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Symptomatic COVID-19 in University Students: A School-Wide Web-Based Questionnaire Survey during the Omicron Variant Outbreak

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Advances in Infectious Diseases 2024年第1期14卷 133-146页

作者： Mai Kitahara Hisami Sameshima Rie Tanuma Kumi Setoyama Yuka Yamaguchi Akiyo Kamachi satoko Nakamura Mayuko Sakuma Yoichi Kawaike Tamotsu Furuya Shinji Ijichi Health Service Center Kagoshima University Kagoshima Japan Center for Management of Information Technologies Kagoshima University Kagoshima Japan

Aim: To detect risk and preventive factors associated with the Omicron variant infection in university students, a combination of a web-based survey and multivariate logistic regression analysis was introduced as the front-line initiatives by the school health practitioners. Design: Questionnaire survey. Methods: The school-wide web-based questionnaire survey was conducted among our university students as a part of the annual health check-up in April, 2023. The positive outcome was confined to the first symptomatic COVID-19 onset during the Omicron variant outbreak. Results: In this self-administered survey, risk or protective associations were merely estimated statistically in university students (n = 5406). In measured factors, karaoke and club/group activities could maintain the statistical significance in adjusted odds ratios (ORs) as relative risk factors, and science course, measles/ rubella (MR) vaccination, and COVID-19 vaccination remained as relative protective factors in adjusted OR analyses. Club/group activities with member gathering and karaoke sing-along sessions in university students may frequently have WHO’s three Cs. These risk factors are still important topics for the infection control of COVID-19 in university students. Together with some recent reports from other researchers, the significant protective role of MR vaccine in our survey warrants further clinical investigation. If the breakthrough infection continuously constitutes the majority of infection, real data in test-negative case-control or web-based questionnaire design continue to be important for statistical analysis to determine the minimal requirement of our strategies which may be equivalent to or replace COVID-19 vaccines.

关键词： Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Coronavirus Disease 2019 (COVID-19) Omicron Variant Risk Behaviors Protective Factors

近代日本作家坪内逍遥、森鸥外和夏目漱石对莎士比亚作品的翻译与解读

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中世纪与文艺复兴研究 2024年第1期 23-44页

作者：川地美子李文超日本庆应义塾大学国际莎士比亚协会浙江大学外国语学院日语所中国日语教育研究会

莎士比亚在明治时期传入日本。当时日本摆脱了长期的民族闭塞,开始吸收西欧文化,开启了现代化进程。本文考察在这样的历史背景下,近代日本作家坪内逍遥、森鸥外和夏目漱石对莎剧的翻译与解读,进而思考日本对莎士比亚的接受与日本的西化... 详细信息

莎士比亚在明治时期传入日本。当时日本摆脱了长期的民族闭塞,开始吸收西欧文化,开启了现代化进程。本文考察在这样的历史背景下,近代日本作家坪内逍遥、森鸥外和夏目漱石对莎剧的翻译与解读,进而思考日本对莎士比亚的接受与日本的西化之间的联系。

关键词：莎士比亚翻译解读日本坪内逍遥森鸥外夏目漱石

Optimal resection of gastric bronchogenic cysts based on anatomical continuity with adherent gastric muscular layer: A case report

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World Journal of Gastrointestinal Surgery 2023年第6期15卷 1216-1223页

作者： Masayoshi Terayama Koshi Kumagai Hiroshi kawachi Rie Makuuchi Masaru Hayami Satoshi Ida Manabu Ohashi Takeshi Sano Souya Nunobe Department of Gastroenterological Surgery Gastroenterological CenterCancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan Department of Pathology Cancer Institute HospitalJapanese Foundation for Cancer ResearchTokyo 135-8550Japan

BACKGROUND Bronchogenic cysts are congenital lesions requiring radical resection because of malignant ***,a method for the optimal resection of these cysts has not been completely *** SUMMARY Herein,we presented three patients with bronchogenic cysts that were located adjacent to the gastric wall and resected *** cysts were detected incidentally with no symptoms and the preoperative diagnosis was challenging to obtain via radiological *** on laparoscopic findings,the cyst was attached firmly to the gastric wall and the boundary between the gastric and cyst walls was difficult to ***,resection of cysts alone caused cystic wall injury in Patient ***,the cyst was resected completely along with a part of the gastric wall in Patient *** examination revealed the final diagnosis of bronchogenic cyst and revealed that the cyst wall shared the muscular layer with the gastric wall in Patients 1 and *** Patient 3,the cyst was located adjacent to the gastric wall but histopathologically originated from diaphragm rather than *** the patients were free from *** The findings of this study state that a safe and complete resection of bronchogenic cysts required the adherent gastric muscular layer or full-thickness dissection,if bronchogenic cysts are suspected via pre-and/or intraoperative findings.

关键词： Bronchogenic cysts Laparoscopic resection Gastric wall Muscular layer Case report

Successful treatment with laparoscopic surgery and sequential multikinase inhibitor therapy for hepatocellular carcinoma:A case report

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World Journal of Gastrointestinal Surgery 2022年第3期14卷 260-267页

作者： Yutaka Endo Motohide Shimazu Tadayuki Sakuragawa Yusuke Uchi Motonori Edanami Ken Sunamura Soji Ozawa Naokazu Chiba Shigeyuki kawachi Department of Surgery Tama Kyuryo HospitalTokyo 1940297Japan Department of Digestive and Transplantation Surgery Tokyo Medical University Hachioji Medical CenterTokyo 1930998Japan

BACKGROUND Hepatocellular carcinoma(HCC)with massive portal vein tumor thrombosis(PVTT)and distant metastasis is considered ***,due to recent developments in systemic chemotherapy,successful cases of conversion therapy for unresectable diseases have been ***,we report a successful multidisciplinary approach for treatment of multi-visceral recurrence with sequential multikinase inhibitor and laparoscopic *** SUMMARY A 63-year-old woman with chronic hepatitis B virus infection was diagnosed with ***,she underwent two rounds of laparoscopic partial hepatectomy,laparoscopic left adrenalectomy,and transcatheter arterial chemoembolization plus sorafenib for *** years after initial hepatectomy,she presented with a 43-mm mass in the spleen and tumor thrombus involving the main portal vein trunk with *** liver function was Child-Pugh B(8),and protein induced by vitamin K absence or antagonist II(PIVKA II)levels were elevated up to 46.291 mAU/*** initial treatment with regorafenib for three months was unsuccessful,the patient was administered *** months post-treatment,there was no contrast enhancement of PVTT or splenic *** was discontinued due to severe ***,splenic metastasis became viable,and PIVKA II ***,hand-assisted laparoscopic splenectomy was *** experienced no clinical recurrence 14 mo after *** Conversion surgery after successful multikinase inhibitor treatment might be considered an effective treatment option for advanced HCC.

关键词： Hepatocellular carcinoma Lenvatinib Portal vein Venous thrombosis Splenic neoplasms Case report

Fantastic Histories： The Battles of Coxinga and the Preservation of Ming in Japan

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Frontiers of Literary Studies in China-Selected Publications from Chinese Universities 2015年第1期9卷 17-53页

作者： satoko SHIMAZAKI Department of East Asian Languages and Cultures University of Southern California LosAngeles CA 90089 USA

People in Japan reacted to the bewilderment they felt at the fall of Ming by creating a bifurcated view of China, evident in encyclopedias and gazeteers： On the one hand, there was the traditional China represented by the Ming; on the other, there was the new China ruled by the Dattan or the Tatars. Such was the power of the Ming as an image that it endured in Japanese literature and theater for centuries after its fall. This article explores the preservation in popular discourse of the Ming as the most natural representation of China, focusing on Chikamatsu Monzaemon＇s hit jrruri play The Battles of Coxinga （Kokusen＇ya kassen）, first staged in 1715 and produced many times after that, showing how the political turmoil was filtered through both misunderstandings and creative fabrications. It shows that The Battles of Coxinga creates a fantastic image of China, as opposed to the barbaric Dattan, by drawing on historical memories internal to Japan and readily available images of foreignness. I argue that the preservation of the Ming in popular theater offered audiences a means of rethinking Japan＇s position as the inheritor of a ＂universal＂ Chinese essence in an age when knowledge of the world was being dramatically expanded by imported European cartography, complicating earlier views of a world centered on the Three Realms or the Sinocentric world order.

关键词： fall of the Ming Chikamatsu Monzaemon The Battles of Coxinga(Kokusen 'ya kassen) Nishikawa Joken Japanese views of China

Potential role of chitinase 3-like-1 in inflammation-associated carcinogenic changes of epithelial cells

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World Journal of Gastroenterology 2009年第42期15卷 5249-5259页

作者： Katrin Eurich Mayuko Segawa satoko Toei-Shimizu Emiko Mizoguchi Gastrointestinal Unit Department of MedicineMassachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States Center for the Study of Inflammatory Bowel Disease Massachusetts General HospitalHarvard Medical SchoolBostonMA 02114United States

The family of mammalian chitinases includes members both with and without glycohydrolase enzymatic activity against chitin,a polymer of *** is the structural component of fungi,crustaceans,insects and parasitic nematodes,but is completely absent in *** to antigens containing chitin-or chitin-like structures sometimes induces strong T helper type-I responses in mammals,which may be associated with the induction of mammalian *** 3-like-1(CHI3L1) ,a member of the mammalian chitinase family,is induced specifically during the course of inflammation in such disorders as inflammatory bowel disease,hepatitis and *** addition,CHI3L1 is expressed and secreted by several types of solid tumors including glioblastoma,colon cancer,breast cancer and malignant *** the exact function of CHI3L1 in inflammation and cancer is still largely unknown,CHI3L1 plays a pivotal role in exacerbating the inflammatory processes and in promoting angiogenesis and remodeling of the extracellular ***3L1 may be highly involved in the chronic engagement of inflammation which potentiates development of epithelial tumorigenesis presumably by activating the mitogen-activated protein kinase and the protein kinase B signaling ***-CHI3L1 antibodies or pan-chitinase inhibitors may have the potential to suppress CHI3L1-mediated chronic inflammation and the subsequent carcinogenic change in epithelial cells.

关键词：几丁质酶活力上皮细胞致癌性炎症潜在作用乙酰氨基葡萄糖哺乳动物蛋白激酶B

Prevaccination Antibody Confers Additional Immune Responses to Repeated Yearly Influenza Vaccination in an Elderly Population

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World Journal of Vaccines 2022年第2期12卷 11-19页

作者： satoko Kitamura Naoki Komatsu Masahide Matsushita Hiromi Seo Seisho Takeuchi Department of General Medicine Kochi Medical School Hospital Nankoku Japan Kochi General Rehabilitation Hospital Kochi Japan

Annual vaccination is necessary to maintain humoral immunity in the elderly population. However, the factors influencing the response to influenza vaccination have not been completely identified. The aim of this study was to explore the factors that influenced antibody responses to repeated vaccination using measures that were both objective and quantitative. A total of 111 volunteers aged > 61 years were vaccinated subcutaneously with one dose of influenza vaccine from the 2005-2006 season through the 2009-2010 season. The factors that influenced antibody responses after vaccination were evaluated. The seroprotection rates (PRs) were significantly higher in responders (subjects with a higher antibody titer in the 2005-2006 season) than in nonresponders only in the 2006-2007 and 2007-2008 seasons. PRs after vaccination were significantly higher in seropositive individuals (subjects with a higher prevaccination antibody titer in the 2006-2007 season) than in seronegative individuals for all three virus strains in almost all of the 5 years. Age, gender, and vaccination in the 2004-2005 season did not influence the response. These results suggest that an immune response at a certain time point would predict immune responses only in the near future. However, prevaccination antibody titer in the following season is the ideal predictor for future responses that last over several influenza seasons.

关键词： Influenza Vaccine Elderly Persons Repeated Vaccination Seroprotection Rate

Edo kabuki in transition

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Edo kabuki in transition

AIM associated with the IgM pentamer: attackers on stand-by at aircraft carrier

作者： Shimazaki satoko

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Cellular & Molecular Immunology 2018年第6期15卷 563-574页

作者： Toru Miyazaki Tomoko Yamazaki Ryoichi Sugisawa M Eric Gershwin satoko Arai Laboratory of Molecular Biomedicine for Pathogenesis Center for Disease Biology and Integrative MedicineFaculty of MedicineThe University of TokyoTokyo 113-0033Japan CREST Japan Agency for Medical Research and DevelopmentTokyo 113-0033Japan Max Planck-The University of Tokyo Center for Integrative Inflammology Tokyo 113-0033Japan Division of Rheumatology Allergy and Clinical Immunology The University of California School of MedicineDavisCA 95616USA

Circulating immunoglobulin M(IgM)exists in a pentameric form,possessing a polyreactive nature that responds not only to foreign antigens but also to autoantigens;thus,it is involved in both beneficial and detrimental immune responses,including protection from infection and the progression of *** the other hand,IgM also behaves as a carrier of the apoptosis inhibitor of macrophage(AIM)protein,storing a large amount of the inactivated form of AIM in the blood through this *** different disease conditions,AIM can dissociate from IgM locally or systemically to exert its function,inducing the removal of various biological debris such as excess fat,bacteria,cancer cells or dead cell *** typically,upon induction of acute kidney injury(AKI),IgM-free AIM is filtered by the glomerulus in the kidney,which stimulates the clearance of intraluminal dead cells debris at the obstructed proximal tubules,thereby facilitating the repair of kidney ***,cats exhibit a deficiency in AIM release from IgM,which may increase their susceptibility to renal ***,association with AIM inhibits IgM binding to the Fcα/μreceptor on follicular dendritic cells at the splenic germinal center,thereby protecting the IgM immune complex from Fcα/μreceptor-mediated internalization,which supports IgM-dependent antigen presentation to B cells and stimulates high-affinity IgG antibody *** regulation of AIM–IgM binding,resulting from the discovery of reciprocal actions between AIM and IgM,could lead to the development of novel therapies against different diseases.

关键词： apoptosis inhibitor of macrophage(AIM) immunoglobulin M(IgM) acute kidney injury(AKI) hepatocellular carcinoma(HCC) cat renal failure