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C3G contributes to platelet activation and aggregation by regulating major signaling pathways

Signal Transduction and Targeted Therapy 2020年第1期5卷 2103-2117页

作者： sara Gutiérrez-Herrero Cristina Fernández-Infante Luis Hernández-Cano sara ortiz-rivero Carlos Guijas Víctor Martín-Granado JoséRamón González-Porras Jesús Balsinde Almudena Porras Carmen Guerrero Instituto de Biología Molecular y Celular del Cáncer(IMBCC) University of Salamanca-CSICSalamancaSpain Instituto de Investigación Biomédica de Salamanca(IBSAL) SalamancaSpain Instituto de Biología y Genética Molecular(IBGM) Consejo Superior de Investigaciones Científicas(CSIC)University of ValladolidValladolidSpain Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas(CIBERDEM) MadridSpain Departamento de Hematologiá Hospital Universitario de Salamanca(HUS)SalamancaSpain Departamento de Bioquímica y Biología Molecular Facultad de FarmaciaComplutense University of Madrid.Instituto de Investigación Sanitaria del Hospital Clínico San Carlos(IdISSC)MadridSpain Departamento de Medicina University of SalamancaSalamancaSpain

C3G is a GEF(guanine nucleotide exchange factor)for Rap GTPases,among which the isoform Rap1b is an essential protein in platelet *** transgenic mouse models with platelet-specific overexpression of C3G or mutant C3GΔCat,we have unveiled a new function of C3G in regulating the hemostatic function of platelets through its participation in the thrombin-PKCRap1b pathway.C3G also plays important roles in angiogenesis,tumor growth,and metastasis through its regulation of the platelet *** addition,C3G contributes to megakaryopoiesis and ***,we used a platelet-specific C3G-KO mouse model to further support the role of C3G in hemostasis.C3G-KO platelets showed a significant delay in platelet activation and aggregation as a consequence of the defective activation of Rap1,which resulted in decreased thrombus formation in ***,we explored the contribution of C3G-Rap1b to platelet signaling pathways triggered by thrombin,PMA or ADP,in the referenced transgenic mouse model,through the use of a battery of specific *** found that platelet C3G is phosphorylated at Tyr504 by a mechanism involving *** phosphorylation was shown to be positively regulated by ERKs through their inhibition of the tyrosine phosphatase ***,C3G participates in the ADP-P2Y12-PI3K-Rap1b pathway and is a mediator of thrombin-TXA2 ***,it inhibits the synthesis of TXA2 through cPLA2 *** together,our data reveal the critical role of C3G in the main pathways leading to platelet activation and aggregation through the regulation of Rap1b.

关键词： C3G platelet activation

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The Security of Platelet-rich Plasma in Sports-relatedInjuries

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Journal of Health Science 2014年第8期2卷 363-369页

作者： Leticia rivero Gonzalez Gabriel Lupon Escobar LluisTil Perez sara Estevez Sarmiento Fuerteventura Hospital Clinica Roca Sports Medical Unit Gran Canaria Hospital Universitario Insular de Gran Canaria LasPalmas de Gran Canaria Las Palmas 35016 Spain Sports Medicine Consorci Sanitari de Terrassa (CST) in Olympic Training Center (CAR) Sant Cugat del Vall~s 08173 Spain Sports Medicine FC Barcelona Barcelona 08028 Spain Hospital Universitario Insular de Gran Canaria Las Palmas de Gran Canaria Las Palmas 35016 Spain

Platelet-rich plasma （PRP） therapy in orthopedics and sports medicine has seen an expansion in use since 2003. Theobjective of this study is to not only review evidence of clinical effectiveness but also to evaluate its security and detect any disparitybetween its use and its popularity. A prospective, descriptive study, which included 104 athletes were performed. Minor adverse effectswere recorded and these were self-limited. Although there is a lack of more detailed studies which compare other factors, PRP therapyhas been shown to have positive results in relation to certain lesions.

关键词： Sports medicine, growth factors, muscles, tendons, ligaments, platelet-rich plasma.

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Whole exome sequencing identifies new susceptibility candidates underlying community-acquired pneumonia

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Genes & Diseases 2024年第6期11卷 47-51页

作者： Jacobo Pardo-Seco Sandra Viz-Lasheras Xabier Bello Alberto Gomez-Carballa Alba Camino-Mera sara Pischedda Maria Jose Curras-Tuala Irene rivero-Calele Ana Dacosta-Urbieta Fernando Caamano-Vina Carmen Rodriguez-Tenreiro Sanchezz Isabel Cifuentes Cristina Mendez Chiea Chuen Khor Federico Martinon-Torres Antonio Salas on behalf of the CAPPRIC study group Unidade de Xenetica Instituto de Ciencias ForensesFacultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstitutode Investigacion Sanitaria(IDIS)Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoUniversidade de Santiago de CompostelaSantiago de CompostelaGalicia 15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBERES) Madrid 28029Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Medical Department Pfizer S.L.U.AlcobendasMadrid 28108Spain Genome Institute of Singapore Agency for ScienceTechnology and ResearchSingapore 138632Singapore 不详

Pneumonia is an inflammatory condition of the lung with symptoms that include productive dry cough,fever,chest pain,and difficulty breathing,and it is usually caused by viruses and bacteria,but also other microorganisms(such as fungi and parasites).Community-acquired pneumonia(CAP)is a major cause of infectious diseases,hospitalization,and mortality,especially in the elderly population.

关键词： pneumonia mortality lung

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Multi-tissue transcriptomics of a unique monozygotic discordant twin case of severe progressive osseous heteroplasia

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Genes & Diseases 2024年第3期11卷 22-25页

作者： Alberto Gomez-Carballa Maria Jose Curras-Tuala sara Pischedda Miriam Cebey-Lopez Jose Gomez-Rial Irene rivero-Cale Jacobo Pardo-seco Xabier Bello Sandra Viz-Lasheras Antonio Justicia-Grande Julian Montoto-Louzao Alba Camino-Mera Isabel Ferreiros-Vidal Maximo Fraga Jose RAntunez Rodolfo Gomez Federico Martinon-Torres Antonio Salas Genetics Vaccines and Infections Research Group(GENVIP)Instituto de Investigacion Sanitaria de SantiagoSantiagode CompostelaGalicia 15706Spain Translational Pediatrics and Infectious Diseases Department of PediatricsHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Laboratorio de Inmunologia Servicio de Andlisis ClinicosHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Unidade de Xenetica Instituto de Ciencias Forenses(INCIFOR)Facultade de MedicinaUniversidade de Santiago de Compostelaand GenPoB Research GroupInstituto de Investigacion SanitariaHospital Clinico Universitario de Santiago de CompostelaServicio Galego de Saude(SERGAS)Galicia 15706Spain Musculoskeletal Pathology Group Instituto de Investigacion Sanitaria de SantiagoServicio Galego de Saude(SERGAS)Santiago de CompostelaGalicia 15706Spain Department of Pathology Hospital Clinico Universitario de Santiago de Compostela(SERGAS)Galicia 15706Spain Unidad Integrada de BiobancosBiomodelos 3D y Modelos Animales IDIS(lnstituto de Investigacion Sanitaria de Santiagode Compostela)Galicia15706Spain Centro de Investigacion Biomedica en Red de Enfermedades Respiratorias(CIBER-ES) MadridSpain

Progressive osseous heteroplasia(POH)is an ultra-rare autosomal dominant disabling disorder characterized by heterotopic ossification(HO).It is caused by heterozygous inactivating mutations in the GNAS(guanine nucleotide-binding protein alpha-stimulating activity polypeptide)***,the molecular mechanisms underlying HO remain poorly *** a treatment for POH is not yet available,the identification of the mechanisms driving POH in affected tissues using gene expression may be of great help to underestand the molecular basis of POH and develop new therapeutic approaches.

关键词： stimulating driving asi

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From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones as NNRTIs with Improved Drug Resistance Properties——A Modular Focused Library Design Approach

From Hit to Lead:Design and Synthesis of Dihydro-pyrimidones...

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中国化学会第二十五届学术年会

作者： George Burton sara Thrall George Freeman Webb Andrews Benjamin Schwartz Elsie Diaz Jerry Jeffery Edward Garvey Bob Nolte Kirk Weaver Ralph rivero GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 . GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals Five Moore Drive Research Triangle Park North Carolina 27709. GlaxoSmithKline Pharmaceuticals 1250 S. Collegeville Road Pennsylvania 19426 .

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