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Inverse modelling of aquifer parameters in basaltic rock with the help of pumping test method using MODFLOW software

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Geoscience Frontiers 2017年第6期8卷 1385-1395页

作者： Kanak Moharir Chaitanya Pande sanjay patil Sant Gadge Baba Amravati University AmravatiIndia Maharashtra Remote Sensing Application Center PuneIndia

The origin and movement of groundwater are the fundamental questions that address both the temporal and spatial aspects of ground water run and water supply related issues in hydrological *** groundwater flows through an aquifer,its composition and temperature may variation dependent on the aquifer condition through which it ***,hydrologic investigations can also provide useful information about the subsurface geology of a *** because such studies investigate processes that follow under the Earth's shallow,obtaining the information necessary to answer these questions is not continuously ***,which discharge groundwater table directly,afford to study subsurface hydrogeological *** present study of estimation of aquifer factors such as transmissivity(T)and storativity(S)are vital for the evaluation of groundwater *** are several methods to estimate the accurate aquifer parameters(*** analysis,pumping test,etc.).In initial days,these parameters are projected either by means of in-situ test or execution test on aquifer well samples carried in the *** simultaneous information on the hydraulic behavior of the well(borehole)that provides on this method,the reservoir and the reservoir boundaries,are important for efficient aquifer and well data management and *** most common in-situ test is pumping test performed on wells,which involves the measurement of the fall and increase of groundwater level with respect to *** alteration in groundwater level(drawdown/recovery)is caused due to pumping of water from the ***(1935)was first to propose method to evaluate aquifer parameters from the pumping test on a bore well in a confined *** is essential to know the transmissivity(T=Kb,where b is the aquifer thickness;pumping flow rate,Q=TW(dh/dl)flow through an aquifer)and storativity(confined aquifer:S=bS_s,unconfined:S=S_y),for the characterization of the aquifer parameters in an unkn

关键词： Pumping test Hantush method GPS MODFLOW Inverse modelling Hydraulic parameters

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Dual-tree complex wavelet transform and super-resolution based video inpainting application to object removal and error concealment

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CAAI Transactions on Intelligence Technology 2020年第4期5卷 314-319页

作者： Gajanan Tudavekar sanjay R.patil Santosh S.Saraf Department of Electronics&Communication Engineering Angadi Institute of Technology and ManagementBelagaviKarnatakaIndia Visvesvaraya Technological University BelagaviKarnatakaIndia Department of Electronics&Telecommunication Engineering Marathwada Institute of TechnologyAurangabadMaharashtraIndia Department of Electronics&Communication Engineering KLS Gogte Institute of TechnologyBelagaviKarnatakaIndia

Video inpainting is a technique that fills in the missing regions or gaps in a video by using its known *** existing video inpainting algorithms are computationally expensive and introduce seam in the target region that arises due to variation in brightness or contrast of the *** overcome these drawbacks,the authors propose a novel two-stage *** the first step,sub-bands of wavelets of a low-resolution image are obtained using the dualtree complex wavelet *** algorithm and auto-regression technique are then applied to these subbands to inpaint the missing *** fuzzy logic-based histogram equalisation is used to further enhance the image by preserving the image brightness and improve the local *** the second step,the image is enhanced using super-resolution *** process of down-sampling,inpainting and subsequently enhancing the video using the super-resolution technique reduces the video inpainting *** framework is tested on video sequences by comparing and analysing the structural similarity index matrix,peak-signal-to-noise ratio,visual information fidelity in pixel domain and execution time with the state-of-the-art *** experimental analysis gives visually pleasing results for object removal and error concealment.

关键词： resolution video image

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Chlorogenic acid may be a potent inhibitor of dimeric SARS-CoV-2 main protease 3CLpro: an in silico study

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Traditional Medicine Research 2021年第2期6卷 135-148页

作者： Rajkumar sanjay patil Nayeem A.Khatib Vishal Shivalingappa patil Shailendra sanjay Suryawanshi Department of Pharmacology and Toxicology KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia Department of Pharmaceutical Chemistry KLE College of PharmacyBelagaviKLE Academy of Higher Education and ResearchJNMC CampusNehru NagarBelagavi 590010KarnatakaIndia

Background:Since the emergence of coronavirus disease 2019 to date,there is no available approved drug or definitive treatment for coronavirus disease 2019 viral infection,and the identification of novel hits against therapeutic targets has become a global *** purpurea is a traditional herb utilized to treat cough,fever,sore throat,respiratory tract infection,and so on as an immune *** this study,in silico molecular docking approach was used to screen phytocompounds from *** against severe acute respiratory syndrome coronavirus 2 main protease 3C-like protease(3CLpro)and severe acute respiratory syndrome coronavirus main peptidase(96%sequence similarity)to blunt the viral gene expression and viral ***:Initially,we screened phytocompounds for their druggability and ADMET ***,x-ray crystallographic structures of main proteases 3CLpro and main peptidase having Protein Data Bank ID 6LU7 and 2GTB were used as protein targets for the identification of potential drug *** performed docking using AutoDock Vina by PyRx 0.8 *** Discovery Studio Visualizer v2019 was used to analyze ligand-protein *** probable protein targets of the selected compound were predicted by BindingDB(P≥0.7).STRING and Kyoto Encyclopedia of Genes and Genomes pathways are utilized to identify the molecular pathways modulated by the predicted targets(FDR≤0.05),and the network interaction between compounds and protein pathways was constructed by Cytoscape ***:Among all the compounds,chlorogenic acid showed druggable characteristics and scored the lowest binding energy with main protease and main peptidase via interacting with active site 1 domain amino acid ***,chlorogenic acid interacted with Phe140 main protease 3CLpro,which is potentially involved in the *** analysis identified chlorogenic acid to modulate insulin resistance,necroptosis,interleukin-17,tumor nec

关键词： Molecular docking Echinacea purpurea Chlorogenic acid COVID-19 Main protease 3CLpro Network pharmacology

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Fabrication of Nanocrystalline TiO<sub>2</sub>Thin Film Ammonia Vapor Sensor

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Journal of Sensor Technology 2011年第1期1卷 9-16页

作者： Shailesh Pawar Manik Chougule sanjay patil Bharat Raut Dhanaji Dalvi Pramod patil Shashwati Sen Pradeep Joshi Vikas patil 不详

Nanocrystalline titanium oxide thin films have been deposited by spin coating technique and then have been analyzed to test their application in NH3 gas-sensing technology. In particular, spectrophotometric and con-ductivity measurements have been performed in order to determine the optical and electrical properties of titanium oxide thin films. The structure and the morphology of such material have been investigated by X ray diffraction, Scanning microscopy, high resolution electron microscopy and selected area electron diffrac-tion. The X-ray diffraction measurements confirmed that the films grown by this technique have good crys-talline tetragonal mixed anatase and rutile phase structure The HRTEM image of TiO2 thin film showed grains of about 50-60 nm in size with aggregation of 10-15 nm crystallites. Selected area electron diffraction pattern shows that the TiO2 films exhibited tetragonal structure. The surface morphology (SEM) of the TiO2 film showed that the nanoparticles are fine The optical band gap of TiO2 film is 3.26 eV. Gas sensing proper-ties showed that TiO2 films were sensitive as well as fast in responding to NH3. A high sensitivity for ammo-nia indicates that the TiO2 films are selective for this gas.

关键词： Sol Gel Method Structural Properties Optical Properties NH3 Sensor

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Nanocrystalline CuO Thin Films for H<sub>2</sub>S Monitoring: Microstructural and Optoelectronic Characterization

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Journal of Sensor Technology 2011年第2期1卷 36-46页

作者： Vikas patil Datta Jundale Shailesh Pawar Manik Chougule Prsad Godse sanjay patil Bharat Raut Shashwati Sen 不详

Nanocrystalline copper oxide (CuO) thin films were deposited onto glass substrates by a spin coating technique using an aqueous solution of copper acetate. These films were characterized for their structural, mor-phological, optoelectronic properties by means of X-ray diffraction (XRD) scanning electron microscopy (SEM), UVspectroscopy and four probe method. The CuO films are oriented along (1 1 1) plane with the monoclinic crystal structure. These films were utilized in H2S sensors. The dependence of the H2S response on the operating temperature, H2S concentration of CuO film (annealed at 700。C) was investigated. The CuO film showed selectivity for H2S. The maximum H2S response of 25.2 % for the CuO film at gas concentra-tion of 100 ppm at operating temperature 200oC was achieved.

关键词： CuO Thin Films Structural Properties Optoelectronic Properties H2S Sensor

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Double-face urethroplasty in patients with obliterative bulbar strictures post-transurethral resection of the prostate mid-term outcomes in high-volume referral center

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Asian Journal of Urology 2023年第4期10卷 512-517页

作者： Pankaj M.Joshi Manuel Hevia Yatam Lakshmi Sreeranga Marco Bandini Amey patil Shreyas Bhadranavar Vipin Sharma Sandeep Bafna sanjay B.Kulkarni Kulkarni Reconstructive Urology Center 3Rajpath SocietyPaud RoadPune 411038India Urology Department Ramón y Cajal University HospitalIRYCISUniversity of AlcaláMadridSpain Urological Research Institute(URI) Unit of UrologyIRCCS Ospedale San RaffaeleVita SaluteSan Raffaele UniversityMilanMIItaly

Objective Incidences of post-transurethral resection of the prostate(post-TURP)strictures are between 2.2%and 9.8%.Stricture commonly occurs within the first 6 *** objective was to assess the outcomes of patients with obliterative strictures post-TURP that underwent a double-face *** This is a single-center prospective study of 17 patients with obliterative proximal bulbar stricture post-TURP who underwent double-face graft urethroplasty by two surgeons between January 2014 and January *** defined post-TURP obliterative strictures as those patients who presented with complete or almost complete obstruction of the urethral lumen and who have had a history of acute urine *** have excluded patients with bladder neck *** outcome was treatment success,defined as the no need for further *** outcome was post-urethroplasty continent *** Seventeen patients were included in the study with median age of 66(interquartile range 40-77)years;median time of follow-up was 24(interquartile range 12-84)months;median stricture length was 4(interquartile range 2-6)*** the 17 patients,15(88.2%)were *** patients were continent after *** With mid-term follow-up,treatment of obliterative proximal bulbar strictures with double-face buccal mucosa graft is a safe and effective *** proximal bulbar strictures merit double-face urethroplasty with high-rate success and functional outcomes.

关键词： Double-face urethroplasty Obliterative urethral stricture Post-transurethral resection of prostate Urethral stricture Spongiofibrosis Iatrogenic stricture

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Enhanced osseointegration of drug eluting nanotubular dental implants: An in vitro and in vivo study

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Bioactive Materials 2023年第10期28卷 432-447页

作者： Pankaj Chauhan Alok Srivastava Pooja Bhati Manish Chaturvedi Vinay patil Sriram Kunnoth Nisha Kumari Vedpal Arya Madhur Pandya Mohit Agarwal Smiti Bhardwaj Farrukh Faraz sanjay Chauhan Mahesh Verma Veena Koul Naresh Bhatnagar Homi Bhabha Cancer Hospital and Research Centre VizagAndhra PradeshIndia Centre for Biomedical Engineering Indian Institute of Technology DelhiIndia Department of Mechanical Engineering Indian Institute of Technology DelhiIndia Mechanical&Automation Engineering Indira Gandhi Delhi Technical University for WomenNew DelhiIndia Rajasthan Technical University Kota RajasthanIndia Applied Mechanics Indian Institute of Technology DelhiIndia National University of Singapore Singapore Department of Periodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia Rajasthan Dental College and Hospital JaipurRajasthanIndia Department of Prosthodontics Maulana Azad Institute of Dental SciencesNew DelhiIndia

Faster and predictable osseointegration is crucial for the success of dental implants, especially in patients with compromised local or systemic conditions. Despite various surface modifications on the commercially available Titanium (Ti) dental implants, the bioactivity of Ti is still low. Thus, to achieve both biological and therapeutic activity on titanium surfaces, surface modification techniques such as titanium nanotubes have been studied as nanotube surfaces can hold therapeutic drugs and molecules. The main aim of the present research work is to study the early osseointegration around the novel Simvastatin drug eluting nanotubular dental implant. In the present research, the titanium nanotubes were fabricated on the screw-shaped dental implant surface and the Simvastatin drug was loaded into the nanotubes using the ultrasonication dip method. In vitro and In vivo studies were carried out on the modified dental implants. In vitro cell culture study reported enhanced osteogenic activity on the drug-loaded nanotube surface implants. The in vivo animal studies were evaluated by micro-CT, histopathology, and reverse torque removal analysis methods. The test results showed faster osseointegration with the strong interface on the Simvastatin drug-loaded implant surface at 4 weeks of healing as compared to the control implants.

关键词： Titanium Biocompatibility Simvastatin Nanotube Micro CT Histopathology Nanoscale

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Potential of herbal constituents as new natural leads against helminthiasis: A neglected tropical disease

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Asian Pacific Journal of Tropical Medicine 2019年第7期12卷 291-299页

作者： Kiran D.patil Shashikant B.Bagade sanjay R.Sharma Ketan V.Hatware NMIMS School of Pharmacy and Technology Management

The WHO reports that billions of people and animals in tropical and subtropical regions are affected by helminthiasis as neglected tropical disease. It is predominant in underdeveloped areas;nevertheless, the increase in the number of travelers and migrants has made this infection more common. The current mass drug treatment produces severe side effects and many strains of helminths are resistant to them. None of the chemotherapeutic drugs meets the ideal requirements of anthelmintics, such as broad spectrum of activity, single dose cure, free from side effect and cost-effectiveness. Today, many researchers are screening the traditional herbal system in search of the anthelmintic herbal constituents which overcome all the problems of synthetic drugs. Several researchers proclaim anthelmintic activity of herbal medicines by using different experimental models. The present review demonstrates natural product drug discovery, outlining potential of herbal constituents from natural sources as natural leads against helminthiasis.

关键词： Neglected tropical diseases Herbal constituents Helminthiasis Herbal anthelmintics

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Dual inhibition of COVID-19 spike glycoprotein and main protease 3CLpro by Withanone from Withania somnifera

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Chinese Herbal Medicines 2021年第3期13卷 359-369页

作者： Vishal Shivalingappa patil Vrushabh B.Hupparage Ajay P.Malgi sanjay H.Deshpande Sathgowda A.patil Shamanand P.Mallapur Department of Pharmacology and Toxicology KLE College of PharmacyKLE Academy of Higher Education and Research(KAHER)Belagavi 590010India Regional Centre for Biotechnology NCR-Biotech Science ClusterFaridabad 121001India

Objective:To identify the safe and effective natural inhibitors of spike glycoprotein and main protease 3CLpro using potential natural antiviral compounds which are studied under various animal models and viral cell ***:First,compounds were retrieved from the Pub Chem database and predicted for their druggability using the Mol Soft web server,and compounds having drug-like property were predicted for major adverse drug reactions like cardiotoxicity,hepatotoxicity,arrhythmia,myocardial infarction,and nephrotoxicity using *** of nontoxic antiviral compounds with spike glycoprotein and main protease 3CLpro was performed using Auto Dock vina by PyRx 0.8 *** stability of compoundprotein interactions was checked by molecular dynamic(MD)simulation using Schrodinger Desmond ***:Based on the druggable and nontoxic profile,nine compounds were *** them,Withanone from Withania somnifera showed the highest binding affinity and best fit at active sites 1 of spike glycoprotein(glycosylation site)and main protease 3CLpro via interacting with active site amino acid residues before and after MD simulation at 50 ***,which may reduce the glycosylation of SARS-CoV-2 via interacting with Asn343 and inhibit viral ***:The current study reports Withanone as a non-toxic antiviral against SARS-CoV-2 and serve as a potential lead hit for further experimental validation.

关键词： antiviral COVID-19 docking dynamics main protease 3CLpro SARS-CoV-2 spike glycoprotein Withanone Withania somnifera(Linn.)Dunal

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Comparison of skeletal, dental and soft tissue changes in young adults with Class II malocclusion, treated either by camouflage, fixed functional appliance or orthognathic surgery—A prospective study on Indian subjects

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Open Journal of Stomatology 2012年第4期2卷 373-382页

作者： Anjana Shetty Anand patil sanjay Ganeshkar Department of Orthodontics and Dentofacial Orthopaedics AECS Maaruthi Dental College Banglore India Department of Orthodontics and Dentofacial Orthopaedics SDM College of Dental Sciences Dharwad India

Introduction: Borderline Class II malocclusion due to deficient mandible can be treated either by orthodontic camouflage, fixed functional appliances or by orthodontics followed by surgical mandibular advancement. Methodology: A prospective study was designed on young adults with Class II malocclusion on account of a deficient mandible. A total of 45 subjects were divided into three groups of 15 individuals each. The patients were treated either by camouflage, fixed functional appliances or by orthognathic surgery. Pre and post treatment cephalograms were used to assess the skeletal, dental and soft tissue changes. Pre and post treatment profile photographs were assessed on a Visual Analogue Scale (VAS) by orthodontists, oral surgeons and laypersons. Results: Each group achieved a reduction in facial convexity, but the results obtained from the surgical group were more pronounced than the camouflage and the fixed functional group. Conclusion: The reduction in convexity in the camouflage group was by retracting the upper anteriors, which increases the nasolabial angle. In the fixed functional appliance a combination of skeletal and dentoalveolar changes can be observed. However the most appropriate reduction in profile convexity can be obtained by combined orthodontic and surgical treatment of malocclusion.

关键词： Class II Malocclulsion Camouflage Fixed Function Appliance Orthognathic Surgery

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