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In vivo study of gold-nanoparticles using different extracts for kidney, liver function and photocatalytic application

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Chemical Reports 2019年第1期1卷 36-42页

作者： Muhammad Isa Khan Seemab Dildar Tahir Iqbal Muhammad Shakil Muhammad Bilal Tahir Muhammad Rafique Farooq Aziz sardar bibi Mohsin Ijaz Department of Physics Faculty of Science University of Gujrat Hafiz Hayat Campus Gujrat 50700 Pakistan Department of Physics The Islamia University of Bahawalpur Bahawalpur Pakistan Department of biotechnology Virtual University Pakistan University of the Punjab Physics Lahore Pakistan

We report novel gold nanoparticles by green method for different fruit extracts have gaining greater attention due to its versatile properties in different applications. In this article, GNPs synthesis is demonstrated successfully using fresh fruit extract of punica granatum and fragaria. The optical properties, morphology and elemental analysis of samples was done by using) different characterization techniques like SEM EDX and UV-Visible spectroscopy Biocompatibility of GNPs was determined by ALT, AST, ALP, Urea, Creatinine tests and also to investigate the effects of prepared GNPs on the kidney and liver functions. The GNPs prepared by fruit extract of punica granatum have more effects on the rabbits than GNPs prepared from fragaria but this effect normalizes after three days which shows its biocompatibility. To explore the photocatalytic activity of the GNPs the photocatalytic degradation of MB dye is also investigated. The results revealed that GNPs prepared through green synthesis route are found to be efficient enhancement in the degradation of MB dye in visible region due to large surface area. These particles were more active in catalytic reduction due to their high surface energy and in bio-medical applications as biocompatibility.

关键词： green method AuNPs biocompatibility photocatalytic activity

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Tobacco plant: A possible key to Ebola vaccine

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Journal of Coastal Life Medicine 2017年第5期5卷 206-211页

作者： Kulsoom Zahara Yamin bibi Maryam Ajmal Huma Mehreen Sadaf Fatima bibi Nadia sardar Sadaf Laraib Iqra Riaz Department of Botany PirMehr Ali Shah Arid Agriculture UniversityRawalpindiPakistan

In 2014, the World Health Organization was notified of an outbreak of a communicable disease characterized by fever, severe diarrhea, vomiting, and a high fatality rate in Guinea. Virologic investigation identified Zaire ebolavirus (EBOV) as the causative agent. Approximately 30 years after the first epidemic, there is no vaccine or therapeutic medication approved to counter the Ebola virus. In this review, it emphasized that plant based antibodies can be an effective cure to Ebola hemorrhagic fever. Genetically modified Nicotiana benthamiana is used to manufacture ZMapp drug by Kentucky BioProcessing. ZMapp three-antibody cocktail binds to the Ebola virus to deactivate it and provides simulated immune response against sugar-tagged proteins on the outside of the Ebola virus, which had verified efficacy against Ebola infection in nonhuman primates and also successfully treated two American medical workers infected with Ebola virus disease.

关键词： Zaire ebolavirus Nicotiana benthamiana ZMapp

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