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Mapping the clinical practice of traditional,complementary and integrative medicine in oncology in Western countries:A multinational cross-sectional survey

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journal of Integrative Medicine 2024年第1期22卷 64-71页

作者： Matthias Huemer Sandro Graca sarah Bitsche Guenter Hofmann Mike Armour Martin Pichler Palliative Care Unit Division of OncologyDepartment of Internal MedicineMedical University of Graz8036 GrazAustria Northern College of Acupuncture York YO16LJUnited Kingdom School of Health and Society Faculty of EducationHealth and WellbeingUniversity of WolverhamptonWolverhampton WV11LYUnited Kingdom National Institute of Complementary Medicine Health Research Institute Western Sydney UniversityPenrith NSW 2751Australia Translational Health Research Institute Western Sydney UniversityPenrith NSW 2751Australia Medical Research Institute of New Zealand Wellington 6021New Zealand Translational Oncology University Hospital of Augsburg86156 AugsburgGermany

Background Many cancer patients seek adjunctive therapies to biomedical cancer treatments at some point of their disease *** acupuncture is increasingly recommended by leading oncological associations,limited evidence exists concerning the evidence-informed practice and adherence to current guidelines of traditional complementary and integrative medicine(TCIM)practitioners treating cancer *** An international online-survey assessed the demographical data,clinical practice,and sources of information used by TCIM practitioners in Austria,Germany,United States of America,Australia,and New *** In total,404 respondents completed the survey,of which 254(62.9%)treated cancer *** practitioners were acupuncturists and herbalists(57.1%),had(16.8±9.9)years of clinical experience and see a median of 2(1,4)cancer patients per *** cancer(61.8%)is the most common cancer type seen in TCIM *** TCIM treatments are frequently concurrent with the patient’s cancer specific treatment(39.9%),which is also reflected by the main goal of a TCIM treatment to alleviate side effects(52.4%).However,only 28.0%of the respondents are in contact with the treating *** to the respondents,pain is most effectively treated using acupuncture,while herbal medicine is best for cancer-related *** practitioners mostly use certified courses(33.1%)or online databases(28.3%)but often believe that experts are more reliable to inform their practice(37.0%)than research publications(32.7%).Conclusion Acupuncturists and herbalists commonly treat cancer *** practitioners use TCIM as an adjunct to biomedicine as supportive care and use it largely in accordance with current oncological guidelines.

关键词： Integrative medicine Acupuncture Oncology Evidence-informed practice International survey

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Differences in neuroplasticity after spinal cord injury in varying animal models and humans

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Neural Regeneration Research 2019年第1期14卷 7-19页

作者： Mallory E.Filipp Benjamin j.Travis Stefanie S.Henry Emma C.Idzikowski sarah A.Magnuson Megan YF Loh Daniel j.Hellenbrand Amgad S.Hanna Department of Neurological Surgery University of Wisconsin

Rats have been the primary model to study the process and underlying mechanisms of recovery after spinal cord injury. Two weeks after a severe spinal cord contusion, rats can regain weight-bearing abilities without therapeutic interventions, as assessed by the Basso, Beattie and Bresnahan locomotor scale. However, many human patients suffer from permanent loss of motor function following spinal cord injury. While rats are the most understood animal model, major differences in sensorimotor pathways between quadrupeds and bipeds need to be considered. Understanding the major differences between the sensorimotor pathways of rats, non-human primates, and humans is a start to improving targets for treatments of human spinal cord injury. This review will discuss the neuroplasticity of the brain and spinal cord after spinal cord injury in rats, non-human primates, and humans. A brief overview of emerging interventions to induce plasticity in humans with spinal cord injury will also be discussed.

关键词： recovery regeneration spinal cord injury plasticity axons animal studies locomotor training functional recovery

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Laser ablation(in situ)Lu-Hf dating of magmatic fluorite and hydrothermal fluorite-bearing veins

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Geoscience Frontiers 2023年第6期14卷 142-154页

作者： Stijn Glorie jacob Mulder Martin Hand Adrian Fabris Alexander Simpson sarah Gilbert Department of Earth Sciences University of AdelaideSA 5005Australia Geological Survey of South Australia Department for Energy and MiningAdelaideSA 5005Australia Adelaide Microscopy University of AdelaideSA 5005Australia

Fluorite(CaF_(2))is a common hydrothermal mineral,which precipitates from fluorine-rich fluids with an exceptional capacity to transport metals and Rare Earth Elements(REEs).Hence,the ability to date fluorite has important implications for understanding the timing of metal transport in hydrothermal *** we present,for the first time,fluorite Lu-Hf dates from fluorite-carbonate veins from the Olympic Cu-Au Province in South *** fluorite dates were obtained in situ using the recently developed LA-ICP-MS/MS Lu-Hf dating method.A fluorite-calcite age of 1588±19 Ma was obtained for the Torrens Dam prospect,consistent with the timing of the formation of the nearby Olympic Dam iron-oxide copper gold Breccia *** in the overlying Neoproterozoic successions were dated at 502±14 Ma,indicating a temporal link between Cu-sulphide remobilisation and the Delamerian ***,we present a multi-session reproducible date for magmatic fluorite from a monzogranite in the Pilbara Craton(Lu-Hf age of 2866±19 Ma).This age is consistent with a garnet Lu-Hf age from the same sample(2850±12 Ma)and holds potential to be developed into a secondary reference material for future fluorite Lu-Hf dating.

关键词： Reaction-cell ICP-MS In-situ geochronology Fluorite-calcite veins Iron oxide copper-gold Critical mineral exploration Rare Earth Elements

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LHP1 Interacts with ATRX through Plant-Specific Domains at Specific Loci Targeted by PRC2

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Molecular Plant 2018年第8期11卷 1038-1052页

作者： Haifeng Wang Danhua jiang Elin Axelsson Zdravko j. Lorkovic Sean Montgomery sarah Holec Bas j.G.E. Pieters Abbas H.K. AI Temimi jasmin Mecinovic Frederic Berger Gregor Mendel Institute (GMI) Austrian Academy of Sciences Vienna Biccenter (VBC) Dr. Bohr-Gasse 3 1030 Vienna Austria Temasek Lifesciences Laboratory 1 Research Link Nationat University of Singapore 117604 Singapore Singapore Department of Biological Sciences National University of Singapore 14 Science Drive 4 117543 Singapore Singapore Institute for Molecules and Materials Radboud University Heyendaalseweg 135 6525 AJ Nijmegen the Netherlands

Heterochromatin Protein 1 （HP1） is a major regulator of chromatin structure and function. In animals, the network of proteins interacting with HP1 is mainly associated with constitutive heterochromatin marked by H3K9me3. HP1 physically interacts with the putative ortholog of the SNF2 chromatin remodeler ATRX, which controls deposition of histone variant H3.3 in mammals. In this study, we show that the Arabidopsis thaliana ortholog of ATRX participates in H3.3 deposition and possesses specific conserved domains in plants. We found that plant Like HP1 （LHP1） protein interacts with ATRX through domains that evolved specifically in land plant ancestors. Loss of ATRX function in Arabidopsis affects the expression of a limited subset of genes controlled by PRC2 （POLYCOMB REPRESSIVE COMPLEX 2）, including the flowering time regulator FLC. The function of ATRX in regulation of flowering time requires novel LHPl-interacting domain and ATPase activity of the ATRX SNF2 helicase domain. Taken together, these results suggest that distinct evolutionary pathways led to the interaction between ATRX and HP1 in mammals and its counterpart LHP1 in plants, resulting in distinct modes of transcriptional regulation.

关键词： ATRX LHPI1 H3 variants Chromatin Histone Evolution

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Escherichia coli O157:H7 sepsis following fecal microbiota transplant in an IgA-deficient inflammatory bowel disease patient

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Gastroenterology Report 2022年第1期10卷 609-611页

作者： Landen S.Burstiner jared Silver Logan j.Burstiner Arian Teymoorian Kumar Pallav Demarre jones Anna Owings sarah Glover Nova Southeastern University Dr.Kiran C.Patel College of Osteopathic Medicine DavieFLUSA Department of Gastroenterology University of Mississippi Medical CenterJacksonMSUSA Department of Medicine Division of RheumatologyImmunologyand AllergyBrigham and Women’s HospitalHarvard Medical SchoolBostonMAUSA Department of Medicine Memorial Healthcare SystemHollywoodFLUSA Department of Gastroenterology GI Associates&Endoscopy CenterFlowoodMSUSA

Introduction Clostridioides difficile infection(CDI)is a common gastrointestinal illness worldwide,with increased prevalence and worse outcomes in patients with inflammatory bowel disease(IBD)[1].Fecal microbiota transplant(FMT)is an effective treatment for recurrent CDIs(RCDIs)with minimal serious adverse events(SAEs)reported[2].While immunosuppressive medications increase susceptibility to infections,studies have shown that FMT does not increase SAE risk in immunocompromised patients(including IBD patients on immunosuppressive therapy)[3].

关键词： O157:H7 inflammatory patients

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HIV/HCV Antiviral Drug Interactions in the Era of Direct-acting Antivirals

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journal of Clinical and Translational Hepatology 2016年第3期4卷 234-240页

作者： Donald P.Rice jr. john j.Faragon sarah Banks Lisa M.Chirch Division of Infectious Diseases Department of Medicine University of Connecticut School of Medicine Farmington CT USA Division of HIV Medicine Albany Medical Center Albany NY USA Department of Medicine The Hospital of Central ConnecticutUniversity of Connecticut School of Medicine Farmington CT USA

Therapy for human immunodeficiency virus (HIV) and chronic hepatitis C has evolved over the past decade,resulting in better control of infection and clinical outcomes;however,drug-drug interactions remain a significant *** recommendations from the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America regarding drug-drug interactions between HIV antiretroviral agents and direct-acting antiviral agents for treatment of hepatitis C virus (HCV) infection are reviewed *** review is oriented to facilitate appropriate selection of an antiviral therapy regimen for HCV infection based on the choice of antiretroviral therapy being administered and,if necessary,switching antiretroviral regimens.

关键词： HIV Hepatitis C Direct-acting antivirals Drug interactions Pharmacokinetics Antiretroviral therapy

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Graphene/carbon structured catalyst layer to enhance the performance and durability of the high-temperature proton exchange membrane fuel cells

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journal of Energy Chemistry 2022年第12期75卷 399-407,I0011页

作者： Zhaoqi ji jianuo Chen Zunmin Guo Ziyu Zhao Rongsheng Cai Maxwell T.P.Rigby sarah j.Haigh Maria Perez-Page Yitao Shen Stuart M.Holmes School of Automotive Engineering Harbin Institute of Technology(Weihai)Weihai 264209ShandongChina Department of Chemical Engineering The University of ManchesterManchester M139PLUK Department of Materials The University of ManchesterManchester M139PLUK

In this study,nitrogen doped electrochemically exfoliated reduced graphene oxide and carbon black supported platinum(Pt/Nr EGO_(2)-CB_(3))has been prepared to enhance the performance and durability of hightemperature PEMFCs with lower Pt *** the one hand,Pt/Nr EGO_(2)-CB_(3)with the strong interaction between the Pt and nitrogen(N)prevent agglomeration of Pt particles and Pt particles is 5.46±1.46 nm,which is smaller than that of 6.78±1.34 nm in Pt/***,ECSA of Pt/Nr EGO_(2)-CB_(3)decrease 13.65%after AST,which is much lower than that of 97.99%in Pt/*** the other hand,the Nr EGO flakes in MEAac act as a barrier to mitigate phosphoric acid redistribution,which improves the formation of triple-phase boundaries(TPBs)and gives stable operation of the MEAacwith a lower decay rate of 0.02 mV h^(-1)within100 *** steady-state operation,the maximum power density of Pt/Nr EGO_(2)-CB_(3)(0.411 W cm^(-2))is three times higher than that of conventional Pt/C(0.134 W cm^(-2))in high-temperature *** AST,the mass transfer resistance of Pt/Nr EGO_(2)-CB_(3)electrode(0.560Ωcm^(2))is lower than that in Pt/C(0.728Ωcm^(2)).

关键词： High-temperature proton exchange membrane fuel cell Phosphoric acid loss Pt catalyst degradation Accelerated stress test Durability

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Comparison of the extrusion rate of Crawford tubes

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International journal of Ophthalmology(English edition) 2015年第4期8卷 791-793页

作者： Kira L.Segal sarah H.Van Tassel Charles Kim Nicole Hsu Ashutosh Kacker Gary j.Lelli jr Department of Ophthalmology Weill Cornell Medical College Department of Otolaryngology Weill Cornell Medical College

· AIM: To compare the outcomes of dacryocystorhinostomy(DCR) using traditional Crawford tubes(TCT) and Crawford tubes with suture(CTS) in the lumen.· METHODS: Retrospective case series consisting of patients who underwent DCR between 2008 and 2013.·RESULTS: A total of 61 DCRs were performed on 50 patients. Patients who underwent DCR using CTS had higher rates of prolapse compared to the TCT group(50% vs 9.4%; P =0.003). Stent removal occurred earlier in patients who received CTS(3.3mo vs 5.1mo; P =0.004). Success rates were equivalent between the two groups(75% vs 81.1%; P =0.684).·CONCLUSION: CTS in the lumen increases the risk of prolapse, prompting earlier tube removal in patients following DCR for nasolacrimal duct obstruction(NLDO).Earlier removal of tubes does not appear to significantly decrease success rates.

关键词： nasolacrimal duct obstruction dacryocystorhinostomy dacryocystitis

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Steroidal scaffold decorations in Solanum alkaloid biosynthesis

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Molecular Plant 2024年第8期17卷 1236-1254页

作者： Rosalind Lucier Mohamed O.Kamileen Yoko Nakamura Sofiia Serediuk Ranjit Barbole jens Wurlitzer Maritta Kunert sarah Heinicke sarah E.O'Connor Prashant D.Sonawane Department of Natural Product Biosynthesis Max Planck Institute for Chemical Ecology07745 JenaGermany Research Group Biosynthesis and NMR Max Planck Institute for Chemical Ecology07745 JenaGermany Biochemical Sciences Division CSIR-National Chemical LaboratoryPune 411008MaharashtraIndia

Steroidal glycoalkaloids(SGAs)are specialized metabolites produced by hundreds of Solanum species,including important vegetable crops such as tomato,potato,and *** it has been known that SGAs play important roles in defense in plants and“anti-nutritional"effects(e.g.,toxicity and bitterness)to humans,many of these molecules have documented anti-cancer,anti-microbial,antiinflammatory,anti-viral,and anti-pyretic *** these,α-solasonine andα-solamargine isolated from black nightshade(Solanum nigrum)are reported to have potent anti-tumor,anti-proliferative,and anti-inflammatory ***,α-solasonine andα-solamargine,along with the core steroidal aglycone solasodine,are the most widespread SGAs produced among the Solanum ***,it is still unknown how plants synthesize these bioactive steroidal *** comparative metabolomictranscriptome-guided approach,biosynthetic logic,combinatorial expression in Nicotiana benthamiana,and functional recombinant enzyme assays,here we report the discovery of 12 enzymes from *** that converts the starting cholesterol precursorto solasodine aglycone,and the downstreamα-solasonine,α-solamargine,and malonyl-solamargine SGA *** further identified six enzymes from cultivated eggplant that catalyze the production ofα-solasonine,α-solamargine,and malonyl-solamargine SGAs from solasodine aglycone via glycosylation and atypical malonylation *** work provides the gene tool box and platform for engineering the production of high-value,steroidal bioactive molecules inheterologoushosts usingsyntheticbiology.

关键词： steroidal glycoalkaloids Solanum biosynthetic pathway α-solamargine malonyl-solamargine specialized metabolites

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Preprocessing of 2-Dimensional Gel Electrophoresis Images Applied to Proteomic Analysis： A Review

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Genomics, Proteomics & Bioinformatics 2018年第1期16卷 63-72页

作者： Manuel Mauricio Goez Maria Constanza Torres-Madronero sarah Rothlisberger Edilson Delgado-Trejos Automatics Electronics and Computer Science Research Group Faculty of Engineering Instituto Tecnologico Metropolitano Medellin 050012 Colombia Biomedical Innovation and Research Group Faculty of Applied and Exact Sciences lnstituto Tecnologico Metropolitano Medellin 050012 Colombia Quality Metrology and Production Research Group Faculty of Economic and Management Sciences Instituto Tecnologico Metropolitano Medellin 050012 Colombia

Various methods and specialized software programs are available for processing two- dimensional gel electrophoresis （2-DGE） images. However, due to the anomalies present in these images, a reliable, automated, and highly reproducible system for 2-DGE image analysis has still not been achieved. The most common anomalies found in 2-DGE images include vertical and hor- izontal streaking, fuzzy spots, and background noise, which greatly complicate computational anal- ysis. In this paper, we review the preprocessing techniques applied to 2-DGE images for noise reduction, intensity normalization, and background correction. We also present a quantitative comparison of non-linear filtering techniques applied to synthetic gel images, through analyzing the performance of the filters under specific conditions. Synthetic proteins were modeled into a two-dimensional Gaussian distribution with adjustable parameters for changing the size, intensity, and degradation. Three types of noise were added to the images： Gaussian, Rayleigh, and exponen- tial, with signal-to-noise ratios （SNRs） ranging 8-20 decibels （dB）. We compared the performanceof wavelet, contourlet, total variation （TV）, and wavelet-total variation （WTTV） techniques using parameters SNR and spot efficiency. In terms of spot efficiency, contourlet and TV were more sen- sitive to noise than wavelet and WTTV. Wavelet worked the best for images with SNR ranging 10- 20 dB, whereas WTTV performed better with high noise levels. Wavelet also presented the best per- formance with any level of Gaussian noise and low levels （20-14 dB） of Rayleigh and exponential noise in terms of SNR. Finally, the performance of the non-linear filtering techniques was evaluated using a real 2-DGE image with previously identified proteins marked. Wavelet achieved the best detection rate for the real image.

关键词： Background correction Filtering Noise reduction Preprocessing 2D gel electrophoresis

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