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Comparing the demographic data and outcomes of septic shock patients presenting to teaching or non-teaching metropolitan hospitals in the United States

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World Journal of Emergency Medicine 2022年第6期13卷 433-440页

作者： Ralph Bou Chebl Nadim Kattouf Mohamad Assaf Saadeddine Haidar Gilbert Abou Dagher sarah abdul nabi Rana Bachir Mazen El Sayed Department of Emergency Medicine American University of BeirutBeirut 11072020Lebanon

BACKGROUND:Studies looking at the effect of hospital teaching status on septic shock related in-hospital mortality are *** aim of this study was to examine the effect of hospital teaching status on mortality in septic shock patients in the United ***:This was a retrospective observational study,using the Nationwide Emergency Department Sample Database(released in 2018).All patients with septic shock were *** sample logistic regression was performed to assess the impact of hospital teaching status on patient ***:A total of 388,552 septic shock patients were included in the *** average age was 66.93 years and 51.7%were *** of the patients presented to metropolitan teaching hospitals(68.2%)and 31.8%presented to metropolitan non-teaching *** shock patients presenting to teaching hospitals were found to have a higher percentage of medical comorbidities,were more likely to be intubated and placed on mechanical ventilation(50.5%vs.46.9%)and had a longer average length of hospital stay(12.47 d vs.10.20 d).Septic shock patients presenting to teaching hospitals had greater odds of in-hospital mortality compared to those presenting to metropolitan non-teaching hospitals(adjusted odd ratio[OR]=1.295,95%confidence interval[CI]:1.256-1.335).CONCLUSION:Septic shock patients presenting to metropolitan teaching hospitals had significantly higher risks of mortality than those presenting to metropolitan non-teaching *** also had higher rates of intubation and mechanical ventilation as well as longer lengths of hospital stay than those in non-teaching hospitals.

关键词： Sepsis Septic shock In-hospital mortality Hospital teaching status United States Epidemiology Outcome

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Re-analysis of temperature dependent neutron capture rates and stellarβ-decay rates of^(95-98)Mo

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Chinese Physics C 2024年第9期48卷 142-149页

作者： abdul Kabir Jameel-Un nabi Muhammad Tahir abdul Muneem Zain Ul Abideen Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan Faculty of Engineering Sciences GIK Institute of Engineering Sciences and TechnologyTopi 23640Khyber PakhtunkhwaPakistan

The neutron capture rates and temperature dependent stellar beta decay rates of Mo isotopes are investigated within the framework of the statistical code TALYS v1.96 and the proton neutron quasi particle random phase approximation(pn-QRPA)*** Maxwellian average cross-section(MACS)and neutron capture rates for the^(95-98)Mo(n,γ)^(96-99)Mo radiative capture process are analyzed within the framework of the statistical code TALYS v1.96 based on the phenomenological nuclear level density model and gamma strength *** present model-based computations for the MACS are comparable to the existing measured *** sensitivity of stellar weak interaction rates to various densities and temperatures is investigated within the framework of the pn-QRPA *** attention is paid to the impact of thermally filled excited states in the decaying nuclei(^(95-98)Mo)on electron emission and positron capture ***,we compare the neutron capture rates and stellar beta decay *** is found that neutron capture rates are higher than stellar beta decay rates at both lower and higher temperatures.

关键词： cross-section TALYS nuclear level density decay rates capture rates

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Radiative capture of proton through the ^(14)N(p,γ)^(15)O reaction at low energy

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Chinese Physics C 2024年第4期48卷 183-192页

作者： B.F.Irgaziev abdul Kabir Jameel-Un nabi National University of Uzbekistan Tashkent 100174Uzbekistan Space and Astrophysics Research lab National Centre of GIS and Space ApplicationsDepartment of Space ScienceInstitute of Space TechnologyIslamabad 44000Pakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan

The CNO cycle is the main source of energy in stars more massive than our *** process defines the energy production,the duration of which can be used to determine the lifetime of massive *** cycle is an important tool for determining the age of globular *** proton capture via p+^(14)N→^(15)O+γ,at energies of astrophysical interest,is an important process in the CNO *** this project,we apply a potential model to describe both non-resonant and resonant reactions in the channels where radiative capture occurs through electric E1 *** employed the R-matrix method to describe the ongoing reactions via M1 resonant transitions,when it was not possible to correctly reproduce the experimental data using the potential *** partial components of the astrophysical S-factor are calculated for all possible electric and magnetic dipole transitions in ^(15)*** linear extrapolated S-factor at zero energy(S(0))agrees well with earlier reported values for all transition types considered in this *** on the value of the total astrophysical S-factor,depending on the collision energy,we calculate the nuclear reaction rates for p+^(14)N→^(15)O+γ.The computed rates agree well with the results reported in the NACRE II Collaboration and most recent existing measurements.

关键词： CNO cycle potential model R-matrix method cross-section astrophysical S-factor nuclear rates.

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba Aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider Syed Mujahid Hassan Adnan abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih abdullah Saeed Amjad Salamat Ghias-un-nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Incidence and predictors of hypocalcemia in end-stage renal disease patients on denosumab therapy: A systematic review and metaanalysis

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World Journal of Meta-Analysis 2024年第3期12卷 68-78页

作者： abdul Hannan Siddiqui Misbah Shaikh Afia Salman Muhammad Ahmed Ali Fahim Fizzah Batool Tahreem Mari sarah Musani Muneeb Fareed Rooma Rehan Amna Hassni Urooj Nizami Ayesha Amir abdul Moeed Salim R Surani Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Medicine&Pharmacology Texas A&M UniversityCollege StationTX 77843United States

BACKGROUND Denosumab inhibits the receptor activator of nuclear factor *** markedly increases bone mineral density and has been proven to reduce the risk of ***,numerous adverse effects,notably hypocalcemia,are prevalent in patients with end-stage renal disease(ESRD).AIM To analyze the incidence and predictors of hypocalcemia caused by denosumab compared to control in patients with *** We conducted this study in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses ***,Scopus,Cochrane Central,and EMBASE were systematically searched from inception through March *** original studies investigating the effects of denosumab on patients with ESRD compared to control were *** primary outcomes of our study were the incidence of mild,severe,and very severe *** outcomes included serum levels of intact parathyroid hormone,calcium,and *** results were pooled and analyzed using a random-effects *** Seven articles comprising 3240 patients were included in our *** treated with denosumab had a significantly increased incidence of mild hypocalcemia[risk ratio(RR):2.79;95%confidence interval(CI):0.99-7.91;P=0.05;I^(2)=37%]and of very severe hypocalcemia(RR:9.58;95%CI:1.58-57.98;P=0.01;I^(2)=49%).However,an increase in the occurrence of severe hypocalcemia was non-significant(RR:4.23;95%CI:0.47-38.34;P=0.20;I^(2)=96%).Alternatively,denosumab showed a significant decrease in serum intact parathyroid hormone[mean difference(MD):-433.20,95%CI:-775.12 to-91.28,I2=98%,P=0.01],while there was a non-significant decrease in phosphate(MD:-0.47,95%CI:-1.35 to 0.41,I^(2)=88%,P=0.30)and calcium levels(MD:-0.33,95%CI:-0.95 to 0.29,I^(2)=94%,P=0.29).CONCLUSION Our study demonstrated that denosumab is significantly associated with mild and very severe hypocalcemia in patients with ESRD making it necessary to detect and prevent this side effect of treatmen

关键词： Denosumab End-stage renal disease Hypocalcemia Parathyroid hormone Dialysis

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Long-term outcomes of titanium-nitride-oxide coated stents and drug-eluting stents in acute coronary syndrome:A systematic review and meta-analysis

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World Journal of Cardiology 2024年第5期16卷 293-305页

作者： Muhammad Ahmed Ali Fahim Afia Salman Hira Anas Khan Syed Muhammad Hasan Muskan FatimaBhojani sarah Aslam Amna Zia Ul Haq Vishal Reddy Bejugam Beena Muntaha Nasir Wajiha Gul abdul Moeed Abdelrahman S Abdalla Muhammad Majid Muhammad Sohaib Asghar Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200Pakistan Department of Internal Medicine North Central Bronx HospitalBronxNY 10467United States Department of Urology Center for Academic MedicineStanford University School of MedicinePalo AltoCA 33872United States Department of Cardiovascular Imaging Cleveland ClinicClevelandOH 44195United States Division of Nephrology and Hypertension Mayo Clinic RochesterRochesterMN 55905United States Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh

BACKGROUND In severe cases of coronary artery disease,percutaneous coronary intervention provide promising *** stent used could be a drug-eluting stent(DES)or a titanium-nitride-oxide coated stent(TiNOS).AIM To compare the 5-year effectiveness and safety of the two stent *** The following systematic review and meta-analysis was conducted in accordance with the preferred reporting items for systematic reviews and meta-analysis guidelines,and PubMed/MEDLINE,Scopus,and Cochrane Central were searched from inception till August *** outcomes were major adverse cardiac events(MACE),cardiac death,myocardial infarction(MI),cardiac death or MI,and ischemia-driven total lesion revascularization(ID-TLR).RESULTS Four randomized controlled trials(RCT),which analyzed a sum total of 3045 patients with acute coronary syndrome(ACS)after a median follow-up time of 5 years were *** statistically insignificant,an increase in the ID-TLR was observed in patients receiving TiNOSs vs *** addition,MI,cardiac death and MI,and definite stent thrombosis(DST)were significantly decreased in the TiNOS *** analysis revealed no significant results with meta-regression presenting non-ST elevated MI(NSTEMI)as a statistically significant covariate in the outcome of *** TiNOS was found to be superior to DES in terms of MI,cardiac death or MI,and DST outcomes,however,the effect of the two stent types on ID-TLR and MACE was not significant.A greater number of studies are required to establish an accurate comparison of patient outcomes in TiNOS and DES.

关键词： Stents Drug-eluting Major adverse cardiac events All-cause death Meta-analysis

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Chemiluminescent Determination of Cyromazine in Milk Samples Using Copper（III） Chelate-Triton X-100 by Flow Injection Analysis

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Chemical Research in Chinese Universities 2017年第3期33卷 354-359页

作者： Muhammad ASGHAR Mohammad YAQOOB abdul nabi Department of Chemistry University of Baloehistan Quetta 87300 Pakistan

Cyromazine（CYR） was determined in milk samples using copper（HI） chelate-Triton X-100 chemiluminescence（CL） system associated with flow-injection（FI） in KOH medium. The relative CL intensity for CYR concentration was linear over the range of 5×10^-4-10μg/mL（R2=0.9990, n=11） with injection rate of 160 h-1 and the relative standard deviation（RSD, n=4） of 1.2%-2.6%. The limit of detection（LOD） for signal-to-noise ratio of 3 was 1.5×10^4μg/mL. The influences of key chemical and physical parameters, some major fresh water ions at their maximum admissible concentrations and a number of pesticides were examined as potential interferences. The concentrations of CYR in spiked milk samples were successfully determined by the proposed method and the results were in good agreement with that of the previously reported HPLC method, having recovery range of （92% a=4%）-（106% a：2%）. The possible CL reaction mechanism for copper（m） chelate-Triton X-100-CYR was also briefly discussed.

关键词： Chemiluminescence Flow injection analysis Cyromazine Milk sample

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Flow-injection Determination of Cysteine,N-Acetyl Cysteine and Glutathione in Pharmaceuticals via Potassium Ferricyanide-Fe(Ⅲ) Spectrophotometric System

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Chemical Research in Chinese Universities 2010年第6期26卷 893-898页

作者： WASEEM Amir YAQOOB Mohammad nabi abdul Department of Chemistry COMSATS Institute of Information Technology Department of Chemistry University of Balochistan

A simple flow injection spectrophotometric method is reported for the determination of cysteine,N-acetyl cysteine and glutathione based on the reduction of Fe（Ⅲ）/ferricyanide,the in situ reduced ions are reacted with unreduced portion of ferricyanide/Fe（Ⅲ） to form soluble Prussian blue,which is monitored at 735 *** calibration graphs are linear in the concentration ranges of（1―100）×10-6 mol/L for cysteine and N-acetyl cysteine,and（1―50）×10-6 mol/L for *** relative standard deviations of 1.8%,2.5% and 1.9% were found for eleven replicate analyses of 5×10-6 mol/L cysteine,N-acetyl cysteine and *** limits of detection（3σ blank） at 5×10-7 mol/L for cysteine,and 3×10-7 mol/L for N-acetyl cysteine and glutathione were *** proposed method allowed 60 injections/*** effects of common substances present in pharmaceuticals and human physiological fluids were *** method was applied to determining cysteine in pharmaceutical formulations with the recoveries in a range of 97% to 106% and the results obtained are agreed well with labeled values.

关键词： Flow injection Spectrophotometry Cysteine Prussian blue Fe(Ⅲ) Ferricyanide Pharmaceutical

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Flow injection spectrophotometric determination of vitamin E in pharmaceuticals,milk powder and blood serum using potassium ferricyanide-Fe(Ⅲ) detection system

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Chinese Chemical Letters 2010年第6期21卷 712-715页

作者： Saima Jadoon Amir Waseem Mohammad Yaqoob abdul nabi Department of Chemistry University of BalochistanQuettaPakistan

A simple and sensitive flow injection spectrophotometric method is reported for the determination of vitamin E using potassium ferricyanide-Fe(Ⅲ) detection *** the presence of vitamin E,Fe(Ⅲ)/ferricyanide *** in situ reduced ions are then reacted with unreduced portion of ferricyanide/Fe(Ⅲ) to make soluble Prussian blue,which is monitored at absorption wavelength of 735 *** calibration graph was obtained in the concentration range of 0.1-40μg mL^(-1).The relative standard deviations (n=4) were in the range of 1.1-3.6%,with limits of detection(3 s blank) of 0.04μg mL^(-1).The proposed method allowed 12 injections h^(-1).The method is applied to determine vitamin E in pharmaceuticals,infant milk and blood serum samples using hexane extraction with the recoveries in the range of 93±3 to 97.5±4%.The method is validated using certified reference materials SRM 968c for blood serum samples.

关键词： Flow injection Spectrophotometry Vitamin E Prussian blue Fe(III) Ferricyanide Pharmaceuticals Blood serum

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Radiative capture of proton by ^(9)Be(p,γ)^(10)B at low energy

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Communications in Theoretical Physics 2022年第2期74卷 78-82页

作者： abdul Kabir Jameel-Un nabi Sumair Sagheer Laiba Rashid Department of Space Science Institute of Space TechnologyIslamabadPakistan University of Wah Quaid AvenueWah Cantt 47040PunjabPakistan Faculty of Engineering Sciences GIK Institute of Engineering Sciences and TechnologyTopi 23640SwabiKhyber PakhtunkhwaPakistan

Radiative capture p+^(9)Be→^(10)B+γ at energies bearing astrophysical importance is a key process for the spectroscopic study of ^(10)*** this work,we consider the radiative capture cross-section for the ^(9)Be(p,γ)^(10)B within the framework of the potential model and the R-matrix method for the multi-entrance channel *** certain cases,when the potential fails,therefore,the R-matrix approach is better to use for the description of partial components of the cross-section that have sharp or broad *** all possible electric and magnetic dipole transitions,partial components of the astrophysical S-factor are *** computed value of the total S-factor at zero energy is consistent with the reported results.

关键词： potential model R-matrix approach E1 transitions M1 transitions cross-section astrophysical S-factor

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