检索结果-南通市图书馆

检索条件"作者=sangwan Lee"

共 1 条记录，以下是1-10 订阅

全选清除本页清除全部题录导出标记到"检索档案"

详细简洁

排序：

ACID-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavior in Head and Neck Squamous Cell Carcinomas

ACID-Functionalized Porphyrazines Exhibit ANTI-Tumor Behavio...

引用

第四届中国肿瘤学术大会暨第五届海峡两岸肿瘤学术会议

作者： Benjamin J. Vesper Neal D. Hammer sangwan lee Kim Elseth Anthony G. M. Barrett Brian M. Hoffman James A. Radosevich Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA Department of Chemistry Imperial College of Science Technology and MedicineExhibition RoadSouth KensingtonLondonSW7 2AZUK Department of Chemistry Northwestern University 2145 N.Sheridan Rd.EvanstonIL60208USA Center for Molecular Biology of Oral Diseases College of Dentistry University of Illinois at Chicago801 S.Paulina St.ChicagoIL60612USA

＜正＞Background/Aims: The porphyrin drug Photofrin is used in photodynamic therapy applications to clinically treat oral and upper aerodigestive tract tumors;however, this drug is limited by its inadequate tumor selectivity and poor optical properties-common problems for members of the porphyrin family. We are currently studying a class of porphyrin derivatives, the porphyrazines （pzs）, which possess superior optical properties and greater synthetic flexibility than the porphyrins and show promise as both PDT agents and traditional anti - tumor agents. Previous work in our laboratory has shown that a subfamily of acid - functionalized pzs exhibit selective anti - tumor activity in A549 human lung adenocarcinoma cells. We here expand this study to test these same pzs in a number of head and neck squamous cell carcinoma （SCC） cell lines. Methods: MTT proliferation/viability assays were used to test the toxicity of three H2[pz（ An;B4-n） ] pzs, where n = 4, 3, or 2 （ in a trans conformation）, A is [S（CH2）3COOH], and B is a fused β,β’ - diisopropyloxybenzo ring. Five SCC cell lines were exposed to the pzs at concentrations of 12.5 - 50 μM, for periods of 24, 48, and 72 hours. Results: As the number of terminal acid groups on the pzs was increased, the amount of toxicity observed in the SCC cell lines upon 72 hour exposure also increased-a trend which was also observed previously in the A549 adenocarcinoma cell line. Additionally, at any given concentration, each compound was found to kill a greater percentage of tumor cells than normal cells. Normal cells were found to be unaffected by the H2A2B2 pz （four acid groups） at concentrations of 25 μM and below, whereas all five SCC cell lines exhibited toxicity in the presence of each of the three pzs at all concentrations studied （12.5 - 50 μM）. Conclusion: The acid - appended pzs were found to exhibit the same structure - function relationship in both adeno-carcinomas and squamous cell carcinomas. The selective tumor toxicity

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

全选清除本页清除全部题录导出标记到“检索档案”

共1页 << < 1 > >>

回到顶部

执行限定条件

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：