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Soluble factors secreted by human Wharton’s jelly mesenchymal stromal/stem cells exhibit therapeutic radioprotection: A mechanistic study with integrating network biology

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World Journal of Stem Cells 2022年第5期14卷 347-361页

作者： Dharmendra kumar Maurya Mayuri Bandekar santosh kumar Sandur Radiation Biology and Health Sciences Division Bhabha Atomic Research CentreMumbai 400085MaharashtraIndia Homi Bhabha National Institute AnushaktinagarMumbai 400094India University of Mumbai KalinaMumbai 400098India

BACKGROUND Human Wharton’s jelly-derived mesenchymal stromal/stem cells(hWJ-MSCs)have gained considerable attention in their applications in cell-based therapy due to several advantages offered by ***,we reported that hWJ-MSCs and their conditioned medium have significant therapeutic radioprotective *** finding raised an obvious question to identify unique features of hWJ-MSCs over other sources of stem cells for a better understanding of its radioprotective *** To understand the radioprotective mechanism of soluble factors secreted by hWJMSCs and identification of their unique *** Propidium iodide staining,endogenous spleen colony-forming assay,and survival study were carried out for radioprotection ***-driven proliferation assay was performed for in vivo lymphocyte *** of RNAseq data was performed to find the unique genes of WJ-MSCs by comparing them with bone marrow mesenchymal stem cells,embryonic stem cells,and human *** enrichment analysis and protein-protein interaction network were used for pathway *** Co-culture of irradiated murine splenic lymphocytes with WJ-MSCs offered significant radioprotection to ***-MSC transplantation increased the homeostasis-driven proliferation of the *** of WJ-MSC conditioned medium with granulocyte-colony stimulating factor antibody abolished therapeutic *** analysis showed that WJ-MSCs share several common genes with bone marrow MSCs and embryonic stem cells and express high levels of unique genes such as interleukin(IL)1-α,IL1-β,IL-6,CXCL3,CXCL5,CXCL8,CXCL2,CCL2,FLT-1,and *** was also observed that WJ-MSCs preferentially modulate several cellular pathways and processes that handle the repair and regeneration of damaged tissues compared to stem cells from other ***-based network analysis showed that most of the radiosensitive tissues have a more com

关键词： Radioprotection Mesenchymal stem cells Wharton’s jelly-derived mesenchymal stromal/stem cells Cytokines Granulocyte-colony stimulating factor Network biology

Review of preventive and constructive measures for coal mine explosions:An Indian perspective

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International Journal of Mining Science and Technology 2022年第3期32卷 471-485页

作者： santosh kumar Ray Asfar Mobin Khan Niroj kumar Mohalik Debashish Mishra Somu Mandal Jai Krishna Pandey CSIR-Central Institute of Mining and Fuel Research Barwa RoadDhanbad 826015India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Firedamp and coal dust explosion constitute a lion’s share in mine accidents in a global mining *** paper reports a list of mine explosion disasters since last two decades,a critical review of the different prevention and constructive measures,and its recent development to avoid firedamp and coal dust *** legislation in core coal-producing countries,***,USA,Australia,South Africa,and India related to firedamp and coal dust explosion are critically *** occurred due to explosion after Nationalisation of Coal Mines(1973)in India are *** and constructive measures adopted in India are critically analysed with respect to the global mining *** like methane credit concept,classification of mines/seams with respect to explosion risk zone,deflagration index;installation of automatic fire warning devices,canopy air curtain technology,explosion-prevention measures,such as fire-retardant materials,inhibitors,extinguishing agent,dust suppressor,and active explosion barrier are discussed in detail to avoid explosion and thereby adhering to zero accident policy due to coal mine explosion.

关键词： Firedamp explosion Coal dust explosion Preventive measures Constructive measures Legislation

Diagnosis and Detection of Alzheimer’s Disease Using Learning Algorithm

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Big Data Mining and Analytics 2023年第4期6卷 504-512页

作者： Gargi Pant Shukla santosh kumar Saroj kumar Pandey Rohit Agarwal Neeraj Varshney Ankit kumar the Department of Management Doon Business SchoolDehradun 248001India. Jaipuria Institute of Management Jaipur 302033India Department of Computer Engineering and Apllications GLA UniversityMathura 281406India.

In Computer-Aided Detection(CAD)brain disease classification is a vital ***’s Disease(AD)and brain tumors are the primary reasons of *** studies of these diseases are carried out by Magnetic Resonance Imaging(MRI),Positron Emission Tomography(PET),and Computed Tomography(CT)scans which require expertise to understand the *** disease is the most prevalent in the elderly and can be fatal in its later *** result can be determined by calculating the mini-mental state exam score,following which the MRI scan of the brain is *** from that,various classification algorithms,such as machine learning and deep learning,are useful for diagnosing MRI ***,they do have some limitations in terms of *** paper proposes some insightful pre-processing methods that significantly improve the classification performance of these MRI ***,it reduced the time it took to train the model of various pre-existing learning algorithms.A dataset was obtained from Alzheimer’s Disease Neurological Initiative(ADNI)and converted from a 4D format to a 2D *** clipping,grayscale image conversion,and histogram equalization techniques were used to pre-process the *** pre-processing,we proposed three learning algorithms for AD classification,that is random forest,XGBoost,and Convolution Neural Networks(CNN).Results are computed on dataset and show that it outperformed with exiting work in terms of accuracy is 97.57%and sensitivity is 97.60%.

关键词： alzheimer’s disease deep learning random forest XGBoost

A detailed study on trust management techniques for security and privacy in IoT:challenges,trends,and research directions

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高置信计算(英文) 2023年第2期3卷 71-82页

作者： Himani Tyagi Rajendra kumar santosh Kr Pandey Department of Computer Science Jamia Millia IslamiaNew Delhi 110025India Department of EC&IT MeityNew Delhi 110003India

The Internet of Things is a modern technology that is directed at easing human life by automating most of the things used in daily *** never-ending dependency on the network for communication is attracting adversaries to exploit the vulnerabilities of ***,this technology is facing some serious issues and challenges concerning security and *** issues and challenges are the real motivation behind considering this ***,this survey includes a discussion about security and privacy challenges as well as available solutions for IoT based wireless sensor *** systematic literature review(SLR)focuses particularly on a popular and applicable security approach known as Trust Management System(TMS).Firstly,all aspects of trust management,including trust indicators,trust properties,trust evaluation,trust building,trust models and the importance of those models for security and privacy,trust prediction methodologies,and ultimately trust-based attacks,are covered in this ***,trust management schemes are classified into four groups based on the methodology used for trust-based security solutions in the IoT:cryptography-based,computational and probabilistic-based,information theory-based,and ***,an understanding of the problems and difficulties with current methodologies is given,along with suggestions for further ***,the SLR is concluded by formulating the desirable characteristics of a trust management system in the IoT and proposing a trust model suitable for IoT networks.

关键词： Trust Trust management approaches IoT Security Privacy Reliability Attacks Trust attributes Systematic literature review Cybersecurity

Plant endemism in the Nepal Himalayas and phytogeographical implications

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Plant Diversity 2019年第3期41卷 174-182页

作者： Achyut Tiwari yadav Uprety santosh kumar Rana Department of Botany Tri-Chandra Campus Tribhuvan University Kathmandu Nepal Central Department of Botany Tribhuvan University Kirtipur Kathmandu Nepal Research Centre for Applied Science and Technology Tribhuvan University Kathmandu Nepal IUCN (International Union for Conservation of Nature) Kathmandu Nepal Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 Yunnan China University of Chinese Academy of Sciences Beijing 100049 China

Nepal is located in the central part of the greater Himalayan range with a unique series of mountain chains formed by recent mountain building geological events. As one of the youngest mountains in the world it contributes to diversity of plants and also provided barriers to and corridors through which plants migrated during the ice ages. The higher altitudinal variation with the high mountains, deep river valleys and lowland plains combine with the effects of the summer monsoon and dry winter result with an extraordinary diversity of ecosystems including flora and fauna in a relatively small land area. The existing checklists for Nepal record some 6000 species of flowering plants and about 530 ferns. However, the botanical experts estimate that numbers may go up to 7000 when the poorly known remote regions are fully explored. The information on plant endemism in Nepal Himalaya is not adequately known as Nepal is still struggling to complete long awaited Flora of Nepal project. Endemic species are confined to specific areas and are the first to be affected by land use and other global changes. We sought to explore the spatial distribution of endemic plant species in Nepal in relation to the consequences associated with climatic and geologic changes over time in the region with the help of published literature. It was found that the endemism showed marked spatial variation between open moist habitat and dry inner valleys, the former with higher endemism. The updated records showed 312 flowering plant species to be endemic to Nepal with higher endemism around the elevation of 3800e4200 m at sea level. The recent human population explosion, intensified deforestation, habitat fragmentation and modern day environmental changes are posing greater threats to endemic plant in Nepal. The conservation status and threats to these peculiar species are unknown. Nevertheless, environmental degradation and high poverty rates create a potent mix of threats to biodiversity in this l

关键词： Himalaya Topography Endemism

Near-infrared 3D imaging with upconversion detection

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Photonics Research 2022年第12期10卷 2760-2767页

作者： HE ZHANG santosh kumar YONG MENG SUA SHENYU ZHU YU-PING HUANG Department of Physics Stevens Institute of TechnologyHobokenNew Jersey 07030USA Center for Quantum Science and Engineering Stevens Institute of TechnologyHobokenNew Jersey 07030USA

We demonstrate a photon-sensitive,three-dimensional(3D)camera by active near-infrared illumination and fast time-of-flight *** uses picosecond pump pulses to selectively upconvert the backscattered photons according to their spatiotemporal modes via sum-frequency generation in a χ^(2) nonlinear crystal,which are then detected by an electron-multiplying CCD with photon sensitive *** such,it achieves sub-millimeter depth resolution,exceptional noise suppression,and high detection *** results show that it can accurately reconstruct the surface profiles of occluded targets placed behind highly scattering and lossy obscurants of14 optical depth(round trip),using only milliwatt illumination *** technique may find applications in biomedical imaging,environmental monitoring,and wide-field light detection and ranging.

关键词： illumination exceptional multiply

TGA/DSC study to characterise and classify coal seams conforming to susceptibility towards spontaneous combustion

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International Journal of Mining Science and Technology 2022年第1期32卷 75-88页

作者： Niroj kumar Mohalik Somu Mandal santosh kumar Ray Asfar Mobin Khan Debashish Mishra Jai Krishna Pandey CSIR-Central Institute of Mining and Fuel Research(CIMFR) Dhanbad 826015India Academy of Scientific and Innovative Research(AcSIR) Ghaziabad 201002India

Thermogravimetric analysis/differential scanning calorimeter(TGA/DSC)technique along with basic coal characteristics study is carried out for eighty coal samples of Indian coalfields,to determine spontaneous combustion propensity behaviour of *** study of coal samples indicates that there is an increase in the mass of coal samples in the temperature range 150-350℃,which may be due to oxygen adsorption and *** correlation and principal component analysis states that the component of proximate analysis(M_(ad),VM_(d),FR,and VR)have an acceptable correlation with the TGA experiments results i.e.,Tgsh and *** fixed nonlinear regression analysis shows that thermogravimetry(TG)experiment results Tgign may be the best index to categorise/classify the coal as per their susceptibility towards spontaneous *** authors proposed four groups of classification as per their propensity towards spontaneous combustion depending upon the moisture(M_(ad)),volatile matter(VM_(d)),and TG ignition temperature from differential thermogravimetric(DTG)curve(Tgign)using hierarchal clustering *** coal samples of different seams from Indian coalfield may be classified into four different clusters,*** highly/extremely susceptible(Tgign320℃).The field observations and TGA/DSC experiment results with the following statistical analysis substantiate a similar assessment.

关键词： Coal TGA/DSC Spontaneous combustion TG ignition

Impact of COVID-19 Pandemic on Mental Health of Healthcare Workers–A Perception of Indian Hospital Administrators

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International Journal of Mental Health Promotion 2023年第7期25卷 833-845页

作者： Anahita Ali santosh kumar Faculty of Public Health Poornima UniversityJaipur303905India

Since the coronavirus pandemic,many factors led to the change in the mental well-being of hospital administrators and their *** pandemic negatively impacted the availability and capability of health professionals to deliver essential services and meet rising ***,this study aimed to understand the perspective of hospital administrators about issues and challenges that negatively impacted their staff’s mental health and hospital administrators’coping response to mitigate those challenges and *** exploratory qualitative study was conducted with 17 hospital administrators(superintendents,deputy superintendents,nursing in charge and hospital in charge)working in a government district hospital of Rajasthan state during September 2022 and October *** study revealed various emerging themes on mental health-related issues,challenges and coping strategies reported by the *** and sub-themes that emerged from this study were 1)Perceived mental health of HCWs-perceived importance of mental health,2)Impact of COVID-19 on the mental health of HCWs–common mental health issues,changes in mental health pre and post-pandemic,3)Impact of COVID-19 on health behavior of HCWs-increased self-care and awareness,4)Challenges responsible for poor mental health of HCWs-organizational,ethical and societal challenges and 5)Strategies to retain mental health of HCWs-effective coping *** most common problems were increased levels of stress,feeling fatigued,tiredness,weak and anxiety among the *** their staff motivated was the biggest challenge *** support,counseling through professionals and demystifying myths were the most effective coping strategies adopted by the *** conclusion,this study reported poor mental health-related issues,challenges faced by the HCWs and effective strategies adopted by hospital administrators during tough *** study will assist hospital administrators in developing i

关键词： Coping strategies Indian administrators Indian healthcare workers qualitative study COVID-19 mental health

A phase II study of neoadjuvant chemotherapy followed by organ preservation in patients with muscle-invasive bladder cancer

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Asian Journal of Urology 2022年第3期9卷 318-328页

作者： Chinna Babu Dracham Narendra kumar santosh kumar Arun Elangovan Budhi Singh yadav Ravimohan S.Mavuduru Anupam Lal Pramod K.Gupta Rakesh Kapoor Department of Radiotherapy&Oncology PGIMERChandigarhIndia Department of Urology PGIMERChandigarhIndia Department of Radiodiagnosis PGIMERChandigarhIndia Department of Biostatistics PGIMERChandigarhIndia

Objective:Conservative approaches in muscle-invasive bladder cancer(MIBC)have been evolved to avoid aggressive surgery,but are limited to elderly,frail,and patients medically unfit for *** study aimed to assess the response rate of neoadjuvant chemotherapy(NACT)before radiotherapy(RT)in MIBC ***:Forty patients with urothelial carcinoma of stage T2-T4a,N0,M0 were enrolled between November 2013 and November 2015,and treated with three cycles of NACT with ***-NACT response was assessed using Response Evaluation Criteria in Solid Tumors(RECIST)*** who achieved complete response(CR)and partial response(PR)>50%were treated with radical RT,and those who had PR50%or CR,and were treated with ***(12.5%)patients who had PR<50%,SD,or PD underwent *** patients who received radiation showed CR after 6 *** follow-up was 43 months(range:10-66 months)and median overall survival(OS)was not ***-year OS,local control,and disease-free survival were 70.1%,60.9%,50.6%,respectively,and 50%of patients preserved their functioning ***-year OS rate was 88.9%in patients who achieved CR to NACT,73.1%in patients with PR≥50%and 40%in patients with PR<50%.Conclusion:NACT followed by RT provides a high probability of local response with bladder preservation in CR *** use of this treatment regimen in carefully selected patients may omit the need for morbid surgery.

关键词： Bladder preservation Neoadjuvant chemotherapy Radiotherapy Muscle-invasive bladder cancer