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Preoperative Feeding in Single Ventricle Neonates is Predictive of Shorter Time to Goal Feed

Congenital Heart Disease 2022年第5期17卷 505-518页

作者： Alyssia Venna Kathleen Reid sarah davis Jiaxiang Gai Yves d’Udekem sarah Clauss Department of Cardiovascular Surgery Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA Department of Cardiology Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA Department of Biostatistics Children’s National Heart InstituteThe George Washington University School of MedicineWashington DCUSA

Background:Patients with single ventricle anatomy are at increased risk of growth failure and *** cardiac centers,there is little standardization of feeding practices in this complex *** hypothesized that initiation of our center’s preoperative feeding protocol would result in decreased gastrostomy tube(G-tube)use,decreased length of stay and would not result in increased Necrotizing Enterocolitis(NEC)***:A single institution review of 52 patients who had undergone stage I single ventricle palliative repair was *** diagnoses were hypoplastic left heart syndrome(39%),atrioventricular canal(15%),and other(46%).Postoperative parameters such as time to goal feed and need for gastrostomy tube(G-tube)were compared among preoperatively fed and non-preoperatively fed *** to goal feed was calculated as time from first postoperative enteral feed to goal volume of 100 mL/***:Of the 26 patients who met inclusion criteria for preoperative feeding,22 patients(85%)were fed prior to *** proportional hazard ratio revealed that age at surgery(p=0.047)and being preoperatively fed(p=0.001)were associated with reaching goal feed *** analysis revealed that being preoperatively fed made a patient twice as likely to reach goal feed sooner(p=0.047).Univariable logistic regression revealed that days on total parenteral nutrition(p=0.018),length of hospitalization(p=0.008),and time to 1st postoperative feed(p=0.020)were significantly associated with higher odds of needing a G-tube *** logistic regression did not show any predictors of postoperative G-tube ***,there was a trend towards lower G-tube usage in the preoperatively fed ***:Implementing a standardized preoperative feeding protocol in single ventricle neonates can result in significantly shorter time to goal feed in preoperatively fed *** is beneficial for institutions to begin implementi

关键词： Single ventricle feeding guidelines enteral nutrition hypoplastic left heart syndrome necrotizing enterocolitis preoperative

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Human primary muscle stem cells regenerate injured urethral sphincter in athymic rats

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Animal Models and Experimental Medicine 2022年第5期5卷 453-460页

作者： Biniam M.Bekele Verena Schöwel-Wolf Janine Kieshauer Andreas Marg Andreas Busjahn sarah davis Gayle Nugent Anne-Karoline Ebert Simone Spuler Muscle Research Unit Experimental and Clinical Research Centera cooperation between the Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association and the CharitéUniversitätsmedizin BerlinBerlinGermany CharitéUniversitätsmedizin BerlinGermany Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association BerlinGermany Berlin Institute of Health at CharitéUniversitätsmedizin BelrinGermany HealthTwist GmbH BerlinGermany Charles River Laboratories MattawanMichiganUSA Department of Urology and Pediatric Urology University Hospital UlmUlmGermany

Background:The aim of the study was to demonstrate the efficacy of human muscle stem cells(MuSCs)isolated using innovative technology in restoring internal urinary sphincter function in a preclinical animal ***:Colonies of pure human MuSCs were obtained from muscle biopsy *** rats were subjected to internal urethral sphincter damage by *** days after injury,2×105 muscle stem cells or medium as control were injected into the area of sphincter damage(n=5 in each group).Peak bladder pressure and rise in pressure were chosen as outcome *** repeatedly obtain the necessary pressure values,telemetry sensors had been implanted into the rat bladders 10 days prior to ***:There was a highly significant improvement in the ability to build up peak pressure as well as a pressure rise in animals that had received muscle stem cells as compared to control(p=0.007)3 weeks after the cells had been *** mini-mal histologic evidence of scarring was observed in treated ***:Primary human muscle stem cells obtained using innovative technology functionally restore internal urethral sphincter function after *** into use in clinical settings is foreseeable.

关键词： human muscle stem cells sphincter injury telemetry urinary incontinence urodynamics

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Data Management Planning:How Requirements and Solutions are Beginning to Converge

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Data Intelligence 2020年第1期2卷 208-219,314,315,316页

作者： sarah Jones Robert Pergl Rob Hooft Tomasz Miksa Robert Samors Judit Ungvari Rowena I.davis Tina Lee Digital Curation Centre University of GlasgowGlasgow G128QQScotlandUK Czech Technical University in Prague Faculty of Information Technology(FIT CTU)16000 Prague 6Czech Republic Institute of Organic Chemistry and Biochemistry Czech Academy of SciencesCzech Republic Dutch Techcentre for Life Sciences Utrecht 3521 ALThe Netherlands Technische Universität Wien Wien 1040Austria Belmont Forum Western Australia WA 6105Australia

Effective stewardship of data is a critical precursor to making data *** goal of this paper is to bring an overview of current state of the art of data management and data stewardship planning solutions(DMP).We begin by arguing why data management is an important vehicle supporting adoption and implementation of the FAIR principles,we describe the background,context and historical development,as well as major driving forces,being research initiatives and *** we provide an overview of the current leading DMP tools in the form of a table presenting the key ***,we elaborate on emerging common standards for DMPs,especially the topic of machine-actionable *** sound DMP is not only a precursor of FAIR data stewardship,but also an integral part of it,we discuss its positioning in the emerging FAIR tools *** building and training activities are an important ingredient in the whole *** not being the primary goal of this paper,we touch also the topic of research workforce support,as tools can be just as much effective as their users are competent to use them *** conclude by discussing the relations of DMP to FAIR principles,as there are other important connections than just being a precursor.

关键词： FAIR Data management Data stewardship Machine-actionable DMP tools

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The Quantum Consistency of the Ten-Dimensional Heterotic String Effective Action

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Communications in Theoretical Physics 2011年第5期55卷 857-862页

作者： Simon davis Research Foundation of Southern California

The finiteness of superstring theory at each order in perturbation theory is considered with respect to the ten-dimensional effective action. The quantum consistency of the ten-dimensional superstring effective action is confirmed with an analysis of the perturbative expansion of the quartic sector. It is found to be compatible with the finiteness of reduced four-dimensional theory. Furthermore, implications for the validity of superstring perturbation theory at lower energies is considered.

关键词： effective action gauge potential renormalizability

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Univalent Functions and Diff(S^1)/S^1

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Acta Mathematica Sinica,English Series 2012年第6期28卷 1233-1236页

作者： Simon davis Research Foundation of Southern California

The relation between Diff（S^1）/S^1 and the space of univalent analytic functions on the disk is elucidated and shown to provide upper bounds for the volumes of exhaustive approximations to an analytic submanifold of an infinite-dimensional space. The maximum magnitudes of the coefficients in the series expansions of univalent superanalytic functions on the superdisk are inferred.

关键词： Univalent diffeomorphism group superanalytic functions

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Holomorphic Factorization of Superstring Scattering Amplitudes

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Communications in Theoretical Physics 2011年第1期55卷 1-5页

作者： Simon davis Research Foundation of Southern Califoria

The holomorphic factorization of the superstring partition function is verified at arbitrary genus. The evaluation of scattering amplitudes and the implications of genus-dependent estimates on the string coupling are ... 详细信息

关键词： holomorphic factorization Ramond measure supermoduli space coordinate

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Discrete composition control of two-dimensional morphologic all-inorganic metal halide perovskite nanocrystals

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Journal of Energy Chemistry 2021年第8期30卷 257-275,I0006页

作者： Andrew Hunter davis Weiwei Zheng Department of Chemistry Syracuse University13244 SyracuseUnited States

Metal halide perovskite nanocrystals(NCs)exhibit impressive optical and electronic properties,making them an important class of functional materials with promising applications in solar cells,light emitting diodes(LEDs),photodetectors,and *** addition to the widely studied 0-dimensional(0 D)metal halide perovskite NCs,such as nanocubes,low dimensional perovskites,such as 2 D all-inorganic perovskite(AIP)NCs,subsist with directionally relevant quantum *** anisotropic NCs have the propensity to exhibit interesting optoelectronic properties that are exceedingly difficult to introduce into 0 D systems,yet as of late are largely *** this review,we discuss the recent synthetic progress of 2 D all-inorganic metal halide perovskite NCs with ABX3 ***,we highlight the discrete composition control of the cations(A and B sites)and anions(X site)by dopant incorporation and alloying in 2 D metal halide perovskite *** will also discuss more complex perovskite crystal structures,such as Ruddlesden-Popper double perovskites,and compare these materials to 0 D perovskite ***,our work culminates in the future interests and perspectives of this field with a focus on the wide applicability of 2 D systems and the large variance in structure capable with discrete compositional tuning.

关键词： All-inorganic perovskites Two-dimensional nanocrystals Composition Doping Alloying Ion exchange

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INVESTIGATION OF THE ATRP OF n-BUTYL METHACRYLATE USING THE Cu(I)/N,N,N',N",N"-PENTAMETHYLDIETHYLENETRIAMINE CATALYST SYSTEM

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Chinese Journal of Polymer Science 2004年第2期22卷 195-204页

作者： Kelly A. davis Krzysztof Matyjaszewski Center for Macromolecular Engineering Department of Chemistry Carnegie Mellon University 4400 Fifth Ave.Pittsburgh Pennsylvania 15213 USACenter for Macromolecular Engineering Department of Chemistry Carnegie Mellon University 4400 Fifth Ave.Pittsburgh Pennsylvania 15213 USA

The polymerization of n-butyl methacrylate was investigated using the Atom Transfer Radical Polymerization technique with CuBr and CuCl/N,N,N',N',N'-pentamethyldiethylenetriamine catalytic systems. Various combinations of catalyst systems and initiators were utilized in order to optimize the polymerization conditions and to obtain well-defined polymers (i.e. controlled molecular weights and low polydispersities). It has been found that the optimal initiator for this system is a chlorine-based initiator, when the catalyst used is a salt in conjunction with the N,N,N',N',N'- pentamethyldiethylenetriamine ligand. Bromine-based initiators tend to result in large amounts of initial termination, leading to polymers with less than ideal chain end functionality, even if CuCl is used as the species to invoke the halogen exchange. Additionally, the effects of the polymerization temperature, species and the initiator structure were determined.

关键词： ATRP Atom transfer radical polymerization Controlled/living radical polymerization Butyl methacrylate Pentamethyldiethylenetriamine

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DISCONTINUOUS GALERKIN CALCULATIONS FOR A NONLINEAR PDE MODEL OF DNA TRANSCRIPTION WITH SHORT, TRANSIENT AND FREQUENT PAUSING

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Journal of Computational Mathematics 2014年第6期32卷 601-629页

作者： Lisa davis Tomas Gedeon Department of Mathematical Sciences Montana State University P.O. Box 172400 Bozeman MT 59717

A discontinuous Galerkin finite element method is used to approximate solutions to a classical traffic flow PDE. This PDE is used to model the biological process of transcription; the process of transferring genetic information from DNA either to mRNA or to rRNA. The transcription process is punctuated by short, frequent RNAP pauses which are incorporated into the model as traffic lights. These pauses cause a delay in the average transcription process. The DG solution of the nonlinear model is used to calculate the delay and to determine the effect of the pauses on the average transcription time. Numerical error measurements between the DG solution and the true solution （derived by the method of characteristics） are given for a simple model problem. It shows an excellent agreement in a neighborhood away from the shocks as well as C9（Ax） convergence for the delay calculation. Preliminary parameter studies indicate that in a system with multiple pauses both the location and time duration of the pauses can significantly affect the average delay experienced by an RNAP.

关键词： Discontinuous Galerkin finite element method Transcription LWR traffic flowmodel.

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Do black-furred animals compensate for high solar absorption with smaller hairs？ A test with a polymorphic squirrel species

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Current Zoology 2011年第6期57卷 731-736页

作者： Melanie A. FRATTO Andrew K. davis Odum School of Ecology The University of Georgia Athens GA USA 30602

In polymorphic mammalian species that display multiple color forms, those with dark, or melanic pelage would be prone to overheating, especially if they live in warm climates, because their fur absorbs solar energy at a higher rate. However, experimental studies indicate that certain physical properties of fur of dark individuals appear to prevent, or minimize heat stress, although it is not clear what properties do so. Here, we tested the possibility that black-furred individuals simply have shorter or thinner hair fibers, which would create a lighter （in terms of weight） coat or one that allows greater air flow for evaporative coo- ling. We examined museum specimens of eastern fox squirrels Sciurus niger, a species native to the United States and one that displays brown, grey or all-black pelage color, and used image analysis procedures to quantify hairs from the dorsal surface and tail. From examination of 43 specimens （19 brown, 9 black and 15 grey）, and 1,720 hairs, we found no significant difference in hair lengths across color morphs, but significant differences in hair fiber widths. Black squirrels had thinner body hairs than other forms （7% thinner）, but thicker tail hairs （9% thicker） than the others. Given that the dorsal surface would be directly exposed to solar radiation, we interpret this to be an adaptation to prevent heat stress during the day. The thicker tail hairs may be an adapta- tion for nighttime thermoregulation, since squirrels sleep with their tails wrapped around their bodies. These results add to a growing literature body of the functional significance of mammalian pelage [Current Zoology 57 （6）： 731-736, 2011].

关键词： Polymorphism Melanism Fox squirrels Sciurus niger Heat stress Hair morphology

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