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Pseudo-Differential Operators of Homogeneous Symbol Class Associated with the Weinstein Transform

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1533-1562页

作者： santosh kumar UPADHYAY Mohd SARTAJ Department of Mathematical Sciences Indian Institute of Technology(BHU)VaranasiIndia

In this paper,pseudo-differential operators with homogeneous symbol classes associated with the Weinstein transform are *** boundedness of pseudo-differential operators and commutator between two pseudo-differential o... 详细信息

关键词： Pseudo-Differential Operators Homogeneous Symbol Class Weinstein Operator Sobolev space Weinstein transform

Intrusion detection systems for wireless sensor networks using computational intelligence techniques

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Cybersecurity 2024年第2期7卷 81-95页

作者： Vaishnavi Sivagaminathan Manmohan Sharma santosh kumar Henge Lovely Professional University PhagwaraIndia

Network Intrusion Detection Systems(NIDS)are utilized to find hostile network *** can be accom-plished by looking at traffic network activity,but it takes a lot of *** NIDS heavily utilizes approaches for data extraction and machine learning to find *** terms of feature selection,NIDS is far more *** is accurate since anomaly identification uses a number of time-consuming *** of this,the feature selec-tion method influences how long it takes to analyze movement patterns and how clear it *** goal of the study is to provide NIDS with an attribute selection *** has been used for that *** Network Intrusion Detection System that is being developed will be able to identify any malicious activity in the network or any unusual behavior in the network,allowing the identification of the illegal activities and safeguarding the enormous amounts of confidential data belonging to the customers from being *** the research,datasets were produced utilising both a network infrastructure and a simulation *** is used to gather data packets whereas Cisco Packet Tracer is used to build a network in a simulated ***,a physical network consisting of six node MCUs connected to a laptop and a mobile hotspot,has been built and communication packets are being recorded using the Wireshark *** train several machine learning models,all the datasets that were gatheredcre-ated datasets from our own studies as well as some common datasets like NSDL and UNSW acquired from Kaggle-were ***,PsO,which is an optimization method,has been used with these ML algorithms for feature *** the research,KNN,decision trees,and ANN have all been combined with PSO for a specific case *** it was found demonstrated the classification methods PSO+ANN outperformed PSO+KNN and PSO+DT in this case study.

关键词： Network intrusion detection systems(NIDS) Cisco packet tracer Wireshark tool Machine learning PSO Cybersecurity Optimization

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： santosh kumar Rana Hum Kala Rana Jacob BLandis Tianhui Kuang Juntong Chen Hengchang Wang Tao Deng Charles C.Davis Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest China comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第3期13卷 65-94页

作者： Amit Panwar Mohd. Imran Khan Rajesh kumar Rakesh kumar santosh kumar Rai Anil kumar New Drug Discovery Research Mankind Research Centre Mankind Pharma Limited Gurugram India

Alzheimer’s disease (AD) is caused by synaptic failure and the excessive accumulation of misfolded proteins especially A β and tau, and associated with memory loss and cognitive impairment. Treatment of AD mainly consists of symptomatic therapy and disease-modifying therapy (DMT). Several monotherapies including small molecules or antibodies have been evaluated through multiple clinical trials, but a very few have been approved by the USFDA to intervene the disease’s pathogenesis. Past research has shown multifactorial nature of AD, therefore, multi-target drugs were proposed to target different pathways at the same time, however, currently no rationally designed multi-target directed ligand (MTDL) has been clinically approved. Different combinations and bispecific antibodies are also under development. Novel approaches like stem cell-based therapies, microRNAs, peptides, ADCs and vaccines cast a new hope for AD treatment, however, a number of questions remained to be answered prior to their safe and effective clinical translation. This review explores the small molecules, MTDL, and antibodies (monospecific and bispecific) for the treatment of AD. Finally, future perspectives (stem cell therapy, PROTAC approaches, microRNAs, ADC, peptides and vaccines) are also discussed with regard to their clinical applications and feasibility.

关键词： Alzheimer’s Disease (AD) Disease-Modifying Therapy (DMT) MicroRNAs PROTAC

Study of Structural, Optical, Electrical and Dielectric Properties of Gd-Doped ZnO Composites Synthesized by Solid State Reaction Method

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Open Journal of Composite Materials 2024年第2期14卷 91-108页

作者： santosh kumar Kundara Kanhaiya Chawla Dinesh kumar Yadav Chhagan Lal Balram Tripathi Narendra Jakhar Department of Physics University of Rajasthan Jaipur India Sw. P.N.K.S. Government PG College Dausa India Government PG College Pratapgarh India S.S. Jain Subodh PG (Autonomous) College Jaipur India

In this manuscript, we are reporting structural, bonding, optical, dielectric, and electrical properties of Gd-doped ZnO composite samples (Zn1−xGdxO, x = 0, 0.05, 0.10) prepared by solid-state reaction method. XRD spectra confirm the wurtzite hexagonal phase with a grain size distribution of 42 - 47 nm. The FT-IR spectra confirm bonding behavior like Zn-O, O=C=O, and O-H stretching modes. FESEM micrographs show that the grains of crystallites possess nearly spherical morphology. Optical absorption spectra confirm that the optical band gap decreases systematically from 3.19 eV to 3.15 eV for x = 0.0 to x = 0.10 samples. For all samples, PL spectra exhibited near-band emission, blue emission, and green emission peaks. The dielectric constant decreases as the applied frequency increases. Hall effect results show that with increasing doping concentration of Gd, mobility and resistivity increase while bulk concentration decreases. Current-Voltage study shows that current increases when temperature is increased. Rare earth-doped ZnO is potential material used for optoelectronics and spintronics device applications. Properties of Gd-doped ZnO are studied by various research groups, but dielectric studies are limitedly reported. Therefore, the present research work aims to study the change of electrical, optical, and dielectric properties of Gd-doped ZnO for device applications.

关键词： ZnO:Gd Composites Optical Band Gap Green Emission Dielectric Constant

Computation of pressure drop for dilute gas-solid suspension across thin and thick orifices

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Particuology 2021年第2期19卷 209-221页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

The present work deals with the computation of the gas-solid two-phase flow pressure drop across thin and thick orifices for a vertically downward flow configuration at the higher limits of a dilute phase flow situation(0.01≤αs,in≤0.10).The Eulerian-Eulerian(two-fluid)model has been used in conjunction with the kinetic theory of granular flow with a four-way coupling *** validation of the solution process has been performed by comparing the computational result with the existing experimental *** is observed that the two-phase flow pressure drop across the orifice increases with an increase in the thickness of the orifice,and the effect is more prominent at higher solid *** pressure drop is found to increase with an increase in the solid volume *** increase in the Reynolds number or the area ratio increases the pressure *** increase in the size of the particles reduces the pressure drop across the orifice at both small and relatively large solid volume ***,a two-phase multiplier has been proposed in terms of the relevant parameters,which can be useful to evaluate the gas-solid two-phase flow pressure drop across the orifice and can subsequently help to improve the system performance.

关键词： Dilute phase flow Gas-solid flow Thin and thick orifice Vertically downward flow Pressure drop

Pressure recovery characteristics for a dilute gas-particle suspension flowing vertically downward in a pipe with a sudden expansion: A two-fluid modeling approach

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Particuology 2020年第3期18卷 100-111页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

This work applies the Eulerian-Eulerian model in conjunction with the kinetic theory of granular flow and inter-particle collisions to study the characteristics of pressure recovery for a dilute gas-particle suspension flowing through a pipe with a sudden expansion at a relatively higher solid *** do so,the numerical procedure was validated against experimental results for relatively small dilute phase flows in a pipe with a sudden expansion;a satisfactory agreement was ***,the effect of the two significant numerical parameters namely,the speculairty coefficient and the coefficient of restitution for particle-particle collisions were investigated and then,for fixed combinations of these parameters the effect of particle-phase volume fraction,particle density,particle size,and inlet slip ratio were *** was concluded that pressure recovery diminishes as the speculairty coefficient increases and the particle-particle coefficient of restitution *** recovery was found to increase with increasing solid volume fraction for coarse particles whereas,for fine particles,a critical volume fraction is obtained above which pressure recovery *** increase in slip ratio is found to diminish pressure ***,at relatively higher solid volume fractions,a critical diameter was found,above and below which pressure recovery decreases.

关键词： Gas-solid flow Sudden expansion pipe Eulerian-Eulerian model Pressure recovery Vertically downward flow

Inhibition of extracellular vesicle pathway using neutral sphingomyelinase inhibitors as a neuroprotective treatment for brain injury

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Neural Regeneration Research 2021年第12期16卷 2349-2352页

作者： Asit kumar santosh kumar Department of Pharmaceutical Sciences University of Tennessee Health Science CenterMemphisTNUSA

Traumatic brain injury is a sudden trauma or blow on the head,and severe traumatic brain injury is a major cause of death and disability *** acute and chronic consequences following traumatic brain injury can lead to progressive secondary neurodegenerative changes and cognitive *** date,there is no effective pharmaceutical products for the treatment to reduce secondary damage after brain *** discovery of extracellular vesicles has attracted considerable scientific attention due to their role in cell-to-cell *** vesicles have shown their potential to carry not only biological molecules but also as a drug delivery *** a carrier of molecular information,extracellular vesicles have been involved in physiological functions as well as in the modulation of immune ***,we aim to provide new insights into the contrasting role of extracellular vesicles in the propagation of inflammatory responses after brain *** a carrier of pro-inflammatory molecules,their role as functional mediators in the pathophysiology of brain injury is discussed,addressing the inhibition of the extracellular vesicle pathway as an anti-inflammatory or neuroprotective approach to improve the outcome of both acute and chronic inflammation following brain ***,we summarize therapeutic strategies to diminish the risk the neurodegeneration post brain injury and propose that neutral sphingomyelinase inhibitors could be used as potentially useful therapeutic agents for the treatment of brain injury associated neuroinflammation.

关键词： brain injury ceramide extracellular vesicles microglia neuroinflammation neuroprotection neutral sphingomyelinase

Thermo-Magneto-Electric Currents with Dynamical Magnetization Inhomogeneities

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Communications in Theoretical Physics 2011年第9期56卷 504-512页

作者： santosh kumar Kudtarkar Centre for Mathematical Modelling FLAME150/7Jaideep BungalowBaner-Balewadi RoadBanerPune 411 045India

We study the effect of potential and thermal gradient induced non-equilibrium magnetization in quasi1-d itinerant magnets.A semi-phenomenological theory is employed in conjunction with the drift-diffusion model forthis *** the methods of non-equilibrium thermodynamics,we derive the transport currents correspondingto charge,heat,and magnetization flows in the presence of non-equilibrium magnetization *** is shown howtime-dependent magnetic textures give rise to charge and thermal currents even in the absence of external potential andthermal gradients through spin *** presence of dynamical textures also affect the thermodynamic parametersof the *** an application,we consider the case of a helimagnet.

关键词： current and temperature driven spin pumping thermoelectric thermomagnetic