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Pseudo-Differential Operators of Homogeneous Symbol Class Associated with the Weinstein Transform

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Acta Mathematica Sinica,English Series 2024年第6期40卷 1533-1562页

作者： santosh kumar UPADHYAY Mohd SARTAJ Department of Mathematical Sciences Indian Institute of Technology(BHU)VaranasiIndia

In this paper,pseudo-differential operators with homogeneous symbol classes associated with the Weinstein transform are *** boundedness of pseudo-differential operators and commutator between two pseudo-differential o... 详细信息

关键词： Pseudo-Differential Operators Homogeneous Symbol Class Weinstein Operator Sobolev space Weinstein transform

Intrusion detection systems for wireless sensor networks using computational intelligence techniques

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Cybersecurity 2024年第2期7卷 81-95页

作者： Vaishnavi Sivagaminathan Manmohan Sharma santosh kumar Henge Lovely Professional University PhagwaraIndia

Network Intrusion Detection Systems(NIDS)are utilized to find hostile network *** can be accom-plished by looking at traffic network activity,but it takes a lot of *** NIDS heavily utilizes approaches for data extraction and machine learning to find *** terms of feature selection,NIDS is far more *** is accurate since anomaly identification uses a number of time-consuming *** of this,the feature selec-tion method influences how long it takes to analyze movement patterns and how clear it *** goal of the study is to provide NIDS with an attribute selection *** has been used for that *** Network Intrusion Detection System that is being developed will be able to identify any malicious activity in the network or any unusual behavior in the network,allowing the identification of the illegal activities and safeguarding the enormous amounts of confidential data belonging to the customers from being *** the research,datasets were produced utilising both a network infrastructure and a simulation *** is used to gather data packets whereas Cisco Packet Tracer is used to build a network in a simulated ***,a physical network consisting of six node MCUs connected to a laptop and a mobile hotspot,has been built and communication packets are being recorded using the Wireshark *** train several machine learning models,all the datasets that were gatheredcre-ated datasets from our own studies as well as some common datasets like NSDL and UNSW acquired from Kaggle-were ***,PsO,which is an optimization method,has been used with these ML algorithms for feature *** the research,KNN,decision trees,and ANN have all been combined with PSO for a specific case *** it was found demonstrated the classification methods PSO+ANN outperformed PSO+KNN and PSO+DT in this case study.

关键词： Network intrusion detection systems(NIDS) Cisco packet tracer Wireshark tool Machine learning PSO Cybersecurity Optimization

Recombinant vaccines:Current updates and future prospects

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Asian Pacific Journal of Tropical Medicine 2024年第8期17卷 338-350页

作者： Vivek kumar Anuj Verma Riddhi Singh Priyanshi Garg santosh kumar Sharma Himanshu Narayan Singh santosh kumar Mishra Sanjay kumar Department of Allied Medical Sciences School of Allied Medical SciencesLovely Professional UniversityPhagwaraPunjabIndia Bioengineering Division of Department of Bioscience and Biomedical EngineeringIndian Institute of Technology BhilaiChhattisgarhIndia Department of Biotechnology IMS Engineering CollegeGhaziabadU.P.India Department of Chemistry and Biochemistry University of WindsorOntario N9B3P4Canada Biological and Biocomputational Laboratory Department of Life SciencesSharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India Department of System Biology Columbia University Irving Medical CenterNew YorkNY 10032USA Department of Life Sciences Sharda School of Basic Sciences and ResearchSharda UniversityGreater NoidaU.P.India

Recombinant technology-based vaccines have emerged as a highly effective way to prevent a wide range of *** technology improved vaccine manufacturing,rendering it more efficient and *** vaccines have multiple advantages compared to conventional *** pandemic has heightened awareness of the advantages of these vaccine technologies;trust and acceptance of these vaccines are steadily growing *** work offers an overview of the prospects and advantages associated with recombinant ***,it discusses some of the challenges likely to arise in the *** ability to target diverse pathogen classes underscores their contributions to preventing previously untreatable diseases(especially vector-borne and emerging diseases)and hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these ***,their compatibility with emerging vaccination platforms of the future like virus-like particles and CRISPR/Cas9 for the production of next-generation vaccines may offer many *** review also reviewed the hurdles faced throughout the vaccine development process,especially in enhancing the effectiveness of these vaccines against vector-borne diseases,emerging diseases,and untreatable diseases with high mortality rates like AIDS as well as cancer.

关键词： Malaria Dengue Emerging diseases Immunoinformatics Virus-like particles CRISPR-Cas9

Pleistocene glaciation advances the cryptic speciation of Stellera chamaejasme *** a major biodiversity hotspot

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Journal of Integrative Plant Biology 2024年第6期66卷 1192-1205页

作者： santosh kumar Rana Hum Kala Rana Jacob BLandis Tianhui Kuang Juntong Chen Hengchang Wang Tao Deng Charles C.Davis Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China Arkansas Biosciences Institute Arkansas State UniversityJonesboroArkansas 72401USA School of Integrative Plant Science Section of Plant Biology and the L.H.Bailey HortoriumCornell UniversityIthacaNew York 14853USA BTI Computational Biology Center Boyce Thompson InstituteIthacaNew York 14853USA CAS Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture Chinese Academy of SciencesWuhan Botanical GardenWuhan 430074China Department of Organismic and Evolutionary Biology HerbariaHarvard UniversityCambridgeMassachusetts 02138USA

The mountains of Southwest China comprise a significant large mountain range and biodiversity hotspot imperiled by global climate *** high species diversity in this mountain system has long been attributed to a complex set of factors,and recent large-scale macroevolutionary investigations have placed a broad timeline on plant diversification that stretches from 10 million years ago(Mya)to the *** our increasing understanding of the temporal mode of speciation,finer-scale populationlevel investigations are lacking to better refine these temporal trends and illuminate the abiotic and biotic influences of cryptic *** is largely due to the dearth of organismal sampling among closely related species and populations,spanning the incredible size and topological heterogeneity of this *** study dives into these evolutionary dynamics of speciation using genomic and ecomorphological data of Stellera chamaejasme *** identified four previously unrecognized cryptic species having indistinct morphological traits and large metapopulation of evolving lineages,suggesting a more recent diversification(~2.67-0.90 Mya),largely influenced by Pleistocene glaciation and biotic *** factors likely influenced allopatric speciation and advocated cyclical warming–cooling episodes along elevational gradients during the *** study refines the evolutionary timeline to be much younger than previously implicated and raises the concern that projected future warming may influence the alpine species diversity,necessitating increased conservation efforts.

关键词： cryptic speciation glacial-interglacial Hengduan Mountains north-south migration Stellera chamaejasme

Emerging Novel Therapeutic Approaches for the Treatment of Alzheimer’s Disease

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Advances in Alzheimer's Disease 2024年第3期13卷 65-94页

作者： Amit Panwar Mohd. Imran Khan Rajesh kumar Rakesh kumar santosh kumar Rai Anil kumar New Drug Discovery Research Mankind Research Centre Mankind Pharma Limited Gurugram India

Alzheimer’s disease (AD) is caused by synaptic failure and the excessive accumulation of misfolded proteins especially Aβ and tau, and associated with memory loss and cognitive impairment. Treatment of AD mainly consists of symptomatic therapy and disease-modifying therapy (DMT). Several monotherapies including small molecules or antibodies have been evaluated through multiple clinical trials, but a very few have been approved by the USFDA to intervene the disease’s pathogenesis. Past research has shown multifactorial nature of AD, therefore, multi-target drugs were proposed to target different pathways at the same time, however, currently no rationally designed multi-target directed ligand (MTDL) has been clinically approved. Different combinations and bispecific antibodies are also under development. Novel approaches like stem cell-based therapies, microRNAs, peptides, ADCs and vaccines cast a new hope for AD treatment, however, a number of questions remained to be answered prior to their safe and effective clinical translation. This review explores the small molecules, MTDL, and antibodies (monospecific and bispecific) for the treatment of AD. Finally, future perspectives (stem cell therapy, PROTAC approaches, microRNAs, ADC, peptides and vaccines) are also discussed with regard to their clinical applications and feasibility.

关键词： Alzheimer’s Disease (AD) Disease-Modifying Therapy (DMT) MicroRNAs PROTAC

Study of Structural, Optical, Electrical and Dielectric Properties of Gd-Doped ZnO Composites Synthesized by Solid State Reaction Method

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Open Journal of Composite Materials 2024年第2期14卷 91-108页

作者： santosh kumar Kundara Kanhaiya Chawla Dinesh kumar Yadav Chhagan Lal Balram Tripathi Narendra Jakhar Department of Physics University of Rajasthan Jaipur India Sw. P.N.K.S. Government PG College Dausa India Government PG College Pratapgarh India S.S. Jain Subodh PG (Autonomous) College Jaipur India

In this manuscript, we are reporting structural, bonding, optical, dielectric, and electrical properties of Gd-doped ZnO composite samples (Zn1−xGdxO, x = 0, 0.05, 0.10) prepared by solid-state reaction method. XRD spectra confirm the wurtzite hexagonal phase with a grain size distribution of 42 - 47 nm. The FT-IR spectra confirm bonding behavior like Zn-O, O=C=O, and O-H stretching modes. FESEM micrographs show that the grains of crystallites possess nearly spherical morphology. Optical absorption spectra confirm that the optical band gap decreases systematically from 3.19 eV to 3.15 eV for x = 0.0 to x = 0.10 samples. For all samples, PL spectra exhibited near-band emission, blue emission, and green emission peaks. The dielectric constant decreases as the applied frequency increases. Hall effect results show that with increasing doping concentration of Gd, mobility and resistivity increase while bulk concentration decreases. Current-Voltage study shows that current increases when temperature is increased. Rare earth-doped ZnO is potential material used for optoelectronics and spintronics device applications. Properties of Gd-doped ZnO are studied by various research groups, but dielectric studies are limitedly reported. Therefore, the present research work aims to study the change of electrical, optical, and dielectric properties of Gd-doped ZnO for device applications.

关键词： ZnO:Gd Composites Optical Band Gap Green Emission Dielectric Constant

Impact of dental and orofacial trauma on oral health-related quality of life in adults:A systematic review

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Chinese Journal of Traumatology 2024年第5期27卷 249-253页

作者： santosh kumar Verma Awanindra kumar Jha Om Prakash Subia Ekram Chandmani Tigga Mohammad Kashif Noorani Vini Mehta Aida Meto Agron Meto Luca Fiorillo Marco Cicciù Department of Periodontology&Oral Implantology Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Orthodontic and Dentofacial Orthopedic Dental CollegeRajendra Institute of Medical SciencesRanchi834009JharkhandIndia Department of Oral and Maxillofacial Surgery Dental College Rajendra Institute of Medical SciencesRanchi834009JharkhandIndia Prosthodontics and Crown and Bridge and Oral Implantology 800001PatnaIndia Department of Public Health Dentistry Dr.D.Y.Patil Dental College and HospitalDr.D.Y.Patil VidyapeethPimpriPune411018MaharashtraIndia Department of Dentistry Faculty of Dental SciencesUniversity of Aldent1007TiranaAlbania Department of Biomedical and Dental Sciences Morphological and Functional ImagesUniversity of Messina98100MessinaItaly Multidisciplinary Department of Medical-Surgical and Dental Specialties Second University of Naples80100NaplesItaly Department of Surgery and Surgical Specialties University of Catania95100CataniaItaly

Purpose:Dental and orofacial trauma among the adult population constitutes a major public health *** impact is not just physical but also *** analyse the impacts of dental and orofacial trauma on oral health-related quality of life(OHRQoL)in adults and determine whether the 2 variables are closely ***:This is a systematic *** terms“dental trauma”,“orofacial trauma”,“oral health”,“oral health related impact life”,“OHRQoL”,“positive and negative affect scale”,“quality of life”,“facial injuries”,“adults”,and“young adults”were researched in the databases of PubMed,ScienceDirect,Scopus and Google Scholar for associated studies up to December 30,2022.A comprehensive search was designed and the articles were independently screened for eligibility by 2 *** included studies’author,year of publication,the country where the study was conducted,population demographics(number and age),an instrument used for assessing OHRQoL and the relevant result were recorded and *** quality of the evidence was assessed using Joanna Briggs Institute checklist for observational ***:Out of 482 unique records,3 articles were included for data *** studies were *** studies did not mention confounding *** scales were used for dental and orofacial trauma and *** has a directly proportional relationship with orofacial *** with orofacial trauma have a significant impact on this value with a prevalence of 88.4%.Conclusion:The highest impact on OHRQoL was seen immediately after the diagnosis of an orofacial *** impact increases with the severity of the ***,to promote overall dental and general health,health education initiatives should include information on the causes,prevention,and requirement for prompt responses by the populace in seeking dental intervention.

关键词： Dental trauma Oral health Oral health-related quality of life Orofacial trauma

Computation of pressure drop for dilute gas-solid suspension across thin and thick orifices

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Particuology 2021年第2期19卷 209-221页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

The present work deals with the computation of the gas-solid two-phase flow pressure drop across thin and thick orifices for a vertically downward flow configuration at the higher limits of a dilute phase flow situation(0.01≤αs,in≤0.10).The Eulerian-Eulerian(two-fluid)model has been used in conjunction with the kinetic theory of granular flow with a four-way coupling *** validation of the solution process has been performed by comparing the computational result with the existing experimental *** is observed that the two-phase flow pressure drop across the orifice increases with an increase in the thickness of the orifice,and the effect is more prominent at higher solid *** pressure drop is found to increase with an increase in the solid volume *** increase in the Reynolds number or the area ratio increases the pressure *** increase in the size of the particles reduces the pressure drop across the orifice at both small and relatively large solid volume ***,a two-phase multiplier has been proposed in terms of the relevant parameters,which can be useful to evaluate the gas-solid two-phase flow pressure drop across the orifice and can subsequently help to improve the system performance.

关键词： Dilute phase flow Gas-solid flow Thin and thick orifice Vertically downward flow Pressure drop

Pressure recovery characteristics for a dilute gas-particle suspension flowing vertically downward in a pipe with a sudden expansion: A two-fluid modeling approach

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Particuology 2020年第3期18卷 100-111页

作者： santosh kumar Senapati Sukanta kumar Dash Department of Mechanical Engineering Indian Institute of Technology KharagpurWest Bengal 721302India

This work applies the Eulerian-Eulerian model in conjunction with the kinetic theory of granular flow and inter-particle collisions to study the characteristics of pressure recovery for a dilute gas-particle suspension flowing through a pipe with a sudden expansion at a relatively higher solid *** do so,the numerical procedure was validated against experimental results for relatively small dilute phase flows in a pipe with a sudden expansion;a satisfactory agreement was ***,the effect of the two significant numerical parameters namely,the speculairty coefficient and the coefficient of restitution for particle-particle collisions were investigated and then,for fixed combinations of these parameters the effect of particle-phase volume fraction,particle density,particle size,and inlet slip ratio were *** was concluded that pressure recovery diminishes as the speculairty coefficient increases and the particle-particle coefficient of restitution *** recovery was found to increase with increasing solid volume fraction for coarse particles whereas,for fine particles,a critical volume fraction is obtained above which pressure recovery *** increase in slip ratio is found to diminish pressure ***,at relatively higher solid volume fractions,a critical diameter was found,above and below which pressure recovery decreases.

关键词： Gas-solid flow Sudden expansion pipe Eulerian-Eulerian model Pressure recovery Vertically downward flow