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Protocol for the development and validation of a clinical measurement tool for fear of disease progression and recurrence in cardiac patients

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Chronic Diseases and translational Medicine 2024年第3期10卷 195-204页

作者： sarah t.clarke Michael Le Grande Barbara M.Murphy Robert Hester Alun C.Jackson Melbourne School of Psychological Sciences University of MelbourneParkvilleVictoriaAustralia Australian Centre for Heart Health MelbourneVictoriaAustralia Centre on Behavioral Health University of Hong KongPokfulamHong KongChina

Introduction: One in two cardiac patients fear having another heart event or their heart condition getting worse. Research in other chronic illnesses demonstrates that screening for fear of progression and recurrence is vital for adequately addressing such concerns in clinical care. the current project aims to develop and validate a measure for fear of progression and recurrence in cardiac ***: the Fear of Cardiac Recurrence and Progression Scale (FCRP) will be developed through a multistep process. An initial item pool will be generated through a review of the literature and existing measures and consultation with and feedback from key informants. the item pool will be tested in a sample of over 250 adults who have ever had an acute coronary event, undergone cardiac surgery, or a chronic cardiac condition. Exploratory factor analysis will be used to identify the underlying factors, and Rasch analysis will be used to reduce the number of items. A short form version of the FCRP will be developed for use as a brief screening tool, informed by clinical relevance and Rasch psychometric ***: While many cardiac patients experience fears related to the progression or recurrence of their illness, there remains the need for a validated tool with which these concerns can be identified and measured. It is expected that the design and validation of the FCRP will aid identification of cardiac patients suffering from clinically significant levels of fear of progression and recurrence and facilitate the design of tailored psychological interventions to target these fears.

关键词： anxiety cardiac anxiety cardiac recovery cardiac rehabilitation depression fear of progression fear of recurrence psychological measurement psychosocial screening

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Effectiveness of ivermectin mass drug administration in the control of soil-transmitted helminth infections in endemic populations: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第1期13卷 1-15页

作者： Brandon Le Naomi E.clarke Nicolas Legrand Susana Vaz Nery the Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

Background Current soil-transmitted helminth(StH)control guidelines endorse the use of albendazole or meben-dazole for school-based targeted preventive chemotherapy(PC),yet their reduced efficacy against Strongyloides sterc-oralis and trichuris trichiura presents significant *** evidence indicates that community-wide PC[or mass drug administration(MDA)]using ivermectin,commonly used in other neglected tropical disease(NtD)control programs,may play an important role in controlling these *** conducted a systematic review and meta-analysis to evaluate the effectiveness of ivermectin PC in reducing StH prevalence in endemic *** We searched Pubmed,EMBASE,and Web of Science on February 14,2023,for studies that investigated the effectiveness of ivermectin PC,either alone or in combination with other anthelmintic drugs,on StH infec-tions,and provided a measure of StH prevalence before and after *** calculated pooled prevalence reductions for each StH using random-effects *** protocol is available on PROSPERO(registration number CRD42023401219).Results A total of 21 were eligible for the systematic review,of which 15 were eligible for *** studies delivered ivermectin through *** pooled prevalence reduction of *** following MDA with ivermec-tin alone was 84.49%(95%CI:54.96-94.66)across five studies and 81.37%(95% CI:61.62-90.96)across seven studies with or without *** prevalence reduction of *** was 49.93%(95%CI:18.23-69.34)across five studies with ivermectin alone,and 89.40%(95%CI:73.66-95.73)across three studies with the addition of *** was high heterogeneity for all syntheses(I^(2)>65%).Conclusions this study underscores the key role of ivermectin-based MDA in addressing limitations in current global StH guidelines in terms of limited efficacy against *** and *** on these findings,revising inter-national StH guidelines to include i

关键词： Soil-transmitted helminths Ivermectin Albendazole Mass drug administration Preventive chemotherapy

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Comparison of fungal vs bacterial infections in the medical intensive liver unit:Cause or corollary for high mortality?

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World Journal of Hepatology 2024年第3期16卷 379-392页

作者： sarah Khan Hanna Hong Stephanie Bass Yifan Wang Xiao-Feng Wang Omar t Sims Christine E Koval Aanchal Kapoor Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Cleveland Clinic Lerner College of Medicine Cleveland ClinicClevelandOH 44195United States Department of Pharmacy Cleveland ClinicClevelandOH 44195United States Department of Quantitative Health Sciences/Biostatistics Section Cleveland ClinicClevelandOH 44195United States Department of Gastroenterology Hepatology and NutritionCleveland ClinicClevelandOH 44195United States Department of Infectious Disease Cleveland ClinicClevelandOH 44195United States Department of Critical Care Medicine Cleveland ClinicClevelandOH 44195United States

BACKGROUND Due to development of an immune-dysregulated phenotype,advanced liver disease in all forms predisposes patients to sepsis acquisition,including by opportunistic pathogens such as *** data exists on fungal infection within a medical intensive liver unit(MILU),particularly in relation to acute on chronic liver *** to investigate the impact of fungal infections among critically ill patients with advanced liver disease,and compare outcomes to those of patients with bacterial *** From our prospective registry of MILU patients from 2018-2022,we included 27 patients with culture-positive fungal infections and 183 with bacterial *** compared outcomes between patients admitted to the MILU with fungal infections to bacterial *** was extracted through chart *** All fungal infections were due to Candida species,and were most frequently blood *** among patients with fungal infections was significantly worse relative to the bacterial cohort(93%vs 52%,Pthe majority of the fungal cohort developed grade 2 or 3 acute on chronic liver failure(ACLF)(90%vs 64%,P=0.02).Patients in the fungal cohort had increased use of vasopressors(96%vs 70%,P=0.04),mechanical ventilation(96%vs 65%,Pto acute kidney injury(78%vs 52%,P=0.014).On MILU admission,the fungal cohort had significantly higher Acute Physiology and Chronic Health Evaluation(108 vs 91,P=0.003),Acute Physiology Score(86 vs 65,P=0.003),and Model for End-Stage Liver Disease-Sodium scores(86 vs 65,P=0.041).there was no significant difference in the rate of central line use preceding culture(52%vs 40%,P=0.2).Patients with fungal infection had higher rate of transplant hold placement,and lower rates of transplant;however,differences did not achieve statistical *** Mortality was worse among patients with fungal infections,likely attributable to severe ACLF *** studies examinin

关键词： Fungal Infection Sepsis Acute on chronic liver failure Intensive care

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Letter to the Editor: Reverse t3;a Reliable Diagnostic test for Discerning between Euthyroid Sick and Central Hypothyroidism

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Open Journal of Endocrine and Metabolic Diseases 2024年第2期14卷 73-74页

作者： Udaya M. Kabadi sarah Exley Broadlawns Medical Center Des Moines Iowa Faulty of Endocrinology Clinic University of Iowa Iowa City Iowa

Letter to the Editor

关键词： Letter ism Sick

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Functional lumen imaging probe use in a high-volume practice:Practical and technical implications

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World Journal of Gastrointestinal Endoscopy 2024年第7期16卷 396-405页

作者： Yan Jiang Raul Vazquez-Reyes Afrin Kamal thomas Zikos George triadafilopoulos John O clarke Division of Gastroenterology and Hepatology Stanford University School of MedicineRedwoodCA 94063United States

BACKGROUND the functional lumen imaging probe(FLIP)is a Food and Drug Administration approved tool to aid the diagnosis and management of esophageal ***,widespread adoption of FLIP remains limited and its utility in highvolume practices remains *** to analyze large sample data on clinical use of FLIP and provide insight on several technical aspects when performing *** We conducted a retrospective comparative and descriptive analysis of FLIP procedures performed by a single provider at an academic medical *** was a total of 398 FLIP procedures *** medical records were reviewed and data regarding demographics and procedural details were *** tests,including chi-squared,t-test,and multivariable logistic and linear regression,were *** there was an increase in FLIP cases with each successive time period of 13 months(n=68,146,184,respectively)with notable rises specifically for indications of dysphagia and gastroesophageal reflux *** was a shift toward use of the longer FLIP balloon catheter for diagnostic purposes(overall 70.4%vs 29.6%,Ption with other diagnostics/interventions,such as dilation and wireless pH probe *** were nearly equally performed with anesthesia vs moderate sedation(51.4%anesthesia),with no major *** who had anesthesia were less likely to have recurrent antegrade contractions[odds ratio(OR)=0.4,95%CI:0.3-0.8]and were also more likely to have absent contractility(OR=2.4,95%CI:1.3-CONCLUSION FLIP cases have increased in our practice with expanding indications for its *** limited normative data,providers should be aware of several potential technical issues,including the possible impact of sedation choice when assessing esophageal motility patterns.

关键词： Gastroenterology Endoscopy Functional lumen imaging probe Esophagus Motility

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Prenatal multiple micronutrient-fortified balanced energy-protein supplementation and newborn telomere length and mitochondrial DNA content: a randomized controlled efficacy trial in rural Burkina Faso

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Food Science and Human Wellness 2024年

作者： Giles t.Hanley-Cook Yuri Bastos-Moreira Dries S.Martens trenton Dailey-Chwalibóg Laeticia Celine toe Brenda de Kok Lionel Ouédraogo Alemayehu Argaw Kokeb tesfamariam Patrick Kolsteren Lieven Huybregts tim S.Nawrot sarah De Saeger Marthe De Boevre Carl Lachat Department of Food technology Safety and Health Faculty of Bioscience Engineering Ghent University Center of Excellence in Mycotoxicology and Public Health MYtOXSOUtH~(?) Coordination Unit Faculty of Pharmaceutical Sciences Ghent University Centre for Environmental Sciences Hasselt University Unité Nutrition et Maladies Métaboliques Institut de Recherche en Sciences de la Santé (IRSS) Centre Muraz Center of Excellence in Mycotoxicology and Public Health MYtOXSOUtH? Coordination Unit Faculty of Pharmaceutical Sciences Ghent University Nutrition Diets and Health Unit Department of Food and Nutrition Policy International Food Policy Research Institute (IFPRI) Department of Public Health & Primary Care University of Leuven Department of Biotechnology and Food technology Faculty of Science University of Johannesburg Doornfontein Campus

Background: Evidence regarding the effectiveness of prenatal nutritional supplements has mainly considered anthropometric pregnancy outcomes. the effect on markers of health and disease， such as offspring telomere length (tL) and mitochondrial DNA content (mtDNAc) is unknown. Objectives: We assessed the efficacy of maternal multiple micronutrient (MMN)-fortified balanced-energy protein (BEP) and iron-folic acid (IFA) supplementation on newborn tL as a secondary outcome and mtDNAc as a non-declared outcome. Design: We conducted a randomized controlled trial in rural Burkina Faso， among pregnant females (15-40 years old) enrolled at tation. Mothers received either MMN-fortified BEP and IFA (intervention) or IFA only (control) throughout pregnancy. Whole arterial blood samples were collected from the umbilical cord of 104 control and 90 intervention group infants， respectively. Average relative tL and mtDNAc were measured using quantitative polymerase chain reaction. Linear regression models were fitted to assess tL and mtDNAc differences across trial arms. Results: We found that a combined daily MMN-fortified BEP supplement and IFA tablet did not affect newborn tL [β = -0.010 (95% CI: -0.057， 0.036); P = 0.662] or mtDNAc [β = 0.065 (95% CI: -0.203， 0.073); P = 0.354]， as compared to an IFA tablet alone. these findings were confirmed (P > 0.05) by adjusting the regression models for potential prognostic factors of study outcomes at enrollment. Exploratory analyses indicated higher， but non-significantly different mtDNAc among children born either small-for-gestational age， low birthweight， or preterm. Conclusions: Newborns from mothers who received daily nutritional supplements across gestation did not have different relative tL or mtDNAc.

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商界的当红术语

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空中英语教室（高级版．彭蒙惠英语） 2024年第6期 10-11,39,40页

作者： sarah Bregel 不详

过去这一年充满了职场的新趋势与转折点。虽然有越来越多的人居家办公以及自行创业,但也有非常多的人重返办公室,即使这不是他们的首选。尽管如此,如果说这种例行公事感觉比在家里用一半的心思工作还要乏味,那么我们谈论不断发展的商业... 详细信息

过去这一年充满了职场的新趋势与转折点。虽然有越来越多的人居家办公以及自行创业,但也有非常多的人重返办公室,即使这不是他们的首选。尽管如此,如果说这种例行公事感觉比在家里用一半的心思工作还要乏味,那么我们谈论不断发展的商业文化的方式时,绝对永不乏味。

关键词：转折点办公室乏味

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别让幼儿看电视儿童感觉障碍与看电视有关

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空中英语教室（高级版．彭蒙惠英语） 2024年第7期 32-33,48,49页

作者： sarah Bregel 不详

我们早就怀疑电视对幼儿不好,但现在有了证据——而且可能比我们想象的还糟。一项新的研究指出,对于两岁以下的孩子来说,观看电视的时间,无论长短,都可能导致出现感觉差异,例如在幼儿期孤独症谱系障碍中出现的那些差异《美国医学会杂志... 详细信息

我们早就怀疑电视对幼儿不好,但现在有了证据——而且可能比我们想象的还糟。一项新的研究指出,对于两岁以下的孩子来说,观看电视的时间,无论长短,都可能导致出现感觉差异,例如在幼儿期孤独症谱系障碍中出现的那些差异《美国医学会杂志》的研究显示.

关键词：孤独症谱系障碍感觉障碍《美国医学会杂志》幼儿期看电视

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Evaluating the role of 7-tesla magnetic resonance imaging in neurosurgery: trends in literature since clinical approval

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World Journal of Radiology 2024年第7期16卷 274-293页

作者： Arosh S Perera Molligoda Arachchige sarah Meuli Francesca Romana Centini NiccolòStomeo Federica Catapano Letterio S Politi Faculty of Medicine Humanitas UniversityPieve EmanueleMilan 20072Italy Department of Anaesthesiology and Intensive Care IRCCS Humanitas Research HospitalVia Manzoni 56RozzanoMilan 20089Italy Department of Biomedical Sciences Humanitas Universityvia Rita Levi Montalcini 420090 Pieve Emanuele-MilanItaly IRCCS Humanitas Research Hospital Via Manzoni 5620089 Rozzano-MilanItaly Department of Neuroradiology IRCCS Humanitas Research HospitalVia Manzoni 56RozzanoMilan 20089Italy

BACKGROUND After approval for clinical use in 2017,early investigations of ultra-high-field abdominal magnetic resonance imaging(MRI)have demonstrated its feasibility as well as diagnostic capabilities in ***,there are no to few systematic reviews covering the entirety of its neurosurgical applications as well as the trends in the literature with regard to the aforementioned *** to assess the impact of 7-tesla MRI(7t MRI)on neurosurgery,focusing on its applications in diagnosis,treatment planning,and postoperative assessment,and to systematically analyze and identify patterns and trends in the existing literature related to the utilization of 7t MRI in neurosurgical *** A systematic search of PubMed was conducted for studies published between January 1,2017,and December 31,2023,using MeSH terms related to 7t MRI and *** inclusion criteria were:Studies involving patients of all ages,meta-analyses,systematic reviews,and original *** exclusion criteria were:Pre-prints,studies with insufficient data(e.g.,case reports and letters),non-English publications,and studies involving animal *** synthesis involved standardized extraction forms,and a narrative synthesis was *** We identified 219 records from PubMed within our defined period,with no duplicates or exclusions before *** screening,125 articles were excluded for not meeting inclusion criteria,leaving 94 *** these,2 were irrelevant to neurosurgery and 7 were animal studies,resulting in 85 studies included in our systematic *** were categorized by neurosurgical procedures and diseases treated using 7t *** also analyzed publications by country and the number of 7t MRI facilities per country was also ***-mental studies were classified into comparison and non-comparison studies based on whether 7t MRI was compared to lower field *** 7t MRI holds great potential in improving the

关键词： 7-tesla Magnetic resonance imaging Neuroimaging Neurosurgery Pathologies Procedures trends

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Interpreting uninterpretable predictors:kernel methods,Shtarkov solutions,and random forests

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Statistical theory and Related Fields 2022年第1期6卷 10-28页

作者： t.M.Le Bertrand clarke Department of mathematics scienceand informaticsmercer universityatlantagausa department of statistics university of nebraska-lincolnlincolnneusa

Many of the best predictors for complex problems are typically regarded as hard to interpret *** include kernel methods,Shtarkov solutions,and random *** show that,despite the inability to interpret these three predictors to infinite precision,they can be asymptotically approximated and admit conceptual interpretations in terms of their mathe-matical/statistical *** resulting expressions can be in terms of polynomials,basis elements,or other functions that an analyst may regard as interpretable.

关键词： Bayes boosting kernel methods random forest Shtarkov predictor stacking

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