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阴阳理论之前的“阴”和“阳”——以郭店简、清华简相关文献为例

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出土文献 2024年第2期 155-167,174页

作者：艾兰陈鹏宇(译) 达特茅斯学院故宫博物院器物部

学界一般认为,阴阳二元理论直到公元前3世纪才出现。郭店一号墓竹简和清华简的埋藏年代都在公元前300年左右,可以作为验证这一观点的理想材料。本文考察了这些文献中“阴”和“阳”的含义,认为这些例证或用本义,或直接表示自然形象,或... 详细信息

学界一般认为,阴阳二元理论直到公元前3世纪才出现。郭店一号墓竹简和清华简的埋藏年代都在公元前300年左右,可以作为验证这一观点的理想材料。本文考察了这些文献中“阴”和“阳”的含义,认为这些例证或用本义,或直接表示自然形象,或表示相关隐喻。由此证明,在公元前3世纪之前,“阴”和“阳”并不表示二元理论。本文还注意到,这些材料中,阴、阳对自然形象的隐喻决定了后世理论的发展轨迹,在这些隐喻的基础上互补的二元论体系得以形成。

关键词：阴阳气郭店楚简清华简

A chromosome-scale genome assembly of rauvolfia tetraphylla facilitates identification of the complete ajmaline biosynthetic pathway

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Plant Communications 2024年第4期5卷 129-132页

作者： Enzo Lezin Ines Carqueijeiro Clement Cuello Mickael Durand Hans JJansen Valentin Verges Caroline Birer Williams Audrey Oudin Thomas Duge de Bernonville Julien Petrignet Noemie Celton Benoit St-Pierre Nicolas Papon Chao Sun ron P.Dirks sarah Ellen O’Connor Michael Krogh Jensen Sebastien Besseau Vincent Courdavault Biomole´cules et Biotechnologies Vegetales EA2106Universite´de Tours37200 ToursFrance Future Genomics Technologies 2333 BE Leidenthe Netherlands Laboratoire Synthe se et Isolement de Molecules BioActives(SIMBA EA 7502)Universitede Tours37200 ToursFrance Laboratoire de Cytoge´netique Constitutionnelle CHRU de Tours-Hopital Bretonneau37044 ToursFrance University Angers University BrestIRFSFR ICAT49000 AngersFrance Institute of Medicinal Plant Development Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 2800China Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Novo Nordisk Foundation Center for Biosustainability Technical University of Denmark100193 Kgs LyngbyDenmark Present address:Limagrain Center de RechercheRoute d’EnnezatChappesFrance These authors contributed equally to this article

Dear Editor,rauvolfia tetraphylla(aka the Devil pepper)(Supplemental Figure 1)is a well-known medicinal plant that produces monoterpenoid indole alkaloids(MIAs).This MIA biosynthesis occurs in several organs,including leaves,stems,fruit,and roots,which accumulate the famous antiarrhythmic ajmaline(Kumar et al.2016a,2016b;Kumara et al.,2019).MIAs are natural products notably involved in plant adaptation to the environment and defense against *** mainly results from their high biological activities,which also explain their pharmacological properties.

关键词： properties. Figure roots

Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González ramos Luis Antonio González Gómez rubén Alberto Bayardo González sarah Monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent researcher Guadalajara 44340Mexico Department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGrOUND radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTr)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTr technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMArY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTr technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTr technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst Dental root end cyst Case report

Iron and Heart Failure: Current Concepts and Emerging Pharmacological Paradigms

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World Journal of Cardiovascular Diseases 2024年第4期14卷 195-216页

作者： Maria rosaria De Pascale Maria Beatrice rondinelli Flora Ascione Vincenzo Maffei Chiara Di Lorenzo sarah Scagliarini raffaella Faraonio Antonio Faiella Immunohematology and Transfusion Medicine Unit Cardarelli Hospital Naples Italy Immunohematology and Transfusion Medicine Unit San Camillo-Forlanini Hospital Rome Italy Health Management Office Cardarelli Hospital Naples Italy Anesthesiology Unit Cardarelli Hospital Naples Italy Department of Medical and Translational Sciences University of Naples Federico II Naples Italy Oncology Unit Cardarelli Hospital Naples Italy Department of Molecular Medicine and Medical Biotechnologies University of Naples Federico II Naples Italy

Background: Emerging evidence has recognized that anemia and iron deficiency are recurrent comorbidities in chronic heart failure (HF) and several trials have established that iron administration improves myocardial asset and clinical scenario in HF. Purpose: recent acquisitions suggest that iron deficiency represents a concrete bias in the pathogenetic mechanism of chronic HF, so we have investigated the putative role of the hepcidin/ferroportin axis in the cardiovascular setting to advocate novel pharmacological and clinical approaches. Methods: Here, after an excursus on iron metabolism, we first reviewed the ongoing studies on novel iron targeted compounds. Then, we summarize large clinical interventional studies conducted on patient suffering from iron deficiency and HF which have tested the effects of drugging iron regard QoL, hospitalizations and cardiovascular death. results: Novel compounds such as hepcidin agonist (PTG 300), synthetic human hepcidin (LJPC-401) and anti FPN (Vamifeport) are ongoing in iron overloaded patients, while the hepcidin blocker (PrS-080) is under investigation in anemic patients. Noteworthy, novel insights could arise from the results of a Phase IV interventional study regarding the modification of hepcidin pathway in a large cohort of HF patients (n = 1992) by sodium glucose cotransporter 2 inhibitors. To date, several studies highlight the beneficial effect of iron administration in cardiovascular setting and latest evidences consider hepcidin level as a novel biomarker of cardiac injury and atherosclerosis. Conclusions: We advocate that data from ongoing studies will suggest novel iron targeted therapies for diagnosis, prognosis and therapy transferable in selected heart failed patients.

关键词： Heart Failure Iron Anemia Iron Deficiency Hepcidin

Diagnostic and therapeutic challenges of myeloid sarcoma in the oral cavity

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World Journal of Clinical Cases 2024年第32期12卷 6526-6533页

作者： Melissa Martínez Nieto Luis Antonio González Gómez Juan Carlos Gómez Mireles sarah Monserrat LomelíMartínez Department of Integrated Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Department of Well-being and Sustainable Development Centro Universitario del NorteUniversidad de GuadalajaraColotlan 46200JaliscoMexico

Myeloid sarcoma(MS)is a rare neoplasm characterized by the proliferation of immature myeloid precursor cells outside the bone *** pathogenesis of MS is complex and not completely ***,it develops in any extramedullary site of the *** this editorial,we discuss the article published by Li et al,which presents a clinical case involving a 32-year-old man who exhibited gingival inflammation in the maxillary *** was initially diagnosed as periodontal ***,clinical evaluation revealed a firm,grayishwhite mass which underscored the need for comprehensive diagnostics to distinguish MS from other oral *** article emphasizes the different clinical presentations of similar case studies in the literature,and highlights the difficulty in diagnosing oral MS due to its rarity and variability in clinical *** treatment of MS depends on the clinical presentation,tumor location,and the patient's response to conventional *** various therapeutic options currently available are analyzed and *** intervention and multidisciplinary management are crucial for improving treatment *** awareness and education about the various clinical presentations of MS lead to earlier diagnosis and timely treatment,thereby enhancing patients'survival and quality of *** research is essential for optimizing therapeutic strategies and addressing the challenges presented by this rare neoplasm.

关键词： Myeloid sarcoma Acute myeloid leukemia Chloroma Granulocytic sarcoma Oropharyngeal neoplasms Gingiva

Thermo-Mechanical, Physico-Chemical, Morphological, and Fire Characteristics of Eco-Friendly Particleboard Manufactured with Phosphorylated Lignin Addition

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Journal of renewable Materials 2024年第7期12卷 1311-1341页

作者： Apri Heri Iswanto Harisyah Manurung Asma Sohail Lee Seng Hua Petar Antov Deded Sarip Nawawi sarah Latifah Dewi Shafa Kayla Sukma Surya Kusumah Muhammad Adly rahandi Lubis Linda MakovickáOsvaldová MohdHazwan Hussin rangabhashiyam Selvasembian Lum Wei Chen Puji rahmawati Nurcahyani Nam Hun Kim Widya Fatriasari Department of Forest Products Faculty of ForestryUniversitas Sumatera UtaraKampus USU Padang BulanMedanNorth Sumatra20155Indonesia Department of Chemistry Lahore College for Women UniversityLahore4444Pakistan Department of Wood Industry Faculty of Applied SciencesUniversiti Teknologi MARA(UiTM)Cawangan Pahang Kampus JengkaShah Alam26400Malaysia Faculty of Forest Industry University of ForestrySofia1797Bulgaria Department of Forest Product Faculty of Forestry and EnvironmentIPB UniversityBogor16680Indonesia research Center for Biomass and Bioproducts National Research and Innovation Agency(BRIN)Cibinong16911Indonesia Department of Forest Engineering Faculty of Security EngineeringUniversity of ZilinaZilina01001Slovakia Materials Technology research Group(MaTreC) School of Chemical SciencesUniversiti SainsMalaysiaMindenPenang11800Malaysia Department of Environmental Science and Engineering School of Engineering and SciencesSRM University-APAmaravatiAndhra Pradesh522240India Department of Bio and Natural resources Faculty of Bioengineering and TechnologyUniversitiMalaysia KelantanJeliKelantan17600Malaysia Department of Forest Biomaterials Engineering College of Forest and Environmental SciencesKangwon National UniversityChuncheon24341Republic of Korea

Lignin,lignosulfonate,and synthesized phosphorylated lignosulfonate were introduced as greenﬁllers in citric acid-sucrose adhesives for bonding particleboard fabricated from areca leaf sheath(ALS).The characteristics of particleboards were compared to that of ultralow emitting formaldehyde(ULEF-UF).Theﬁllers derived from Eucalyptus ***-lignin were added forﬂame retardancy enhancement.10%of each lignin and modiﬁed lig-nin was added into the ULEF-UF and citric acid-sucrose bonded *** applied to particle-boards included thermal characteristics,X-ray diffraction analysis(XrD),morphological properties,Fourier transform infrared spectroscopy(FTIr),as well as physical,mechanical,andﬁre resistance characteristics of the laboratory-fabricated *** and modiﬁed lignin resulted in improved thermal stability of the composites bonded with ULEF-UF while the improvement in the particleboard bonded with citric acid-sucrose was not signiﬁ*** introduction ofﬁller exerted a higher inﬂuence on the UF-bonded particleboards compared to composites fabricated with citric ***,the presence of lignin,lignosulfonate,and phosphorylated lignosulfonate enhanced the mechanical strength of the ULEF-bonded particleboards,although their dimensional stability has ***,the use of lignin and lignosulfonate enhanced theﬁre resis-tance of the particleboards produced with lower observed weight *** laboratory particleboards exhibited satisfactoryﬁre resistance,attaining a V-0 rating in according to the UL-94 standard.

关键词： Modiﬁed lignin eco-friendly particleboard ﬁre and thermal properties citric acid-sucrose ultralow-emitting urea-formaldehyde resin

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西藏非遗寻迹记

西藏旅游 2024年第4期 82-87页

作者： sarah一直在路上(文/图) 不详

古老的藏香,其香气弥漫天地之间,即便历经千百年的沧桑变迁,依然坚守着它最初的味道。而唐卡如同一部穿越千年的史诗,无须言语表达,它的色彩与画像会永远留在人们心中…西藏非物质遗产的迷人风貌,这些精心打造的藏香、藏面具以及精美的... 详细信息

古老的藏香,其香气弥漫天地之间,即便历经千百年的沧桑变迁,依然坚守着它最初的味道。而唐卡如同一部穿越千年的史诗,无须言语表达,它的色彩与画像会永远留在人们心中…西藏非物质遗产的迷人风貌,这些精心打造的藏香、藏面具以及精美的唐卡,似乎在向我们诉说着一个个关于岁月长河中的故事。在这悠远漫长的时光中,技艺和匠心仿佛星辰璀璨,照亮了这片古老的土地。

关键词：言语表达非物质遗产唐卡天地之间藏香沧桑变迁

Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

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Neural regeneration research 2024年第12期19卷 2773-2784页

作者： Hui Zhu James D.Guest sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo Joe E.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-Ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia Minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-Macao Institute of CNS regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training

Breast Cancer in a Supernumerary Breast at the Yaoundé Gynaeco-Obstetric and Paediatric Hospital: About a Case

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Advances in Breast Cancer research 2024年第3期13卷 43-48页

作者： Michel Auguste Mouelle sarah Gaëlle Adiang Esther Meka Isidore Tompeen Christelle Djapa Claude Hector Mbia Yann Eng Julius Sama Dohbit Zacharie Sando Oncology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon Faculty of Medicine and Biomedical Sciences of Yaound University of Yaound I Yaound Cameroon Obstetrics and Gynaecology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon radiology and Medical Imaging Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon Pathology Department of the Yaound Gynaeco-Obstetric and Paediatric Hospital Yaound Cameroon

Accessory or ectopic breast tissue is an anomaly in the development of the breast. It is a rare condition that occurs along the embryological mammary line. In less than 1% of all breast cancers, supernumerary breast cancer is reported, with the axillary location being the most common in 60% to 90% of cases. Cancerous degeneration of this supernumerary breast tissue can pose a dual diagnostic and therapeutic problem. We report the case of locally advanced adenocarcinoma in a right supernumerary breast. This is a 75-year-old, grand-multiparous, postmenopausal, and known hypertensive patient on treatment. Family history was remarkable for brain cancer in her sister and oesophageal cancer in her mother. She consulted for a mass in the right axillary cavity on supernumerary breast evolving for a year. Clinical examination revealed a large, fixed, budding and haemorrhagic-ulcerated mass of the right axilla, with long axis measuring about 15 cm. There was as wella supernumerary breast on the left, but without particularity. A soft tissue ultrasound showed a large hypoechoicmass in the right axillary region of 116 mm with areas of central necrobiosis. Morphologically, the breasts were normal. A breast MrI revealed a subcutaneous mass in the right axillary cavity with skin ulceration and satellite lymphadenopathy. The extension assessment revealed liver metastases, and a biopsy of the mass revealed a breast adenocarcinoma. The case was the subject of a multidisciplinary consultation meeting following which a wide excision of the mass was indicated. The histo-pathology analysis results of the surgical specimen were in favour of a triple negative papillary adenocarcinoma. After a post-operative multidisciplinary consultation meeting, adjuvant chemotherapy was indicated. The development of supernumerary breasts depends on hormones, just like normal breasts. Breast cancer in accessory breast tissue is quite rare with the incidence being 6%. The most common pathology is invasive

关键词： Adjuvant Chemotherapy Papillary Adenocarcinoma Surgery Supernumerary Breast Treatment of Supernumerary Breast Cancer