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Lubiprostone vs Senna in postoperative orthopedic surgery patients with opioid-induced constipation:A double-blind,active-comparator trial

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World Journal of Gastroenterology 2014年第43期20卷 16323-16333页

作者： Christina M Marciniak santiago Toledo Jungwhalia Lee Michael Jesselson Jillian Bateman Benjamin Grover Joy Tierny Department of Physical Medicine and Rehabilitation School of MedicineNorthwestern UniversityChicagoIL 60611United States Department of Preventive Medicine Feinberg School of MedicineNorthwestern UniversityChicagoIL 60611United States University of Chicago Medical Center ChicagoIL 60637United States The Rehabilitation Institute of Chicago ChicagoIL 60611United States Chicago College of Osteopathic Medicine ChicagoIL 60515United States

AIM: To investigate the efficacy of lubiprostone compared to Senna on bowel symptoms and constipation in post-operative orthopedic patients treated with opioids.

关键词： Constipation Opioids Lubiprostone Senna Orthopedics Rehabilitation

Uncertainty Reduction Through Data Management in the Development, Validation, Calibration, and Operation of a Hurricane Vulnerability Model

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International Journal of Disaster Risk Science 2020年第6期11卷 790-806页

作者： Jean-Paul Pinelli Josemar Da Cruz Kurtis Gurley Andres santiago Paleo-Torres Mohammad Baradaranshoraka Steven Cocke Dongwook Shin College of Engineering and Science Florida Institute of TechnologyMelbourneFL 32901USA Civil and Coastal Engineering University of FloridaGainesvilleFL 32611USA Center for Ocean-Atmospheric Prediction Studies(COAPS) Florida State UniversityTallahasseeFL 32306USA

Catastrophe models estimate risk at the intersection of hazard,exposure,and *** of these areas requires diverse sources of data,which are very often incomplete,inconsistent,or missing *** poor quality of the data is a source of epistemic uncertainty,which affects the vulnerability models as well as the output of the catastrophe *** article identifies the different sources of epistemic uncertainty in the data,and elaborates on strategies to reduce this uncertainty,in particular through identification,augmentation,and integration of the different types of *** challenges are illustrated through the Florida Public Hurricane Loss Model(FPHLM),which estimates insured losses on residential buildings caused by hurricane events in *** define the input exposure,and for model development,calibration,and validation purposes,the FPHLM teams accessed three main sources of data:county tax appraiser databases,National Flood Insurance Protection(NFIP)portfolios,and wind insurance *** data from these different sources were reformatted and processed,and the insurance databases were separately cross-referenced at the county level with tax appraiser *** FPHLM hazard teams assigned estimates of natural hazard intensity measure to each insurance *** efforts produced an integrated and more complete set of building descriptors for each policy in the NFIP and wind *** article describes the impact of these uncertainty reductions on the development and validation of the vulnerability models,and suggests avenues for data *** learned should be of interest to professionals involved in disaster risk assessment and management.

关键词： Catastrophe modeling Data augmentation and integration Florida Public Hurricane Loss Model(FPHLM) Uncertainty reduction Vulnerability model

Epidemiology of inflammatory bowel disease in South America: A systematic review

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World Journal of Gastroenterology 2019年第47期25卷 6866-6875页

作者： Sriharan Selvaratnam santiago Gullino Lisa Shim Eric Lee Alice Lee Sudarshan Paramsothy Rupert W Leong Department of Gastroenterology and Hepatology Macquarie University Hospital

BACKGROUND The worldwide epidemiology of inflammatory bowel disease(IBD)is rapidly *** Crohn’s disease(CD)and ulcerative colitis(UC)incidence and prevalence have been recorded in developing regions such as Asia,Africa and Eastern Europe where it was previously thought to be *** this is also the case in South America is not well *** that developing regions worldwide have increasing IBD incidence would indicate that environmental change plays a significant role in the development of *** To report the incidence,prevalence and disease characteristics of CD and UC within the South American *** A systematic review was conducted by searching published studies in major international and regional databases(MEDLINE,EMBASE and Scopus)between January 1990 and December *** considered were incidence,prevalence,phenotype,environmental and genetic factors,ethnicity and gender.A pair of independent reviewers screened and reviewed all identified *** One hundred and sixty two citations were initially retrieved with 18 studies included in this systematic *** majority of included studies were from Brazil(n=13,72%).The incidence of UC ranged from 4.3-5.3/100000 personyears whilst the incidence of CD ranged from 0.74-3.5/100000 *** ranged from 15.0-24.1/100000 inhabitants for UC and from 2.4-14.1/100000 inhabitants for *** incidence and prevalence of both UC and CD has increased significantly in Brazil over the past 21 *** was the most common disease distribution in patients with UC whilst colonic involvement was the most common distribution in *** residing in urban areas were at higher risk of developing both CD and *** The IBD burden in South America is increasing at a rate possibly even greater than other developing regions around the *** is a paucity of highquality epidemiological studies and further robust and representative data are

关键词： Inflammatory bowel disease Crohn’s disease Ulcerative colitis South America Epidemiology

A guide to diagnosis of iron deficiency and iron deficiency anemia in digestive diseases

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World Journal of Gastroenterology 2009年第37期15卷 4638-4643页

作者： Fernando Bermejo santiago García-López Digestive Service University Hospital of Fuenlabrada Fuenlabrada Madrid 28942 Spain Digestive Service University Hospital Miguel Servet Zaragoza 50009 Spain

Iron deficiency （ID）, with or without anemia, is often caused by digestive diseases and should always be investigated, except in very specific situations, as its causes could be serious diseases, such as cancer. Diagnosis of ID is not always easy. Low serum levels of ferritin or transferrin saturation, imply a situation of absolute or functional ID. It is sometimes difficult to differentiate ID anemia from anemia of chronic diseases, which can coexist. In this case, other parameters, such as soluble transferrin receptor activity can be very useful. After an initial evaluation by clinical history, urine analysis, and serological tests for celiac disease, gastroscopy and colonoscopy are the key diagnostic tools for investigating the origin of ID, and will detect the most important and prevalent diseases. If both tests are normal and anemia is not severe, treatment with oral iron can be indicated, along with stopping any treatment with non-steroidal anti-inflammatory drugs. In the absence of response to oral iron, or if the anemia is severe or clinical suspicion of important disease persists, we must insist on diagnostic evaluation. Repeat endoscopic studies should be considered in many cases and if both still show normal results, investigating the small bowel must be considered. The main techniques in this case are capsule endoscopy, followed by

关键词： Anemia Iron-deficiency Iron deficiency anemia

Tibet under Unstoppable Development

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The Journal of Human Rights 2007年第3期6卷 35-36页

作者： santiago CASTILLO

santiago Castillo, reporter from Agencia Efe, Spain, visited Tibet Autonomous Region on August 11-21, 2005. He published a series of reports after returning to Spain. Following is one of his reports.

关键词： Tibet under Unstoppable Development La high over

Comprehensible Technique in Solving Consecutive Number Problems in Algebra

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Journal of Applied Mathematics and Physics 2018年第3期6卷 447-457页

作者： Gener santiago Subia Graduate School Nueva Ecija University of Science and Technology Cabanatuan City Philippines

This research paper evaluated and investigated the effectiveness of the comprehensible technique (CT) introduced by the researcher as an alternative solution to Algebra’s linear equations in solving consecutive number problems. The CT is a proposed easy and efficient way of solving number problems which aimed to help the learners reduce their difficulties in using variables since the technique only uses basic arithmetic and mental Mathematics. Evaluation research was utilized in this study where 20 people, from various ages and professions, were chosen purposively as respondents of the study. The study found out that CT was very effective for the respondents especially in unlocking difficulties in solving consecutive number problems. Moreover, according to them, the CT is easy to use, it is engaging and enjoyable, direct and simple and can be utilized as shortcut way of solving consecutive number problems when competing in Math quiz bees or taking board examinations where time is of the essence.

关键词： Algebra Comprehensible Technique Consecutive Number Problems Linear Equation

Multiple color patches and parasites in Sceloporus occidentalis:differential relationships by sex and infection

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Current Zoology 2018年第6期64卷 703-711页

作者： Rodrigo MEGIA-PALMA Dhanashree PARANJPE Senda REGUERA Javier MARTINEZ Robert D COOPER Pauline BLAIMONT santiago MERINO Barry SINERVO Department of Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSICJose Gutierrez Abascal 2.Madrid E-28006Spain Departrnent of Ecology and Evolutionary Biology University of CaliforniaSanta Cruz1156High StSanta CruzCA 95064USA Department of Zoologia Facultad de CienciasUniversidad de GranadaGranada E-18071Spain Area Parasitologia Department of Biomedicina y BiotecnologiaArea de ParasitologiaFacultad de FarmaciaUniversidad de Alcala de HenaresAlcala de HenaresMadrid E-28871Spain

Parasites generally have a negative influence on the color expression of their *** selection theory predicts resistant high-quality individuals should show intense coloration,whereas susceptible low-quality individuals would show poor ***,intensely colored males of different species of Oid and New World lizards were more often infected by *** results suggest that high-quality males,with intense coloration,would suffer higher susceptibility to *** hypothesis remains poorly understood and contradicts general theories on sexual *** surveyed a population of Sceloporus occidentalis for parasites and found infections by the parasite genera Lankesterella and *** this population,both males and females express ventral blue and yellow color *** was almost exclusively infecting *** body size of the males significantly predicted the coloration of both blue and yellow *** males showed darker (lower lightness)blue ventral patches and more saturated yellow patches that were also ***,these males were more often infected by Lankesterella than smaller *** intestinal parasite Acroeimeria infected both males and *** infection by intestinal parasites of the genus Acroeimeria was the best predictor for the chroma in the blue patch of the males and for hue in the yellow patch of the *** males infected by Acroeimeria expressed blue patches with significantly lower chroma than the uninfected ***,the hue of the yellow patch was not significantly different between infected and uninfected *** results suggest a different effect of Lankesterella and Acroeimeria on the *** the one hand,the intense coloration of male lizards infected by Lankesterella suggested high-quality male lizards may tolerate *** the other hand,the low chroma of the blue coloration of the infected males suggested that this coloration could honest

关键词： animal communication coloration Hamilton and Zuk parasites sexual selection

Hyperthermic intraperitoneal chemotherapy:Rationale and technique

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World Journal of Gastrointestinal Oncology 2010年第2期2卷 68-75页

作者： santiago González-Moreno Luis A González-Bayón Gloria Ortega-Pérez Peritoneal Surface Oncology Program Department of Surgical OncologyCentro Oncológico MD Anderson International Espaa28033 MadridSpain

The combination of complete cytoreductive surgery and perioperative intraperitoneal chemotherapy provides the only chance for long-term survival for selected patients diagnosed with a variety of peritoneal neoplasms,either primary or secondary to digestive or gynecologic *** intraperitoneal chemotherapy (HIPEC) delivered in the operating room once the cytoreductive surgical procedure is fi nalized,constitutes the most common form of administration of perioperative intraperitoneal *** may be complemented in some instances with early postoperative intraperitoneal chemotherapy (EPIC).HIPEC combines the pharmacokinetic advantage inherent to the intracavitary delivery of certain cytotoxic drugs,which results in regional dose intensification,with the direct cytotoxic effect of *** exhibits a selective cell-killing effect in malignant cells by itself,potentiates the cytotoxic effect of certain chemotherapy agents and enhances the tissue penetration of the administered *** chemotherapeutic agents employed in HIPEC need to have a cell cycle nonspecific mechanism of action and should ideally show a heat-synergistic cytotoxic *** of HIPEC requires an apparatus that heats and circulates the chemotherapeutic solution so that a stable temperature is maintained in the peritoneal cavity during the *** open abdomen (Coliseum) or closed abdomen technique may be used,with no signif icant differences in eff icacy proven to *** ic technical training and a solid knowledge of regional chemotherapy management are *** about safety of the procedure for operating room personnel are expected but are manageable if universal precautions and standard chemotherapy handling procedures are *** HIPEC drug regimens and dosages are currently in use.A tendency for concurrent intravenous chemotherapy administration (bidirectional chemotherapy,so-called "HIPEC plus") has been observed in rece

关键词： Hyperthermia Intracavitary chemotherapy Peritoneal neoplasms Peritoneal carcinomatosis Cytoreductive surgery

Impact of sports participation on cardiovascular health markers of children and adolescents: Systematic review and meta-analysis

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World Journal of Clinical Pediatrics 2022年第4期11卷 375-384页

作者： Wesley Torres santiago Maillane-Vanegas Jacqueline Bexiga Urban Romulo Araujo Fernandes Department of Physical Education Sao Paulo State University-UNESPPresidente Prudente 19060900Sao PauloBrazil

BACKGROUND Cardiovascular diseases have a high prevalence in adults and their development begins in the first decades of *** the other hand,sports participation in childhood and adolescence provides benefits which can delay the onset of these *** To synthesize the available literature on the impact of sports participation on cardiovascular outcomes in children and *** This systematic review was conducted on studies of children and adolescents(aged 8-18 years)who regularly practiced a sport and had reported cardiovascular outcomes(blood pressure and intima-media thickness)*** Medline/PubMed,SciELO,Reference Citation Analysis(https://*** ***/)and Bireme databases were *** In total,3314 publications for blood pressure and 122 publications for intimamedia thickness were identified in the *** exclusions(e.g.,duplicate articles,animal studies and those that did not meet the inclusion criteria),four publications for blood pressure(449 adolescents)and two publications for intimamedia thickness were included(402 adolescents).For blood pressure,all publications were longitudinal in design(follow-up ranging from 12 wk to 12 mo)and involved adolescents aged from 8 years to 18 years of *** intima-media thickness,both publications were longitudinal in design and involved adolescents aged from 11 years to 18 years of *** Sports participation seems to promote benefits to cardiovascular structure and function in ***,studies with adolescents are scarce and further research is needed to understand this phenomenon.

关键词： Pediatrics Adolescents Sports Blood pressure Intima-media thickness