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Status and prospects for symmetric organic redox flow batteries

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Journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

Acquired sensorineural hearing loss,oxidative stress,and microRNAs

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Neural Regeneration Research 2025年第9期20卷 2513-2519页

作者： Desmond A.Nunez Ru c.Guo Division of Otolaryngology–Head&Neck Surgery Department of SurgeryFaculty of MedicineThe University of British ColumbiaVancouverBCCanada Division of Otolaryngology–Head&Neck Surgery Gordon&Leslie Diamond Health Care CentreVancouver General HospitalVancouverBCCanada Faculty of Medicine–The University of British columbia VancouverBCCanada

Hearing loss is the third leading cause of human ***-related hearing loss,one type of acquired sensorineural hearing loss,is largely responsible for this escalating global health ***-induced,ototoxic,and idiopathic sudden sensorineural are other less common types of acquired hearing *** etiology of these conditions is complex and multi-fa ctorial involving an interplay of genetic and environmental *** stress has recently been proposed as a likely linking cause in most types of acquired sensorineural hearing *** non-coding RNA sequences known as microRNAs(miRNAs)have increasingly been shown to play a role in cellular hypoxia and oxidative stress responses including promoting an apoptotic *** hair cell death is a central histopathological finding in sensorineural hearing *** these cells do not regenerate in humans,it underlies the irreversibility of human age-related hearing *** EMBASE,Ovid MEDLINE,Web of Science core collection,and *** databases over the period August 1,2018 to July 31,2023 were searched with"hearing loss,""hypoxamiRs,""hypoxia,""microRNAs,""ischemia,"and"oxidative stress"text words for English language primary study publications or registered clinical *** red clinical trials known to the senior author we re also assessed.A total of 222studies were thus *** excluding duplicates,editorials,retra ctions,secondary research studies,and non-English language articles,39 primary studies and clinical trials underwent full-text *** resulted in 11 animal,in vitro,and/or human subject journal articles and 8 registered clinical trial database entries which form the basis of this narrative *** miR-34a and miR-29b levels increase with age in *** miRNAs were demonstrated in human neuroblastoma and murine cochlear cell lines to target Sirtuin 1/peroxisome proliferato r-activated receptor gamma coactivator-1-alpha(SIRT1/P Gc-1α),SIRT

关键词： hearing loss hypoxia microRNAs oxidative stress sensorineural

Detailed Analysis of Quantum Phase Transitions Within the u(2) Algebra

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communications in Theoretical Physics 2010年第10期54卷 589-593页

作者： L.Fortunato L.sartori Dipartimento di Fisica“G.Galilei”and INFN the EcT Europen Center for Theoretical Nuclear Physics cISAS G.colombo

We analyze in detail the quantum phase transitions that arise in models based on the u(2) algebraicdescription for bosonic systems with two types of scalar *** we discuss the quantum phase transition thatoccurs in hamiltonians that admix the two dynamical symmetry chains u(2)  u(1) and u(2)  so(2) by diagonalizingthe problem exactly in the u(1) *** we apply the coherent state formalism to determine the energy *** we show that a quantum phase transition of a different nature, but displaying similar characteristics, may arisealso within a single chain just by including higher order terms in the hamiltonian.

关键词： algebraic models Lie algebra quantum phase transitions Lipkin model

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon c.Smith Jessica L.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(cNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

central nervous system manifestations due to iatrogenic adrenal insuffi ciency in a Ewing sarcoma patient

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World Journal of Emergency Medicine 2019年第2期10卷 119-121页

作者： coralie Galland-Decker Vanessa Kraege claudio sartori Internal Medicine University HospitalLausanne-CHUV

Dear editor,Several types of tumors affect *** being rare,the Ewing sarcoma fami ly of tumors represents the second most common primary bone malignancy in children and *** cushing syndrome i s a wel l-known condi t ion characterized by an ectopic secretion of AcTH(or cRH),and in turn of cortisol by tumor *** cushing syndrome is however very rare in Ewing sarcoma,and to our knowledge,it was only described once.

关键词： Several types adolescents primary bone

Reduced Basis Approaches in Time-Dependent Non-coercive Settings for Modelling the Movement of Nuclear Reactor control Rods

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communications in computational Physics 2016年第6期20卷 23-59页

作者： Alberto sartori Antonio cammi Lelio Luzzi Gianluigi Rozza Politecnico di Milano–Department of Energy CeSNEFEnrico Fermi Center for Nuclear Studiesvia La Masa 3420156MilanoItaly SISSA International School for Advanced StudiesMathematics Area–mathLabVia Bonomea 26534136 TriesteItaly.

In this work,two approaches,based on the certified Reduced Basis method,have been developed for simulating the movement of nuclear reactor control rods,in time-dependent non-coercive settings featuring a 3D geometrical *** particular,in a first approach,a piece-wise affine transformation based on subdomains division has been implemented for modelling the movement of one control *** the second approach,a“staircase”strategy has been adopted for simulating themovement of all the three rods featured by the nuclear reactor chosen as case *** neutron kinetics has been modelled according to the so-called multi-group neutron diffusion,which,in the present case,is a set of ten coupled parametrized parabolic equations(two energy groups for the neutron flux,and eight for the precursors).Both the reduced order models,developed according to the two approaches,provided a very good accuracy comparedwith high-fidelity results,assumed as“truth”*** the same time,the computational speed-up in the Online phase,with respect to the fine“truth”finite element discretization,achievable by both the proposed approaches is at least of three orders of magnitude,allowing a real-time simulation of the rod movement and control.

关键词： Reduced basis method control rod movement spatial kinetics parametrized geometry multi-group neutron diffusion non-coercive operators

Thermal ablation in colorectal liver metastases: Lack of evidence or lack of capability to prove the evidence?

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World Journal of Gastroenterology 2016年第13期22卷 3511-3515页

作者： Sergio sartori Paola Tombesi Francesca Di Vece Section of Interventional Ultrasound St Anna Hospital

Many studies suggest that combined multimodality treatments including ablative therapies may achieve better outcomes than systemic chemotherapy alone in patients with colorectal liver metastases. Nevertheless, ablative therapies are not yet considered as effective options because their efficacy has never been proved by randomized controlled trials (RcT). However, there are in literature no trials that failed in demonstrating the effectiveness of ablative treatments: what are lacking, are the trials. All the attempts to organize phase III studies on this topic failed as a result of non accrual. Just one prospective RcT comparing radiofrequency ablation combined with systemic chemotherapy vs chemotherapy alone has been published. It was designed as a phase III study, but it was closed early because of slow accrual, and was downscaled to phase II study, with the consequent limits in drawing definite conclusions on the benefit of combined treatment. However, the combination treatment met the primary end point of the study and obtained a significantly higher 3-year progression-free survival than systemic chemotherapy alone. It is very unlikely that ultimate efficacy of ablation treatments will ever be tested again, and the best available evidence points toward a benefit for the combination strategy using ablative treatments and chemotherapy.

关键词： Liver metastases colorectal cancer Thermal ablation Radiofrequency ablation Microwave ablation Laser ablation Systemic chemotherapy

Liver-directed therapies for liver metastases from neuroendocrine neoplasms:can laser ablation play any role?

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World Journal of Gastroenterology 2020年第23期26卷 3118-3125页

作者： Sergio sartori Lara Bianchi Francesca Di Vece Paola Tombesi Department of Internal Medicine Section of Interventional UltrasoundSt.Anna HospitalFerrara 44100Italy

Aggressive cytoreduction can prolong survival in patients with unresectable liver metastases(LM)from neuroendocrine neoplasms(NEN),and minimally invasive,liver-directed therapies are gaining increasing ***-based treatments are used in disseminated disease,whereas ablation techniques are usually indicated when the number of LM is *** radiofrequency ablation(RFA)is by far the most used ablative technique,the goal of this opinion review is to explore the potential role of laser ablation(LA)in the treatment of LM from *** uses thinner needles than RFA,and this is an advantage when the tumors are in at-risk ***,the multi-fiber technique enables the use of one to four laser fibers at once,and each fiber provides an almost spherical thermal lesion of 12-15 mm in *** a characteristic enables to tailor the size of each thermal lesion to the size of each tumor,sparing the liver parenchyma more than any other liver-directed therapy,and allowing for repeated treatments with low risk of liver failure.A recent retrospective study reporting the largest series of LM treated with LA documents both safety and effectiveness of LA,that can play a useful role in the multimodality approach to LM from NEN.

关键词： Neuroendocrine neoplasms Liver metastases Liver-directed therapies Ablation techniques Laser ablation Radiofrequency ablation

Should mast cells be considered therapeutic targets in multiple sclerosis?

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Neural Regeneration Research 2020年第11期15卷 1995-2007页

作者： Karen Henriette Pinke Sofia Fernanda Goncalves Zorzella-Pezavento Vanessa Soares Lara Alexandrina sartori Institute of Biosciences Department of Microbiology and ImmunologySao Paulo State University(UNESP)BotucatuSao PauloBrazil Bauru School of Dentistry Department of SurgeryStomatologyPathology and RadiologyUniversity of Sao PauloBauruSao PauloBrazil

Mast cells are immune cells of the myeloid lineage that are found throughout the body,including the central nervous *** perform many functions associated with innate and specific immunity,angiogenesis,and vascular ***,they have been implicated in a series of pathologies(e.g.,hypersensitivity reactions,tumors,and inflammatory disorders).In this review,we propose that this cell could be a relevant therapeutic target in multiple sclerosis,which is a central nervous system degenerative *** support this proposition,we describe the general biological properties of mast cells,their contribution to innate and specific immunity,and the participation of mast cells in the various stages of multiple sclerosis and experimental autoimmune encephalomyelitis *** final part of this review is dedicated to an overview of the available mast cells immunomodulatory drugs and their activity on multiple sclerosis and experimental autoimmune encephalomyelitis,including our own experience related to the effect of ketotifen fumarate on experimental autoimmune encephalomyelitis evolution.

关键词： central nervous system degenerative disease experimental autoimmune encephalomyelitis immunity immunomodulatory drugs inflammatory disease ketotifen fumarate mast cells multiple sclerosis therapeutic target