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A case of acute infectious mononucleosis presenting with very high ferritin

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World Journal of Gastroenterology 2007年第4期13卷 637-638页

作者： Muhammed Hameed Thoufeeq Shahul Leyakath Ali Khan sanjiv kumar jain Hasanain Al-Shakerchi Munem Hussain Department of Medicine Pilgrim Hospital Boston United States Department of Medicine Bronglais Hospital Aberystwyth Wales United Kingdom

Hepatitis is an important but uncommon manifestation of acute Epstein Barr infection. Infectious mononucleosis is usually a disease of young adults. We report a case of infectious mononucleosis in a 72-year old jaundi... 详细信息

关键词：单核细胞增多症铁蛋白肝炎治疗方法

Ethnopharmacological,phytochemical and clinical studies on Fenugreek(Trigonella foenum-graecum L.)

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Food Bioscience 2022年第2期46卷 24-54页

作者： Neetu Singh Surender Singh Yadav sanjiv kumar Balasubramaniam Narashiman Department of Botany Maharshi Dayanand UniversityRohtakHaryana124001India Department of Pharmaceutical Sciences Ch.Bansi Lal UniversityBhiwaniHaryanaIndia Department of Pharmaceutical Sciences M.D.UniversityRohtakHaryana124001India

Trigonella foenum-graecum(fenugreek)belonging to the family Fabaceae,is widely used for both culinary as well as clinical purposes since *** medicines across globe particularly use this plant for boosting immunity and combating digestive and reproductive *** plant is rich reservoir of different phytoconstituents attributed to their diverse pharmacological ***,the present article is planned on its ethnomedicinal uses,botanical description,phytochemistry,pharmacology,toxicology,clinical efficacy,mechanism of action and nanoparticle *** all pharmacological studies,the dose,major bioactive,type of extract and possible outcomes is also discussed,to establish its specific role against a particular *** was hypothesized that the nanoparticle synthesis will lead to the enhanced *** showed that ethnomedicinal data well supports the different pharmacological aspects of Trigonella formulations in different ***(phytoestrogen)renders most of therapeutic potential of *** reported therapeutics can also be accounted as the synergistic pharmacology of different *** synthesis significantly improves its pharmacological *** studies well validated its antidiabetic and reproductive health improving *** no serious toxic effects were observed with the use of this plant but further well-designed placebo trials are still needed to demonstrate its full therapeutic potential.

关键词： Trigonella Fenugreek Traditional uses Pharmacology Clinical study Toxicology

实习医师施行巩膜扣带术治疗视网膜脱离的效果

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国际眼科杂志 2020年第9期20卷 1477-1481页

作者： kumar Aalok Singh Vipin Gupta sanjiv kumar Hind医学科学研究所眼科印度巴拉班基225003 乔治国王医科大学眼科印度勒克瑙226003

目的:评估实习医师施行巩膜扣带术治疗视网膜脱离的效果。方法:非比较回顾性病例。评估2017-07/2018-02在印度三级护理中心接受巩膜扣带术修复的孔源性视网膜脱离(RRD)患者的人口学、临床特征和效果。对所有患者的记录进行了筛查。统计... 详细信息

目的:评估实习医师施行巩膜扣带术治疗视网膜脱离的效果。方法:非比较回顾性病例。评估2017-07/2018-02在印度三级护理中心接受巩膜扣带术修复的孔源性视网膜脱离(RRD)患者的人口学、临床特征和效果。对所有患者的记录进行了筛查。统计分析采用Fisher确切干预,Mann-Whitney检验和Logistic回归分析。结果:共41例患者,其中男32例(78%),女9例(22%)。在我们的研究中,Ⅰ期解剖成功率为95%,视力明显提高。2例患者术后出现并发症—眼压升高、新裂孔以及再次脱离,经玻璃体切除术(PPV)内填塞及激光成功治疗。结论:研究表明,通过指导,实习医生对RRD患者行巩膜扣带术无论从术后解剖成功率、视力还是并发症发生率来看,均能获得较高的成功率。因此,尽管现有的治疗方法多种多样,但对于实习医生来说,巩膜扣带术是一种可接受的治疗RRD的主要方法。

关键词：巩膜扣带术孔源性视网膜脱离实习医师视网膜疾病眼部手术

Accuracy of preoperative CT liver volumetry in living donor hepatectomy and its clinical implications

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Hepatobiliary Surgery and Nutrition 2018年第3期7卷 167-174页

作者： Sanjay Goja Sanjay kumar Yadav Amardeep Yadav Tarun Piplani Amit Rastogi Prashant Bhangui sanjiv Saigal Arvinder Singh Soin Institute of Liver Transplant and Regenerative Medicine MedantaThe MedicityGurgaonDelhi(NCR)India Department of Radiology and Nuclear Medicine MedantaThe MedicityGurgaonDelhi(NCR)India

Background: An accurate preoperative volumetric assessment of donor liver is essential for successful living donor liver transplant by ensuring adequate remnant and graft recipient weight ratio (GRWR). Methods: The study cohort consisted of 744 right lobe (RL), 65 left lobe (LL) and 33 left lateral sector (LLS) grafts from July 2010 to January 2014. A semi-automated interactive commercial software called AW Volume share 6 was used for volumetry. Bland Altman plot was used for assessing the agreement between estimated graft weight (EGW) and actual graft weight (AGW). Results: There was no statistically significant difference between EGW and AGW for RL graft weight (722±134 vs. 717±126 gm;P=0.06). Although Bland Altman graph showed that 95% limits of agreement was more in LL (?164 to +110) than RL (?156 to +147) and LLS grafts (?137 to +239), CT scan significantly overestimated LL graft weight (EGW =460±118 gm vs. AGW =433±102 gm;P=0.003) and underestimated LLS graft weight (EGW =203±48 gm vs. AGW =254±49 gm;P<0.001). Conclusions: CT volumetry overestimate LL graft and underestimate LLS graft weight. This should be factored in when selecting LL graft by taking higher GRWR.

关键词： Liver transplantation graft weight CT volumetry living donor

A Prospective, Multicentric, Post Marketing Surveillance to Evaluate Efficacy & Safety of Ranitidine HCl (150 & 300 mg IR/CR) in Indian Patients with Gastroesophageal Reflux Disease (PROGRADE)

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Open Journal of Gastroenterology 2023年第7期13卷 237-249页

作者： Akash Shukla Anil kumar Awasthi Ramesh Rao Dawesh Prakash Yadav Nilesh Nolkha Rajesh Pendlimari sanjiv Dua Shrish Bhatnagar Ravindra Mote Ashish Birla Jay Savai Kapil Mehta Shashank Salunke Department of Gastroenterology Gastro Universe Mumbai India Department of Medicine Ajanta Research Centre Ajanta Hospital & IVF Centre Lucknow India Departmentof Nephrology Sanjeevani Kidney Care Mumbai India Department of Gastroenterology Institute of Medical Sciences Banaras Hindu University Varanasi India Department of Rheumatology Wockhardt Hospitals Mumbai India Department of Gastroenterology Rajalakshmi Hospital and Research Center Bangalore India Department of General Surgery SaiKripa Hospital Mumbai India Department of Gastroenterology Sparsh Child Care and Gastro Centre Lucknow India Department of Clinical Research Mediclin Clinical Research Mumbai India Department of Medical Affairs JB Chemicals & Pharmaceuticals Ltd. Mumbai India

Purpose: Ranitidine hydrochloride (HCl) remains an important medication for treating acid-peptic ailments such as Gastroesophageal reflux disease (GERD). The main objective of this Post Marketing Surveillance (PMS) clinical study was to test the efficacy and safety of Ranitidine HCl in Indian patients suffering from GERD. Patients and Methods: Data of 2446 patients (1307 males;1121 females) from 21 centers across India were analyzed. Patients received either of the three treatments: Ranitidine HCl 150 mg twice a day (BID) (ARM-A), Ranitidine HCl 300 mg once daily (OD) or BID (ARM-B), and Ranitidine HCl 300 mg OD (ARM-C). Gastroesophageal Reflux Disease Symptom Assessment Scale (GSAS) score and Heartburn Severity score were used to assess the drug’s efficacy. The adverse events reported by patients or investigators were analyzed to assess the safety profile of Ranitidine. Results: Of the 2446 subjects screened, 2428 were enrolled. There was a significant reduction in GSAS scores from baseline to the end of the study visit in all three ARMs. The GSAS scores reduced from 2.02 to 0.23 in ARM-A, 2.01 to 0.24 in ARM-B, and 2.07 to 0.26 in ARM-C patients. In ARM A, 72.82% had 24 hours heartburn-free days, and 66.89% had 7 consecutive heartburn-free days, which was more significant than the other two ARMs. 128 (5.27%) patients reported ADRs due to Ranitidine HCl at different doses. The most frequently reported ADR was constipation (17.18%), followed by oliguria (14.06%), cold (13.28%), and dysuria (12.5%). Of 128 ADRs, 113 (88.28%) were mild, and only 11 (8.59%) ADRs were related to the study drug. No severe ADRs were reported during the study. Conclusion: Ranitidine HCl 150/300 mg tablet was found to be an effective and safe H2-receptor antagonist for treating GERD in Indian Patients.

关键词： Ranitidine Hydrochloride GERD Heartburn H2-Receptor Antagonists

Groundwater pollution by arsenic concentration in sedimentary aquifers in the Indo-Gangetic Basin of Nepal

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Chinese Journal Of Geochemistry 2006年第B8期25卷 139-139页

作者： Sunil kumar Dwivedi Pusker Raj Joshi sanjiv Shrestha Yaga Raj Bhandari Ram Bhadur Sah Department of Physics and Earth Sciences University of the Ryukyus Okinawa 903-0213 Japan Department of Geology Tri-Chandra College Ghantaghar Kathmandu Nepal Department of Environment Science Tri-Chandra College Ghantaghar Kathmandu Nepal United Nation Development Programme （UNDP） Kathmandu Nepal Central Department of Geology Tirbhuvan University Kirtipur Kathmandu Nepal

白花蛇舌草激发肿瘤细胞产生超氧化物和激活半胱氨酸天冬氨酸蛋白酶诱导肿瘤细胞凋亡(英文)

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中西医结合学报 2006年第5期4卷 485-489页

作者：雅达赋李少钦新加坡国立大学杨潞龄医学院新加坡117597

背景与目的:白花蛇舌草是常用于抗肿瘤的中药之一。实验研究和临床使用表明该药有明显的抗肿瘤作用,但是该药抗癌作用的原理尚不清楚。本文研究了白花蛇舌草的乙醇和水的提取物对人急性髓样白血病细胞HL60生存和死亡的影响及其机制。方... 详细信息

背景与目的:白花蛇舌草是常用于抗肿瘤的中药之一。实验研究和临床使用表明该药有明显的抗肿瘤作用,但是该药抗癌作用的原理尚不清楚。本文研究了白花蛇舌草的乙醇和水的提取物对人急性髓样白血病细胞HL60生存和死亡的影响及其机制。方法:我们用白花蛇舌草的提取物处理细胞,在处理后2h开始测量细胞内的超氧化物及各种半胱氨酸天冬氨酸蛋白酶(caspase)的水平,并于24h测量细胞的生存及凋亡情况。结果:我们发现乙醇和水的提取物对HL60细胞的生存有较强的抑制作用。对乙醇提取物的进一步研究则表明该提取物能有效地激活caspase-2和caspase-3并诱发癌细胞凋亡。乙醇提取物在较短的时间(2h)内诱导细胞产生超氧化物。结论:白花蛇舌草乙醇提取物能有效地激发肿瘤细胞产生超氧化物并诱导肿瘤细胞凋亡。由于细胞内产生超氧化物能诱导细胞凋亡,我们认为白花蛇舌草的抗癌机制是通过激发肿瘤细胞产生大量超氧化物,致使癌细胞内氧爆破,最终激活凋亡信号网络而使癌细胞凋亡。

关键词：白花蛇舌草肿瘤超氧化物半胱氨酸天冬氨酸蛋白酶细胞凋亡