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Microbe/Bug-Busters Visit the Interactive House: An Itinerant Scenographic Device for Health education

Open Journal of Animal Sciences 2021年第2期11卷 333-353页

作者： Ana Márcia Suarez-Fontes Juliana Almeida-Silva sarah Cristina dos Santos Silva Letícia Sant’Anna de Souza Daniele Brum de Souza Conceição Suarez Fontes de Araújo Lima Marcos André Vannier-Santos Laboratório de Inovações em Terapia Ensino e Bioprodutos (LITEB) Instituto Oswaldo Cruz (IOC)—Funda&#231&#227o Oswaldo Cruz (Fiocruz) Rio de Janeiro Brazil

The term ecology is derived from οἶκος (Greek “house” or environment), but our habitations usually overlooked in ecology or environmental studies. The expression “at home” usually means safety and comfort, but at home we are under risk of innumerous parasitic/microbial infections and contaminations/ envenomation. During the COVID-19 pandemic we were forced to stay at home, but the virus and other pathogens were also home-delivered. Education for health is highly effective in health promotion, particularly in poor areas. Thus, prophylactic interventions approaching household environment are required. The present activity aims community empowerment and engagement in controlling parasitic diseases and other infections such as Chagas disease, leishmaniasis, malaria, arboviruses etc. Inspired on the use of a house maket by Dr. Virgínia Schall to demonstrate Aedes mosquitoes breeding sites. We also employ house makets displaying pathogen vectors breeding/hiding sites. Although some makets can be opened, revealing intradomiciliary milieu, we intended to offer the public a literally “insider” view of this largely overlooked scenery. The “Interactive House”, also known as “House with no viruses and other bugse="font-family:Verdana;">” is an educative, interactive, ludic device elaborated on an inflatable igloo, with furniture and utensils crafted using reused/recycled or low-cost materials. Live mosquito larvae were placed at peridomicile in water-accumulating plant pot saucer, leaves-clogged gutter, used tire, dog water bowl as well as within the domicile, in the shower dra

关键词： Science Communication Health education One Health environmental Health Parasitic Diseases

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儿童扩张型心肌病的发病率、病因及预后

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美国医学会杂志（中文版） 2007年第4期26卷 217-225页

作者： Jeffrey A. Towbin April M. Lowe Steven D. Colan Lynn A. Sleeper e. John Orav sarah Clunie Jane Messere Gerald F. Cox Paul R. Lurie Daphne Hsu Charles Canter James D. Wilkinson Steven e. Lipshultz 康俊萍（译）马长生（校） Texas Children＇s Hospital Baylor College of Medicine Houston New england Research Institutes Watertown Mass Children＇s Hospital Brigham and Women＇s Hospital Harvard Medical School Boston Mass Genzyrne Corp Cambridge Mass Albany Medical College Albany NY Columbia University New York NY Washington University School of Medicine Saint Louis Mo Department of Pediatrics University of Miami Miller School of Medicine Miami Fla 不详

背景：扩张型心肌病（dilated cardiomyopathy，DCM）是儿童心肌病最常见的类型，也是小儿心脏移植最常见的原因。但是，目前尚不清楚儿童DCM的流行病学特点和临床过程。目的：详细描述儿童DCM的发病率、病因、预后及相关危险因素。设... 详细信息

背景：扩张型心肌病（dilated cardiomyopathy，DCM）是儿童心肌病最常见的类型，也是小儿心脏移植最常见的原因。但是，目前尚不清楚儿童DCM的流行病学特点和临床过程。目的：详细描述儿童DCM的发病率、病因、预后及相关危险因素。设计及地点：本项以人群为基础的前瞻性纵向队列研究入选1996年1月至2003年2月在89个儿科心脏中心诊断为DCM的儿童以及1990年1月至1995年12月在北美大型三级治疗中心诊断的患儿。参试者：共入选1426例来自美国和加拿大的18岁以下DCM患儿。通过严格的超声心动图和／或病理学标准来诊断原发性DCM。因内分泌、免疫、药物中毒及其他原因患病者除外。主要观测指标：每年每10万儿童的发病率、死亡率和心脏移植率。结果：18岁以下儿童DCM每年的总发病率为0．57／10万，男孩的年发病率高于女孩（分别为0．66／10万和0．47／10万；P〈0．001），黑人的年发病率高于白人（分别为0．98／10万和0．46／10万；P〈0．001），婴儿（〈1岁）的年发病率高于儿童（分别为4．40／10万和0．34／10万；P〈0．001）。绝大部分属特发性，最常见的病因为心肌炎（46％）和神经肌肉性疾病（26％）。1年和5年死亡／移植率分别为31％和46％。死亡／移植的独立危险因素包括患儿诊断DCM时年龄较大、伴有充血性心力衰竭、左室收缩期Z评分较低以及DCM的病因（P均〈0．001）。结论：儿童DCM有其多样性。患儿预后主要取决于病因、年龄和心力衰竭状况。人种、性别和年龄对发病率有一定影响。大部分患儿无明确病因，限制了特异性治疗。

关键词：儿童扩张型心肌病总发病率病因预后充血性心力衰竭神经肌肉性疾病心脏移植流行病学特点

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*** measures of stigma stereotypes

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Annals of eye Science 2018年第1期 502-502页

作者： Corina Lacombe Karine elalouf Walter Wittich sarah Fraser Aaron Johnson Department of Psychology Concordia UniversityMontrealQCCanada School of Optometry Universitéde MontréalQCCanada CRIR/Centre de réadaptation MAB-Mackay du CIUSSS du Centre-Ouest-de-l’Île-de-Montréal MontréalQCCanada CRIR/Institut Nazareth et Louis-Braille du CISSS de la Montérégie-Centre MontréalQCCanada Interdisciplinary School of Health Sciences Ottawa UniversityONCanada

Background:The perceptions surrounding assistive technology have been shown to be increasingly stigmatizing in older adult *** stigmatization can lead individuals to the abandonment of the assistive *** now,the methods of identifying or predicting the stigma surrounding assistive technology has mostly been qualitative in *** we present a novel quantitate and qualitative research study that uses neuro-cognitive(psychophysics and eeG)and eye tracking technology,in addition to a new questionnaire to investigate the stigma associated with assistive ***,this approach plays a major role in understanding and predicting the neural and physiological correlates associated to ***:Thirty-four older adults(>50 years)took part in the *** determine the psychophysiological predictors of stigma surrounding assistive technologies,we monitored brain activity using eeG,heart rate and eye movements using an eye-tracker while participants viewed a series of images containing either an older or younger individual in different social scenarios(e.g.,talking to doctor,at coffee shop).In each scenario,the individual uses either no assistive device,a low stigmatizing device(e.g.,iPad),or a high stigmatizing device(e.g.,electronic magnifier).Results:Here we present preliminary analysis of the eye movement *** shows that in comparison to images that contained a low stigmatizing device,in images that contain high stigmatizing devices,the latency to fixate the device is shorter,first fixation duration is longer,and the total number of fixations on the device are *** environment that the devices is used in has no effect on eye movement ***:Although the sample size is small,and based on a healthy older-adult population,these initial observations would indicate that latency to fixate and first fixation duration are predictors of stigma associated with assistive *** research should expand this predi

关键词： Assistive technology stigma

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Antibacterial Activity of Silver Nanoparticles Using Salvia officinalis extract on Some Pathogenic Bacteria

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Journal of Pharmacy and Pharmacology 2019年第5期7卷 237-248页

作者： sarah Mohanad Yaseen Asmaa A.Hussein Ruqaya M.Al-ezzy Department of Molecular and Medical Biotechnology College of BiotechnologyAl-Nahrain UniversityBaghdadIraq

This study included evaluation for the effects of green synthetic nanoparticles of Salvia officinalis aqueous leaf extract loaded with silver nitrate on antibacterial activity. Green synthetic nanoparticles were synthesized by mixing the plant extract with different AgNO3 concentrations (1 mM, 1.5 mM, 1.75 mM, and 2 Mm) then they were detected by color changing and UV visible spectroscopy, which gave indication for the creation of silver nanoparticles. A characteristic and definite surface plasmon resonance (SPR) band for silver nanoparticles was obtained at around 433 nm. The SPR peak of silver nanoparticles extreme peak intensity was obtained at 1.75 mM of AgNO3. Atomic Force Microscopy analysis was used to characterize silver nanoparticles which declared that the shape of green synthetic nanoparticles had different average size depending on sliver concentrations. Since it was observed that the shape and size of green synthetic nanoparticles were concentrations dependent (89.69 nm, 80.94 nm, 76.98 nm and 60.28 nm) respectively for AgNO3 concentrations tested (1 mM, 1.5 mM, 1.75 mM and 2 mM). The antibacterial activity of green synthetic sliver nanoparticles was studied for all G+ve and G-ve selected isolates (Staphylococcus aureus, Staphylococcus heamolytics, Streptococcus pnemoniae, enterococcus faecalis) and others G-ve bacterial isolates (escherichi coli, Klebsiella pneumoniae, Proteus vulgaris, Pseudomonas aeruginosa) and the result showed that different green synthetic nanoparticles concentrations (1, 1.5, 1.75, 2 mM) have the ability to inhibit all bacterial isolates with varying zones of inhibition higher than the inhibition observed by ready to use sliver nanoparticles. Minimum inhibitory concentrations (MIC) of green synthetic nanoparticles were obtained in concentration of (31, 27, 23 and 16 μm/mL) for G+ve (S. auerus) and (187, 125, 125, 109 μm/mL) for G-ve (e. coli) at (1, 1.5, 1.75, 2 mM) respectively. The activity of green synthetic sliver nanopartic

关键词： Salvia officinalis sliver nitrate antibacterial minimum inhibitory concentrations biofilm

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Review of key telepsychiatry outcomes

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World Journal of Psychiatry 2016年第2期6卷 269-282页

作者： Sam Hubley sarah B Lynch Christopher Schneck Marshall Thomas Jay Shore Helen and Arthur e Johnson Depression Center Department of Family Medicine Department of Clinical Health Psychology University of Colorado Denver

AIM: To conduct a review of the telepsychiatry ***: We conducted a systematic search of the literature on telepsychiatry using the search terms, "telepsychiatry", "telemental health", "telecare", "telemedicine", "e-health", and "videoconferencing". To meet criteria for inclusion, studies had to:(1) be published in a peer-reviewed journal after the year 2000;(2) be written in english;(3) use videoconferencing technology for the provision of mental health assessment or treatment services; and(4) use an adequately-powered randomized controlled trial design in the case of treatment outcome studies. Out of 1976 studies identified by searches in Pub Med(Medline database), Ovid medline, Psych Info, embase, and eBSCO PSYCH, 452 met inclusion criteria. Studies that met all inclusion criteria were organized into one of six categories:(1) satisfaction;(2) reliability;(3) treatment outcomes;(4) implementation outcomes;(5) cost effectiveness; and(6) and legal issues. All disagreements were resolved by reassessing study characteristics and ***: Overall, patients and providers are generally satisfied with telepsychiatry services. Providers, however, tend to express more concerns about the potentially adverse of effects of telepsychiatry on therapeutic rapport. Patients are less likely to endorse such concerns about impaired rapport with their provider. Although few studies appropriately employ non-inferiority designs, the evidence taken together suggests that telepsychiatry is comparable to face-to-face services in terms of reliability of clinical assessments and treatment outcomes. When non-inferiority designs were appropriately used, telepsychiatry performed as well as, if not better than face-to-face delivery of mental health services. Studies using both rudimentary and more sophisticated methods for evaluating cost-effectiveness indicate that telepsychiatry is not more expensive than face-to-face delivery of mental health services and that telepsy

关键词： Telepsychiatry Telemental health Videoconferencing Treatment access Implementation

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多不饱和脂肪酸代谢，嘌呤代谢和肌苷作为主要的潜在的独立诊断生物标志物儿童和青少年的抑郁症

多不饱和脂肪酸代谢，嘌呤代谢和肌苷作为主要的潜在的独立诊断生...

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中国睡眠研究会第十一届全国学术年会

作者：周新雨刘兰香兰兴会 David Cohen 张玉清 Arun V Ravindran 袁帅郑鹏 David Coghill 杨力凝 sarah e Hetrick 蒋晓峰 Jean-Jacques Benoliel Andrea Cipriani 谢鹏重庆医科大学附属第一医院重庆医科大学神经科学研究所重庆医科大学附属儿童医院 H?pital Pitié–Salpétrière 重庆医科大学附属第二医院 University of Toronto 成都市精神病院 University of Melbourne University of Auckland Site Pitie′-Salpe?trie’re Universite′ Pierre et Marie Curie-Paris 6 University of Oxford Oxford Health NHS Foundation Trust

目的儿童青少年重度抑郁症（MDD）是一种在全球范围内以高复发率、高致残率为特点的疾病,但其病理机制尚未得到充分阐明并且有效治疗方式有限。方法利用超高效液相色谱-四极杆飞行时间质谱对血浆进行了代谢组学分析,以寻找儿童青少年抑...

目的儿童青少年重度抑郁症（MDD）是一种在全球范围内以高复发率、高致残率为特点的疾病,但其病理机制尚未得到充分阐明并且有效治疗方式有限。方法利用超高效液相色谱-四极杆飞行时间质谱对血浆进行了代谢组学分析,以寻找儿童青少年抑郁症的潜在生物标志物。我们共招募了134名儿童和青少年,包括52名首发DN-MDD患者（男性/女性:27/25）、32名DT-MDD患者（男性/女性:15/17）和50名HCs患者（男性/女性:27/23）,分别采集其血浆样本进行代谢谱和生物信息学分析。结果发现了几种紊乱的通路与儿童青少年抑郁症密切相关,包括脂肪酸代谢（尤其是多不饱和脂肪酸代谢）和嘌呤代谢,共鉴定出35种代谢物（DN-MDD vs. HCs）, 36种代谢物（DT-MDD vs. HCs）, 6种代谢物（DT-MDD ***-MDD）组间差异具有统计学意义。为进一步探索识别儿童和青少年MDD潜在生物诊断标志物的可能性,我们进行了二元逻辑回归分析,证明肌苷是潜在的MDD独立诊断生物标志物。通过ROC分析,在区分未用药的MDD患者和健康对照组,其ROC曲线下面积达到0.999,并且区分药物治疗后的MDD患者和健康对照组的曲线下面积为0.866。同时,我们还发现了儿童青少年MDD病理生理学与成人MDD不同,后者主要是与色氨酸代谢相关。结论通过代谢组学分析,发现代谢紊乱与儿童青少年MDD的病理机制和诊断生物标志物之间存在紧密联系。

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effect of ethnicity on weight loss among adolescents 1 year after bariatric surgery

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World Journal of Diabetes 2013年第5期4卷 202-209页

作者： sarah e Messiah Gabriela Lopez-Mitnik Deborah Winegar Bintu Sherif Kristopher L Arheart Kirk W Reichard Marc P Michalsky Steven e Lipshultz Tracie L Miller Alan S Livingstone Nestor de la Cruz-Muoz Division of Pediatric Clinical Research Department of PediatricsDepartment of Public Health SciencesUniversity of Miami Leonard M Miller School of MedicineMiami Division of Pediatric Clinical Research Department of PediatricsDepartment of Public Health SciencesDivision of BiostatisticsUniversity of Miami Leonard M Miller School of MedicineMiami Surgical Review Corporation Department of Surgery Nemours Alfred I.DuPont Hospital for Children Department of Pediatric Surgery Nationwide Children's Hospital The Ohio State University College of Medicine Department of Surgery University of Miami Leonard M Miller School of Medicine

AIM:To investigate whether or not bariatric surgeryweight outcomes vary by ethnicity in a large,nationally representative sample of ***:The Bariatric Outcomes Longitudinal Database was used for analysis and contains data on surgeries performed on adolescents from 2004 to 2010from 423 surgeons at 360 facilities across the United States Adolescents(n=827)between 11 and 19 years old who underwent either gastric bypass or adjustable gastric banding surgery were included in the *** measures included changes in anthropometric measurements[weight(kg)and body mass index]from baseline to 3(n=739),6(n=512),and 12(n=247)mo after ***:A year after patients underwent either gastric bypass(51%)or adjustable gastric banding(49%)surgery,mean estimated weight loss for all ethnic groups differed by a maximum of only 1.5 kg,being34.3 kg(95%CI:30.0-38.5 kg)for Hispanics,33.8 kg(95%CI:27.3-40.3 kg)for non-Hispanic blacks,and32.8 kg(95%CI:30.9-34.7 kg)for non-Hispanic *** overall pairwise group comparisons were significant,indicating that no ethnic group had better weight loss outcomes than did ***:Bariatric surgery substantially reduces the weight of severely obese adolescents at 1 year post-procedure with little variation by ethnicity and/or *** results suggest that bariatric surgery is a safe and reasonable treatment for all severely obese adolescents with the appropriate indications.

关键词： Bariatric surgery Gastric bypass surgery Adjustable gastric band surgery Adolescents Severe obesity ethnicity Weight loss

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美国、欧洲联盟和加拿大能否在放射性药物的临床首次应用规范方面达成共识?

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中华核医学与分子影像杂志 2021年第3期41卷 185-192页

作者：谢卿李慧刘特立翟士桢王风王丽杨建华(译) 朱华杨志(审校) 北京大学肿瘤医院暨北京市肿瘤防治研究所核医学科、恶性肿瘤发病机制及转化研究教育部重点实验室 100036

近年来,多种新型放射性示踪剂和放射性核素疗法被开发和应用。核医学和分子影像技术正在复兴,比如在显像和治疗神经内分泌肿瘤和前列腺癌方面。为实现新药从研究到临床的转化应用,在服务于患者的同时保证患者安全,必须相应地实施严格的... 详细信息

近年来,多种新型放射性示踪剂和放射性核素疗法被开发和应用。核医学和分子影像技术正在复兴,比如在显像和治疗神经内分泌肿瘤和前列腺癌方面。为实现新药从研究到临床的转化应用,在服务于患者的同时保证患者安全,必须相应地实施严格的监管要求。然而,各国相关政策法规间的差异可能会阻碍全球合作、增加费用并延缓研究进程。这种差异源自于司法政治的不同,而非不同的科学证据。为克服这种差异对医学发展带来的影响,核医学专业机构、监管部门和国际机构已开始寻找不同国家法规间的共性,以求协调。实际上,可以通过对临床前研究和生产标准提出统一要求,实现放射性药物跨司法辖区开发,这样可以使放射性药物的研发和推广更为高效。该文旨在概述欧洲和北美大陆在用于首次人体研究放射性药物研发方面的法律法规和相关要求。希望通过持续的合作,能够最终实现不同国家监管机制改革和相关法律法规和谐化,并为所有患者提供最新的、基于循证医学的有效诊疗。

关键词：神经内分泌肿瘤临床前研究放射性药物循证医学放射性示踪剂北美大陆前列腺癌核医学

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新研究确定了与肝病和脂肪代谢有关的肝细胞突变

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中西医结合肝病杂志 2021年第11期31卷 1011-1011页

作者： Stanley W. K. Ng Foad J. Rouhani Simon F. Brunner Natalia Brzozowska Federico Abascal Luiza Moore Lia Chappell Daniel Leongamornlert Aleksandra Ivovic Philip Robinson Timothy Butler Mathijs A. Sanders Nicholas Williams Tim H. H. Coorens Jon Teague Keiran Raine Adam P. Butler Yvette Hooks Beverley Wilson Natalie Birtchnell Michael R. Stratton Iñigo Martincorena Raheleh Rahbari Peter J. Campbell Foad J. Rouhani & Huw Naylor sarah J. Aitken & Matthew Hoare sarah J. Aitken & Susan e. Davies sarah J. Aitken Ming Yang efterpi Nikitopoulou Christian Frezza Matthew Hoare Cancer Genome Project Wellcome Sanger Institute Hinxton UK Department of Hematology Erasmus University Medical Center Rotterdam The Netherlands Stem Cell Institute University of Cambridge Cambridge UK Department of Surgery Addenbrooke’s Hospital Cambridge UK CRUK Cambridge Institute Cambridge UK Department of Pathology Addenbrooke’s Hospital Cambridge UK MRC Toxicology Unit University of Cambridge Cambridge UK MRC Cancer Unit University of Cambridge Cambridge UK Department of Medicine University of Cambridge Addenbrooke’s Hospital Cambridge UK

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NeAT1、FOXO1和GP... 详细信息

一项来自英国韦尔科姆基金会桑格研究所和剑桥大学等研究机构的研究人员的新研究分析了来自34例患者肝脏样本的1590个基因组,包括健康对照、酒精相关肝病和非酒精性脂肪肝疾病患者的肝脏样本,结果发现ACVR2A、TNRC6B、NeAT1、FOXO1和GPAM 五个基因在肝病患者的肝细胞中发生了突变,过程如图a所示。而其中的FOXO1、CIDeB、GPAM三个基因是对肝细胞如何代谢脂肪和对胰岛素作出反应有直接影响的基因。

关键词： FOXO1 肝病患者细胞突变肝细胞脂肪代谢胰岛素 GPA 剑桥大学

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理想受述者与读者修辞模式

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河北师范大学学报（哲学社会科学版） 2022年第6期45卷 1-15页

作者： [加拿大]莎拉·科普兰 [美国]詹姆斯·费伦刘巨文(译) 麦克尤恩大学英语系加拿大阿尔伯达省埃德蒙顿T5J5E8 俄亥俄州立大学英语系美国俄亥俄州哥伦布43210 广西师范大学文学院广西桂林541006

在把理想叙述读者的术语/概念替换为理想受述者的术语/概念的基础上,我们提议修改修辞性叙述理论的小说读者模型(真实的、作者的、叙述的、理想叙述的,和受述者),这里理想受述者被定义为叙述者希望他们正对之讲话的读者。这一修改提请... 详细信息

在把理想叙述读者的术语/概念替换为理想受述者的术语/概念的基础上,我们提议修改修辞性叙述理论的小说读者模型(真实的、作者的、叙述的、理想叙述的,和受述者),这里理想受述者被定义为叙述者希望他们正对之讲话的读者。这一修改提请关注作者处理真实受述者和理想受述者之间关系的各种方式(真实受述者可能与理想受述者一致,也可能不一致),这种多样性反过来又表明需要对作者使用受述者的情况进行更为通用的分类。该分类法依照真实和理想受述者之间各种一致程度确定了三个可辨识的不同系列:(1)明显一致,(2)不确定一致,(3)不一致。基于作者对一致程度的处理如何引导读者的关注点,该分类法还确定了每一类别中的两个主要变体:主要关于被叙,叙述行动,还是两者兼有?这一点通过广泛的案例分析可以得到阐释和证明。

关键词：修辞性叙述理论作者叙述者受述者理想受述者

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