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Assessing bioactivity of environmental water samples filtered using nanomembrane technology and mammalian cell lines

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eco-environment & Health 2024年第3期3卷 347-354页

作者： sarah e.Morgan Lisa A.DeLouise Department of environmental Medicine University of Rochester Medical CenterRochesterNY 14642USA Department of Biomedical engineering University of RochesterRochesterNY 14627USA Department of Dermatology University of Rochester Medical CenterRochesterNY 14642USA Lake Ontario Center for Microplastics and Human Health in a Changing environment University of Rochester Medical CenterRochesterNY 14642USA

This project reports on the use of a novel nanomembrane filtering technology to isolate and analyze the bioactivity of microplastic(MP)-containing debris from Lake Ontario water *** MPs are a complex mixture of polymers and sorbed chemicals that are persistent and can exhibit a wide range of toxic *** human exposure to MPs is unavoidable,it is necessary to characterize their bioactivity to assess potential health *** work seeks to quantify MP presence in the nearshore waters of Lake Ontario and begin to characterize the bioactivity of the filtrate containing *** utilized silicon nitride(SiN)nanomembrane technology to isolate debris sized between 8 and 20μm from lake water samples collected at various times and *** were identified with Nile red ***-based assays were conducted directly on the filtered debris to test for cell viability,aryl hydrocarbon receptor(AhR)activity,and interleukin 6(IL-6)levels as a measure of proinflammatory *** samples contained *** of the isolated debris impacted cell ***,AhR activity and IL-6 levels varied over ***,no associations were observed between the amount of plastic and *** differences in activity are likely due to variations in the physiochemical properties of debris between *** results highlight the need for increased sampling to fully characterize the bioactivity of MPs in human cells and to elucidate the role that sample physiochemical and spatiotemporal properties play in this activity.

关键词： Microplastics SiN nanomembranes Lake Ontario Aryl hydrocarbon receptor(AhR)activity IL-6 levels Bioactivity

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Steroidal scaffold decorations in Solanum alkaloid biosynthesis

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Molecular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucier Mohamed O.Kamileen Yoko Nakamura Sofiia Serediuk Ranjit Barbole Jens Wurlitzer Maritta Kunert sarah Heinicke sarah e.O'Connor Prashant D.Sonawane Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Research Group Biosynthesis and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Biochemical Sciences Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Steroidal glycoalkaloids(SGAs)are specialized metabolites produced by hundreds of Solanum species,including important vegetable crops such as tomato,potato,and *** it has been known that SGAs play important roles in defense in plants and“anti-nutritional"effects(e.g.,toxicity and bitterness)to humans,many of these molecules have documented anti-cancer,anti-microbial,antiinflammatory,anti-viral,and anti-pyretic *** these,α-solasonine andα-solamargine isolated from black nightshade(Solanum nigrum)are reported to have potent anti-tumor,anti-proliferative,and anti-inflammatory ***,α-solasonine andα-solamargine,along with the core steroidal aglycone solasodine,are the most widespread SGAs produced among the Solanum ***,it is still unknown how plants synthesize these bioactive steroidal *** comparative metabolomictranscriptome-guided approach,biosynthetic logic,combinatorial expression in Nicotiana benthamiana,and functional recombinant enzyme assays,here we report the discovery of 12 enzymes from *** that converts the starting cholesterol precursorto solasodine aglycone,and the downstreamα-solasonine,α-solamargine,and malonyl-solamargine SGA *** further identified six enzymes from cultivated eggplant that catalyze the production ofα-solasonine,α-solamargine,and malonyl-solamargine SGAs from solasodine aglycone via glycosylation and atypical malonylation *** work provides the gene tool box and platform for engineering the production of high-value,steroidal bioactive molecules inheterologoushosts usingsyntheticbiology.

关键词： steroidal glycoalkaloids Solanum biosynthetic pathway α-solamargine malonyl-solamargine specialized metabolites

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Linear endoscopic ultrasound:Current uses and future perspectives in mediastinal examination

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World Journal of Gastroenterology 2024年第33期30卷 3803-3809页

作者： eyad Gadour sarah Al Ghamdi Bogdan Miutescu Hossam e Shaaban Zeinab Hassan Aymen Almuhaidb Hussein H Okasha Department of Gastroenterology and Hepatology King Abdulaziz National Guard HospitalAhsa 36428Saudi Arabia Department of Internal Medicine Zamzam University CollegeSchool of MedicineKhartoum 11113Sudan Department of Medicine Division of GastroenterologyKing Abdulaziz UniversityJeddah 3646Saudi Arabia Department of Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Advanced Regional Research Center in Gastroenterology and Hepatology Victor Babes University of Medicine and PharmacyTimisoara 300041Romania Department of Internal Medicine and Gastroenterology NhtmriCairo 11796Egypt Department of Internal Medicine Stockport Hospitals NHS Foundation TrustManchester SK27JEUnited Kingdom Department of Gastroenterology King Faisal Specialist Hospital and Research CenterRiyadh 11211Saudi Arabia Department of Internal Medicine Division of Gastroenterology and HepatologyKasr Al-Aini School of MedicineCairo UniversityCairo 11562Egypt

This editorial elaborates on the current and future applications of linear endoscopic ultrasound(eUS),a substantial diagnostic and therapeutic modality for various anatomical *** scope of endosonographic assessment is broad and,among other factors,allows for the evaluation of the mediastinal anatomy and related pathologies,such as mediastinal lymphadenopathy and the staging of central malignant lung ***,eUS assessment has proven more accurate in detecting small lesions missed by standard imaging examinations,such as computed tomography or magnetic resonance *** focus on its current uses in the mediastinum,including lung and esophageal cancer staging,as well as evaluating mediastinal lymphadenopathy and submucosal *** editorial also explores future perspectives of eUS in mediastinal examination,including ultrasound-guided therapies,artificial intelligence integration,advancements in mediastinal modalities,and improved diagnostic approaches for various mediastinal lesions.

关键词： Linear endoscopic ultrasound Mediastinal examination Lung cancer Computed tomography Magnetic resonance imaging

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Implementation and evaluation of exercise is Medicine in primary care clinics within a large academic health system

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Family Medicine and Community Health 2024年第1期12卷 16-27页

作者： John Kevin Ong Dayao Caroline e L Duffy Amalia M Cristiano Gene'Rusty'Kallenberg sarah e Linke University of California San Diego School of Medicine La JollaCaliforniaUSA Milken Institute of Public Health The George Washington UniversityWashingtonDistrict of ColumbiaUSA The University of Texas Medical Branch at Galveston School of Medicine GalvestonTexasUSA Scripps Family Medicine Residency Scripps Mercy Hospital Chula VistaChula VistaCaliforniaUSA Herbert Wertheim School of Public Health&Human Longevity Science University of California San DiegoLa JollaCaliforniaUSA Department of Family Medicine University of California San DiegoLa JollaCaliforniaUSA Omada Health San FranciscoCaliforniaUSA

Objective exercise is Medicine(eIM)is a global initiative encouraging healthcare providers to routinely assess and promote physical activity(PA)among *** objective of this study was to evaluate the feasibility,adoption,implementation and effectiveness of eIM from patient,clinician and healthcare staff perspectives using a combination of electronic health record(eHR),survey and interview *** This study used a combination of the Practical Robust Implementation and Sustainability Model(PRISM)and the Learning evaluation model to implement *** captured from the eHR,including Physical Activity Vital Sign(PAVS)scores,and data collected from qualitative surveys and interviews were used to evaluate the programme’s Reach,effectiveness,Adoption,Implementation,Maintenance(Re-AIM,which is embedded within PRISM)from provider,staff and patient *** Five primary care clinics within a large academic health *** A total of 24443 patients from all participating clinics had at least one PAVS score during the study period.A total of 17 clinicians completed surveys,and 4 clinicians,8 medical assistants and 9 patients completed *** Implementation fidelity metrics varied widely between components and across clinics but were generally consistent over time,indicating a high degree of programme *** was highest during the first 6 months of the COVID-19 pandemic when most visits were *** PAVS scores increased from 57.7(95%CI:56 to 59.4)to 95.2(95%CI:91.6 to 98.8)min per week at 6 months for patients not meeting PA guidelines at baseline and decreased from 253.84(95%CI:252 to 255.7)to 208.3(95%CI:204.2 to 212.4)min per week at 6 months for patients meeting PA guidelines at *** eIM implementation,clinician-estimated time spent discussing PA with patients increased for 35%of providers and stayed the same for 53%.Conclusion Overall,this study established eIM’s feasibility,adoption,implementation

关键词： routine qualitative completed

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心理疗法治疗儿童青少年焦虑障碍的网络meta分析

心理疗法治疗儿童青少年焦虑障碍的网络meta分析

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中国睡眠研究会第十一届全国学术年会

作者：周新雨张玉清 Toshiaki A.Furukawa Pim Cuijpers 蒲俊材 John R.Weisz 杨力凝 sarah e.hetrick Cinzia Del Giovane David Cohen Anthony C.James 袁帅 Craig Whittington 蒋晓峰滕腾 Andrea Cipriani 谢鹏重庆医科大学附属第一医院重庆医科大学附属第二医院 Kyoto University Graduate School of Medicine/School of Public Health Amsterdam Public Health Research Institute Harvard University University of Auckland University of Melbourne Centre of Youth Mental Health University of Melbourne Institute of Primary Health Care University of Bern H?pital Pitié–Salpétrière Institut des Systèmes Intelligents et RobotiquesUniversité Pierre et Marie Curie Warneford Hospital University of Oxford Oxford Health NHS Foundation Trust Warneford Hospital 成都市精神病院 Doctor evidence Santa Monica

目的通过网络meta分析比较不同类型和方式的心理治疗在青少年焦虑障碍患者中的效果。方法检索PubMed, Cochrane CeNTRAL, embase, PsycINFO, Web of Science,CINAHL, ProQuest Dissertations, LILACS, international trial registers以及FDA报道的从建库至2016年6月31日的文献。筛选出比较两种结构化心理治疗或结构化心理治疗与对照组在儿童青少年焦虑障碍患者中效果的随机对照试验。4位研究者分为两组独立地进行数据提取与质量评价。使用随机效应模型的成组meta分析和贝叶斯网络meta分析来整合数据。评价治疗结束和随访结束时的疗效（焦虑症状的改变）,耐受性（治疗结束时的失访）,以及生活质量和功能改善。短程和长程的随访的疗效同样也被测量。通过GRADe框架评估证据质量对每个网络的贡献。评价治疗结束和随访结束时的疗效（焦虑症状的改变）,耐受性（治疗结束时的失访）,以及生活质量和功能改善,同时评价短程和长程的随访的疗效。通过GRADe框架评估证据质量对每个网络的贡献。结果共纳入96个临床试验包括6256名参与者,比较了11种心理治疗与4种不同的对照措施。基于GRADe框架,大多数证据被评为低风险或极低风险。疗效结果显示,大多数心理治疗在治疗结束时（SMDs:-1.44到-0.65）和最长随访时（SMDs:-1.84到-1.64）显著优于等待治疗组。然而,只有团体CBT治疗比某些心理治疗和所有对照措施在治疗结束时和短期随访时有显著疗效。耐受性结果显示,阅读疗法比大多数心理疗法和对照措施具有更多的全因失访（ORs:0.06到0.37）。生活质量和功能改善结果显示,只有不同方式的CBT治疗比心理安慰剂治疗和等待治疗组显着有益（SMDs:0.65到2.01）。结论团体CBT是儿童青少年焦虑障碍患者的首选心理治疗。其他类型和方式的心理治疗可作为替代治疗选择。需进一步研究特定的焦虑障碍,特定障碍的心理治疗方法,以及影响疗效的因素。

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In situ apatite and carbonate Lu-Hf and molybdenite Re-Os geochronology for ore deposit research:Method validation and example application to Cu-Au mineralisation

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Geoscience Frontiers 2024年第5期15卷 339-354页

作者： Alexander Simpson Stijn Glorie Martin Hand sarah e.Gilbert Carl Spandler Marija Dmitrijeva Greg Swain Angus Nixon Jacob Mulder Carsten Münker Department of earth Sciences University of AdelaideSA 5005Australia Mineral exploration Cooperative Research Centre University of AdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia Fortescue Level 287Adelaide TerraceEast PerthWA 6005Australia Institute of Geology und Mineralogy University of Köln50674 KölnGermany British Geological Survey NottinghamUK

The development of laser ablation inductively coupled plasma quadrupole tandem mass spectrometry(LA-ICP-Q-MS/MS)opens new opportunities to rapidly date a variety of hydrothermal *** we present in situ Lu-Hf and Re-Os dates for hydrothermal apatite and molybdenite,*** further report the first in situ Lu-Hf dates for bastnäsite,dolomite,and siderite,and assess their potential for constraining ore deposit *** method validation,we report isotope-dilution Lu-Hf dates for apatite reference material Bamble-1(1102±5 Ma)and calcite reference material Me-1(1531±7 Ma),enabling improved accuracy on matrix-matched calibration for LA-ICP-MS/MS Lu-Hf *** new methods are applied to the Vulcan Iron-Oxide Copper-Gold(IOCG)prospect in the Olympic Cu-Au Province of South *** deposits have been difficult to accurately date,given the general lack of reliable mineral geochronometers that are cogenetic with IOCG *** apatite Lu-Hf dates and molybdenite Re-Os dates demonstrate that mineralisation at Vulcan largely occurred at ca.1.6 Ga,contemporaneous with the world class Olympic Dam *** data also indicates that the Lu-Hf system in apatite is more robust than the U-Pb system for determining the timing of primary apatite formation in an IOCG *** further demonstrate that dolomite can retain Lu-Hf growth ages over an extended time period(>1.5 billion years),providing constraints on the timing of primary ore mineral crystallisation during brecciation and IOCG ***,late Neoproterozoic(ca.589–544 Ma)and Carboniferous(ca.334±7 Ma)Lu-Hf dates were obtained for texturally late Cubearing carbonate veins,illustrating that the carbonate Lu-Hf method allows direct dating of Cu remobilisation *** has important implications for mineral exploration as the remobilised Cu may have been transferred to younger deposits hosted in Neoproterozoic sedimentary basins overlaying the Olympic IOCG provi

关键词： Reaction-cell ICP-MS In-situ geochronology Lu-Hf Re-Os Iron Oxide Copper Gold Metal fluids

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Oryza CLIMtools:A genome–environment association resource reveals adaptive roles for heterotrimeric G proteins in the regulation of rice agronomic traits

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Plant Communications 2024年第4期5卷 145-165页

作者： Angel Ferrero-Serrano David Chakravorty Kobie J.Kirven sarah M.Assmann Biology Department Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA Intercollege Graduate Degree Program in Bioinformatics and Genomics Pennsylvania State University208 Mueller LaboratoryUniversity ParkPA 16802USA

Modern crop varieties display a degree of mismatch between their current distributions and the suitability of the local climate for their *** address this issue,we present Oryza CLIMtools(https://***/CLIMtools/oryza_v1.0/),thefirst resource for pan-genome prediction of climate-associated genetic variants in a crop *** CLIMtools consists of interactive web-based databases that enable the user to(1)explore the local environments of traditional rice varieties(landraces)in South-east Asia and(2)investigate the environment by genome associations for 658 Indica and 283 Japonica rice landrace accessions collected from georeferenced local environments and included in the 3K Rice Ge-nomes *** demonstrate the value of these resources by identifying an interplay betweenflowering time and temperature in the local environment that is facilitated by adaptive natural variation in OsHD2 and disrupted by a natural variant in *** quantitative trait locus analysis has suggested the impor-tance of heterotrimeric G proteins in the control of agronomic ***,we analyzed the climate associations of natural variants in the different heterotrimeric G protein *** identified a coordi-nated role of G proteins in adaptation to the prevailing potential evapotranspiration gradient and revealed their regulation of key agronomic traits,including plant height and seed and panicle *** conclude by highlighting the prospect of targeting heterotrimeric G proteins to produce climate-resilient crops.

关键词： Oryza sativa rice G by e adaptation flowering time GWAS OsHD2 OsSOC1 heterotrimeric G pro-tein OsRGA1 d1 OsGS3 OsDeP1 OsGGC2

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Comparison of fungal vs bacterial infections in the medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar T Sims Christine e Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** To investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,Pe majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pe to acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for end-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).There was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

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Design and synthesis of synthetic promoters for consistency of gene expression across growth phases and scale in ***

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Synthetic and Systems Biotechnology 2024年第2期9卷 330-339页

作者： Kristin V.Presnell Omar Melhem sarah M.Coleman Nicholas J.Morse Hal S.Alper McKetta Department of Chemical engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute for Cellular and Molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

Metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently(or robustly)with respect to cellular growth phase(exponential and stationary)and fermentation scale(microtiter plates,tubes,flasks,and bioreactors).However,nearly all endogenous promoters(especially in Saccharomyces cerevisiae)do not perform in this *** this work,a hybrid promoter engineering strategy is leveraged to create novel synthetic promoters with robustness across these *** a multi-dimensional RNA-seq dataset,promoters with specific phase dependencies were *** enriched with functional transcription factors were identified using MeMe *** motif-containing fragments could impart activity dependence in the opposing ***,we obtain two new promoters with high and consistent expression across both phases by increasing the exponential phase activity of the starting stationary-phase scaffold by 38 and 23-fold ***,we show that these promoters function consistently across various laboratory growth scales over time in a microtiter plate and in ***,this work presents and validates a new strategy for engineering promoters in *** with high levels of expression that are robust to cellular growth phase and the scale of the culture.

关键词： endogenous synthetic stationary

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Surgical intervention combined with weight-bearing walking training promotes recovery in patients with chronic spinal cord injury:a randomized controlled study

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Neural Regeneration Research 2024年第12期19卷 2773-2784页

作者： Hui Zhu James D.Guest sarah Dunlop Jia-Xin Xie Sujuan Gao Zhuojing Luo Joe e.Springer Wutian Wu Wise Young Wai Sang Poon Song Liu Hongkun Gao Tao Yu Dianchun Wang Libing Zhou Shengping Wu Lei Zhong Fang Niu Xiaomei Wang Yansheng Liu Kwok-Fai So Xiao-Ming Xu Kunming Tongren Hospital KunmingYunnan ProvinceChina Neurological Surgery and the Miami Project to Cure ParalysisMiller School of MedicineUniversity of MiamiMiamiFLUSA School of Biological Sciences The University of Western AustraliaPerthWAAustralia Minderoo Foundation PerthWAAustralia Clinical Center for Spinal Cord Injury Kunming General Hospital of Chengdu Military CommandKunmingYunnan ProvinceChina Department of Biostatistics and Health Data Science Indiana University School of MedicineIndianapolisINUSA Department of Orthopedic Spinal Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Spinal Cord and Brain Injury Research Center Department of Physical Medicine and RehabilitationUniversity of Kentucky College of MedicineLexingtonKYUSA Guangdong-HongKong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouGuangdong ProvinceChina W.M.Keck Center for Collaborative Neuroscience Rutgers UniversityPiscatawayNJUSA Neurosurgery Department Chinese University of Hong KongPrince of Wales HospitalHong Kong Special Administration RegionChina Spinal Cord and Brain Injury Research Group Stark Neurosciences Research InstituteDepartment of Neurological SurgeryIndiana University School of MedicineIndianapolisINUSA

For patients with chronic spinal cord injury,the co nventional treatment is rehabilitation and treatment of spinal cord injury complications such as urinary tract infection,pressure sores,osteoporosis,and deep vein *** is rarely perfo rmed on spinal co rd injury in the chronic phase,and few treatments have been proven effective in chronic spinal cord injury *** of effective therapies fo r chronic spinal co rd injury patients is *** conducted a randomized controlled clinical trial in patients with chronic complete thoracic spinal co rd injury to compare intensive rehabilitation(weight-bearing walking training)alone with surgical intervention plus intensive *** clinical trial was registered at ***(NCT02663310).The goal of surgical intervention was spinal cord detethering,restoration of cerebrospinal fluid flow,and elimination of residual spinal cord *** found that surgical intervention plus weight-bearing walking training was associated with a higher incidence of American Spinal Injury Association Impairment Scale improvement,reduced spasticity,and more rapid bowel and bladder functional recovery than weight-bearing walking training ***,the surgical procedures and intensive rehabilitation were *** Spinal Injury Association Impairment Scale improvement was more common in T7-T11 injuries than in T2-T6 *** combined with rehabilitation appears to have a role in treatment of chronic spinal cord injury patients.

关键词： chronic spinal cord injury intensive rehabilitation locomotor training neurological recovery surgical intervention weightbearing walking training

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