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New drug delivery system for liver sinusoidal endothelial cells for ischemia-reperfusion injury

World Journal of Gastroenterology 2015年第45期21卷 12778-12786页

作者： Naoki sano takafumi tamura Naoyuki toriyabe takeshi Nowatari Ken Nakayama tomohito tanoi Soichiro Murata Yu Sakurai Mamoru Hyodo Kiyoshi Fukunaga Hideyoshi Harashima Nobuhiro Ohkohchi Department of Surgery Doctoral Program in Clinical Science Graduate School of Comprehensive Human Sciences University of Tsukuba Faculty of Pharmaceutical Sciences Hokkaido University

AIM: to investigate the cytoprotective effects in hepatic ischemia-reperfusion injury, we developed a new formulation of hyaluronic acid(HA) and sphingosine ***: We divided Sprague-Dawley rats into 4 groups: control, HA, sphingosine 1-phosphate(S1P), and HA-S1 P. After the administration of each agent, we subjected the rat livers to total ischemia followed by reperfusion. After reperfusion, we performed the following investigations: alanine aminotransferase(ALt), histological findings, td t-mediated d UtP-biotin nick end labeling(tUNEL) staining, and transmission electron microscopy(tEM). We also investigated the expressionof proteins associated with apoptosis, hepatoprotection, and S1 P accumulation. RESULtS: S1 P accumulated in the HA-S1 P group livers more than S1 P group livers. Serum ALt levels, tUNEL-positive hepatocytes, and expression of cleaved caspase-3 expression, were significantly decreased in the HA-S1 P group. tEM revealed that the liver sinusoidal endothelial cell(LSEC) lining was preserved in the HA-S1 P group. Moreover, the HA-S1 P group showed a greater increase in the HO-1 protein levels compared to the S1 P ***: Our results suggest that HA-S1 P exhibits cytoprotective effects in the liver through the inhibition of LSEC apoptosis. HA-S1 P is an effective agent for hepatic ischemia/reperfusion injury.

关键词： Hyaluronic acid Sphingosine 1-phosphate Liver sinu

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Sitagliptin counteracts seasonal fluctuation of glycemic control

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World Journal of Diabetes 2012年第6期3卷 118-122页

作者： tomohiro Matsuhashi Motoaki sano Keiichi Fukuda Shun Kohsaka Yoshihiko Suzuki Department of Cardiology Keio University School of MedicineTokyo 160-8582Japan Division of Cardiovascular Inflammation Department of MedicineKeio University School of MedicineTokyo 160-8582Japan HDC Atlas Clinic Tokyo 102-0082Japan

AIM:to assess the effect of sitagliptin therapy on seasonal fluctuation of glycemic control in Japanese type 2 diabetic ***:Participating patients(age:29-80 years) had been treated with conventional oral antidiabetic agents and/or diet and exercise therapy for over 6 *** December 2009,35 patients were additionally prescribed oral sitagliptin starting from 50 mg once daily,while 19 patients taking-glucosidase inhibitors were switched to ***-four patients who refused sitagliptin formed the control *** of mean monthly hemoglobin A 1c(HbA 1c) during the "winter holiday season" were compared between groups using Student's t-test(2008-2009 vs 2009-2010).Statistical significance was accepted at P to assess whether sitagliptin use was associated with deterioration or improvement of glycemic ***:Both add-on sitagliptin and switching from-glucosidase inhibitors to sitagliptin prevented the seasonal deterioration of glycemic control and tended to improve HbA *** analysis revealed that both adding and switching to sitagliptin were negatively correlated with deterioration of glycemic *** 44 patients who continued sitagliptin therapy for another year,elevation of HbA 1c was suppressed without adverse ***:Sitagliptin is a suitable oral agent for preventing deterioration of glycemic control during the winter holiday season.

关键词： type 2 diabetes mellitus Dipeptidyl-peptidase 4 inhibitors Sitagliptin Seasonal variation Hemoglobin A 1c

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伴睑板腺炎的疱性角膜炎青年患者

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世界核心医学期刊文摘（眼科学分册） 2005年第12期1卷 10-10页

作者： Suzuki t Mitsuishi Y sano Y 陈立军 Department of Ophthalmology Kyoto Prefectural University of Medicine Kajii-cho Kamigyo-ku Kyoto City 602- 0841 JapanDr

PURPOSE: to describe the unique clinical features of phlyctenular keratitis, including the association with meibomitis, in young patients. DESIGN: Observational case series. MEtHODS: the study population consisted of 23 Japanese patients aged under 35 years with phlyctenular keratitis. We examined their clinical history, signs and symptoms, human leukocyte antigen (HLA), bacterial cultures of meibum, and the efficacy of antibiotics. the minimal diagnostic criteria included corneal nodules consisting of cellular infiltrates and superficial neovascularization. RESULtS: Of the 23 patients, 20 (87% )- were women, and 13 (56.5% ) had a history of chalazia. In all cases, the lesions and the severity of corneal nodules and neovascularization corresponded well with the location and the severity of meibomitis. the frequency of HLA- A26 and HLA- B35 was significantly increased in our patients (P=.003 and .016, respectively). Propionibacterium acnes in bacterial cultures of pure meibum in 12 of the 20 patients (60% ) was statistically more highly positive than those in four of the 17 age-matched normal control subjects (23.5% ; P=.028). CONCLUSION: the characteristics of phlyctenular keratitis in our cases include significantly higher prevalence in female patients, severity variation of ocular surface manifestation corresponding to meibomitis, specific HLA association, and possible P. acnes involvement.

关键词：睑板腺炎小疱棒状杆菌霰粒肿人白细胞抗原研究人群严重度病例研究观察性

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肝细胞期延迟时间缩短在减少肝脏GD-EOB-DtPA增强MRI检查时间的可行性研究

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国际医学放射学杂志 2010年第1期 90-90页

作者： U.Motosugi t.Ichikawa L.tominaga H.Sou K.sano S.Ichikawa 王大丽 Department of Radiology University of Yamanashi

探索在局灶性肝脏病变检出中,是否能够通过省略延迟20min的时间的肝细胞期(Im-20)来缩短Gd-EOB-DtPA增强MRI的检查时间。本研究共包括265例病人,在Im-20上检出了495个恶性的局灶性肝病灶。肝细胞期在注射Gd-EOB后10min和20min获得。肝... 详细信息

探索在局灶性肝脏病变检出中,是否能够通过省略延迟20min的时间的肝细胞期(Im-20)来缩短Gd-EOB-DtPA增强MRI的检查时间。本研究共包括265例病人,在Im-20上检出了495个恶性的局灶性肝病灶。肝细胞期在注射Gd-EOB后10min和20min获得。肝脏强化程度的评估采用4点分级法[优秀、良好、差

关键词： GD-EOB-DtPA MRI 肝脏细胞期

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肝脏组织特征的MR指纹技术与组织病理学相关性研究

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国际医学放射学杂志 2023年第2期 229-229页

作者： S.Fujita K.sano G.Cruz Y.Fukumura H.Kawasaki I.Fukunaga 李文萃

摘要肝脏MR指纹技术(MRF)能够在单次屏息采集中同时量化t1、t2、t2*和质子密度脂肪分数(PDFF)图。其临床应用需要进行组织病理学相关性研究。目的比较弥漫性肝

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