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Real-world clinical efficacy of tofacitinib in moderate-to-severe ulcerative colitis

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World Journal of Gastroenterology 2024年第34期30卷 3929-3931页

作者： sara R lopes Claudio Martins Madalena Teixeira David Tomás Department of Gastroenterology Unidade Local de Saúde da Arrábida-Hospital de São BernardoSetúbal 2910-446Portugal

Tofacitinib is an oral small-molecule Janus kinase(JAK)inhibitor that preferentially inhibits JAK1 and *** efficacy in inducing and maintaining remission in ulcerative colitis(UC)as well as its safety profile has been demonstrated in multicenter,randomized,double-blind,placebo-controlled ***,real-world studies evaluating the effectiveness and adverse effects of tofacitinib have been conducted,affirming its clinical efficacy in moderate-to-severe UC.

关键词： Ulcerative colitis Tofacitinib Real-world studies Inflammatory bowel disease Janus kinase inhibitor

Delay Times and Clinical Outcomes in Acute Myocardial Infarction: Comparison of Periods before and during the COVID-19 Pandemic—Myocardial Infarction and the Pandemic

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World Journal of Cardiovascular Diseases 2024年第6期14卷 392-400页

作者： Clarice Teixeira Silva Araújo Arnon Salviato Mameri Thúlio Carrera Guarçoni Venturini Marcus Tadeu Aguilar Constantino Matos Igor Morais Araujo lopes Luiz Gustavo Ribeiro de Carvalho Murad Cleberson Duartes Ovani Guilherme Vassalo Morais Fernanda Venturini de Castro Danielle lopes Rocha Lucas Crespo de Barros Rodolfo Costa Sylvestre Luiz Fernando Machado Barbosa Roberto ramos Barbosa Internal Medicine Universidade Federal do Esprito Santo (UFES) Vitria Brazil Hospital Santa Casa de Misericrdia de Vitria Vitria Brazil Hospital Santa Rita de Cssia Vitria Brazil Hospital Estadual Dr. Jayme Santos Neves Serra Brazil Grupo Kora Sade Vitria Brazil Hospital Estadual Infantil e Maternidade Alzir Bernardino Alves (HIMABA) Vila Velha Brazil

Introduction: At the beginning of the COVID-19 pandemic, a drop in the number of patients treated for cardiac emergencies raised concern about cardiovascular mortality in that period. An increase in care delay for patients with ST-segment elevation myocardial infarction (STEMI) may have affected clinical outcomes. Objectives: To analyze delay times and clinical outcomes of patients with STEMI undergoing primary percutaneous coronary intervention (PPCI), before and during the COVID-19 pandemic. Methods: Retrospective observational study that included patients with STEMI undergoing PPCI from December 2018 to July 2021. The COVID-19 pandemic cases were divided into two groups: pandemic I—from March to August 2020;and pandemic II—from September 2020 to July 2021. Patients were compared according to the period of hospitalization. Primary outcomes were delay times in assistance and clinical outcomes (acute kidney injury [AKI], post-procedural vascular complications and in-hospital mortality). Results: 108 patients were included, 39 (36.1%) in the pre-pandemic period, 13 (12.1%) in pandemic I and 56 (51.8%) in pandemic II. Time from onset of symptoms to arrival at the service and door-to-balloon time did not differ significantly among groups. Vascular complications were more frequent during the pandemic (I and II) than in the pre-pandemic period (2.5% pre-pandemic vs 15.4% pandemic vs 12.5% pandemic II;p = 0.03). AKI incidence was similar in all three periods. There was a non-significant increase in in-hospital mortality during the COVID-19 pandemic. Conclusion: In patients with STEMI, there was an increase in vascular complications and a trend toward increased mortality during the COVID-19 pandemic. Delay times to admission and reperfusion did not differ significantly between before and during the pandemic.

关键词： Myocardial Infarction Primary Percutaneous Coronary Intervention Coronary Reperfusion Pandemic COVID-19

Behavioral and endocrine responses to noninteractive live and video conspecifics in males of the Siamese fighting fish

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Current Zoology 2023年第5期69卷 568-577页

作者： Deepa Alex sara DCardoso Andreia ramos David Gonçalves Institute of Science and Environment University of Saint JosephRua de Londres 106Macao SARChina

The physiological mechanisms underlying variation in aggression in fish remain poorly *** possibly confounding variable is the lack of standardization in the type of stimuli used to elicit *** presentation of controlled stimuli in videos,*** playback,can provide better control of the fight ***,this technique has produced conflicting results in animal behavior studies and needs to be carefully *** this,a similar response to the video and an equivalent live stimulus needs to be ***,different physiological responses may be triggered by live and video stimuli,and it is important to demonstrate that video images elicit appropriate physiological ***,the behavioral and endocrine responses of male Siamese fighting fish Betta splendens to a matched-for-size conspecific fighting behind a one-way mirror,presented live or through video playback,were *** video playback and live stimulus elicited a strong and similar aggressive response by the focal fish,with a fight structure that started with stereotypical threat displays and progressed to overt *** plasma levels of the androgen 11-ketotestosterone were elevated as compared to controls,regardless of the type of *** also increased in response to the video images,as previously described for live fights in this *** results show that the interactive component of a fight and its resolution are not needed to trigger an endocrine response to aggression in this *** study also demonstrates for the first time in a fish a robust endocrine response to video stimuli and supports the use of this technique for researching aggressive behavior in ***.

关键词： aggression androgens corticosteroids Betta splendens one-way mirror video playback

Antihypertensive drugs in pregnancy

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Family Medicine and Community Health 2013年第1期1卷 37-50页

作者： ROSE GASNIER EDIMARLEI GONSALES VALERIO JOSE GERALDO lopes ramos Post Graduate Program in Medicine Universidade Federal do Rio Grande do SulHospital de Clinicas de Porto AlegreBrazil Service of Obstetrician and Gynecology Hospital de Clinicas de Porto AlegreBrazil Universidade Federal do Rio Grande do Sul Porto AlegreBrazil

Chronic hypertension complicates 3%-5% of pregnancies and gestational hypertension occurs in 6% of *** complicates 25% of the pregnancies with chronic hypertension,and approximately 15%-45% of the patients with gestational hypertension will develop preeclampsia,a dangerous condition that harms the maternal and fetal *** medication is used to treat severe hypertension to prevent serious maternal and fetal complications,but there is no consensus on when and how to treat mild-to-moderate hypertension in *** article reviews the usage,effect and safety of first,second and third line antihypertensive drugs for mild-to-moderate hypertension in pregnancy.

关键词： Gestational hypertension Mild-to-moderate hypertension Antihypertensive drugs

What do we know about pseudodementia?

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General Psychiatry 2023年第4期36卷 231-238页

作者： SaloméMouta Isabel Fonseca Vaz Miguel Pires sara ramos Diana Figueiredo Departamento de Psiquiatria e Saúde Mental Unidade Local de Saude da Guarda EPEGuardaPortugal Departamento de Saúde Mental Unidade Local de Saúde de Matosinhos EPEMatosinhosPortugal

Depression and dementia can lead to generalised cognitive and memory ***,differentiating these disorders is important and *** is a term used clinically to describe symptoms that resemble dementia but are caused by other conditions(most frequently depression),rather than being recognised as an official *** is characterised by a cognitive impairment that mimics dementia but which does not have its origin in neurological degeneration,deriving instead from functional psychiatric *** condition is more commonly observed in older adults(particularly those over the age of 50 or 60 years),and its risk factors overlap with those for *** is essentially characterised by deficits in memory,executive function and speech and,therefore,can easily be confused with dementia,although there are aspects that allow its *** pseudodementia can be difficult,especially as there is significant overlap between its symptoms and those of other ***,it is important to recognise characteristic aspects of this disorder,as its correct identification is essential for proper treatment.

关键词： degeneration overlap instead

“Love Is Strong, and You＇re so Sweet”： JAGGER Is Essential for Persistent Synergid Degeneration and Polytubey Block in Arabidopsis thaliana

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Molecular Plant 2016年第4期9卷 601-614页

作者： Ana Marta Pereira Margarida Sofia Nobre sara Cristina Pinto Ana Lucia lopes Mario Luis Costa Simona Masiero Silvia Coimbra Departamento de Biologia Faculdade de Ciencias da Universidade do Porto Rua do Campo Alegre 4169-007 Porto Portugal Plant Functional Genomics Group Biosystems and Integrative Sciences Institute (BiolSI) 4169-007 Porto Portugal Dipartimento di BioScienze Universita degli Studi di Milano 20133 Milan Italy Present address: Institute of Plant Biology and ZUrich-Basel Plant Science Center University of ZUrich Zolikerstrasse 107 8008 Zurich Switzerland

Successful double fertilization and subsequent seed development in flowering plants requires the delivery of two sperm cells, transported by a pollen tube, into the embryo sac of an ovule. The embryo sac cells tightly control synergid cell death, and as a result the polyspermy block. Arabinogalactan proteins are highly glycosylated proteins thought to be involved in several steps of the reproductive process. We show that JAGGER, Arabinogalactan Protein 4, is an important molecule necessary to prevent the growth of multiple pollen tubes into one embryo sac in Arabidopsis thaliana. In jagger, an AGP4 knockout mutant, the pistils show impaired pollen tube blockage as a consequence of the survival of the persistent synergid. JAGGER seems to be involved in the signaling pathway that leads to a blockage of pollen tube attraction. Our results shed light on the mechanism responsible for preventing polyspermy in Arabidopsis and for safe- guarding successful fertilization of all ovules in one pistil, ensuring seed set and the next generation.

关键词： Polytubey persistent synergid arabinogalactan proteins polyspermy

Antibacterial,pro-angiogenic and pro-osteointegrative zein-bioactive glass/copper based coatings for implantable stainless steel aimed at bone healing

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Bioactive Materials 2021年第5期6卷 1479-1490页

作者： Laura ramos Rivera Andrea Cochis sarah Biser Elena Canciani sara Ferraris Lia Rimondini Aldo R.Boccaccini Institute of Biomaterials Department of Materials Science and EngineeringUniversity of Erlangen-NurembergErlangenGermany Department of Health Sciences Universita del Piemonte UPONovaraItaly Center for Translational Research on Autoimmune and Allergic Diseases-CAAD NovaraItaly Department of Department of Biomedical Surgical and Dental SciencesThin Section LabUniversity of MilanMilanItaly Department of Applied Science and Technology Politecnico di TorinoTurinItaly

Stainless steel implants are suitable candidates for bone replacement due to their cytocompatibility and mechanical resistance,but they suffer from lack of bioactivity and are prone to bacterial ***,to overcome those limitations,in this study we developed by electrophoretic deposition(EPD),an innovative surface coating made of(i)zein,a natural fibroblast-friendly polymer,(ii)bioactive glass,a pro-osteogenic inorganic material and(iii)copper containing bioactive glass,an antibacterial and pro-angiogenic *** images confirmed that porous,uniform and free of cracks coatings were obtained by EPD;moreover,coatings were resistant to mechanical stress as demonstrated by the tape test,resulting in a 4B classification of adhesion to the *** coatings were cytocompatible as indicated by metabolism evaluation of human fibroblasts,endothelial cells and mature or progenitor osteoblasts cultivated in direct contact with the *** also maintained pro-osteogenic properties towards undifferentiated progenitor cells that expressed osteogenic genes after 15 days of direct *** conferred antibacterial properties as biofilm formation of the joint pathogens Staphylococcus aureus,Staphylococcus epidermidis and Escherichia coli was significantly reduced in comparison with copper-free coatings(p<0.05).Moreover,this anti-infective activity resulted as targeted towards bacteria while the cells viability was preserved when cells and bacteria were cultivated in the same environment by a co-culture ***,copper ability to recruit blood vessels and to inhibit bacterial infection was confirmed in vivo where the growth of *** biofilm was inhibited and the formation of new(<50μm diameter spread)blood vessels was observed.

关键词： Zein Bioactive glass Copper Bone Antibacterial

An overview of resistance to chemotherapy in osteosarcoma and future perspectives

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Cancer Drug Resistance 2022年第3期5卷 762-793页

作者： Dorian Yarih Garcia-Ortega sara Aileen Cabrera-Nieto Haydee sarai Caro-Sanchez Marlid Cruz-ramos Cirugia Oncologica Instituto Nacional de Cancerologia(INCAN)Ciudad de Mexico 14080Mexico Posgrado en Ciencias Medicas Facultad de Ciencias de la SaludUniversidad AnahuacCiudad de Mexico 52786Mexico Departamento de Patologi Instituto Nacional de Cancerologia(INCAN)Ciudad de México 14080Mexico Catedras de Consejo Nacional de Ciencia y Tecnologia(CONACYT) Instituto Nacional de CancerologiaCiudad de Mexico 14080Mexico

Osteosarcoma(OS)is the most common type of bone *** the availability of multimodal treatment with surgery and chemotherapy,the clinical results remain *** main reason for the poor outcomes in patients with OS is the development of resistance to methotrexate,cisplatin,doxorubicin,and *** and cellular mechanisms associated with resistance to chemotherapy include DNA repair and cell-cycle alterations,enhanced drug efflux,increased detoxification,resistance to apoptosis,autophagy,tumor extracellular matrix,and *** versatility of cells to generate chemoresistance has motivated the use of anti-angiogenic therapy based on tyrosine kinase *** approach has shown that other therapies,along with standard chemotherapy,can improve responses to therapy in patients with ***,microRNAs may act as predictors of drug resistance in *** review provides insight into the molecular and cellular mechanisms involved in the development of resistance during the treatment of OS and discusses promising novel therapies(e.g.,afatinib and palbociclib)for overcoming resistance to chemotherapy in OS.

关键词： Osteosarcoma therapy resistance tyrosine kinase inhibitor tumoral extracellular microenvironment cell cycle

Association between Hearing Loss and Vestibular Disorders: A Review of the Interference of Hearing in the Balance

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International Journal of Otolaryngology and Head & Neck Surgery 2015年第3期4卷 173-179页

作者： Tatiana G. T. Santos Alessandra ramos Venosa Andre Luiz lopes Sampaio University of Catholic Medical School Brasilia Brazil Department of Otolaryngology University Hospital of Brasilia Brasilia Brazil

Introduction: Dizziness is very prevalent and makes a great impact on people’s life. Because of anatomical and functional similarities of hearing and vestibular systems, it is noted that there is a big relation between hearing loss and vestibular disorders. Depending on the age onset of hearing loss, it can cause even delay on motor development. Objective: To find literature that demonstrates the relation between hearing and balance. Confirming that hearing loss or even intervention to improve quality of hearing can interfere on vestibular system. Methodology: Revision of literature was carried out, preferring recent research only in English. Conclusion: Cochlea and vestibular systems have a close relationship;changes in one of them can cause big damage in the other. So, a complete evaluation of vestibular system is recommended before ear surgeries. Video Head Impulse Test is a new procedure able to evaluate high frequency movements of the head. It was an additional exam of vestibular status and came to help detect problems that were not diagnosed before. Efforts must be directed in order to protect the balance.

关键词： Hearing Loss Cochlear Implant Vestibular Disorders Dizziness and Vertigo