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Interactions of primary neuroepithelial progenitor and brain endothelial cells: distinct effect on neural progenitor maintenance and differentiation by soluble factors and direct contact

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Cell Research 2007年第7期17卷 619-626页

作者： Miguel A Gama sosa Rita De Gasperi Anne B Rocher Gissel M Perez Keila Simons Daniel E Cruz Patrick R Hof Gregory A Elder Departments of Psychiatry Research and Development Service James J. Peters Department of Veterans Affairs Medical Center 130 West Kingsbridge Road Bronx New York 10468 USA Neuroscience Mount Sinai School of Medicine of New York University New York NY Department of Research and Development Service James J. Peters Department of Veterans Affairs Medical Center 130 West Kingsbridge Road Bronx New York 10468 USA

Neurovascular interactions are crucial for the normal development of the central nervous system. To study suchinteractions in primary cultures, we developed a procedure to simultaneously isolate neural progenitor and endothelialcell fractions from embryonic mouse brains. Depending on the culture conditions endothelial cells were found to favormaintenance of the neuroprogenitor phenotype through the production of soluble factors, or to promote neuronal differ-entiation of neural progenitors through direct contact. These apparently opposing effects could reflect differential cellularinteractions needed for the proper development of the brain.

关键词： differentiation culture endothelial cells neuroepithelial cells

Nightlife in the city: drivers of the occurrence and vocal activity of a tropical owl

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Avian Research 2020年第2期11卷 92-105页

作者： Oscar Humberto Marín‑Gómez Michelle García‑Arroyo Camilo ESánchez‑Sarria JRoberto sosa‑López Diego Santiago‑Alarcon Ian MacGregor‑Fors Red de Ambiente y Sustentabilidad Instituto de Ecología A.C.Carretera antigua a Coatepec 351El Haya91073 XalapaVeracruzMexico Departamento de Ciencias Naturales y Matemáticas Pontificia Universidad Javeriana Cali760044 CaliColombia Centro Interdisciplinario de Investigación para el Desarrollo Integral Regional Unidad Oaxaca(CIIDIR) Instituto Politécnico NacionalOaxacaMexico Dirección de Cátedras Consejo Nacional de Ciencia y Tecnología(CONACYT)Mexico CityMexico Red de Biología y Conservación de Vertebrados Instituto de Ecología A.C91073 XalapaVeracruzMexico

Background:Cities differ from non-urban environments by the intensity,scale,and extent of anthropogenic pres-sures,which can drive the occurrence,physiology,and behavior of the organisms thriving in these *** as green cover often predict the occurrence patterns of bird species in urban ***,anthropogenic noise and artificial light at night(ALAN)could also limit the presence and disrupt the behavior of ***,there is still a dearth of knowledge about the influence of urbanization through noise and light pollution on nocturnal bird species *** this study,we assessed the role of green cover,noise,and light pollution on the occurrence and vocal activity of the Mottled Owl(Ciccaba virgata)in the city of Xalapa(Mexico).Methods:We obtained soundscape recordings in 61 independent sites scattered across the city of Xalapa using autonomous recording *** performed a semi-automated acoustic analysis of the recordings,corroborating all Mottled Owl *** calculated two measures of anthropogenic noise at each study site:daily noise(during 24 h)and masking noise(mean noise amplitude at night per site that could mask the owl’s vocalizations).We further performed generalized linear models to relate green cover,ALAN,daily noise,and masking noise in relation to the owl’s occurrence(i.e.,detected,undetected).We also ran linear models to assess relationships among the beginning and ending of vocal activity with ALAN,and with the anthropogenic and masking noise levels at the moment of which vocalizations were ***,we explored variations of the vocal activity of the Mottled Owl measured as vocalization rate across ***:The presence of Mottled Owls increased with the size of green cover and decreased with increases in both artificial light at night and noise *** the temporal scale,green cover was positively related with the ending of the owl’s vocal activity,while daily noise and ALAN levels were not related to the tim

关键词： Anthropogenic noise Acoustic monitoring Nighttime ecology Urban ecology Urbanization Vocal activity

Isotropic compression behavior of granular assembly with non-spherical particles by X-ray micro-computed tomography and discrete element modeling

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Journal of Rock Mechanics and Geotechnical Engineering 2021年第5期13卷 972-984页

作者： Nan Zhang Ahmadreza Hedayat Shaoyang Han Runlin Yang Héctor Gelber Bolaños sosa Juan JoséGonzález Cárdenas Guido Edgard SalasÁlvarez Department of Civil and Environmental Engineering Colorado School of Mines1500 Illinois St.GoldenCO80401USA Key Laboratory of Ministry of Education for Geomechanics and Embankment Engineering Hohai UniversityNanjing210098China School of Civil and Resource Engineering University of Science and Technology BeijingBeijing100083China Universidad Nacional de San Agustín de Arequipa ArequipaPeru

The particle morphological properties,such as sphericity,concavity and convexity,of a granular assembly significantly affect its macroscopic and microscopic compressive behaviors under isotropic loading ***,limited studies on investigating the microscopic behavior of the granular assembly with real particle shapes under isotropic compression were *** this study,X-ray computed tomography(mCT)and discrete element modeling(DEM)were utilized to investigate isotropic compression behavior of the granular assembly with regard to the particle morphological properties,such as particle sphericity,concavity and interparticle *** mCT was first used to extract the particle morphological parameters and then the DEM was utilized to numerically investigate the influences of the particle morphological properties on the isotropic compression *** image reconstruction from mCT images indicated that the presented particle quantification algorithm was robust,and the presented microscopic analysis via the DEM simulation demonstrated that the particle surface concavity significantly affected the isotropic compression *** observations of the particle connectivity and local void ratio distribution also provided insights into the granular assembly under isotropic *** found that the particle concavity and interparticle friction influenced the most of the isotropic compression behavior of the granular assemblies.

关键词： X-ray computed tomography(mCT) Discrete element modeling(DEM) Isotropic compression Particle surface curvature Particle morphology

Granulomatous Mastitis, Radio-Histological Correlation

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Open Journal of Radiology 2020年第4期10卷 223-229页

作者： Priscila Falla Berganza Mariela sosa Ramos Master's Degree in Radiology and Diagnostic Imaging San Carlos University Guatemala City Guatemala

Granulomatous mastitis, also called granulomatous lobular mastitis, is a benign pathology of the mammary gland characterized by chronic inflammation of the gland tissue, which becomes erythematous, manifesting itself as a palpable and painful mass on physical examination, sometimes it can be accompanied by abscesses. The following case is a 45-year-old Guatemalan female, with a history of increased volume in the left breast, compromising the upper quadrants. A mammogram was performed, followed by breast ultrasound;the diagnosis was confirmed by histology. The treatment offered was surgery with image controls every six months.

关键词： Breast Density BIRADS Mastitis Granulomatous Mastitis Biopsy Histological Mammography Echography

Surgical perspectives in gastrointestinal disease: A study of quality of life outcomes in esophageal, pancreatic, colon, and rectal cancers

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World Journal of Gastroenterology 2006年第20期12卷 3213-3218页

作者： Kate V Viola Charlotte Ariyan Julie Ann sosa Department of Surgery Yale University School of MedicineNew HavenCT 06520-8062United States MD Department of Surgery Yale University School of MedicineNew HavenCT 06520-8062United States MD FACS

在外科的结果评价传统地包括了考虑的数据在外科的肿瘤学的仙子起作用的死亡和病态，以及长期的幸存和复发。然而，生命(QOL ) 的质量是另一项重要病人相关的结果措施。QOL 数据能被用来定制治疗并且由在可能不那样被俯看的病人检测物... 详细信息

在外科的结果评价传统地包括了考虑的数据在外科的肿瘤学的仙子起作用的死亡和病态，以及长期的幸存和复发。然而，生命(QOL ) 的质量是另一项重要病人相关的结果措施。QOL 数据能被用来定制治疗并且由在可能不那样被俯看的病人检测物理或心理的问题改进临床的结果，但是它为照顾的有效交货有深刻含意。我们考察仪器与胃肠的恶意在病人为使用明确地开发了的几验证得好的 QOL，包括食道，胰腺并且渲染表面的癌症，并且断定 QOL 评价应该习惯性地在新奇治疗的临床的试用被包括。

关键词：手术治疗透视检查胃肠疾病生活质量食管疾病

Model based current mode control design and experimental validation for a 3φ rectifier under unbalanced grid voltage conditions

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Journal of Modern Power Systems and Clean Energy 2018年第4期6卷 777-790页

作者： P.R.MARTíNEZ-RODRIGEZ Jose M.sosa Samuel ITURRIAGA-MEDINA Gerardo ESCOBAR Gerardo VáZQUEZ-GUZMáN Andres A.VALDEZ-FERNáNDEZ School of Sciencies UASLP Laboratory of Electrical and Power Electronics ITESI School of Engineering Universidad Modelo

This paper addresses the control design and the experimental validation of a current mode control for a three phase voltage source rectifier. The proposed control law is able to fulfill the voltage regulation and the current tracking control objectives despite of unbalanced and distorted grid voltages. The proposed control law consists of two loops, which are referred as inner tracking loop and the outer voltage regulation loop. The inner loop is designed to provide damping to the system, which also includes and adaptive mechanism. The construction of the current reference is based on the positive component detection of thegrid voltage. Therefore, the current produced by the power rectifier is proportional to the fundamental component of the grid voltage, despite of the presence of unbalanced grid voltages. The voltage regulation loop is designed as a proportional-integral controller, which is aimed to regulate the DC output voltage to a desired level. Finally, experimental results are obtained in an experimental prototype of2 kW to evaluate the performance of the proposed controller.

关键词： Pulse-width modulation rectifier Power factor correction Positive-component Current mode control

Morphological Characterization and Phenological Modeling of <i>Jatropha platyphylla</i>(Euphorbiaceae) Muell. Arg. Genotypes

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American Journal of Plant Sciences 2022年第1期13卷 23-35页

作者： Edith Salazar-Villa Martha Lidia Gutiérrez-Pérez Federico Soto-Landeros Karla Marina Báez-Parra María de la Paz sosa-Segura Miguel Angel Angulo-Escalante Centro de Investigación en Alimentación y Desarrollo AC Culiacán México Facultad de Agronomía Universidad Autónoma de Sinaloa Culiacán México Instituto Tecnológico Superior de Guasave Guasave México Facultad de Ciencias Químico Biológicas Universidad Autónoma de Sinaloa Culiacán México Colegio de Bachilleres del Estado de Sinaloa Culiacán México

Morphological characterization and phenological modeling were carried out on genotypes of Jatropha platyphylla collected from the states of Sinaloa and Durango, Mexico. The morphological characterization evidenced the existence of monoecious plants, finding individuals with male and female flowers in the same inflorescence. Fruit with four seeds was also found. The phenological study was divided into two phases and calculated in thermal requirement (°D): Vegetative [seedtime (0), germination (24), emergence (98), cotyledons (87), second (302) and fourth (524) true leaves, end of vegetative growth (302)] and reproductive [flowering (303), fructification (342), maturation (126), defoliation and senescence (450)]. The thermal constant (2558) was similar in all eight genotypes. The phenological stages and the accumulated degree days were adjusted with a third-degree polynomial (Stage = -0.0041x3 + 0.7446x2 - 8.6808x + 6.2448) (R2 = 0.99%) stage. The development of phenological models facilitates the prediction of the flowering date for the selection of varieties with high oil and protein content.

关键词： Degree-Days Monoecious Phenological Modeling Plant Breeding Varietal Selection

入侵植物喜旱莲子草——生物学、生态学及管理

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植物分类学报 2007年第6期45卷 884-900页

作者：潘晓云耿宇鹏 Alejandro sosa 张文驹李博陈家宽生物多样性和生态工程教育部重点实验室复旦大学生物多样性科学研究所长江河口湿地生态系统野外科学观测研究站上海200433 南美生物防治实验室

喜旱莲子草Alternanthera philoxeroides原产于南美洲,属于苋科Amaranthaceae莲子草属Alternanthera。一百多年来,该物种通过压舱水或军马饲料被传播到北美洲、大洋洲、欧洲,以及东南亚和中国等地,成为暖温带-热带湿润气候区淡水生态系... 详细信息

喜旱莲子草Alternanthera philoxeroides原产于南美洲,属于苋科Amaranthaceae莲子草属Alternanthera。一百多年来,该物种通过压舱水或军马饲料被传播到北美洲、大洋洲、欧洲,以及东南亚和中国等地,成为暖温带-热带湿润气候区淡水生态系统的重要外来入侵种。本文结合对喜旱莲子草在原产地的分布状况的考察、原产地和入侵地喜旱莲子草的比较研究,以及入侵生态学研究的最新成果,对该物种在原产地的地理分布和种内变异、生活史特征、入侵机制和控制策略等方面进行评述,以提高我国科研人员对这一外来入侵种的认识,为科学管理和控制提供依据。

关键词：喜旱莲子草生物入侵扩散干扰种内变异生活史集合种群流域管理

Role of colonoscopy in the diagnostic work-up of bowel endometriosis

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World Journal of Gastroenterology 2015年第16期21卷 4997-5001页

作者： Marco Milone Antonio Mollo Mario Musella Paola Maietta Loredana Maria sosa Fernandez Olena Shatalova Alessandro Conforti Gianni Barone Giuseppe De Placido Francesco Milone Department of Advanced Biomedical Science University of Naples "Federico II" Department of Neuroscience Reproductive Science and OdonstostomatologyUniversity of Naples "Federico II" Department of Surgery Fatebenefratelli Hospital

AIM:To evaluate the accuracy of colonoscopy for the prediction of intestinal involvement in deep pelvic ***:This prospective observational study was performed between September 2011 and July *** women with both a clinical and imaging diagnosis of deep pelvic endometriosis were *** study was approved by the local ethics committee and written informed consent was obtained in all *** colonoscopy and laparoscopy were performed by expert surgeons with a high level of expertise with these *** was performed within4 wk of colonoscopic *** hypothetical colonoscopy findings(eccentric wall thickening with or without surface nodularities and polypoid lesions with or without surface nodularities of endometriosis)were compared with laparoscopic and histological *** calculated the sensitivity,specificity,positive predictive value and negative predictive value for the presence of colonoscopic findings of intestinal ***:A total of 174 consecutive women aged between 21-42 years with a diagnosis of deep pelvic endometriosis who underwent colonoscopy andsurgical intervention were included in our *** 76 of the women(43.6%),intestinal endometrial implants were found at surgery and histopathological ***,38 of the 76 lesions(50%)were characterized by the presence of serosal bowel nodules;28 of the 76 lesions(36.8%)reached the muscularis layer;8 of the 76 lesions(10.5%)reached the submucosa;and 2 of the 76 lesions(2.6%)reached the *** findings suggestive of intestinal endometriosis were detected in 7 of the174(4%)*** failed to diagnose intestinal endometriosis in 70 of the 76 women(92.1%).A colonoscopic diagnosis of endometriosis was obtained in all cases of mucosal involvement,in 3of 8 cases(37.5%)of submucosal involvement,in no cases of muscularis layer involvement and in 1 of 38cases(2.6%)of serosa *** sensitivity,s

关键词： Endometriosis Colonoscopy Intestinal Bowel Laparoscopy