检索结果-南通市图书馆

Nuclear receptors and pathogenesis of pancreatic cancer

World Journal of Gastroenterology 2014年第34期20卷 12062-12081页

作者： Simone Polvani Mirko Tarocchi sara Tempesti Andrea Galli Department of Experimental and Clinical Biomedical Sciences University of Florence50134 FlorenceItaly

Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a median overall survival time of 5 mo and the five years survival less than 5%, a rate essentially unchanged over the course of the years. A well defined progression model of accumulation of genetic alterations ranging from single point mutations to gross chromosomal abnormalities has been introduced to describe the origin of this disease. However, due to the its subtle nature and concurring events PDAC cure remains elusive. Nuclear receptors (NR) are members of a large superfamily of evolutionarily conserved ligand-regulated DNA-binding transcription factors functionally involved in important cellular functions ranging from regulation of metabolism, to growth and development. Given the nature of their ligands, NR are very tempting drug targets and their pharmacological modulation has been widely exploited for the treatment of metabolic and inflammatory diseases. There are now clear evidences that both classical ligand-activated and orphan NR are involved in the pathogenesis of PDAC from its very early stages; nonetheless many aspects of their role are not fully understood. The purpose of this review is to highlight the striking connections that link peroxisome proliferator activated receptors, retinoic acid receptors, retinoid X receptor, androgen receptor, estrogen receptors and the orphan NR Nur, chicken ovalbumin upstream promoter transcription factor II and the liver receptor homologue-1 receptor to PDAC development, connections that could lead to the identification of novel therapies for this disease.

关键词： Peroxisome proliferator activated receptor Pancreatic intraepithelial neoplasia COUP-TFⅡ Nuclear receptors Orphan nuclear receptor Nuclear receptors 4A2 Nuclear receptors 2F2 Pancreatic cancer Retinoid X receptor Testicular receptor 3

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Engineering carbon quantum dots for photomediated theranostics

引用

Nano Research 2018年第1期11卷 1-41页

作者： Mahbub Hassan Vincent G. Gomes Alireza Dehghani sara M. Ardekani School of Chemical and Biomolecular Engineering The University of Sydney NSW 2006 Australia

Carbon quantum dots （CQDs） have emerged as potential alternatives to classical metal-based semiconductor quantum dots （QDs） due to the abundance of their precursors, their ease of synthesis, high biocompatibility, low cost, and particularly their strong photoresponsiveness, tunability, and stability. Light is a versatile, tunable stimulus that can provide spatiotemporal control. Its interaction with CQDs elicits interesting responses such as wavelength-dependent optical emissions, charge/electron transfer, and heat generation, processes that are suitable for a range of photomediated bioapplications. The carbogenic core and surface characteristics of CQDs can be tuned through versatile engineering strategies to endow specific optical and physicochemical properties, while conjugation with specific moieties can enable the design of targeted probes. Fundamental approaches to tune the responses of CQDs to photo-interactions and the design of bionanoprobes are presented, which enable biomedical applications involving diagnostics and therapeutics. These strategies represent comprehensive platforms for engineering multifunctional probes for nanomedicine, and the design of QD probes with a range of metal-free and emer^in~ 2D materials.

关键词： carbon quantum dots nanobiophotonics therapeutics diagnostics nanomedicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Synthesis and Characterization of Z-scheme BiOBr/MIL-125(Ti) Composite for Nitrate Reduction with Advance Nitrogen Selectivity

Synthesis and Characterization of Z-scheme BiOBr/MIL-125(Ti)...

引用

作者： sara Khan 东北师范大学

学位级别：硕士

人类日益增多的工业活动造成了严重的水环境污染,而水体中硝酸盐的去除一直是水污染防控与治理的关键。硝酸盐(NO)是一种高度稳定的常见污染物,广泛存在于地表水和地下水中。硝酸盐能直接导致水体富营养化,对人体健康构成重大威胁。光... 详细信息

人类日益增多的工业活动造成了严重的水环境污染,而水体中硝酸盐的去除一直是水污染防控与治理的关键。硝酸盐(NO)是一种高度稳定的常见污染物,广泛存在于地表水和地下水中。硝酸盐能直接导致水体富营养化,对人体健康构成重大威胁。光催化还原硝酸盐产生氮气具有条件温和、操作简单、效率高、环境友好等优点,受到了科学家们的广泛关注。然而,传统的光催化材料存在载流子复合率高和光谱吸收范围窄等缺点,阻碍了光催化技术的进一步应用。因此,开发新型光催化材料是一个重大的挑战。本研究综合MOFs比表面积较大、导带位置负、BiOBr禁带窄等特点,构建了一系列新型BiOBr/MIL-125(Ti)复合材料,对其物理化学性质进行了表征,并将其应用于硝酸盐还原。最后对光催化活性的提高进行了合理的解释,并推测了可能的光催化机理。(1)通过溶剂热制备了一系列Z型BiOBr/MIL-125(Ti)复合材料。用X射线衍射(XRD)表征了样品的结晶度,用透射电镜(TEM)观察了样品的形貌,用傅立叶变换红外光谱(FT-IR)和X射线光电子能谱(XPS)分析了样品的化学组成,用紫外-可见漫反射(UV-vis-DRS)光谱和光致发光(PL)光谱分析了其光学性质。XRD、XPS和FT-IR结果表明,成功制备了BiOBr/MIL-125(Ti)复合材料。TEM结果表明BiOBr的薄片均匀分布在复合材料中MIL-125(Ti)的表面。UV-vis-DRS分析表明,MIL-125(Ti)光谱吸收范围主要在紫外光区域,引入BiOBr后,复合材料的光谱吸收范围拓展到可见光区域。(2)光催化实验结果表明,经过60 min的紫外光照射,在160℃下制备的BiOBr/MIL-125(Ti)复合材料(40%BiOBr)与原始BiOBr和MIL-125(Ti)(0.1mol L甲酸作为清除剂)相比,具有最高的硝酸盐还原能力(81.1%)和优良的氮选择性(95.3%)。BiOBr与MIL-125(Ti)的复合不仅拓宽了光谱吸收范围,而且形成了直接Z型异质结,增强了界面光生载流子的分离,从而显著提高了硝酸盐的还原活性和氮气选择性。PL光谱、瞬态光电流响应和电化学阻抗谱的结果进一步证实BiOBr/MIL-125(Ti)具有最高的光生载流子迁移效率。此外,BiOBr/MIL-125(Ti)复合材料表现出高的重复使用性能,连续三次循环后,硝酸盐转化率保持在81%以上。不同阴离子对硝酸盐还原效率的抑制作用大小顺序为PO>CO>Cl,其中PO抑制作用最强,导致硝酸盐还原率降至64.9%。通过自由基捕获实验和Mott-Schottky实验,提出了MIL-125(Ti)Z-scheme异质结光生电子空穴转移和光催化还原硝酸盐的可能机制。综上,本研究拓宽了MOFs材料在还原硝酸盐中的应用,同时为光催化技术还原硝酸盐提供了有效数据。

关键词：光催化 MIL-125(Ti) BiOBr Z-scheme 硝酸盐还原

来源：

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Growth of TiO2 Nanotube on Titanium Substrate to Enhance its Biotribological Performance and Biocorrosion Resistance

引用

Journal of Bionic Engineering 2019年第6期16卷 1039-1051页

作者： Jiajun Luo Bianhong Li sara Ajami Shuanhong Ma Feng Zhou Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science Division of Surgery&Interventional ScienceUniversity College LondonRoyal National Orthopaedic HospitalStanmoreHA14LPUnited Kingdom School of Mechatronical Engineering Beijing Institute of TechnologyBeijing 100081China State Key Laboratory of Solid L ubrication Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China

TiO2 nanotubes(NTs)have a great potential in improving the osetointegration of titanium(Ti)-based *** efforts have been made to evaluate the biological performance of the TiO2 nanotube in regulating protein adsorption and cells *** often used in orthopaedic applications,although biotribological performance and biocorrosion are important issues in these applications,few researches have been reported on the biotribological perfonnance of NT *** paper reports the preparation of a structure-optimised TiO2 NT(SO-NT)material via a multi-step oxidation strategy,as well as its biotribological and biocorrosion *** this procedure,an interfacial bonding layer of approximately 120 nm=150 nm was first formed on the titanium substrate,which was then joined to the NT *** mechanical testing with respect to impact,bending,and biotribological perfbnnance have demonstrated the resultant SO-NT layer possess improved mechanical stability compared to conventional *** uniform hyperfine interfacial bonding layer with nano-sized grains exhibited a strong bonding to NT layer and Ti *** was observed that the layer not only effectively dissipates external impacts and shear stress but also acts as a good corrosion resistance barrier to prevent the Ti substrate from *** models were proposed to analyze and predict the shear performance and corrosion-resistance mechanisms of the resultant *** obtained results demonstrated that the SO-NT material has great potential in orthopaedic applications.

关键词： TiO2 nanotubes tribology titanium implant surface modification biomaterials

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Micronutrient deficiencies in patients with chronic atrophic autoimmune gastritis: A review

引用

World Journal of Gastroenterology 2017年第4期23卷 563-572页

作者： Federica Cavalcoli Alessandra Zilli Dario Conte sara Massironi Gastroenterology and Endoscopy Unit Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico Postgraduate School of Gastroenterology Department of Pathophysiology and TransplantationUniversitàdegli Studi di Milano

Chronic atrophic autoimmune gastritis (CAAG) is an organ-specific autoimmune disease characterized by an immune response, which is directed towards the parietal cells and intrinsic factor of the gastric body and fundus and leads to hypochlorhydria, hypergastrinemia and inadequate production of the intrinsic factor. As a result, the stomach’s secretion of essential substances, such as hydrochloric acid and intrinsic factor, is reduced, leading to digestive impairments. The most common is vitamin B12 deficiency, which results in a megaloblastic anemia and iron malabsorption, leading to iron deficiency anemia. However, in the last years the deficiency of several other vitamins and micronutrients, such as vitamin C, vitamin D, folic acid and calcium, has been increasingly described in patients with CAAG. In addition the occurrence of multiple vitamin deficiencies may lead to severe hematological, neurological and skeletal manifestations in CAAG patients and highlights the importance of an integrated evaluation of these patients. Nevertheless, the nutritional deficiencies in CAAG are largely understudied. We have investigated the frequency and associated features of nutritional deficiencies in CAAG in order to focus on any deficit that may be clinically significant, but relatively easy to correct. This descriptive review updates and summarizes the literature on different nutrient deficiencies in CAAG in order to optimize the treatment and the follow-up of patients affected with CAAG.

关键词： Chronic atrophic autoimmune gastritis Nutritional deficiency Vitamin B12 Iron Vitamin C Vitamin D Calcium Malabsorption

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Different behavioral profles between invasive and native nudibranchs:means for invasion success?

引用

Current Zoology 2024年第3期70卷 406-417页

作者： Armando Macali sara Ferretti Serena Scozzafava Elia Gatto Claudio Carere Ichthyogenic Experimental Marine Centre(CISMAR) Department of Ecological and Biological SciencesTuscia University01016 Borgo Le SalineTarquiniaItaly Department of Chemical Pharmaceutical and Agricultural SciencesFerrara Universityvia Luigi Borsari 4644121 FerraraItaly Department of Life Sciences and Biotechnology Ferrara Universityvia Luigi Borsari 4644121 FerraraItaly

Behavior is predicted to be a primary determinant of the success of the invasion process during the early phases of *** invaders with sympatric native species may provide a good approach to unravel behavioral traits involved in an invasion *** this study,we carried out an experimental simulation of the introduction and the acclimatization phase into a new environment and assessed the expression of activity,alertness,and habituation in an invasive Mediterranean population of the South African nudibranch Godiva quadricolor comparing its profles with those of the sympatric Mediterranean native nudibranchs Cratena peregrina and Caloria *** of these 3 species were subjected to 3 behavioral tests:spontaneous activity,carried out in the introduction phase(immediately after sampling)and after a week of acclimatization;alert test,in which a potential threat was simulated by means of a tactile stimulus,and habituation test,in which the same alert test stimulus was repeated 5 times at 30-min *** invasive *** showed higher levels of exploration activity,thigmotaxis,alertness,and sensitization than the native *** behavioral traits may represent pivotal drivers of the ongoing invasion process.

关键词： biological invasion invasive phenotype invertebrate cognition molluscs personality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surface area-volume ratios in insects

引用

Insect Science 2017年第5期24卷 829-841页

作者： sara Kuhsel Adrian Bruckner Sebastian Schmelzle Michael Heethoff Nico Bluthgen Department of Biology Technische Universitat Darmstadt Schnittspahnstrasse 3 D-64287 Darmstadt Germany

Body mass, volume and surface area are important for many aspects of the physiology and performance of species. Whereas body mass scaling received a lot of attention in the literature, surface areas of animals have not been measured explicitly in this context. We quantified surface area-volume （SA/V） ratios for the first time using 3D surface models based on a structured light scanning method for 126 species of pollinating insects from 4 orders （Diptera, Hymenoptera, Lepidoptera, and Coleoptera）. Water loss of 67 species was measured gravimetrically at very dry conditions for 2 h at 15 and 30 ℃ to demonstrate the applicability of the new 3D surface measurements and relevance for predicting the performance of insects. Quantified SA/V ratios significantly explained the variation in water loss across species, both directly or after accounting for isometric scaling （residuals of the SA/V - mass2/3 relationship）. Small insects with a proportionally larger surface area had the highest water loss rates. Surface scans of insects to quantify allometric SA/Vratios thus provide a promising method to predict physiological responses, improving the potential of body mass isometry alone that assume geometric similarity.

关键词： body size body shape 3D surface imaging sphericity structured light water loss

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Couple stress fluid flow in a rotating channel with peristalsis

引用

Journal of Hydrodynamics 2018年第2期30卷 307-316页

作者： Y.Abd elmaboud sara I.Abdelsalam Kh.S.Mekheimer Mathematics Department Faculty of Science and Arts Khulais University Of Jeddah Mathematics Department Faculty of Science Al-Azhar University (Assiut Branch) Department of Mechanical Engineering University of CaliforniaRiverside USA Basic Science Department Faculty of Engineering The British University in Egypt Mathematics Department Faculty of Science Al-Azhar University

This article describes a new model for obtaining closed-form semi-analytical solutions of peristaltic flow induced by sinusoidal wave trains propagating with constant speed on the walls of a two-dimensional rotating infinite channel. The channel rotates with a constant angular speed about the z-axis and is filled with couple stress fluid. The governing equations of the channel deformation and the flow rate inside the channel are derived using the lubrication theory approach. The resulting equations are solved, using the homotopy perturbation method（HPM）, for exact solutions to the longitudinal velocity distribution, pressure gradient, flow rate due to secondary velocity, and pressure rise per wavelength. The effect of various values of physical parameters, such as, Taylor＇s number and couple stress parameter, together with some interesting features of peristaltic flow are discussed through graphs. The trapping phenomenon is investigated for different values of parameters under consideration. It is shown that Taylor＇s number and the couple stress parameter have an increasing effect on the longitudinal velocity distribution till half of the channel, on the flow rate due to secondary velocity, and on the number of closed streamlines circulating the bolus.

关键词： Homotopy perturbation method (HPM) couple stress fluid rotating channel peristaltic transport

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simultaneous effects of magnetic field and space porosity on compressible Maxwell fluid transport induced by a surface acoustic wave in a microchannel

引用

Chinese Physics B 2013年第12期22卷 323-332页

作者： Khaled S.Mekheimer Soliman R.Komy sara I.Abdelsalam Mathematics & Statistics Department Faculty of Science Taif University Department of Mathematics Faculty of Science (Men) Al-Azhar University Department of Mathematics Faculty of Science Helwan University Basic Science Department Faculty of Engineering The British University in Egypt

Peristaltic motion induced by a surface acoustic wave of a viscous, compressible and electrically conducting Maxwell fluid in a confined parallel-plane microchannel through a porous medium is investigated in the presence of a constant magnetic field. The slip velocity is considered and the problem is discussed only for the free pumping case. A perturbation technique is employed to analyze the problem in terms of a small amplitude ratio. The phenomenon of a “backward flow” is found to exist in the center and at the boundaries of the channel. In the second order approximation, the net axial velocity is calculated for various values of the fluid parameters. Finally, the effects of the parameters of interest on the mean axial velocity, the reversal flow, and the perturbation function are discussed and shown graphically. We find that in the non-Newtonian regime, there is a possibility of a fluid flow in the direction opposite to the propagation of the traveling wave. This work is the most general model of peristalsis created to date with wide-ranging applications in biological, geophysical and industrial fluid dynamics.

关键词： peristaltic flow Maxwell fluid porous medium slip flow microchannel

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Advances and challenges in diagnosing and managing adult autoimmune enteropathy

引用

World Journal of Gastroenterology 2025年第2期31卷 128-131页

作者： Grigorios Christodoulidis sara E Agko Marina N Kouliou Konstantinos E Koumarelas Dimitris Zacharoulis Department of General Surgery University Hospital of LarissaLarissa 41110Greece Department of Intensive Care Unit Asklepios Paulinen Clinic WiesbadenWiesbaden 65197Germany Department of Emergency Medicine General Hospital of LarissaLarissa 41221Greece Department of Surgery University Hospital of LarissaLarissa 41334Greece

Autoimmune enteropathy(AIE)is a rare immune mediated disorder primarily affecting children,characterized by chronic diarrhea,malabsorption,vomiting,weight loss and villous *** has also been observed in adults presenting diagnostic and treatment challenges due to its overlap with other gastrointestinal disorders such as celiac *** diagnostic criteria for AIE include small bowel villous atrophy,lack of response to dietary restrictions,presence of anti-enterocyte antibodies,and predisposition to autoimmunity without severe *** criteria emphasize characteristic histological findings and exclusion of other causes of villous *** is associated with various autoimmune disorders and can present with overlapping features with Celiac disease,including villous atrophy but without significant intraepithelial *** primarily involves immunosuppression using corticosteroids,calcineurin inhibitors,and anti-tumor necrosis factor therapy,alongside nutri-tional *** the challenges,understanding AIE’s diverse manifest-ations and improving diagnostic criteria are essential for effective management and improved patient *** research is needed to elucidate the pathogenesis,disease progression and long-term outcomes of AIE.

关键词： Autoimmune enteropathy Diagnosis Prognosis Adult autoimmune enter-opathy and challenges Autoimmune enteropathy and treatment Autoimmune enteropathy and diagnostic criteria Pathophysiology of autoimmune enteropathy

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：