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Uncoupling protein 2 deficiency reduces proliferative capacity of murine pancreatic stellate cells

Hepatobiliary & Pancreatic Diseases International 2016年第6期15卷 647-654页

作者： sarah muller Sandra Maria Klingbeil Andreea Sandica Robert Jaster Department of Medicine II Division of Gastroen-terologyRostock University Medical CenterE.-Heydemann-Str.618057 RostockGermany

BACKGROUND： Uncoupling protein 2 （UCP2） has been suggested to inhibit mitochondrial production of reactive oxygen species （ROS） by decreasing the mitochondrial membrane potential. Experimental acute pancreatitis is associated with increased UCP2 expression, whereas UCP2 deficiency retards regeneration of aged mice from acute pancreatitis. Here, we have addressed biological and molecular functions of UCP2 in pancreatic stellate cells （PSCs）, which are involved in pancreatic wound repair and fibrogenesis. METHODS： PSCs were isolated from 12 months old （aged） UCP2^-/- mice and animals of the wild-type （WT） strain C57BL/6. Proliferation and cell death were assessed by em- ploying trypan blue staining and a 5-bromo-2＇-deoxyuridine incorporation assay. Intracellular fat droplets were visualized by oil red O staining. Levels of mRNA were determined by RT-PCR, while protein expression was analyzed by immunoblotting and immunofluorescence analysis. Intracellular ROS levels were measured with 2＇,7＇-dichlorofluorescin diacetate. Expression of senescence-associated β-galactosidase （SA β-Gal） was used as a surrogate marker of cellular senescence. RESULTS： PSCs derived from UCP2^-/- mice proliferated at a lower rate than cells from WT mice. In agreement with this observation, the UCP2 inhibitor genipin displayed dose- dependent inhibitory effects on WT PSC growth. Interestingly, ROS levels in PSCs did not differ between the two strains, and PSCs derived from UCP2^-/- mice did not senesce faster than those from corresponding WT cells. PSCs from UCP2^-/- mice and WT animals were also indistinguishable with respect to the activation-dependent loss of intracellular fat droplets, expression of the activation marker α-smooth muscle actin, type I collagen and the autocrine/paracrine mediators interleukin-6 and transforming growth factor-I~ 1. CONCLUSIONS： A reduced proliferative capacity of PSC from aged UCP2^-/- mice may contribute to the retarded regeneration after acute pancreatitis.

关键词： pancreatitis proliferation stellate cell biology uncoupling protein 2

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Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

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Neural Regeneration Research 2025年第1期20卷 205-206页

作者： sarah Fullam Sean O’Dowd Antoinette O’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

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Nanodiamonds as nanomaterial for biomedical field

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Frontiers of Materials Science 2021年第3期15卷 334-351页

作者： sarah GARIFO Dimitri STANICKI Gamze AYATA Robert Nmuller Sophie LAURENT General Organic and Biomedical Chemistry UnitNuclear Magnetic Resonance(NMR)and Molecular Imaging LaboratoryUniversity of Mons(UMONS)Avenue Maistriau 197000 MonsBelgium Center for Microscopy and Molecular Imaging(CMMI) Rue Adrienne Bolland 86041 GosseliesBelgium

Recent advances in nanotechnology have attracted significant attention to nanodiamonds(NDs)in both industrial and research areas thanks to their remarkable intrinsic properties:large specific area,poor cytotoxicity,chemical resistance,magnetic and optical properties,ease of large-scale production,and surface reactivity make them suitable for numerous applications,including electronics,optics,sensors,polishing materials,and more recently,biological *** interest in diamond platforms for bioimaging and chemotherapy is *** the outstanding features of these particles and their ease of tuning,current and future applications in medicine have the potential to display innovative imaging applications and to be used as tools for monitoring and tracking drug delivery in vivo.

关键词： nanodiamond scale-up synthesis bioimaging hyperpolarization drug delivery

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Uncovering material deformations via machine learning combined with four-dimensional scanning transmission electron microscopy

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npj Computational Materials 2022年第1期8卷 1072-1080页

作者： Chuqiao Shi Michael C.Cao sarah M.Rehn Sang-Hoon Bae Jeehwan Kim Matthew RJones David A.muller Yimo Han Department of Materials Science and NanoEngineering Rice UniversityHoustonTXUSA School of Applied and Engineering Physics Cornell UniversityIthacaNYUSA Department of Chemistry Rice UniversityHoustonTXUSA Department of Mechanical Engineering and Materials Science Washington University in Saint LouisSaint LouisMOUSA Institute of Materials Science and Engineering Washington University in Saint LouisSaint LouisMOUSA Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMAUSA Kavli Institute for Nanoscale Science Cornell UniversityIthacaNYUSA

Understanding lattice deformations is crucial in determining the properties of nanomaterials,which can become more prominent in future applications ranging from energy harvesting to electronic ***,it remains challenging to reveal unexpected deformations that crucially affect material properties across a large sample ***,we demonstrate a rapid and semi-automated unsupervised machine learning approach to uncover lattice deformations in *** method utilizes divisive hierarchical clustering to automatically unveil multi-scale deformations in the entire sample flake from the diffraction data using four-dimensional scanning transmission electron microscopy(4D-STEM).Our approach overcomes the current barriers of large 4D data analysis without a priori knowledge of the *** this purely data-driven analysis,we have uncovered different types of material deformations,such as strain,lattice distortion,bending contour,etc.,which can significantly impact the band structure and subsequent performance of nanomaterials-based *** envision that this data-driven procedure will provide insight into materials’intrinsic structures and accelerate the discovery of materials.

关键词： utilize purely overcome

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Apportioning aldehydes:Quantifying industrial sources of carbonyls

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Journal of Environmental Sciences 2015年第4期27卷 132-134页

作者： sarah A.Styler Leibniz Institute for Tropospheric Research

In their recent Journal of Environmental Sciences publication,Wang and colleagues provide field evidence that industrial activities can contribute substantially to atmospheric carbonyl concentrations（Wang et al.,2015）.These results may helpto explain underestimations of carbonyl emissions in currently available emission inventories,and highlight the need for an improved understanding of industrial sources of this class of compounds.

关键词： Carbonyl compounds Source apportionment Industrial emissions

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Assessing the impact of network factors and Twitter data on Ethereum's popularity

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Blockchain(Research and Applications) 2023年第3期4卷 123-131页

作者： sarah Bouraga Namur Digital Institute(NADI) University of NamurBelgium

In March 2021,we witnessed a surge in Bitcoin *** cause seemed to be a tweet by Elon *** other blockchains as sensitive to social media as Bitcoin?And more precisely,could Ethereum's popularity be explained using social media data?This work aims to explore the determinants of Ethereum's *** use both data from Etherscan to retrieve the relevant historic Ethereum factors and Twitter *** sample consists of data ranging from 2015 to *** use Ordinary Least Squares to assess the relationship between these factors(Ethereum characteristics and Twitter data)and Ethereum's *** findings show that Ethereum's popularity—translated here by the number of daily new addresses—is related to the following elements:the Ether(ETH)price,the transaction fees,and the polarity of tweets related to *** results could have multiple practical implications for both researchers and *** of all,we believe that it will enable readers to better understand the technology of Ethereum and its ***,it will help the community identify pointers for anticipating or explaining the popularity of existing or future *** finally,the results could help in understanding the factors facilitating the design of future platforms.

关键词： Blockchain technology Ethereum Twitter data Platform's popularity

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Co-culture methods to study neuronal function and disease

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Neural Regeneration Research 2021年第5期16卷 972-973页

作者： sarah B.Peters Division of Biosciences College of DentistryThe Ohio State UniversityColumbusOHUSA

Co-culture methods to study neuronal function and disease:Injury,infection and degenerative diseases can occur throughout the body,potentially causing impaired organ function,loss of sensation,increased pain and/or tissue ***,researchers have begun to investigate ways to better mimic organ physiology by culturing neurons with the cell-type(s)-ofinterest toward the goals of regenerating organs that accurately communicate with autonomic and sensory-somatic nervous systems.

关键词： impaired sensation organs

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The dawn and rise of antimony use in the southern Caucasus

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Science China Earth Sciences 2022年第11期65卷 2037-2056页

作者： sarah DILLIS Patrick DEGRYSE Department of Earth and Environmental Sciences Katholieke Universiteit LeuvenCelestjnenlaan 200 EHeverlee 3001Belgium Faculty of Archaeology Leiden UniversityEinsteinweg 2Leiden 2333 CCThe Netherlands

Antimony(Sb)was utilised over several millennia as the prime material to opacify or decolour glass and glazes,as well as an accompanying element in copper(Cu)*** antimony objects are rare,and mostly confined to Chalcolithic Central Italy and to the first millennia BCE in the southern *** innovation of antimony use in metallurgy seems to be confined to the southern Caucasus,and the invention of it might be even more specifically situated in the Great *** knowledge of mining set the pathway for the initial stage of antimonial copper alloys in the first half of the third millennium BCE and for metallic antimony ornaments in the second half of the third millennium ***,the first major expansion of antimony in the metallurgy of the Racha-Lechkumi district in the southern Caucasus(present-day Georgia)started around 1700 BCE,while its spreading in glassmaking occurred in the Late Bronze Age(LBA).Explanations that place antimony adoption within its broader social context are favoured over those that consider material or geological properties in isolation.A recurring theme is the importance of comparative analysis,both geographically and between the different pyrotechnologies,including the precious metals and glass industries,to explore how social,political,climatic and economic conditions affected adoption and innovation *** these factors are considered to explain why the extraction of antimony blossomed in the Late Bronze Age in the southern Caucasus and to reconstruct a framework of exploitation,distribution/trade and use of antimony in the Caucasus and its neighbouring regions in the south and east.

关键词： Antimony Caucasus Metallurgy Glass Gold

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Truth and consequences:the bioinvasion of the Mediterranean Sea

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Integrative Zoology 2012年第3期7卷 299-311页

作者： Bella sarah GALIL National Institute of Oceanography Israel Oceanographic and Limnological ResearchHaifaIsrael

Over 660 alien marine multicellular species have been recorded in the Mediterranean Sea,with many establishing viable populations and subsequently dispersing from their points of entry.A brief overview is presented of the current state of knowledge of bioinvasions in the Mediterranean Sea,with particular attention paid to gelatinous invasive species.A database of alien species records was used to characterize their identity,pattern of expansion and native region,and to discuss the relative importance of different taxa and vectors in the various regions of the *** temporal and spatial spread of 4 alien scyphozoans and 2 alien ctenophores is *** thermophilic species constitute the majority of Mediterranean aliens,Erythrean aliens are predominant in the east,with shipping and mariculture being mainly responsible for introductions in the *** propagule pressure driving the Erythrean invasion is powerful in the establishment and spread of alien species in the eastern *** implications of the enlargement of the Suez Canal,reflecting patterns in global trade and economy,are briefly ***,as alien species inventories play a pivotal role in informing regional policy and management decisions and identifying resource priorities,the scientific community is called upon to pay particular attention to their accuracy and veracity.

关键词： alien gelatinous inventories Mediterranean Sea trends vectors

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How plants grow up

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Journal of Integrative Plant Biology 2019年第3期61卷 257-277页

作者： sarah M McKim Division of Plant Sciences University of Dundee at The James Hutton Institute

A plant's lateral structures, such as leaves,branches and flowers, literally hinge on the shoot axis,making its integrity and growth fundamental to plant *** all plants, subapical proliferation within the shoot tip displaces cells downward to extrude the cylindrical *** the transition to flowering, many plants show extensive axial elongation associated with increased subapical proliferation and expansion. However, the cereal grasses also elongate their stems, called culms, due to activity within detached intercalary meristems which displaces cells upward, elevating the grain-bearing inflorescence. Variation in culm length within species is especially relevant to cereal crops, as demonstrated by the high-yielding semi-dwarfed cereals of the Green Revolution. Although previously understudied, recent renewed interest the regulation of subapical and intercalary growth suggests that control of cell division planes,boundary formation and temporal dynamics of differentiation, are likely critical mechanisms coordinating axial growth and development in plants.

关键词： plants grow up^FA lateral structures

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