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Predicting the impact of climate change on the distribution of two threatened Himalayan medicinal plants of Liliaceae in Nepal

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Journal of Mountain Science 2017年第3期14卷 558-570页

作者： RANA santosh kumar RANA Hum Kala GHIMIRE Suresh Kulllar SHRESTHA Krishna kumar RANJITKAR Sailesh Key Laboratory for Plant Diversity and Biogeography of EastAsia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of Chinese Academy of Sciences Beijing 100049China Central Department of Botany Tribhuvan UniversityKirtipurKathmanduNepal World Agroforestry Centre East and Central Asia 132 Lanhei RdHeilongtanKunming 650201China

Predicting the potential distribution of medicinal plants in response to climate change is essential for their conservation and management. Contributing to the management program, this study aimed to predict the distribution of two threatened medicinal plants, Fritillaria cirrhosa and Lilium nepalense. The location of focal species gathered from herbarium specimen housed in different herbaria and online databases were geo-referenced and checked for spatial autocorrelation. The predictive environmental variables were selected, and MaxEnt software was used to model the current and future distributions of focal species. Four Representative Concentration Pathway （RCP） trajectories of the BCC-CSMI.1 model were used as the future （2050） projection layer. The MaxEnt modelling delineated the potential distribution of F. cirrhosa and L. nepalense. The current suitability is projected towards Central and Eastern Hilly/Mountainous regions. Both species gain maximum suitability in RCP 4.5 which decline towards other trajectories for L. nepalense. Overall, both the focal species shift towards the north-west, losing their potential habitat in hilly and lower mountainous regions by 2050 across all trajectories. Our results highlight the impact of future climate change on two threatened and valuable species. The results can be further useful to initiate farming of these medicinally and economically important species based on climatically suitable zone and for designing a germplasm conservation strategy.

关键词： Commercial exploitation Conservation Lily Fritillaria cirrhosa Lilium nepalense MaxEntmodelling Species distribution

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Otological manifestations in pregnant women-A study at a tertiary care hospital of eastern India

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Journal of Otology 2020年第3期15卷 103-106页

作者： santosh kumar Swain Basanta kumar Pati Jatindra Nath Mohanty Department of Otorhinolaryngology IMS and SUM HospitalSiksha“O”Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia Department of Obstetric&Gynaecology IMS and SUM HospitalSiksha“O”Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia Directorate of Medical Research IMS and SUM HospitalSiksha“O”Anusandhan UniversityK8KalinganagarBhubaneswar751003OdishaIndia

Background:There are several physiological changes found in pregnant women and amongst them,otological changes are quite *** otological manifestations in pregnant women are mainly due to changes of sex hormones levels,which return to normal in the postpartum ***:To report otological manifestations among pregnant *** and methods:Eighty-four pregnant women participated in this prospective study.A questionnaire was administered in all participants for assessing otological *** pregnant women were in the age range of 22e35 *** underwent thorough otological and obstetric *** tone audiometry(PTA)was done for assessment of hearing ***:The mean age of the pregnant women in this study was 26.23 *** most common otological manifestation was sensation of ear *** tube dysfunction was common in the last trimester of *** manifestations included vertigo and ***:The alteration of hormonal milieu in pregnant women can lead to several otological manifestations,including eustachian tube dysfunction,hearing impairment,otitis externa,Bell’s palsy,vertigo and *** these otological manifestations found in pregnant women,yet they are often neglected in clinical practice.

关键词： Pregnancy Hearing loss Tinnitus Vertigo

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AI-Based Hybrid Models for Predicting Loan Risk in the Banking Sector

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Big Data Mining and Analytics 2023年第4期6卷 478-490页

作者： Vikas kumar Shaiku Shahida Saheb Preeti Atif Ghayas Sunil kumari Jai Kishan Chandel Saroj kumar Pandey santosh kumar Humanities and Management Department Dr.B.R.Ambedkar National Institute of Technology JalandharJalandhar 144027India. Mittal School of Business Lovely Professional UniversityPhagwara 144402India. Department of Commerce&Business Administration Kanya Maha Vidyalaya(KMV)Jalandhar 144004India School of Management Gitam(to be deemed university)Bangalore 561203India Government College for Women Indra Gandhi UniversityAteli 123021India. Institute of Management Studies Kurukshetra UniversityKurukshetra 136119India Department of Computer Engineering and Applications GLA UniversityMathura 281406India Department of Management Jaipuriya Institute of ManagementJaipur 302033India

Every real-world scenario is now digitally replicated in order to reduce paperwork and human labor *** Learning(ML)models are also being used to make predictions in these *** forecasting requires knowledge of these machine learning models and their distinguishing *** datasets we use as input for each of these different types of ML models,yielding different *** choice of an ML model for a dataset is critical.A loan risk model is used to show how ML models for a dataset can be linked *** purpose of this study is to look into how we could use machine learning to quantify or forecast mortgage credit *** phrase refers to the process of evaluating massive amounts of data in order to derive useful information for making decisions in a variety of *** credit risk is considered,a method based on an examination of what caused and how mortgage credit risk affected credit defaults during the still-current economic crisis of 2021 will be *** approaches to credit risk calculation will be examined,ranging from the most basic to the most *** addition,we will conduct a case study on a sample of mortgage loans and compare the results of three different analytical approaches,logistic regression,decision tree,and gradient boost to see which one produced the most commercially useful insights.

关键词： Artificial Intelligence(AI) Machine Learning(ML) loan prediction Support Vector Machine(SVM) Random Forest(RF) accuracy

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Molecular phylogeny,biogeography and character evolution of the montane genus Incarvillea Juss.(Bignoniaceae)

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Plant Diversity 2021年第1期43卷 1-14页

作者： santosh kumar Rana Dong Luo Hum Kala Rana Shaotian Chen Hang Sun CAS Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of BotanyChinese Academy of SciencesKunming 650201China University of the Chinese Academy of Sciences Beijing 100049China College of Pharmaceutical Science Yunnan University of Chinese MedicineKunming 650500China

The complex orogeny of the Himalaya and the Qinghai-Tibet Plateau(QTP)fosters habitat fragmentation that drives morphological differentiation of mountain plant ***,determining phylogenetic relationships between plant subgenera using morphological characters is ***,we used both molecular phylogeny and historical biogeographic analysis to infer the ancestral states of several vegetative and reproductive characters of the montane genus *** determined the taxonomic position of the genus Incarvillea within its family and inferred the biogeographical origin of taxa through Bayesian inference(BI),maximum likelihood(ML)and maximum parsimony(MP)analyses using three molecular data sets(trnL-trnF sequences,nr ITS sequences,and a data set of combined sequences)derived from 81%of the total species of the genus *** the genus-level phylogenetic framework,we examined the character evolution of 10 key morphological characters,and inferred the ancestral area and biogeographical history of the *** analyses revealed that the genus Incarvillea is monophyletic and originated in Central Asia during mid-Oligocene ca.29.42 *** earliest diverging lineages were subsequently split into theWestern Himalaya and Sino-Himalaya during the early Miocene ca.21.12 *** lineages resulted in five re-circumscribed subgenera(Amphicome,Olgaea,Niedzwedzkia,Incarvillea,and Pteroscleris).Moreover,character mapping revealed the ancestral character states of the genus Incarvillea(e.g.,suffruticose habit,cylindrical capsule shape,subligneous capsule texture,absence of capsule wing,and loculicidal capsule dehiscence)that are retained at the earliest diverging ancestral nodes across the *** phylogenetic tree of the genus Incarvillea differs from previously proposed phylogenies,thereby recommending the placement of the subgenus Niedzwedzkia close to the subgenus Incarvillea and maintaining two main divergent lineages.

关键词： Biodiversity hotspots Biogeography Incarvillea Molecular phylogeny Phytools Stochastic character mapping

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Enhanced electrical and photocatalytic activities in Na_(0.5)Bi_(0.5)TiO_(3) through structural modulation by using anatase and rutile phases of TiO_(2)

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Journal of Materiomics 2022年第1期8卷 18-29页

作者： Cilaveni Goutham Kinjarapu Venkata Ashok kumar Sai santosh kumar Raavi Challapalli Subrahmanyam Saket Asthana Advanced Functional Materials Laboratory Department of PhysicsIndian Institute of Technology HyderabadKandiSangareddy502285TelanganaIndia Department of Chemistry Indian Institute of Technology HyderabadKandiSangareddy502285TelanganaIndia

This paper deals with an in-depth analysis on the role of the microstructure phase of titanium dioxide(TiO_(2))precursor in sodium bismuth titanate(Na_(0.5)Bi_(0.5)TiO_(3),hereafter represented as NBT)ceramics prepared through the hydrothermal *** comparison of the grain size,microstructure,crystal structure,and electrical properties of the NBT ceramics is carried out using anatase and rutile TiO_(2).NBT ceramics with anatase TiO_(2)(denoted by NBT_(A))displayed superior dielectric and ferro/piezoelectric properties along with the additional functionality in terms of *** studies of functional properties such as piezoelectric,ferroelectric,and dielectric stressed the far-reaching influence of effects on grain *** mechanisms and functional properties of grain quantitative effects are also *** boundaries volume fraction increment has decreased the dielectric peak but increased the diffusiveness in the case of the NBT with rutile TiO_(2) precursor(denoted as NBT_(R)).Similarly,elastic stiffness increment restricts the movement of the domain wall and led to a decrement in remnant polarization along with an increase in the values of the corresponding piezoelectric coefficient in finegrain NBT_(R) samples.

关键词： Lead-free ferroelectrics Grain size(microstructure) X-ray diffraction Electrical properties(dielectric and ferroelectric) Piezo-photocatalysis

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MicroRNA-99a mimics inhibit M1 macrophage phenotype and adipose tissue inflammation by targeting TNFα

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Cellular & Molecular Immunology 2019年第5期16卷 495-507页

作者： Anant Jaiswal Sukka santosh Reddy Mohita Maurya Preeti Maurya Manoj kumar Barthwal Division of Pharmacology Council of Scientific and Industrial Research-Central Drug Research Institute(CSIR-CDRI)Lucknow 226031 U.P.India Academy of Scientific and Innovative Research New Delhi 110025India

In human adipose tissue and obesity,miR-99a expression is negatively correlated with ***,the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation.M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and M1 ***-switching experiments established an association between upregulated miR-99a expression and the M2 *** of miR-99a prevented M1 phenotype activation and attenuated bactericidal ***,knockdown of miR-99a abolished M2 phenotype *** means of in silico target prediction tools and a luciferase reporter assay,TNFαwas identified as a direct target of *** of TNFαrecapitulated the effect of miR-99a overexpression in M1 *** a db/db mice model,miR-99a expression was reduced in eWAT and F4/80+*** overexpression of miR-99a in db/db mice attenuated adipocyte hypertrophy with increased CD301 and reduced CD86 *** cytometry analysis also showed an increased M2 and a reduced M1 macrophage *** of miR-99a also improved the diabetic dyslipidemia and insulin signaling in eWAT and liver,with an attenuated expression of gluconeogenesis and cholesterol metabolism genes in the ***,adoptive transfer of miR-99a-overexpressing macrophages in the db/db mice recapitulated in vivo miR-99a mimic effects with increased M2 and reduced M1 macrophage populations and improved systemic glucose,insulin sensitivity,and insulin signaling in the eWAT and *** present study demonstrates that miR-99a mimics can regulate macrophage M1 phenotype activation by targeting TNFα.miR-99a therapeutics in diabetic mice reduces the adipose tissue inflammation and improves insulin sensitivity.

关键词： inflammation macrophage CD86

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Blockchain Merkle-Tree Ethereum Approach in Enterprise Multitenant Cloud Environment

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Computers, Materials & Continua 2023年第2期74卷 3297-3313页

作者： Pooja Dhiman santosh kumar Henge Sartaj Singh Avinash Kaur Parminder Singh Mustapha Hadabou School of Computer Applications Lovely Professional UniversityPhagwara144001India School of Computer Science and Engineering Lovely Professional UniversityPhagwara144001India School of Computer Science Mohammed VI Polytechnic UniversityBen Guerir43150Morocco

This research paper puts emphasis on using cloud computing with Blockchain(BC)to improve the security and privacy in a *** security of data is not guaranteed as there is always a risk of leakage of users’*** can be used in a multi-tenant cloud environment(MTCE)to improve the security of data,as it is a decentralized *** is saved in unaltered ***,Blockchain is not owned by a single *** encryption process can be done using a Homomorphic encryption(HE)algorithm along with hashing technique,hereby allowing computations on encrypted data without the need for *** research paper is composed of four objectives:Analysis of cloud security using Blockchain technology;Exceptional scenario of Blockchain architecture in an enterprise-level MTCE;Implementation of cipher-text policy attribute-based encryption(CPABE)algorithm;Implementation of Merkle tree using Ethereum(MTuE)in a Multi-tenant *** of these four objectives,the main focus is on the implementation of CP-ABE ***-ABE parameters are proposed for different levels of *** levels include inner tenant,outer tenant,Inner-Outer-Tenant,Inner-Outer-External-Tenant,Outer-Inner-Tenant,External-Outer-Inner-Tenant and the parameters such as token,private key,public key,access tree,message,attribute set,node-level,cipher-text,salting which will help in providing better security using CP-ABE algorithm in a multitenant environment(MTE)where tenants can be provided with different levels of security and achieved 92 percentage of authenticity and access-control of the data.

关键词： Blockchain(BC) merkle tree using ethereum(MTuE) multi-tenant environment(MTE) homomorphic encryption(HE) ciphertext policy attribute-based encryption(CP-ABE)

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Analysis of asphalt mix surface-tread rubber interaction by using finite element method

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Journal of Traffic and Transportation Engineering(English Edition) 2017年第4期4卷 395-402页

作者： santosh kumar Srirangam kumar Anupam Cor Kasbergen Athanasios (Tom) Scarpas HSL Constructor Pte Ltd. Singapore 609162 Singapore Faculty of Civil Engineering and Geosciences Delft University of Technology Delft The Netherlands

The surface texture of the pavement plays a very important role in driving the frictional properties at the tire rubber-pavement interface. Particularly, the hysteretic friction due to viscoelastic deformations of rubber depends mainly on the pavement surface texture. In the present paper, the effect of micromechanical pavement surface morphology on rubber block friction was brought in by comparing the friction results for three different asphalt mix morphological surfaces, named stone mastic asphalt （SMA）, ultra-thin surfacing （UTS） and porous asphalt （PA）. The asphalt surface morphologies of these mixes were captured by using an X-ray tornographer, from which the resulting images micromechanical finite element （FE） meshes for SMA, UTS and PA pavements were developed by means of the SimpleWare software. In the FE model, the rubber and asphalt binder were modeled as viscoelastic （V-E） materials and the formulation was given in the large deformation frame- work. FE simulations were then carried out by using contact algorithm between rubber and the road surface. It was observed that the rubber friction inversely varies with the sliding speed and positively varies with the pressure for all the pavement morphological and stiffness conditions. Furthermore, it was observed that the highly porous pavement surface results in large dissipation of energy, hence, large rubber friction which shows that the mix characteristics of pavements have a simaificant effect on rubber friction.

关键词： Surface texture Hysteretic friction Micromechanical analysis Finite element Contact

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Wound healing activity of Delonix elata stem bark extract and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside in rats

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Journal of Pharmaceutical Analysis 2016年第6期6卷 389-395页

作者： Pradeepa Krishnappa Krishna Venkatarangaiah Venkatesh santosh kumar Shimoga Rajanna Rebijith Kayattukandy Balan Department of Post Graduate Studies and Research in Biotechnology Kuvempu University Department of Biotechnology MS Ramaiah Institute of Technology Department of Biochemistry Indian Institute of Science(IISc) Division of Biotechnology Indian Institute of Horticultural Research(IIHR)

Delonix elata *** a Ceasalpinaceae species and is traditionally used in India for treatment of skin diseases,liver diseases and rheumatic ***,systematic evaluation of its wound healing activity is ***,in the present study,we aimed to assess the wound healing activity of *** stem bark extract(DSE) and its isolated constituent quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside(QRPG) in *** formulations effects on wound healing were assessed by the wound contraction rate,epithelialization period,tensile strength,content of the hydroxyproline,hexosamine and uronic acid in granulation tissue,histopathological studies and Col 1 α(I) expression level in wound tissue by reverse transcription polymerase chain reaction(RT-PCR) *** topical application of DSE ointment caused faster epithelialization,significant wound contraction(100%),and better tensile strength(710.5 ± 10.5 g/cm^2),while QRPG showed wound epithelialization with 98.2%contraction,better than that of the control group(78.18%).The biochemical analysis of granulation tissue revealed that DSE and QRPG significantly increased hydroxyproline,hexosamine and uronic acid content.A significant increase in the expression of Col 1 α(I) was observed in the wound tissue of DSE and QRPG treated *** and QRPG were shown to enhance wound healing by increasing collagen synthesis through upregulation of Col 1 α(I),thus validating ethnomedicinal uses.

关键词： Delonix elata Quercetin-3-rhamnopyranosyl-(1-6) glucopyranoside (QRPG) Wound healing Hydroxyproline Tensile strength

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Three dimensional flow motions in the viscous sublayer

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Theoretical & Applied Mechanics Letters 2021年第2期11卷 105-109页

作者： S.santosh kumar Xinyi Huang Xiang Yang Jiarong Hong Department of Mechanical Engineering University of MinnesotaMinneapolisMN55455 Saint Anthony Falls Laboratory University of MinnesotaMinneapolisMN55414 Department of Mechanical Engineering Penn State UniversityUniversity ParkPA16802

We employ novel digital Fresnel reflection holography to capture the 3D flows within the viscous sublayerof a smooth-wall turbulent channel flow at Reτ=*** measurements reveal unsteady and diverse flow patterns in the sublayer including nearly uniform high and low speed flows and strong small-scale(onthe order of viscous wall units)spanwise meandering *** probability density functions(PDFs)ofwall shear stresses show a clear discrepancy in high stress range with those from direct numerical simu-lation(DNS),which is attributed to the unresolved streamwise and spanwise motions by ***,the PDF of Lagrangian particle accelerations yields a stretched exponential shape like that in homogenousisotropic turbulence,indicating strong intermittency in the *** find a significant fraction of highaccelerations is associated with the small-scale meandering *** study helps explain the effectof sublayer-scale roughness on reducing drag and flow separation reported in the literature.

关键词： Viscous sublayer Digital holography Meandering motions Turbulent channel flow Sublayer-scale roughness DNS

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