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Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

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Bioactive Materials 2021年第5期6卷 1479-1490页

作者： Laura Ramos Rivera Andrea Cochis sarah biser Elena Canciani Sara Ferraris Lia Rimondini Aldo R.Boccaccini Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergErlangenGermany Department of Health Sciences Universita del Piemonte UPONovaraItaly Center for Translational Research on Autoimmune and Allergic Diseases-CAAD NovaraItaly Department of Department of Biomedical Surgical and Dental SciencesThin Section LabUniversity of MilanMilanItaly Department of Applied Science and Technology Politecnico di TorinoTurinItaly

Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial ***,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic *** images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the *** coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the *** also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct *** conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture ***,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of *** biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed.

关键词： Zein Bioactive glass Copper Bone Antibacterial

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Reliability of Baseload Electricity Generation from Fossil and Renewable Energy Sources

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Energy and Power Engineering 2021年第5期13卷 190-206页

作者： Aleksa Z. biserčić Uglješa S. Bugarić Mechanical Engineering Faculty University of Belgrade Belgrade Serbia

With expanding environmental and climate change regulatory frameworks, the fossil-based baseload generation is forced to decline, thus making room for more and more generation based on renewable and other carbon-free energy sources. This paper deals with a number of controversial issues and open questions concerning the growing penetration of renewable energy sources into power generation systems, often without due care of the impacts of variable as compared to conventional generation on the reliability of electricity supply. Particular attention is paid to baseload generation, power market design, system operation under extreme weather conditions, energy storage, back-up, and reserve power, as well as to the role of mechanical inertia and reliability of on-site fuel supply, demonstrated on an example of coal excavation and delivery to a power plant.

关键词： Power System Baseload RES Emergencies Storage Reliability On-Site Coal Supply

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