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Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 386-397页

作者： Vilma Pacheco-Barcia sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez Department of Medical Oncology Hospital Universitario de TorrejonMadrid 28850Spain Department of Internal Medicine Hospital Universitario de TorrejonMadrid 28850Spain Department of Medical Oncology Hospital Universitario Central de AsturiasOviedo 33011Spain Department of Medical Oncology Hospital Universitario Morales MeseguerUniversity of MurciaMurcia 30001Spain Department of Medical Oncology Hospital General Universitario de ElcheElche 03202Spain Department of Medical Oncology Hospital General Universitario Gregorio MarañónUniversidad Complutense MadridMadrid 28007Spain Universidad Francisco de Vitoria Madrid 28223Spain

BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains *** To study the prognostic significance of SIRI and weight loss in metastatic pancreatic *** The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work *** pilot study sought to analyze the association between weight loss and inflammatory status as defined by *** cohort stems from a proof-of-concept pilot study conducted at one of the coordinating *** with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were *** index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation *** study evaluated associations between overall survival(OS),SIRI and weight *** A total of 50 patients were included.66%of these patients were male and the median age was 66 *** sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple *** the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI *** difference was statistically significant(P<0.000).For pat

关键词： Pancreatic cancer Nutrition Prognostic factor Inflammation Advanced cancer Systemic inflammatory response index Weight loss

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Identification of druggable host dependency factors shared by multiple SARS-CoV-2 variants of concern

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Journal of Molecular Cell Biology 2024年第3期16卷 9-23页

作者： Ilaria Frasson Linda Diamante Manuela Zangrossi Elena Carbognin Anna Dalla Pietà Alessandro Penna Antonio Rosato Ranieri Verin Filippo Torrigiani Cristiano Salata Marìa Paula Dizanzo Lorenzo Vaccaro Davide Cacchiarelli sara N.Richter Marco Montagner Graziano Martello Department of Molecular Medicine University of PaduaPadua 35121Italy Department of Biology Armenise/Harvard Pluripotent Stem Cell Biology LaboratoryUniversity of PaduaPadua 35131Italy Department of Surgery Oncology and GastroenterologyUniversity of PaduaPadua 35128Italy Veneto Institute of Oncology IOV-IRCCS Padua 35128Italy Department of Comparative Biomedicine and Food Science University of PaduaPadua 35020Italy Telethon Institute of Genetics and Medicine(TIGEM) Armenise/Harvard Laboratory of Integrative GenomicsPozzuoli 80078Italy Department of Translational Medicine University of Naples Federico IINaples 80138Italy School for Advanced Studies Genomics and Experimental Medicine ProgramUniversity of Naples Federico IINaples 80138Italy Microbiology and Virology Unit Padua University HospitalPadua 35128Italy

The high mutation rate of SARS-CoV-2 leads to the emergence of multiple variants,some of which are resistant to vaccines and drugs targeting viral *** host dependency factors,*** proteins required for viral replication,would help prevent the development of ***,it remains unclear whether different SARS-CoV-2 variants induce conserved cellular responses and exploit the same core host *** this end,we compared three variants of concern and found that the host transcriptional response was conserved,differing only in kinetics and *** regularly interspaced short palindromic repeats screening identified host genes required for each variant during *** of the genes were shared by multiple *** validated our hits with small molecules and repurposed the US Food and Drug Administration-approved *** the drugs were highly active against all the tested variants,including new variants that emerged during the study(Delta and Omicron).Mechanistically,we identified reactive oxygen species production as a key step in early viral *** such as N-acetyl cysteine(NAC)were effective against all the variants in both human lung cells and a humanized mouse *** study supports the use of available antioxidant drugs,such as NAC,as a general and effective anti-COVID-19 approach.

关键词： SARS-CoV-2 variants of concern host dependency factors antivirals N-acetyl cysteine

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The Impact of Psychosocial Influences on Chronic Wound Healing

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Open Journal of Medical Psychology 2024年第3期13卷 39-57页

作者： Kelly Frasier Vivian Li sara Christoforides Kathleen Daly Alexandra Loperfito Karina Stech Milena Dragovic Nuvance Health/Vassar Brothers Medical Center Poughkeepsie NY USA Lake Erie College of Osteopathic Medicine New York NY USA Medical College of Georgia Augusta University Augusta GA USA Edward Via College of Osteopathic Medicine Blacksburg VA USA Lewis Katz School of Medicine Temple University Philadelphia PA USA College of Osteopathic Medicine California Health Sciences University Clovis CA USA

This comprehensive review explores the intricate dynamics between psychosocial factors and chronic wound healing processes, specifically focusing on prevalent conditions such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers. By examining the roles of psychiatric conditions, including depression, anxiety, and post-traumatic stress disorder (PTSD), this paper illuminates how these factors intricately influence wound healing dynamics, including mechanisms of pain perception and inflammatory responses. Furthermore, we evaluate the effectiveness of integrated biopsychosocial interventions, which encompass a holistic approach to wound care, thereby enhancing healing outcomes for dermatology patients. Future studies should focus on investigating the specific psychosocial determinants that significantly influence wound healing, exploring novel therapeutic strategies, and implementing personalized interventions to meet the unique needs of each patient. Such endeavors hold promise in advancing the fields of psychodermatology and wound management, fostering a deeper understanding and application of psychosocial considerations in dermatological care.

关键词： Psychosocial Factors Chronic Wound Healing Biopsychosocial Interventions Psychiatric Conditions Dermatology Patients

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Storylines of family medicine Ⅶ: family medicine across the lifespan

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Family Medicine and Community Health 2024年第S3期12卷 61-69页

作者： William B Ventres Leslie A Stone Katharine C Barnard sara G Shields Mark J Nelson Maria Verónica Svetaz Clara M Keegan Joel J Heidelbaugh Paige B Beck Lucille Marchand Family and Preventive Medicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Family Medicine and Community Health UMass Chan Medical SchoolWorcesterMassachusettsUSA John Peter Smith Hospital Family Medicine Residency Fort WorthTexasUSA Family and Community Medicine Hennepin HealthcareMinneapolisMinnesotaUSA Family Medicine University of Vermont Larner College of MedicineBurlingtonVermontUSA Family Medicine University of Michigan Medical SchoolAnn ArborMichiganUSA Family Medicine and Community Health University of Wisconsin-Madison School of Medicine and Public HealthMadisonWisconsinUSA

Storylines of Family Medicine is a 12-part series of thematically linked mini-essays with accompanying illustrations that explore the many dimensions of family medicine as interpreted by individual family physicians and medical educators in the USA and elsewhere around the ***‘Ⅶ:family medicine across the lifespan’,authors address the following themes:‘Family medicine maternity care’,‘Seeing children as patients brings joy to work’,‘Family medicine and the care of adolescents’,‘Reproductive healthcare across the lifespan’,‘Men’s health’,‘Care of older adults’,and‘Being with dying’.May readers appreciate the range of family medicine in these essays.

关键词： life illustration family

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柔性神经探针：当前的优点、缺点及未来需求（英文）

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2024年第2期 153-168页

作者： sara PIMENTA Jo?o R.FREITAS José H.CORREIA CMEMSUMinho 米尼奥大学 LABBELS联合实验室

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流... 详细信息

脑部疾病影响着数百万人，并对社会和经济产生巨大影响。在动物研究中，神经探针的应用一直是增进神经网络功能知识的主要途径。神经科学家正在努力开发新型且更加有效的神经疾病治疗方法。近年来，多功能神经探针（包括电学、光学和流体相互作用）的研发不断增加，产生了更高时空分辨率的设备。增加神经探针的适用性以及集成元素，促进了柔性接口的需求，减少了探针植入期间对神经组织的损伤，并提高了神经采集数据的质量。本文综述了几种柔性神经探针的制备、表征和验证，探讨了这些器件的主要优缺点。最后，对其今后的发展及应用作了展望。总体而言，本综述旨在介绍目前可用的柔性神经探针设备及其未来可能的发展途径，为未来设备设计提供指导。

关键词：脑神经柔性接口多功能探针

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Preliminary Palynostratigraphic Data on the Middle Albian-Lower Cenomanian of the Tarfaya Basin, Southwest Morocco

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Open Journal of Geology 2024年第4期14卷 548-568页

作者： Khaoula Chafai Touria Hssaida Wafaa Maatouf Mohamed Z. Yousfi sara Chakir Soukaina Jaydawi Hanane Khaffou Department of Geology Faculty of Sciences Ben M&#8217Sik University Hassan II Casablanca Morocco Department of Petroleum Laboratory Office National des Hydrocarbures et des Mines Rabat Morocco Department of Geology Faculty of Sciences Dhar El Mahraz Sidi Mohamed Ben Abdellah University Fes Morocco Department of Geology Faculty of Sciences Mohammed V University Rabat Morocco

The Tarfaya-Laayoune-Boujdour basin is of great interest to oil exploration;on this aspect, there has been exploration by the Moroccan National Office of Hydrocarbons and Mining, which has shown indices of oil and/or gas recorded in most wells drilled in the Moroccan Atlantic margin. FD-1 well, object of this study, is one of these wells located in the offshore Tarfaya-Laayoune-Boujdour basin. A palynological examination of the processed samples revealed the existence of organic palynomorphs, well conserved and rich in dinoflagellate cysts. The latter are composed of worldwide marker taxa of high stratigraphic resolutions. Thus, the middle upper Albian (3408 - 3408.5 m) is determined by the presence of Cribroperidinium tensiftense, Tehamadinium coummia, Spiniferella cornuta, Chichaouadinium vestitum, Dinopterygium alatum and Litosphaeridium arundum. The upper Albian (3406.5 - 3408 m) is characterized by the FOs of marker taxa: Cyclonephelium chabaca, Cribroperidinium auctificum and Chichaouadinium vestitum. Lastly, the upper Albian-lower Cenomanian transition is defined between 3404 m and 3406.50 m, as suggested by the FOs of Chichaouadinium boydii, Dinopterygium tuberculatum, Sepispinula ancorifera, Litosphaeridium conispinum, Prolixosphaeridium conulum and Xenascus ceratioides.

关键词： Morocco Tarfaya-Laayoune-Boujdour Basin Albian-Cenomanian Transition Dinoflagellate Cysts Palynostratigraphy

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Primary Hyperoxaluria Type 1 in Adulthood: Case Series

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Open Journal of Nephrology 2024年第3期14卷 350-360页

作者： sara El Maakoul Nada El Kadiri Nabil Hmaidouch Salma Belmokadem Loubna Benamar Tarik Bouattar Naima Ouzeddoun Department of Nephrology Dialysis Renal Transplantation Ibn Sina University Hospital-Rabat Rabat Morocco Faculty of Medicine and Pharmacy Mohammed V University Rabat Morocco

Introduction: Primary hyperoxaluria type 1 (HP1) is a rare lithiasis with systemic involvement, due to the accumulation of calcium oxalate crystals. In the absence of therapeutic management, it progresses to end-stage chronic renal failure. The aim of this study is to describe and analyse the observations of our patients with HP1. Patients and methods: This is a retrospective study carried out between 2014 and 2023 in the Nephrology-Dialysis Transplant Department of the Ibn Sina University Hospital in Rabat. The clinical, paraclinical and evolutionary elements were taken from the patients’ medical records. Results: We collected 11 cases, with a mean age of 27 ± 8.5 years and a M/F sex ratio of 1.7. The diagnosis of HP1 was made on the basis of genetic analysis in 8 patients, morphological and spectro-photometric analysis of the calculus in one patient, biopsy of the graft in one patient and crystalluria and a family history of PH1 in one patient. Two patients died, and 8 patients were on chronic haemdialysis with systemic damage. Only one patient maintained a stable GFR at 60 ml/min. Conclusion: Early diagnosis combined with conservative treatment is the only way to limit the rapid progression of this disease. This requires awareness and collaboration between nephrologists, urologists and biologists within a specialised team.

关键词： Primary Hyperoxaluria Adulthood Kidney Disease

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负载二氢杨梅素的玉米醇溶蛋白-阿拉伯胶纳米粒子的制备及分析

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食品工业科技 2024年

作者：常大伟曹佳怡任娜王虎玄孙玉娇沈文 sara Sendi 陕西科技大学食品科学与工程学院

本研究将二氢杨梅素（Dihydromyricetin，DMY）作为核心来构建纳米粒子，并借助纳米粒子对DMY予以包封，旨在解决其水溶性差以及稳定性欠佳的难题，从而提高其利用率与生物活性。采用反溶剂沉淀法，以DMY为芯材，以玉米醇溶蛋白（Zein... 详细信息

本研究将二氢杨梅素（Dihydromyricetin，DMY）作为核心来构建纳米粒子，并借助纳米粒子对DMY予以包封，旨在解决其水溶性差以及稳定性欠佳的难题，从而提高其利用率与生物活性。采用反溶剂沉淀法，以DMY为芯材，以玉米醇溶蛋白（Zein）为载体，构建Zein-阿拉伯胶（GA）纳米营养递送体系，以粒径、多分散指数（PDI）、zeta电位、包封率为指标优化了Zein/GA-DMY纳米粒子的制备条件。同时，采用傅里叶红外光谱（FT-IR）和X射线衍射（XRD）探讨了Zein、GA和DMY之间的相互作用，利用扫描电子显微镜（SEM）观察了该体系的微观形貌。结果表明，当Zein与阿拉伯胶的质量比为1:2，Zein与DMY质量比为10:1时，制备的纳米粒子粒径较小（191.04 nm），PDI为0.164，zeta电位为-17.70 mV，包封率为76.17%。氢键、静电和疏水相互作用是使该纳米粒子形成的主要驱动力，DMY以非晶体状态成功包埋在Zein/GA-DMY纳米粒子中，复合物呈球形，且分布均匀。GA的包覆使纳米粒子在一定条件下具备pH、加热、盐离子及储藏稳定性，扩展了其应用范围；体外抗氧化和模拟胃肠道消化实验表明经复合纳米粒子包封后DMY仍具备较强的抗氧化活性，同时呈现缓释特性。因此，本研究可为DMY在功能性食品领域的应用提供一定的理论基础。

关键词：二氢杨梅素玉米醇溶蛋白阿拉伯胶纳米粒子稳定性生物利用度壳-核结构

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Lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal force of rugby players

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Sports Medicine and Health Science 2024年第2期6卷 173-178页

作者： Rafael R.Machado Marcelo Palinkas Paulo B.de Vasconcelos sara Gollino Veridiana W.Arnoni Marcos Vinicios R.Prandi Isabela H.Regalo Selma Siessere Simone C.H.Regalo School of Dentistry of Ribeirao Preto University of Sao PauloBrazil National Institute for Translational Medicine(INCT-TM) Ribeirao PretoBrazil

This cross-sectional study examined the lower limb balance,ankle dorsiflexion,orofacial tissue pressure,and occlusal strength of rugby ***-six participants were divided into groups:rugby players(n=13)and healthy sedentary adults(n=13).Participants underwent an analysis of lower limb balance using a composite score(Y-Balance Test).Ankle dorsiflexion was measured using the Lunge *** Iowa Oral Performance Instrument was employed to measure orofacial tissue *** force was measured with a dynamometer,and T-Scan assessed occlusal contact *** were analyzed using the t-test(p<0.05)and ANCOVA with age and weight as covariates,where it is possible to verify that these factors did not influence the results *** differences were observed in the balance of the right(p=0.07)and left(p=0.02)lower limbs,where rugby players had lower composite *** were significant differences in the right(p=0.005)and left(p=0.004)lunges,with rugby players showing lower values,as well as lower tongue pressure(p=0.01)and higher lip pressure(p=0.03),with significant differences to sedentary *** was no significant difference in molar bite force and distribution occlusal contacts between *** seems to reduce lower limb displacement,cause ankle hypomobility,lead to changes in orofacial tissues,particularly the tongue and *** study is significant for identifying significant differences between rugby players and sedentary individuals,providing new insights into the impact of rugby on health and performance,which can benefit sports training and injury prevention.

关键词： Rugby Y-balance test Lunge test Orofacial tissues Occlusal force

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Extracellular vesicles as tools and targets in therapy for diseases

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Signal Transduction and Targeted Therapy 2024年第3期9卷 872-912页

作者： Mudasir A.Kumar Sadaf K.Baba Hana Q.Sadida sara Al.Marzooqi Jayakumar Jerobin Faisal H.Altemani Naseh Algehainy Mohammad A.Alanazi Abdul-Badi Abou-Samra Rakesh Kumar Ammira S.Al-Shabeeb Akil Muzafar A.Macha Rashid Mir Ajaz A.Bhat Watson-Crick Centre for Molecular Medicine Islamic University of Science and TechnologyAwantiporaKashmir 192122India Department of Human Genetics-Precision Medicine in Diabetes Obesity and Cancer ProgramSidra MedicineDohaQatar Qatar Metabolic Institute Academic Health SystemHamad Medical CorporationDohaQatar Department of Medical Laboratory Technology Prince Fahad Bin Sultan Chair for Biomedical ResearchFaculty of Applied Medical SciencesUniversity of TabukTabukSaudi Arabia School of Biotechnology Shri Mata Vaishno Devi UniversityKatraIndia

Extracellular vesicles(EVs)are nano-sized,membranous structures secreted into the extracellular *** exhibit diverse sizes,contents,and surface markers and are ubiquitously released from cells under normal and pathological *** serum is a rich source of these EVs,though their isolation from serum proteins and non-EV lipid particles poses *** vesicles transport various cellular components such as proteins,mRNAs,miRNAs,DNA,and lipids across distances,influencing numerous physiological and pathological events,including those within the tumor microenvironment(TME).Their pivotal roles in cellular communication make EVs promising candidates for therapeutic agents,drug delivery systems,and disease *** in cancer diagnostics,EV detection can pave the way for early identification and offers potential as diagnostic ***,various EV subtypes are emerging as targeted drug delivery tools,highlighting their potential clinical *** need for non-invasive biomarkers to monitor biological processes for diagnostic and therapeutic purposes remains *** into the unique composition of EVs could unlock advanced diagnostic and therapeutic avenues in the *** this review,we discuss in detail the roles of EVs across various conditions,including cancers(encompassing head and neck,lung,gastric,breast,and hepatocellular carcinoma),neurodegenerative disorders,diabetes,viral infections,autoimmune and renal diseases,emphasizing the potential advancements in molecular diagnostics and drug delivery.

关键词： diseases sized sizes

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