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Orchestrating stem cell fate: Novel tools for regenerative medicine

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World Journal of Stem Cells 2019年第8期11卷 464-475页

作者： sara Cruciani sara Santaniello Andrea Montella Carlo Ventura Margherita Maioli Department of Biomedical Sciences University of Sassari Sassari 07100 Italy Laboratory of Molecular Biology and Stem Cell Engineering National Institute of Biostructures and Biosystems – Eldor Lab Innovation Accelerator Consiglio Nazionale delle Ricerche Bologna 40129 Italy Operative Unit of Clinical Genetics and Developmental Biology Sassari 07100 Italy Istituto di Ricerca Genetica e Biomedica Consiglio Nazionale delle Ricerche Cagliari 09042 Italy Center for Developmental Biology and Reprogramming-CEDEBIOR Department of Biomedical Sciences University of Sassari Sassari 07100 Italy

Mesenchymal stem cells are undifferentiated cells able to acquire different phenotypes under specific stimuli. In vitro manipulation of these cells is focused on understanding stem cell behavior, proliferation and pluripotency. Latest advances in the field of stem cells concern epigenetics and its role in maintaining self-renewal and differentiation capabilities. Chemical and physical stimuli can modulate cell commitment, acting on gene expression of Oct-4, Sox-2 and Nanog, the main stemness markers, and tissue-lineage specific genes. This activation or repression is related to the activity of chromatin-remodeling factors and epigenetic regulators, new targets of many cell therapies. The aim of this review is to afford a view of the current state of in vitro and in vivo stem cell applications, highlighting the strategies used to influence stem cell commitment for current and future cell therapies. Identifying the molecular mechanisms controlling stem cell fate could open up novel strategies for tissue repairing processes and other clinical applications.

关键词： Stem cells Epigenetics Self-renewal In vitro differentiation Physical stimuli Stem cell fate Clinical practice Cell transplantation

Fuzzy-entropy based robust optimization criteria for tuned mass dampers

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Earthquake Engineering and Engineering Vibration 2010年第2期9卷 285-294页

作者： Giuseppe Carlo Marano Giuseppe Quaranta sara Sgobba Department of Environmental Engineering and Sustainable Development Technical University of Bari Department of Structural Engineering and Geotechnics University of Rome "La Sapienza" Faculty of Engineering International University UNINETTUNO

Tuned mass dampers (TMD) are well known as one of the most widely adopted devices in vibration control passive strategies. In the past few decades,many methods have been developed to find the optimal parameters of a TMD installed on a structure and subjected to a random base excitation process,but most of them are usually based on an implicit assumption that all of the structural parameters are deterministic. However,in many real cases this simplification is unacceptable,so robust optimal design criteria becomes aviable alternative to better support engineers in the design process. In Robust Design Optimization (RDO) approaches,indeed the solution must be able to not only minimize the performance but also to limitits variation induced by uncertainty. Most of the currently available RDO methods are based on a probabilistic description of the model uncertainty,even if in many cases they are not able to explicitly include the influence of all the possible sources of uncertainties. Therefore,in this study,a fuzzy version of the robust TMD design optimization problem is proposed. The consistency of the fuzzy approach is studied with respect to the available non-probabilistic formulations reported in the literature and an application to an example of a robust design of a linear TMD subjected to base random vibrations in the presence of fuzzy uncertainties. The results show that the proposed fuzzy-based approach is able to give a set of optimal solutions both in terms of structural efficiency and sensitivity to mechanical and environmental uncertainties.

关键词： tuned mass damper random vibration robust design fuzzy variable expected value fuzzy entropy

Machine Learning Techniques for Software Maintainability Prediction:Accuracy Analysis

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Journal of Computer Science & Technology 2020年第5期35卷 1147-1174页

作者： sara Elmidaoui Laila Cheikhi Ali Idri Alain Abran Softtrare Project Management TeamEcole Nationale Superieure d'Informattique et d'Analyse des SystemesMadinate Al IrfaneMohammed V University in Rabat.Agdal RabatBP 713Morocco Department of Software Engineering&Infonnation Technology Ecole de Technologie Superieure(ETS)Montreal HSC IKSCanada

Maintaining software once implemented on the end-user side is laborious and,over its lifetime,is most often considerably more expensive than the initial software *** prediction of software maintainability lias emerged as an important research topic to address industry expectations for reducing costs,in particular,maintenance *** and practitioners have been working on proposing and identifying a variety of techniques ranging from statistical to machine learning(ML)for better prediction of software *** review has been carried out to analyze the empirical evidence on the accuracy of software product maintainability prediction(SPMP)using ML *** paper analyzes and discusses the findings of 77 selected studies published from 2000 to 2018 according to the following criteria:maintainability prediction techniques,validation methods,accuracy criteria,overall accuracy of ML techniques,and the techniques offering the best *** review process followed the well-known syslematic review *** results show that ML techniques are frequently used in predicting *** particular,artificial neural network(ANN),support vector machine/regression(SVM/R).regression&decision trees(DT),and fuzzy neuro fuzzy(FNF)techniques are more accurate in terms of PRED and *** N-fold and leave-one-out cross-validation methods,and the MMRE and PRED accuracy criteria are frequently used in empirical *** general,ML techniques outperformed non-machine learning techniques,e.g.,regression analysis(RA)techniques,while FNF outperformed SVM/*** ANN in most ***,while many techniques were reported superior,no specific one can be identified as the best.

关键词： accuracy criterion accuracy value machine learning technique maintainability prediction

Optimization of the treatment with immunosuppressants and biologics in inflammatory bowel disease

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World Journal of Gastroenterology 2014年第29期20卷 9675-9690页

作者： sara Renna Ambrogio Orlando Division of Internal Medicine ‘‘Villa Sofia-V.Cervello’’ Hospital

Many placebo controlled trials and meta-analyses evaluated the efficacy of different drugs for the treatment of inflammatory bowel disease (IBD), including immunosuppressants and biologics. Their use is indicated in moderate to severe disease in non responders to corticosteroids and in steroid-dependent patients, as induction and maintainance treatment. Infliximab, as well as cyclosporine, is considered a second line therapy in the case of severe ulcerative colitis, or non-responders to intravenous corticosteroids. An adequate dosage and duration of therapy with thiopurines should be reached before evaluating their efficacy. Methotrexate is a valid option in patients with Crohn’s disease but its use is confined to patients who are intolerant or non-responders to thiopurines. Evidence for the use of methotrexate in ulcerative colitis is insufficient. The use of thalidomide and mycophenolate mofetil is not recommended in patients with inflammatory bowel disease, these treatments could be considered in case of failure of all other therapeutic options. In patients with moderately active ulcerative colitis, refractory to thiopurines, the use of tacrolimus is considered an alternative to biologics. An increase of the dose or a decrease in the interval of administration of biological treatment could be useful in the presence of an incomplete clinical response. In the case of primary failure of an anti-tumor necrosis factor alpha a switch to another one should be considered. Data on the efficacy of combination therapy are up to now insufficient to consider this strategy in all IBD patients. The final outcome of the treatment should be considered the clinical remission, with mucosa healing, and not the clinical response. The evaluation of serum concentration of thiopurine methyl transferase activity, thiopurine metabolites, biologic serum levels and antibiologic antibodies could be useful for the management of the treatment but it has not been routinely applied in cl

关键词： Inflammatory bowel disease Optimization Immosuppressants Biologics Crohn's disease Ulcerative colitis

A comparison of condensate mass of QCD vacuum between Wilson line approach and Schwinger effect

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Chinese Physics C 2021年第4期45卷 123-129页

作者： sara Tahery Xurong Chen Liping Zou Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China University of Chinese Academy of Sciences Beiing 100049China Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China

We studied the condensate mass of QCD vacuum through the duality approach via dilaton wall back-ground in the presence of the parameter c,which represents the condensation in a holographic set ***,fromWilson line calculation,we found m_(0)^(2)(i.e.,the condensate parameter in mixed non-local condensation),whose beha-vior mimics that of *** value of m_(0)^(2)that we found by this approach is in agreement with QCD *** we considered the produced mass m via the Schwinger effect mechanism in the presence of the parameter *** show that vacuum condensation generally contributes the mass dominantly and that the produced mass via *** effect is suppressed by m_(0).

关键词： AdS/QCD holographic Schwinger effect gluon condensation of vacuum

Photocatalytic activity of cation(Mn) and anion(N) substitution in LaCoO3 nanoperovskite under visible light

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Rare Metals 2020年第2期39卷 139-146页

作者： Parvaneh Nakhostin Panahi Mohammad Hossein Rasoulifard sara Babaei Department of Chemistry Faculty of ScienceUniversity of ZanjanZanjan ***Iran

LaCoO3 compound and novel photocatalysts of LaCo0.8Mn0.2O3 and N-doped LaCoO3 were synthesized by sol-gel *** structure,morphology,size of particles and optical properties of the obtained powders were characterized by X-ray diffractometer(XRD),scanning electron microscopy(SEM) and ultraviolet-visible(UV-Vis)(DRS mode) *** perovskite structure obtained for all the prepared samples and doping Mn and N do not change the perovskite *** results revealed that the size of particles of all perovskites was less than 100 *** to that of parent LaCoO3,the band gap energy of LaCo0.8Mn0.2O3 and N-doped LaCoO3 considerably reduced due to the formation of impurity *** photocatalytic activity of all samples was evaluated by the degradation of malachite green as a model dye under visible light *** discoloration induced by LaCo0.8Mn0.2O3 was twice that induced by pure LaCoO3 because of Mn ions with variable valance and smaller band gap *** nitrogen incorporation also significantly improved the photocatalytic activity of LaCoO3 due to more oxygen vacancies and the stronger absorption in visible *** general,doping has been served as one of the most efficient methods for the improvement in band gap of photocatalysts.

关键词： Nanoperovskite Photocatalyst Dyes contaminant Mn doping N doping

PGA and structural dynamics input motion at a given site

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Earthquake Engineering and Engineering Vibration 2003年第1期2卷 25-34页

作者： Fabio Casciati sara Casciati Alberto Marcellini Dept.of Structural Mechanics University of Pavia27100 PaviaItaly Professor Dept.of Structural Mechanics University of Pavia27100 PaviaItaly Ph.D.Student CNR-IDPA 20133 MilanoItaly Research Director

The computation of the representative ground motions,to be used as input for the dynamic analyses of a struc- ture at a particular site,can be approached by several *** choice of the approach depends on two factors:the da- ta available and the type of problem to be *** paper reports the experience of the authors in approaching a specific case study:the Southern Memnon Colossus,located in Luxor,*** results are of interest when the hazard analysis estimation in developing countries and the safeguard of cultural heritage are *** have to be treated as important structures,due to their historical and economical ***,standard procedures of probabilistic seismic haz- ard analysis for the seismic classification of common buildings have to be *** the other hand,the consequences of the collapse of a monument are not comparable to those related to structures such as nuclear power plants and large dams, for which the deterministic seismic hazard analysis provides a straightforward framework for evaluation of the worst case ground ***'intermediate'approach,which requites a lower amount of input data with respect to the deterministic one,is *** stochastic component can eapture significant eharacteristics of earthquakes,primarily the frequency contents which depend on the magnitude(often referred to as the earthquake scaling law).

关键词： accelerograms hazard analysis site effects structural dynamics

Combining Knowledge-and Data-Driven Fuzzy Approach to Evaluate Shelf-Life of Various Seafood Products

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Food Quality and Safety 2021年第4期5卷 351-360页

作者： Marzieh Moosavi-Nasab sara Khoshnoudi-Nia Department of Food Science and Technology School of AgricultureShiraz UniversityShirazIran and"Seafood Processing Research GroupSchool of AgricultureShiraz UniversityShirazIran

Due to the complexity of the deterioration process of seafood products,relying on one indicator is not adequate to determine the quality of such ***,shelf-life was estimated based on various indicators complicating the decision-making *** Support Systems are considered as a good *** current study aims to establish a simple and novel fuzzy model based on a combination of knowledge-and data-driven approaches to define a fuzzy quality deterioration index(FQDI)in various seafood products(rainbow trout,threadfin bream,and white shrimp samples)during cold *** volatile basic nitrogen(TVB-N)and psychrotrophic microorganisms counts(PMCs)were determined based on traditional *** sensory analysis was performed by a data-driven fuzzy ***,the shelf-life of the rainbow trout fillet was estimated to be 8 d,based on all the freshness ***,the shelf-life of the Japanese threadfin bream fillet was 5-7 d according to the microbial and chemical parameters,*** time for shrimp samples was 6-8 d using sensory score and TVB-N *** results of data-driven fuzzy approach showed all of the quality properties were considered as the'Important'-'Very Important'(defuzzification score>75).The TVB-N and PMCs were the most and weakest freshness quality properties(defuzzified-values:84.64 and 78.75,respectively).Based on FQDI,the shelf-life of the rainbow trout,Japanese threadfin bream,and shrimp samples were estimated to be 8,5,and 7 d,*** method was able to successfully provide a comprehensive deterioration index for evaluating the seafood *** a total index can be considered as a comprehensive output(y variable)to predict seafood freshness by rapid and nondestructive method.

关键词： Decision Support Systems shelf-life fuzzy quality deterioration index seafood

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外国语 2007年第5期30卷 56-63页

作者： sara Laviosa Facoltà di Lingue e Letterature Straniere Università di BadItaly

Corpus-based translation studies has grown considerably over the past fifteen years or *** paper appraises the uniformity and diversity of descriptive corpus studies of translation in terms of divergent similarity,as intended by Andrew Chesterman(1996,2004a,2006).The analysis focuses on the state of the art of research into translation universals,highlighting the interdisciplinary nature of current investigations and their contribution to the progress of the discipline as a *** general framework proposed by Chesterman is also used to introduce an envisaged study of Anglieisms whose aim is twofold:to unveil the translation-specific lexical primings of English loan words in the Italian language of business,finance and economics vis -à-vis donor and roceptor languages,and to infer the norms that govern the translation of Anglicisms vis-à-vis original text production in a specific domain and genre.

关键词：相似性差异性翻译英语教学全局观大学