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Atlanto-axial langerhans cell histiocytosis in a child presented as torticollis

World Journal of Clinical Cases 2017年第8期5卷 344-348页

作者： Miniar Tfifha Mehdi Gaha Nadia Mama Mohamed Taher Yacoubi saoussen abroug Hela Jemni Pediatrics Department Sahloul University Hospital Radiology Department Sahloul University Hospital Pathology Department Farhat Hached University Hospital

Langerhans cell histiocytosis(LCH) is a rare condition mostly seen in children and adolescents. Eosinophilic granuloma(EG) is one of its three clinical entities and is considered as a benign osteolytic lesion. Many reports of patients with spine histiocytosis are well documented in the literature but it is not the case of atlantoaxial localization. We report here a new observation of atlantoaxial LCH in a 4-year-old boy revealed by persistent torticollis. He was successfully treated with systemic chemotherapy and surgery. Inter-body fusion packed by autologous iliac bone was performed with resolution of his symptoms. It is known that conservative treatment is usually sufficient and surgery should be reserved for major neurologic defects in spine EG. In atlantoaxial lesion, surgical treatment should be frequently considered.

关键词： Langerhans cell histiocytosis Eosinophilic granuloma Torticollis Cervical spine

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Pseudotumoral acute cerebellitis associated with mumps infection in a child

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World Journal of Clinical Cases 2017年第8期5卷 340-343页

作者： Houda Ajmi Mehdi Gaha Sameh Mabrouk Saida Hassayoun Noura Zouari Jalel Chemli saoussen abroug Pediatrics Depart-ment Sahloul University Hospital Radiology Department Sahloul University Hospital

Pseudotumoral cerebellitis in childhood is an uncommon presentation of cerebellitis mimicking a brain tumor. It often follows an inflammatory or infectious event, particularly due to varicella virus. Patients could have a wide clinical spectrum on presentation. Some patients may be asymptomatic or present at most with mild cerebellar signs, whereas others may suffer severe forms with brainstem involvement and severe intracranial hypertension mimicking tumor warranting surgical intervention. Imaging techniques especially multimodal magnetic resonance imaging represent an interesting tool to differentiate between posterior fossa tumors and acute cerebellitis. We describe a case of pseudotumoral cerebellitis in a 6-year-old girl consequent to mumps infection and review the literature on this rare association.

关键词： Acute cerebellitis Pseudotumoral cerebellitis Posterior fossa tumor Children Mumps

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Kawasaki disease, <i>Mycoplasma pneumoniae</i>infection and anaplastic large cell lymphoma: An uncommon association

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Open Journal of Pediatrics 2012年第3期2卷 250-252页

作者： Jalel Chemli Saida Hassayoun Soumaya Ketata Ajmi Houda Moncef Mokni Noura Zouari saoussen abroug Abdelaziz Harbi Department of Cytopathology Farhat Hached Hospital Sousse Tunisia Department of Paediatrics Sahloul Hospital Sousse Tunisia Laboratory of Bacteriology-Virology Sahloul Hospital Sousse Tunisia

Kawasaki disease (KD) is an acute febrile systemic vasculitis occurring predominantly in young children less than 5 years of age. Although imperfectly known, the aetiopathogenesis of KD would be secondary to immunological abnormalities that could constitute a favourable terrain for neoplasms. We report on a case in a 2-year-old girl who presented clinical manifestations compatible with Kawasaki disease complicated by coronary aneurysm. Aetiopathological investigations revealed M. pneumoniae infection as specific IgM were present in the serum (Elisa). The patient was initially treated by intravenous immunoglobulins (IVIG) and aspirin to anti-inflammatory dose. Following a few days of desquamation, resolution of the symptomatology occurred. Four weeks later she developed disseminated tumorous syndrome. Lymph node biopsy revealed massive infiltration by large cells lymphomatous proliferation. Histologic and immunophenotypic findings were characteristic of ALK-1+ anaplastic large cell lymphoma. Four weeks later, the patient died from a severe nosocomial infection complicated by septic shock. Our observation is the first cases describing the association between anaplastic large cell lymphoma, KD and M. pneumoniae. Immunologic disorder due to KD and M. pneumoniae infection may play probably a central role for malignancy.

关键词： Kawasaki Disease Mycoplasma pneumoniae Anaplastic Large Cell Lymphoma Immunological Abnormality

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