in acute myeloid leukemia in Japan

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World Journal of Hematology 2014年第3期3卷 105-114页

作者： Hiroaki Ohnishi Osamu Imataki Yasunori kawachi Makoto Ide Kimihiro Kawakami Masato Waki Hidetaka Takimoto Yasuo Hoshijima Tetsuya Fukumoto Kensuke Matsumoto Fusako Waki Akihito Matsuoka Takamichi Shintani Makiko Uemura Shigeyuki Yokokura Teruhisa Taoka Takuya Matsunaga Department of Internal Medicine Division of En-docrinology and MetabolismHematologyRheumatology and Respiratory MedicineFaculty of MedicineKagawa University Department of Internal Medicine Division of HematologyTakamatsu Red Cross Hospital Department of Internal Medicine Division of HematologyKagawa Prefectural Central Hospital Department of Internal Medicine Division of HematologyKagawa Rosai Hospital Department of Internal Medicine Division of HematologyTakamatsu Municipal Hospital Department of Internal Medicine Division of HematologySakaide City Hospital

AIM: To elucidate risk factors for survival of elderly acute myeloid leukemia(AML) patients in a real-world practice by observational study. METHODS: We conducted a population-based study in 213 adult and elderly AML patients(127 males and 86 females) in Kagawa Prefecture, Japan. To construct this cohort, we gathered all data for patients diagnosed with AML at 7 hospitals in Kagawa between 2006 and 2010. The primary end point was overall survival(OS) after AML diagnosis. Unadjusted Kaplan-Meier survival plots were used to determine OS in the overall cohort. Multivariate analysis was used to determine the independent adverse prognostic factors for OS, with the covariates of interest including age, gender, race/ethnicity, CCI, education, median income, metropolitan statistical area size and history of myelodysplastic ***: The average population of Kagawa during the study period was 992489, and the incidence of AML was 4.26 per 100000 person-years. A total of 197 patients with non-acute promyelocytic leukemia(non-APL)(119 males and 78 females) were also included. The median age of non-APL patients was 70 years(average 67, range 24-95). The 5-year OS rate was 21.1%. Subsequent analysis by age group showed that the survival rate declined with age; the 5-year OS rates of non-APL patients younger than 64 years, 65-74 years, and older than 75 years were 41.5%, 14.1%, and 8.9%, respectively. Multivariate analysis revealed that unfavorable risk karyotype, older age, poor performance status(PS)(3-4), lack of induction chemotherapy, and antecedent haematological disease were independent prognostic predictors. In the subgroup analysis, we also found that older patients with non-APL had lower complete remission rates and higher early death rates than younger patients, irrespective of PS. However, intensive chemotherapy was a significant predictor for longer survival not only in the patients < 75 years of age, but also in those over 75 with PS 0-2. CONCLUSION: Age wou

关键词： Acute myeloid leukemia Elderly Adverse prognostic factor Overall survival Population-based study

East Asian VLBI Network observations of active galactic nuclei jets:imaging with KaVA+Tianma+Nanshan

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Research in Astronomy and Astrophysics 2021年第8期21卷 220-234页

作者：崔玉竹 Kazuhiro Hada Motoki Kino Bong-Won Sohn Jongho Park Hyun-Wook Ro satoko Sawada-Satoh Wu Jiang Lang Cui Mareki Honma 沈志强 Fumie Tazaki 安涛 Ilje Cho Guang-Yao Zhao Xiao-Peng Cheng Kotaro Niinuma Kiyoaki Wajima Ying-Kang Zhang Noriyuki Kawaguchi Juan-Carlos Algaba Shoko Koyama Tomoya Hirota Yoshinori Yonekura Nobuyuki Sakai Bo Xia Yong-Bin Jiang Lin-Feng Yu Wei Gou Ju-Yeon Hwang Yong-Chen Jiang Yun-Xia Sun Dong-Kyu Jung Hyo-Ryoung Kim Jeong-Sook Kim Hideyuki Kobayashi Jee-Won Lee Jeong-Ae Lee Hua Zhang Guang-Hui Li Zhi-Qiang Xu Peng Li Jung-Hwan Oh Se-Jin Oh Chung-Sik Oh Tomoaki Oyama Duk-Gyoo Roh Katsunori-M.Shibata 郭文 Rong-Bing Zhao Wei-Ye Zhong Jin-Qing Wang Wen-Jun Yang 闫浩 Jae-Hwan Yeom Bin Li 李笑飞 Jian-Ping Yuan Jian Dong Zhong Chen Kazunori Akiyama Keiichi Asada Do-Young Byun Yoshiaki Hagiwara Jeffrey Hodgson Tae-Hyun Jung Kee-Tae Kim Sang-Sung Lee Kunwoo Yi Qing-Hui Liu Xiang Liu Ru-Sen Lu Masanori Nakamura Sascha Trippe Na Wang Xue-Zheng Wang 张波 Department of Astronomical Science The Graduate University for Advanced StudiesSOKENDAI2-21-1 OsawaMitakaTokyo 181-8588Japan Mizusawa VLBI Observatory National Astronomical Observatory of Japan2-12 HoshigaokaMizusawaOshuIwate 023-0861Japan Kogakuin University of Technology and Engineering Academic Support Center2665-1 NakanoHachiojiTokyo 192-0015Japan Korea Astronomy and Space Science Institute Yuseong-guDaejeon 34055Korea Department of Astronomy Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Korea Department of Astronomy and Space Science University of Science and Technology217 Gajeong-roDaejeonKorea Institute of Astronomy and Astrophysics Academia Sinica645 N Aohoku PIHiloHI 96720USA Graduate School of Sciences and Technology for Innovation Yamaguchi UniversityYoshida 1677-1YamaguchiYamaguchi 753-8512Japan Shanghai Astronomical Observatory Chinese Academy of SciencesShanghai 200030China Xinjiang Astronomical Observatory Chinese Academy of SciencesUrumqi 830011China Key Laboratory of Radio Astronomy Chinese Academy of SciencesNanjing 210008China Institute of Astronomy The University of Tokyo2-21-1 OsawaMitakaTokyo 181-0015Japan Instituto de Astrofísica de Andalucía-CSIC Glorieta de la Astronomia s/nGranada E-18008Spain Department of Physics Faculty of ScienceUniversity of MalayaKuala Lumpur 50603Malaysia Center for Astronomy Ibaraki University2-1-1 BunkyoMitoIbaraki 310-8512Japan Space Light Laboratory 77Yangjaedae-ro 86 roadGangdong-guSeoulKorea Massachusetts Institute of Technology Haystack Observatory 99 Millstone RoadWestfordMA 01886USA National Radio Astronomy Observatory 520 Edgemont RdCharlottesvilleVA 22903USA Toyo University 5-28-20 HakusanBunkyo-kuTokyo 112-8606Japan Department of Physics and Astronomy Seoul National UniversityGwanak-guSeoul 08826Korea Max Planck Institute for Radio Astronomy Auf dem hiigel 69Bonn 53121Germany SNU Astronomy Research Center Seoul National UniversityGwanak-guSeoul 08826Korea

The East Asian Very Long Baseline Interferometry(VLBI) Network(EAVN) is a rapidly evolving international VLBI array that is currently promoted under joint efforts among China,Japan and *** aims at forming a joint VLBI Network by combining a large number of radio telescopes distributed over East Asian *** the combination of the Korean VLBI Network(KVN) and the VLBI Exploration of Radio Astrometry(VERA) into Ka VA,further expansion with the joint array in East Asia is actively *** we report the first imaging results(at 22 and 43 GHz) of bright radio sources obtained with Ka VA connected to Tianma 65-m and Nanshan 26-m Radio Telescopes in *** test the EAVN imaging performance for different sources,we observed four active galactic nuclei(AGN) having different brightness and *** a result,we confirmed that the Tianma 65-m Radio Telescope(TMRT) significantly enhances the overall array sensitivity,a factor of 4 improvement in baseline sensitivity and 2 in image dynamic range compared to the case of Ka VA *** addition of the Nanshan 26-m Radio Telescope(NSRT) further doubled the east-west angular *** the resulting high-dynamic-range,high-resolution images with EAVN(Ka VA+TMRT+NSRT),various fine-scale structures in our targets,such as the counter-jet in M87,a kink-like morphology of the 3 C 273 jet and the weak emission in other sources are successfully *** demonstrates the powerful capability of EAVN to study AGN jets and to achieve other science goals in *** expansion of EAVN will further enhance the angular resolution,detection sensitivity and frequency coverage of the network.

关键词： galaxies:active galaxies:jets instrumentation:interferometers radio continuum:galaxies